{"title":"Some pharmaceutical properties of novobiocin.","authors":"J D MULLINS, T J MACEK","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23444713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A preliminary pharmacologic investigation of the roots of Bixa orellana.","authors":"N W DUNHAM, K R ALLARD","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23439594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Bickerton, M. Jacquart, W. Kinnard, J. A. Bianculli, J. Buckley
The hypotensive activity of a series of diquaternarized tetrahydroisoquinoline and tetrahydroquinoiine derivatives was investigated in the anesthetized rat. The compounds were evaluated according to the mean duration of action of the dose of the compound producing a mean drop in blood pressure of approximately 50 per cent. Several of the compounds were further evaluated in normotensive dogs. The most active compounds were 1-(1,2,3,4-tetrahydroisoquinolino)-5-dimethylamino-3-hydroxy-3-ethinyl pentane dimethobromide (JB-5037), N-(3-dimethylamino-propyl)-1,2,3,4-tetrahydroisoquinoline dimethobromide (JB-621, IN-243) and 1-(1,2,3,4-tetrahydroisoquinolino)-5-dimethylamino-2-pentyne dimethiodide (JB-679).
{"title":"An evaluation of certain hypotensive agents. III. Tetrahydroisoquinoline and tetrahydroquinoline derivatives.","authors":"R. Bickerton, M. Jacquart, W. Kinnard, J. A. Bianculli, J. Buckley","doi":"10.1002/JPS.3030490402","DOIUrl":"https://doi.org/10.1002/JPS.3030490402","url":null,"abstract":"The hypotensive activity of a series of diquaternarized tetrahydroisoquinoline and tetrahydroquinoiine derivatives was investigated in the anesthetized rat. The compounds were evaluated according to the mean duration of action of the dose of the compound producing a mean drop in blood pressure of approximately 50 per cent. Several of the compounds were further evaluated in normotensive dogs. The most active compounds were 1-(1,2,3,4-tetrahydroisoquinolino)-5-dimethylamino-3-hydroxy-3-ethinyl pentane dimethobromide (JB-5037), N-(3-dimethylamino-propyl)-1,2,3,4-tetrahydroisoquinoline dimethobromide (JB-621, IN-243) and 1-(1,2,3,4-tetrahydroisoquinolino)-5-dimethylamino-2-pentyne dimethiodide (JB-679).","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90554255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation and properties of new gastric antacids. II. Aluminum hydroxide-protein dried gels.","authors":"S M BEEKMAN, C H VOGEL","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23441800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Binding of drugs by plastics. II. Interaction of weak organic acids with plastic syringes.","authors":"H K KIM, J AUTIAN","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23443855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serotonin-induced apnea.","authors":"D C KROEGER, L J LUCCO","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23443111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Color stability of tablet formulations. II. Influence of light intensity on the fading of several water-soluble dyes.","authors":"L LACHMAN, C J SWARTZ, T URBANYI, J COOPER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23442731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enteric coatings. III. An improved enteric coating and its in vitro evaluation.","authors":"J G WAGNER, S LONG","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23447023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enteric coatings. V. pH Dependence and stability.","authors":"J G WAGNER, G W RYAN, E KUBIAK, S LONG","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23447024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enteric coatings. IV. In vivo testing of granules and tablets coated with styrene-maleic acid copolymer.","authors":"J G WAGNER, W VELDKAMP, S LONG","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23447026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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