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Contraceptive Use and Missed Opportunities for Family Planning Discussions in Women Living with Human Immunodeficiency Virus at an HIV Clinic. 艾滋病毒诊所中感染人类免疫缺陷病毒的妇女的避孕使用和错过的计划生育讨论机会。
Q3 INFECTIOUS DISEASES Pub Date : 2022-01-01 DOI: 10.1177/23259582221144449
Ashley Winters, Bernadette Jakeman, Kelsea Gallegos Aragon, Zoe Kasten, Alexander Bos, Jeremy Snyder, Alexandra Herman

The objective of this study was to examine contraception use and family planning discussions (FPD) in female people living with HIV (PLWH). A retrospective cohort study was conducted. Female PLWH were included if they were 18-44 years and received care in 2019 at an HIV clinic. 74 patients met inclusion; mean age was 35 years, 53% were white. All patients were prescribed antiretroviral therapy. 48.6% of patients had documented FPD. 64.9% of patients were using contraception; sterilization was most common (41.7%). Only five patients had a contraindication to hormonal contraception. No differences in contraception use were observed based on age, race, HIV viral load, number of visits, or past pregnancies. However, patients with documented FPD were more likely to use contraception (OR 4.55; 95% CI 1.35-15.29). Routine FPD and contraception use in female PLWH were low. Rates of sterilization were high in female PLWH. Providing quality family planning services is critical to increase contraception use and selection of the most appropriate contraception form.

