{"title":"Emulsification with ultrasonic waves. I. Evaluation of the minisonic and a modified analysis procedure.","authors":"R E SINGISER, H M BEAL","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23447876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interaction of preservatives with macromolecules. IV. Binding of quaternary ammonium compounds by nonionic agents.","authors":"P P DELUCA, H B KOSTENBAUDER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23440363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A method was developed to calculate drug absorption rate from urinary excretion rate measurements and applied to study tetracycline absorption in humans after oral ingestion of 25, 50, 100, and 200-mg. doses. Calculation of absorption rate indicated that this drug was absorbed at a rate of about 100 to 140 mg./hr., one hour after 200-mg. doses, and at about 20 to 30 mg./hr., one hour later. Rates at these times decreased when the dose was reduced. Wide individual variation in absorption rate was observed among members of the test panel.
{"title":"Urinary excretion kinetics for evaluation of drug absorption. III. Method for calculation of absorption rate and application to tetracycline absorption in humans.","authors":"E. Nelson","doi":"10.1002/JPS.3030490709","DOIUrl":"https://doi.org/10.1002/JPS.3030490709","url":null,"abstract":"A method was developed to calculate drug absorption rate from urinary excretion rate measurements and applied to study tetracycline absorption in humans after oral ingestion of 25, 50, 100, and 200-mg. doses. Calculation of absorption rate indicated that this drug was absorbed at a rate of about 100 to 140 mg./hr., one hour after 200-mg. doses, and at about 20 to 30 mg./hr., one hour later. Rates at these times decreased when the dose was reduced. Wide individual variation in absorption rate was observed among members of the test panel.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83954713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Three ultrasonic generators and a colloid mill were evaluated with 25 per cent mineral oil, peanut oil, and safflower oil emulsions, each made with four emulsifier systems. Emulsions were exposed in each apparatus for periods up to fifteen minutes. The best of these emulsions were analyzed after zero, fifteen, thirty, and sixty days storage. From the size-frequency analysis data specific interfacial area, mean globule diameter, and standard deviation were calculated. The Minisonic homogenizer produced emulsions distinctly superior to those made on any other apparatus.
{"title":"Emulsification with ultrasonic waves. II. Evaluation of three ultrasonic generators and a colloid mill.","authors":"R. Singiser, H. M. Beal","doi":"10.1002/JPS.3030490719","DOIUrl":"https://doi.org/10.1002/JPS.3030490719","url":null,"abstract":"Three ultrasonic generators and a colloid mill were evaluated with 25 per cent mineral oil, peanut oil, and safflower oil emulsions, each made with four emulsifier systems. Emulsions were exposed in each apparatus for periods up to fifteen minutes. The best of these emulsions were analyzed after zero, fifteen, thirty, and sixty days storage. From the size-frequency analysis data specific interfacial area, mean globule diameter, and standard deviation were calculated. The Minisonic homogenizer produced emulsions distinctly superior to those made on any other apparatus.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83015209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complexing tendecies of saccharin in aqueous solutions.","authors":"J R MARVEL, A P LEMEBERGER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23443136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The preparation and use of radioiodinated Congo red in detecting amyloidosis.","authors":"M TUBIS, W H BLAHD, R A NORDYKE","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23448348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An investigation of particle-medium interactions in suspensions.","authors":"W A HADDAD-LOUIS, A P LEMBERGER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23443301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Congo red concentrates in amyloid tissue. This study was undertaken to prepare a radioactive congo red which would concentrate in amyloid, permitting external counting and, thereby, scanning and localization, as well as blood concentration measurement. Two methods were used to trace-label the dye to an adequate specific activity for such studies. Injection into guinea pigs with amyloidosis resulting from induced chronic scurvy indicated deposits and radioactivity in the liver and other organs. The “tagged” dye shows promise for locating amyloid and may serve as a means for evaluating drugs for the resorption of amyloid. The method of direct radioiodination is applicable to other similar chemical compounds.
{"title":"The preparation and use of radioiodinated Congo red in detecting amyloidosis.","authors":"M. Tubis, W. Blahd, R. Nordyke","doi":"10.1002/JPS.3030490706","DOIUrl":"https://doi.org/10.1002/JPS.3030490706","url":null,"abstract":"Congo red concentrates in amyloid tissue. This study was undertaken to prepare a radioactive congo red which would concentrate in amyloid, permitting external counting and, thereby, scanning and localization, as well as blood concentration measurement. Two methods were used to trace-label the dye to an adequate specific activity for such studies. Injection into guinea pigs with amyloidosis resulting from induced chronic scurvy indicated deposits and radioactivity in the liver and other organs. The “tagged” dye shows promise for locating amyloid and may serve as a means for evaluating drugs for the resorption of amyloid. The method of direct radioiodination is applicable to other similar chemical compounds.","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90498469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new method of manufacture of tablet granulations. II.","authors":"P A TUERCK, E L WALTERS, E D CARKHUFF","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23448349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Studies on the stability of filipon. I. Thermal degradation in the presence of air.","authors":"J E TINGSTAD, E R GARRETT","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17210,"journal":{"name":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1960-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23445701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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