Pub Date : 2025-01-01Epub Date: 2024-11-15DOI: 10.1681/ASN.0000000562
Qais Al-Awqati
{"title":"Comparing Torsemide with Furosemide: Finally a Mechanistic Approach that Says, \"Enough Already\".","authors":"Qais Al-Awqati","doi":"10.1681/ASN.0000000562","DOIUrl":"10.1681/ASN.0000000562","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"36 1","pages":"10-12"},"PeriodicalIF":10.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-12-03DOI: 10.1681/ASN.0000000573
Allison E Norlander, David P Basile
{"title":"ST2 + T-Regulatory Cells as a Potential Immunotherapy Target for Kidney Fibrosis.","authors":"Allison E Norlander, David P Basile","doi":"10.1681/ASN.0000000573","DOIUrl":"10.1681/ASN.0000000573","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"7-9"},"PeriodicalIF":10.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-08-28DOI: 10.1681/ASN.0000000000000481
Veena S Rao, Zachary L Cox, Juan B Ivey-Miranda, Daniel Neville, Natasha Balkcom, Julieta Moreno-Villagomez, Daniela Ramos-Mastache, Christopher Maulion, Lavanya Bellumkonda, W H Wilson Tang, Sean P Collins, Eric J Velazquez, Robert J Mentz, F Perry Wilson, Jeffrey M Turner, Christopher S Wilcox, David H Ellison, James C Fang, Jeffrey M Testani
{"title":"Mechanistic Differences between Torsemide and Furosemide.","authors":"Veena S Rao, Zachary L Cox, Juan B Ivey-Miranda, Daniel Neville, Natasha Balkcom, Julieta Moreno-Villagomez, Daniela Ramos-Mastache, Christopher Maulion, Lavanya Bellumkonda, W H Wilson Tang, Sean P Collins, Eric J Velazquez, Robert J Mentz, F Perry Wilson, Jeffrey M Turner, Christopher S Wilcox, David H Ellison, James C Fang, Jeffrey M Testani","doi":"10.1681/ASN.0000000000000481","DOIUrl":"10.1681/ASN.0000000000000481","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"99-107"},"PeriodicalIF":10.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-10-25DOI: 10.1681/ASN.0000000563
Thomas Körtl, Niklas Hankowitz, Laura Stengel, Oliver Pfeuffer, Dominic Riedl, Frank Schweda, Katrin Streckfuß-Bömeke, Samuel Sossalla
{"title":"In Vitro Simulation of Hemodialysis Reveals Hemodialysis-Associated Pro-Arrhythmic Effects in a Human Cardiomyocyte Model.","authors":"Thomas Körtl, Niklas Hankowitz, Laura Stengel, Oliver Pfeuffer, Dominic Riedl, Frank Schweda, Katrin Streckfuß-Bömeke, Samuel Sossalla","doi":"10.1681/ASN.0000000563","DOIUrl":"10.1681/ASN.0000000563","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"133-135"},"PeriodicalIF":10.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-09-03DOI: 10.1681/ASN.0000000000000488
Yujie Huang, Ansheng Cong, Jinjin Li, Zhanmei Zhou, Hong Zhou, Cailing Su, Zuoyu Hu, Fan Fan Hou, Wei Cao
{"title":"Glycolysis in Peritubular Endothelial Cells and Microvascular Rarefaction in CKD.","authors":"Yujie Huang, Ansheng Cong, Jinjin Li, Zhanmei Zhou, Hong Zhou, Cailing Su, Zuoyu Hu, Fan Fan Hou, Wei Cao","doi":"10.1681/ASN.0000000000000488","DOIUrl":"10.1681/ASN.0000000000000488","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"19-33"},"PeriodicalIF":10.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-08-27DOI: 10.1681/ASN.0000000000000480
Frida Lona-Durazo, Kohei Omachi, Damian Fermin, Felix Eichinger, Jonathan P Troost, Meei-Hua Lin, Ian R Dinsmore, Tooraj Mirshahi, Alexander R Chang, Jeffrey H Miner, Andrew D Paterson, Moumita Barua, Sarah A Gagliano Taliun
{"title":"Association of Genetically Predicted Skipping of COL4A4 Exon 27 with Hematuria and Albuminuria.","authors":"Frida Lona-Durazo, Kohei Omachi, Damian Fermin, Felix Eichinger, Jonathan P Troost, Meei-Hua Lin, Ian R Dinsmore, Tooraj Mirshahi, Alexander R Chang, Jeffrey H Miner, Andrew D Paterson, Moumita Barua, Sarah A Gagliano Taliun","doi":"10.1681/ASN.0000000000000480","DOIUrl":"10.1681/ASN.0000000000000480","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"48-59"},"PeriodicalIF":10.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Opening New Routes for Kidney Therapy.","authors":"Sara Kinstlinger, Moran Dvela-Levitt","doi":"10.1681/ASN.0000000616","DOIUrl":"https://doi.org/10.1681/ASN.0000000616","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Shear Forces and the Vulnerability of the Podocyte.","authors":"Josephine P Briggs,Mark A Knepper","doi":"10.1681/asn.0000000590","DOIUrl":"https://doi.org/10.1681/asn.0000000590","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"41 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Iltis,Glenda V Roberts,Marva Moxey-Mims,Alexis Conell,Jennifer Davis,Rasheed Gbadegesin,Patrick Gee,Nichole Jefferson,Heather Johnson,Giftay Kingston,Kathryn Lindsay,Mariella Ortigosa-Goggins,Sylvia Rosas,Laurie Russell,Krista L Lentine,