本研究的目的是检查女性艾滋病毒感染者(PLWH)的避孕使用和计划生育讨论(FPD)。进行回顾性队列研究。如果她们年龄在18-44岁之间,并于2019年在艾滋病毒诊所接受治疗,则将其纳入其中。74例患者符合纳入标准;平均年龄35岁,白人占53%。所有患者均接受抗逆转录病毒治疗。48.6%的患者有FPD记录。64.9%的患者采取了避孕措施;绝育最为常见(41.7%)。只有5名患者有激素避孕的禁忌症。没有观察到年龄、种族、HIV病毒载量、就诊次数或怀孕史在避孕使用方面的差异。然而,记录在案的FPD患者更有可能采取避孕措施(OR 4.55;95% ci 1.35-15.29)。女性PLWH的常规FPD和避孕药具使用率较低。女性产妇绝育率较高。提供高质量的计划生育服务对于增加避孕措施的使用和选择最适当的避孕方式至关重要。
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引用次数: 0
“We Feel Like Everybody's Going to Judge us”: Black Adolescent Girls’ and Young Women's Perspectives on Barriers to and Opportunities for Improving Sexual Health Care, Including PrEP, in the Southern U.S “我们觉得每个人都会评判我们”:美国南部黑人少女和年轻女性对改善性健康护理(包括PrEP)的障碍和机会的看法
Q3 INFECTIOUS DISEASES Pub Date : 2022-01-01 DOI: 10.1177/23259582221107327
M. C. Pratt, S. Jeffcoat, Samantha V. Hill, E. Gill, L. Elopre, T. Simpson, R. Lanzi, L. Matthews
Black adolescent girls and young women (AGYW) are disproportionately affected by HIV in the southern U.S.; however, PrEP prescriptions to Black AGYW remain scarce. We conducted in-depth interviews (IDIs) with Black AGYW ages 14-24 in Alabama to explore opportunities for and barriers to sexual health care including PrEP prescription. Twelve AGYW participated in IDIs with median age 20 (range 19-24). All reported condomless sex, 1-3 sexual partners in the past 3 months, and 6 reported prior STI. Themes included: 1) Stigma related to sex contributes to inadequate discussions with educators, healthcare providers, and parents about sexual health; 2) Intersecting stigmas around race and gender impact Black women's care-seeking behavior; 3) Many AGYW are aware of PrEP but don't perceive it as an option for them. Multifaceted interventions utilizing the perspectives, voices, and experiences of Black cisgender AGYW are needed to curb the HIV epidemic in Alabama and the U.S. South.
在美国南部,黑人少女和年轻妇女受到艾滋病毒的影响尤为严重。;然而,针对黑人AGYW的PrEP处方仍然很少。我们对阿拉巴马州14-24岁的黑人AGYW进行了深入采访,以探索性健康护理的机会和障碍,包括PrEP处方。12名AGYW参与IDI,中位年龄为20岁(19-24岁)。所有人都报告了无配偶性行为,在过去3个月内有1-3名性伴侣,6人报告了既往性传播感染。主题包括:1)与性有关的污名导致与教育工作者、医疗保健提供者和家长关于性健康的讨论不足;2) 种族和性别的交叉污名影响了黑人女性寻求照顾的行为;3) 许多AGYW知道PrEP,但并不认为它是他们的一个选择。需要利用黑人顺性别AGYW的观点、声音和经验进行多方面的干预,以遏制阿拉巴马州和美国南部的艾滋病毒流行。
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引用次数: 6
Adherence to and Forgiveness of 3TC/DTG in a Real-World Cohort 在现实世界中对3TC/DTG的遵守和宽恕
Q3 INFECTIOUS DISEASES Pub Date : 2022-01-01 DOI: 10.1177/23259582221101815
F. Maggiolo, D. Valenti, Rodolfo Teocchi, L. Comí, E. Filippo, M. Rizzi
Background: adherence and forgiveness are key factors for virologic success. We evaluated them for 3TC/DTG. Methods: pharmacy refills were used to calculate the proportion of days covered (PDC). Forgiveness was calculated as the achieved rate of HIV-RNA threshold by a given level of imperfect adherence. Results: 240 PLWH were included. The median follow-up was 819 days (IQR 450-1459) for a total of 681 person/years of follow-up. Adherence was very high with a median of 99% (IQR 95%-100%). Consequently, the virologic response was sustained with 83.8% of PLWH never exceeding a HIV RNA of 50 copies/ml and 95.8% of subjects with a steadily HIV-RNA < 200 copies/ml. A PDC lower than 80% was associated with a negative outcome irrespective of the HIV-RNA threshold considered. Conclusions: The extensive virologic efficacy of 3TC/DTG demonstrated both in clinical trials and real-world experiences seems to rely more on its friendliness than on its forgiveness.
背景:坚持和宽恕是病毒学成功的关键因素。我们对它们进行了3TC/DTG评估。方法:使用药房续费来计算覆盖天数的比例(PDC)。宽恕被计算为在给定的不完全依从性水平下实现HIV-RNA阈值的比率。结果:纳入PLWH 240例。中位随访时间为819天(IQR 450-1459),共随访681人/年。依从性非常高,中位数为99%(IQR 95%-100%)。因此,病毒应答持续,83.8%的PLWH从未超过50拷贝/ml的HIV RNA,95.8%的受试者的HIV RNA稳定低于200拷贝/ml。PDC低于80%与阴性结果相关,与所考虑的HIV-RNA阈值无关。结论:3TC/DTG在临床试验和现实生活中的广泛病毒学疗效似乎更多地依赖于它的友好性,而不是宽恕。
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引用次数: 4
Low Incidence and Brief Duration of Gastrointestinal Adverse Events with Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Over 96 Weeks: Post hoc Analyses of AMBER and EMERALD 达芦那韦/科比西司他/恩曲他滨/替诺福韦-阿拉芬胺(D/C/F/TAF)治疗96周胃肠道不良事件的低发病率和短暂持续时间:AMBER和EMERALD的事后分析
Q3 INFECTIOUS DISEASES Pub Date : 2022-01-01 DOI: 10.1177/23259582221088202
K. Dunn, B. Baugh, Nika Bejou, D. Luo, Jennifer Campbell, Sareh Seyedkazemi, David Anderson
Gastrointestinal intolerance has been associated with ritonavir-boosted protease inhibitors. This post hoc analysis evaluated gastrointestinal adverse events of interest (AEOIs; diarrhea, nausea, abdominal discomfort, flatulence [MedDRAv21]) through Wk96 among patients enrolled in the phase 3 AMBER (treatment-naïve) and EMERALD (virologically suppressed) studies of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg. 362 and 763 patients initiated D/C/F/TAF in AMBER and EMERALD, respectively. All D/C/F/TAF-related gastrointestinal AEOIs were grade 1/2 in severity; none were serious. Across studies, incidence of D/C/F/TAF-related diarrhea and nausea were each ≤5% in Wk1 (≤1% post-Wk2); prevalence of each decreased to <5% post-Wk2. In each study, there was 1 case of D/C/F/TAF-related abdominal discomfort during Wk1 and none thereafter. Incidence of D/C/F/TAF-related flatulence was <1% throughout. Median duration of D/C/F/TAF-related gastrointestinal AEOIs was 16.5 (AMBER) and 8.5 (EMERALD) days. In conclusion, in treatment-naïve and virologically suppressed patients, incidences and prevalences of D/C/F/TAF-related gastrointestinal AEOIs were low and tended to present early.
胃肠不耐受与利托那韦增强的蛋白酶抑制剂有关。该事后分析评估了感兴趣的胃肠道不良事件(aeoi;在darunavir/cobicistat/emtricitabine/替诺福韦alafenamide (D/C/F/TAF) 800/150/200/10 mg的3期AMBER (treatment-naïve)和EMERALD(病毒学抑制)研究中,患者参加了腹泻、恶心、腹部不适、肠胃胀气[MedDRAv21])至Wk96。AMBER组和EMERALD组分别有362例和763例患者启动D/C/F/TAF。所有与D/C/F/ taf相关的胃肠道aei严重程度均为1/2级;没有一个是认真的。在所有研究中,与D/C/F/ taf相关的腹泻和恶心发生率在Wk1中均≤5% (wk2后≤1%);wk2后,两者的患病率均降至<5%。在每项研究中,在Wk1期间有1例D/C/F/ taf相关腹部不适,此后无一例。D/C/F/ taf相关肠胃胀气的发生率均<1%。D/C/F/ taf相关胃肠道aei的中位持续时间分别为16.5 (AMBER)和8.5 (EMERALD)天。综上所述,在treatment-naïve和病毒学抑制的患者中,D/C/F/ taf相关胃肠道aei的发病率和患病率较低,且倾向于早期出现。
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引用次数: 2
The Outcomes of Transition from Pediatrics to Adult Care among Adolescents and Young Adults with HIV at a Tertiary Care Center in Bangkok. 在曼谷的一个三级保健中心,感染艾滋病毒的青少年和年轻人从儿科转到成人护理的结果。
Q3 INFECTIOUS DISEASES Pub Date : 2022-01-01 DOI: 10.1177/23259582221143673
Supattra Rungmaitree, Nuchanat Thamniamdee, Saranya Sachdev, Wanatpreeya Phongsamart, Keswadee Lapphra, Orasri Wittawatmongkol, Alan Maleesatharn, Benjawan Khumcha, Risa M Hoffman, Kulkanya Chokephaibulkit

