Journal of The American Society of Nephrology最新文献

{"title":"Genetic Determinants of Steroid Responsiveness in IgA Nephropathy.","authors":"Lin-Lin Xu, Xu-Jie Zhou, Wenjian Bi, Peipei Zhang, Su-Fang Shi, Li-Jun Liu, Ji-Cheng Lv, Hong Zhang","doi":"10.1681/ASN.0000000977","DOIUrl":"https://doi.org/10.1681/ASN.0000000977","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Resistance on Hypothermic Machine Perfusion and Acceptance of Deceased Donor Kidney Allografts.","authors":"Toshihiro Nakayama, Antony Attia, Daniel J Ahn, Michael McCabe, Yutaka Endo, Randeep S Kashyap, Thomas A Pham, Marc L Melcher, Kazunari Sasaki, Yuki Bekki","doi":"10.1681/ASN.0000000986","DOIUrl":"https://doi.org/10.1681/ASN.0000000986","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Localization Microscopy to Assess the Intrarenal Microvasculature in Autosomal Dominant Polycystic Kidney Disease.","authors":"Chengwu Huang, Ahmed Abdelfattah, Ryan M DeRuiter, Nathan Zhang, Kate M Knoll, Kendra E Petersen, Tao Wu, Youwen Zhang, Marie C Hogan, Alfonso Eirin, Lilach O Lerman, Shigao Chen, Maria V Irazabal","doi":"10.1681/ASN.0000000968","DOIUrl":"https://doi.org/10.1681/ASN.0000000968","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping of Phospholipase A2 Receptor Epitopes in Idiopathic Membranous Nephropathy and Clinical Relevance of Epitope Profiles.","authors":"Yanan Liu, Peng Chen, Gang Chen, Junxian Hong, Yangzhong Zhou, Ke Zheng, Sanxi Ai, Zhiying Gao, Peng Xia, Haoyuan Cui, Ruoke Wang, Xuanling Shi, Xuemei Li, Xuewang Li, Linqi Zhang, Yan Qin","doi":"10.1681/ASN.0000000962","DOIUrl":"10.1681/ASN.0000000962","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply: Clarifying On-Target p38 Inhibition and Protein Restriction Effects in CKD-Associated Vascular Calcification.","authors":"Ying Jin, Raul J Guzman, Yujun Cai","doi":"10.1681/ASN.0000000972","DOIUrl":"https://doi.org/10.1681/ASN.0000000972","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of IL-33 in Diabetic Kidney Disease: A Randomized, Placebo-Controlled Phase 2b Trial.","authors":"Alexis Hofherr, Kaisa Mäki-Petäjä, Viknesh Selvarajah, Daniel Grice, Stefano Bartesaghi, Eulalia Jimenez, Roberto Pecoits-Filho, Hiddo J L Heerspink","doi":"10.1681/ASN.0000000966","DOIUrl":"https://doi.org/10.1681/ASN.0000000966","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Lymphocyte Topology: A Roadmap to Mechanism and Clinical Translation?","authors":"Wei Zhou, Hanyan Meng, Jiao Li, Jianhua Mao","doi":"10.1681/ASN.0000000957","DOIUrl":"https://doi.org/10.1681/ASN.0000000957","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply: Computational Lymphocyte Topology: A Roadmap to Mechanism and Clinical Translation?","authors":"Xiang Li, Kyle J Lafata, Laura Barisoni","doi":"10.1681/ASN.0000000958","DOIUrl":"https://doi.org/10.1681/ASN.0000000958","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying On-Target p38 Inhibition and Protein Restriction Effects in CKD-Associated Vascular Calcification.","authors":"Defeng Zhao, Dailin Li, Peng Sun","doi":"10.1681/ASN.0000000971","DOIUrl":"https://doi.org/10.1681/ASN.0000000971","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix Stiffness Directs Early Injury and Ketogenesis Programs to Prime Kidney Repair.","authors":"Yuan Gui, Yuanyuan Wang, Wenxue Li, Jia-Jun Liu, Kelly Zheng, Jianzhong Li, Henry Wells Shaffer, Cameron Jones, Samantha Mae Mallari, Yanbao Yu, Silvia Liu, Yansheng Liu, Dong Zhou","doi":"10.1681/ASN.0000000967","DOIUrl":"10.1681/ASN.0000000967","url":null,"abstract":"<p><strong>Background: </strong>Although traditionally considered a tubule-centric disorder, AKI is increasingly recognized as involving early and active participation of fibroblasts and pericytes, the primary producer of extracellular matrix (ECM). These cells are rapidly mobilized to injury sites to support repair. Therefore, successful recovery from AKI requires not only cellular regeneration but also a finely tuned ECM, which ensures structural support and transmits essential mechanical cues. Despite its importance, the mechanistic basis by which the ECM regulates AKI repair remains incompletely understood.</p><p><strong>Methods: </strong>We combined genetic and pharmacologic AKI animal models with tissue engineering approaches, data-independent acquisition–based global and phosphoproteomics, and spatial transcriptomics to profile the ECM proteome landscape of decellularized kidney matrix scaffolds after injury, uncover mechanometabolic pathways driving repair, and evaluate potential therapeutic strategies.</p><p><strong>Results: </strong>We generated a comprehensive proteomic map of the AKI kidney matrix scaffold and highlighted microfibrillar-associated protein 2 (Mfap2) as a key core matrisome component primarily derived from fibroblasts and pericytes. Mfap2 loss disrupted kidney architecture and metabolic homeostasis, aggravating AKI severity. Global proteomics revealed that Mfap2 deficiency downregulated tubular 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) through estrogen receptor 2 (Esr2)–mediated transcriptional repression and increased protein succinylation. Phosphoproteomic and spatial transcriptomic analysis showed that Mfap2 loss altered mechanotransduction, leading to mitogen-activated protein kinases hyperactivation and upregulation of large tumor suppressor kinase 1 in tubular cells, without affecting integrin receptor activity. Although large tumor suppressor kinase 1 is a key Hippo pathway kinase, its activation suppressed Esr2 transcription independently of the canonical yes-associated protein/transcriptional coactivator with PDZ-binding motif effectors and without affecting Esr2 degradation. Therapeutically, Esr2 agonist restored Hmgcs2 levels and improved kidney function in Mfap2-deficient models.</p><p><strong>Conclusions: </strong>Mfap2, a fibroblast/pericyte-derived core matrisome component, preserved kidney architecture and supported tubular ketogenesis by regulating Hmgcs2 via Esr2 in the AKI microenvironment.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}