{"title":"Practical Considerations for Sharing Race-Based Genetic Research Findings.","authors":"Ana Iltis,Glenda V Roberts,Marva Moxey-Mims,Alexis Conell,Jennifer Davis,Rasheed Gbadegesin,Patrick Gee,Nichole Jefferson,Heather Johnson,Giftay Kingston,Kathryn Lindsay,Mariella Ortigosa-Goggins,Sylvia Rosas,Laurie Russell,Krista L Lentine,","doi":"10.1681/asn.0000000607","DOIUrl":"https://doi.org/10.1681/asn.0000000607","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir Roointan, Rong Xu, Simon Corrie, Christoph E Hagemeyer, Karen Alt
The treatment and management of kidney diseases present a significant global challenge, affecting over 800 million individuals and necessitating innovative therapeutic strategies that transcend symptomatic relief. The application of nanotechnology to therapies for kidney diseases, while still in its early stages, holds transformative potential for improving treatment outcomes. Recent advancements in nanoparticle-based drug delivery leverage the unique physicochemical properties of nanoparticles for targeted and controlled therapeutic delivery to the kidneys. Current research is focused on understanding the functional and phenotypic changes in kidney cells during both acute and chronic conditions, allowing for the identification of optimal target cells. In addition, the development of tailored nanomedicines enhances their retention and binding to key renal membranes and cell populations, ultimately improving localization, tolerability, and efficacy. However, significant barriers remain, including inconsistent nanoparticle synthesis and the complexity of kidney-specific targeting. To overcome these challenges, the field requires advanced synthesis techniques, refined targeting strategies, and the establishment of animal models that accurately reflect human kidney diseases. These efforts are critical for the clinical application of nanotherapeutics, which promise novel solutions for kidney disease management. This review evaluates a substantial body of in vivo research, highlighting the prospects, challenges, and opportunities presented by nanotechnology-mediated therapies and their potential to transform kidney disease treatment.
{"title":"Nanotherapeutics in Kidney Disease: Innovations, Challenges, and Future Directions.","authors":"Amir Roointan, Rong Xu, Simon Corrie, Christoph E Hagemeyer, Karen Alt","doi":"10.1681/ASN.0000000608","DOIUrl":"10.1681/ASN.0000000608","url":null,"abstract":"<p><p>The treatment and management of kidney diseases present a significant global challenge, affecting over 800 million individuals and necessitating innovative therapeutic strategies that transcend symptomatic relief. The application of nanotechnology to therapies for kidney diseases, while still in its early stages, holds transformative potential for improving treatment outcomes. Recent advancements in nanoparticle-based drug delivery leverage the unique physicochemical properties of nanoparticles for targeted and controlled therapeutic delivery to the kidneys. Current research is focused on understanding the functional and phenotypic changes in kidney cells during both acute and chronic conditions, allowing for the identification of optimal target cells. In addition, the development of tailored nanomedicines enhances their retention and binding to key renal membranes and cell populations, ultimately improving localization, tolerability, and efficacy. However, significant barriers remain, including inconsistent nanoparticle synthesis and the complexity of kidney-specific targeting. To overcome these challenges, the field requires advanced synthesis techniques, refined targeting strategies, and the establishment of animal models that accurately reflect human kidney diseases. These efforts are critical for the clinical application of nanotherapeutics, which promise novel solutions for kidney disease management. This review evaluates a substantial body of in vivo research, highlighting the prospects, challenges, and opportunities presented by nanotechnology-mediated therapies and their potential to transform kidney disease treatment.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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