Background: Adolescents and young adults with HIV (AYHIV) are at high-risk of loss to follow up and virologic failure, particularly during transition from pediatric to adult clinics. Methods: We reviewed the medical records of AYHIV to characterize retention and virologic suppression following their transition. Results: 101 AYHIV, 97% perinatally infected, were transferred at the median age of 20 (IQR: 19-21) years. At 1-year post-transition, 92.1% were retained in care and 73.3% had viral suppression and at 2-years the retention and viral suppression were 87.1% and 76.7%, respectively. Factors associated with viral suppression were transition at ≥ 20 years of age (aOR 4.38, 95% CI 1.41-13.65) and receiving first-line ART regimen, compared to second- or third-line regimens, at transition (aOR 6.05, 95% CI 1.55-23.58). Conclusion: Transition outcomes of AYHIV in our setting were suboptimal. There is a need for interventions to support AYHIV transition during this vulnerable period.

背景:感染艾滋病毒(AYHIV)的青少年和年轻成人处于随访失败和病毒学失败的高风险中,特别是在从儿科到成人诊所的过渡期间。方法:我们回顾了AYHIV的医疗记录,以表征其转移后的保留和病毒学抑制。结果:101例AYHIV, 97%围生期感染,中位年龄为20岁(IQR: 19-21)。转换后1年,92.1%的患者仍在护理中,73.3%的患者病毒抑制,2年的患者保留率和病毒抑制率分别为87.1%和76.7%。与病毒抑制相关的因素是≥20岁时的转移(aOR 4.38, 95% CI 1.41-13.65),以及与二线或三线方案相比,在转移时接受一线ART方案(aOR 6.05, 95% CI 1.55-23.58)。结论:在我们的环境中,AYHIV的过渡结局不是最理想的。在这一脆弱时期,有必要采取干预措施,支持艾滋病病毒的过渡。
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引用次数: 0
Integration of Early Infant Diagnosis of HIV Services Into Village Health Clinics in Ntcheu, Malawi: An Exploratory Qualitative Study. 将艾滋病毒服务的早期婴儿诊断纳入马拉维恩丘的乡村卫生诊所:一项探索性定性研究。
IF 2.2 Q3 INFECTIOUS DISEASES Pub Date : 2021-01-01 DOI: 10.1177/2325958220981256
Felix Chinguwo, Alinane Linda Nyondo-Mipando

Integration of Early Infant Diagnosis(EID) of HIV into Village Health Clinics (VHCs) would increase the uptake of services. This study assessed mothers and health care workers' acceptability of integration of EID of HIV services into VHCs in Ntcheu, Malawi. We conducted an exploratory qualitative study in the phenomenological tradition among 20 mothers of either HIV exposed or non-exposed infants and 18 health care workers (HCWs) from February to July 2019. We analyzed the data using a thematic approach and guided by the theoretical framework for acceptability. There were positive perceptions of the integration of services. Acceptability is influenced by attitudes, perceived burden, intervention coherent services, and perceived effectiveness of services. The successful integration of EID of HIV into VHCs requires strengthening of the health system and community awareness. Efforts to mitigate stigma should be prioritized when integrating the services to optimize uptake of the services at a community level.

将艾滋病毒早期婴儿诊断纳入乡村卫生诊所将提高服务的接受率。这项研究评估了马拉维Ntcheu的母亲和医护人员对将艾滋病毒EID服务纳入VHC的可接受性。2019年2月至7月,我们对20名接触或未接触艾滋病毒婴儿的母亲和18名医护人员进行了一项现象学传统的探索性定性研究。我们使用主题方法分析数据,并以可接受性的理论框架为指导。对服务一体化有着积极的看法。可接受性受态度、感知负担、干预连贯服务和感知服务有效性的影响。要成功地将艾滋病毒EID纳入VHCs,就需要加强卫生系统和社区意识。在整合服务以优化社区一级对服务的接受时,应优先考虑减轻耻辱感的努力。
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引用次数: 0
Emergency Department Utilization Among People Living With HIV on Chronic Opioid Therapy. 长期接受阿片类药物治疗的艾滋病病毒感染者使用急诊室的情况。
Q3 INFECTIOUS DISEASES Pub Date : 2021-01-01 DOI: 10.1177/23259582211010952
Kinna Thakarar, Amoli Kulkarni, Sara Lodi, Alexander Y Walley, Marlene C Lira, Leah S Forman, Jonathan A Colasanti, Carlos Del Rio, Jeffrey H Samet

Chronic pain among people with HIV (PWH) is a driving factor of emergency department (ED) utilization, and it is often treated with chronic opioid therapy (COT). We conducted a cross-sectional analysis of a prospective observational cohort of PWH on COT at 2 hospital-based clinics to determine whether COT-specific factors are associated with ED utilization among PWH. The primary outcome was an ED visit within 12 months after study enrollment. We used stepwise logistic regression including age, gender, opioid duration, hepatitis C, depression, prior ED visits, and Charlson comorbidity index. Of 153 study participants, n = 69 (45%) had an ED visit; 25% of ED visits were pain-related. High dose opioids, benzodiazepine co-prescribing, and lack of opioid treatment agreements were not associated with ED utilization, but prior ED visits (p = 0.002), depression (p = 0.001) and higher Charlson comorbidity score (p = 0.003) were associated with ED utilization. COT-specific factors were not associated with increased ED utilization among PWH.

艾滋病病毒感染者(PWH)中的慢性疼痛是急诊科(ED)使用率的一个驱动因素,通常采用慢性阿片类药物治疗(COT)。我们对在两家医院诊所接受慢性阿片类药物治疗的艾滋病患者前瞻性观察队列进行了横断面分析,以确定慢性阿片类药物治疗的特异性因素是否与艾滋病患者使用急诊室有关。研究的主要结果是入组后 12 个月内的急诊就诊情况。我们采用了逐步逻辑回归法,包括年龄、性别、阿片类药物使用时间、丙型肝炎、抑郁症、既往 ED 就诊情况和 Charlson 合并症指数。在 153 名研究参与者中,有 69 人(45%)曾到急诊室就诊;25% 的急诊室就诊与疼痛有关。高剂量阿片类药物、苯二氮卓类药物联合处方和缺乏阿片类药物治疗协议与急诊就医无关,但既往急诊就医(p = 0.002)、抑郁(p = 0.001)和较高的 Charlson 合并症指数(p = 0.003)与急诊就医有关。COT特异性因素与威利人使用急诊室的增加无关。
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引用次数: 0
Comment on Project THANKS: Examining HIV/AIDS-Related Barriers and Facilitators to Care in African American Women: A Community Perspective 项目感谢:审查非洲裔美国妇女中与艾滋病毒/艾滋病有关的障碍和促进因素:社区视角
Q3 INFECTIOUS DISEASES Pub Date : 2020-08-14 DOI: 10.1177/2325958220936406
Ndidiamaka N. Amutah-Onukagha, M. Mahadevan, I. Opara, M. Rodriguez, Aminah Baxter, Megan Trusdell, J. Kelly
The aim of Project THANKS (Turning HIV/AIDS into Knowledge for Sisters) was to provide resources for African American women living with a dual diagnosis of HIV and associated comorbidities such as a chronic illness, and substance use disorder. HIV self-management is viewed within a larger context that addresses HIV and comorbidities concurrently. Project THANKS is an evidence-based, culturally competent curriculum that provides African American women with the necessary knowledge and tools to manage their complications associated with having multiple chronic diseases. The intervention was piloted in 2015 and later conducted in 2018 in 3 community-based health centers in New Jersey. Future interventions of Project THANKS will address the social support, mental health, and health literacy needs expressed by participants as well as incorporating a licensed social worker to further improve their physical and mental health outcomes.
THANKS项目(将艾滋病毒/艾滋病转化为姐妹的知识)的目的是为患有艾滋病毒和相关合并症(如慢性病和药物使用障碍)双重诊断的非裔美国妇女提供资源。艾滋病毒自我管理是在一个更大的背景下看待的,同时解决艾滋病毒和合并症。THANKS项目是一门基于证据、具有文化能力的课程,为非裔美国妇女提供必要的知识和工具,以管理她们患多种慢性病的并发症。该干预措施于2015年进行了试点,随后于2018年在新泽西州的3个社区卫生中心进行。THANKS项目的未来干预措施将解决参与者表达的社会支持、心理健康和健康素养需求,并引入一名持证社会工作者,以进一步改善他们的身心健康结果。
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引用次数: 1
Oral Abstracts From Adherence 2019 Conference 2019年坚持大会的口头摘要
Q3 INFECTIOUS DISEASES Pub Date : 2020-04-03 DOI: 10.1177/2325958219892705
Ashley J. Mayo, E. Montgomery, Kristine Torjesen, T. Palanee-Phillips, Nitesha Jeenarain, Linly Seyama, K. Woeber, Ishana Harkoo, K. Reddy, F. Ssewamala, C. Mellins, F. Makumbi, T. Neilands, M. McKay, Christopher Damulira, P. Nabunya, O. Bahar, G. Nakigozi, William Byansi, Miriam N Mukasa, Flavia Namuwonge
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引用次数: 0
Clinician Barriers and Facilitators to Routine HIV Testing: A Systematic Review of the Literature. 临床医生的障碍和促进常规艾滋病毒检测:文献的系统回顾。
Q3 INFECTIOUS DISEASES Pub Date : 2020-01-01 DOI: 10.1177/2325958220936014
Ann Dalton Bagchi, Tracy Davis

Background: Routine HIV screening rates are suboptimal.

Objectives: This systematic review identified barriers to/facilitators of routine HIV testing, categorized them using the socioecological model (SEM), and provided recommendations for interventions to increase screening.

Data sources: Included articles were indexed in PubMed, EBSCO CINAHL, Scopus, Web of Science, and the Cochrane Library between 2006 and October 2018.

Eligibility criteria: Included studies were published in English or Spanish and directly assessed providers' barriers/facilitators to routine screening.

Data extraction: We used a standardized Excel template to extract barriers/facilitators and identify levels in the SEM.

Data synthesis: Intrapersonal factors predominated as barriers, while facilitators were directed at the institutional level.

Limitations: Policy barriers are not universal across countries. Meta-analysis was not possible. We could not quantify frequency of any given barrier/facilitator.

Conclusions: Increasing reimbursement and adding screening as a quality measure may incentivize HIV testing; however, many interventions would require little resource investment.

背景:常规HIV筛查率不理想。目的:本系统综述确定了常规HIV检测的障碍/促进因素,使用社会生态学模型(SEM)对其进行分类,并提供了增加筛查的干预措施建议。数据来源:收录的文章在PubMed、EBSCO CINAHL、Scopus、Web of Science和Cochrane Library中检索,检索时间为2006年至2018年10月。入选标准:纳入的研究以英语或西班牙语发表,并直接评估提供者对常规筛查的障碍/促进因素。数据提取:我们使用标准化的Excel模板提取障碍/促进因素,并确定SEM中的水平。数据综合:个人因素作为障碍占主导地位,而促进因素则针对机构一级。限制:政策障碍在各国并不普遍。meta分析是不可能的。我们无法量化任何给定障碍/促进者的频率。结论:增加报销和增加筛查作为一种质量措施可以激励HIV检测;然而,许多干预措施只需要很少的资源投资。
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引用次数: 16
期刊
Journal of the International Association of Providers of AIDS Care
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