Journal of Trauma and Acute Care Surgery最新文献

Background: Rib fractures, constituting 10% to 15% of trauma admissions, contribute significantly to morbidity and mortality. Effective postdischarge patient care remains a challenge. Our system has operationalized patient-reported outcome measures (PROMs) via a mobile platform into routine postdischarge monitoring for rib fracture patients. This study aimed to use PROMs to investigate the association between patient factors and postdischarge pain and mental health.

Methods: We collected PROMs from nine Midwest trauma hospitals (2021-2022) using a mobile platform. The platform provided automated check-ins, education, health reminders, and 24/7 monitored interventions based on PROM responses. Multivariate logistic regression was used to investigate the association of patient factors for the primary outcome. The primary outcome was pain 2 weeks postdischarge (days 4-14). Secondary outcomes were mental health at 1 week, with long-term assessments at one and 3 months.

Results: Of 72 patients, 55.6% reported moderate to severe pain at 2 weeks, with higher admission pain scores associated with increased pain (odds ratio, 1.69; 95% confidence interval, 1.15-2.5; p < 0.01). By 4 weeks, 29.4% of responding patients reported persistent moderate-to-severe pain, decreasing to 4.0% by 12 weeks. Patients with moderate-to-severe pain within the first 2 weeks also reported significantly higher rates of mental health symptoms at (44.8% vs. 16.7%) compared with mild pain. By weeks 4 and 12, mental health differences between pain groups were insignificant.

Conclusion: This study suggests a potential link between early pain and mental health symptoms. In addition, higher pain at admission may predict worse pain outcomes 2 weeks postdischarge. Patients in our cohort showed improvement in both pain and mental health symptoms within 4 to 12 weeks. These findings highlight the opportunity for PROMs and mobile apps to support optimal postdischarge follow-up and help minimize persistent pain, particularly for rib fracture patients with identifiable risk factors.

Level of evidence: Therapeutic/Care Management; Level IV.

Introduction: Multiple studies have indicated that isolated abnormal laboratory results necessitate obtaining abdominal computed tomography (CT) for pediatric patients with blunt abdominal trauma (BAT), regardless of the normal abdominal examination. This study aims to identify the predictors of intra-abdominal injury (IAI) and the role of laboratory tests in CT imaging among pediatric BAT patients.

Methods: This is a retrospective review at a Level II pediatric trauma center (2018-2022). Children (younger than 18 years) who presented with BAT and received abdominal CT imaging were included. Outcomes were rates of IAI and interventions. Multivariable regression analysis was performed.

Results: Over 5 years, 483 patients met the inclusion criteria. The mean age was 13 years, 58.2% were male, and the median Glasgow Coma Scale was 15. Overall, 19.3% had abdominal pain; 6.2%, postinjury emesis; 26.1%, abdominal tenderness; and 10.6%, pelvic tenderness. On initial imaging, 7.0% had a positive focused assessment with sonography in trauma examination, and 7.2% had an abnormal plain x-ray. On initial laboratory testing, 7.9% had abnormal serum aspartate aminotransferase (AST), 3.1% had abnormal hematocrit, 1.2% had abnormal urine analysis, and 0.8% had abnormal lipase. Seventeen percent had at least one IAI, of which 17% underwent intervention. Multivariable regression analysis identified abdominal tenderness, abnormal plain x-ray, positive focused assessment with sonography in trauma, blood transfusion requirements, and abnormal AST as independent predictors of IAI on abdominal CT imaging. Moreover, among patients with IAI, only 37.3% had abnormal laboratory results, and all had at least one of the predictors of IAI (in addition to or other than abnormal AST). Among patients with abnormal laboratory results (n = 57), nine patients had none of the predictors of IAI, out of which none were found to have IAI on abdominal CT.

Conclusion: More than 80% of all abdominal CT imaging had negative results. Our findings highlight the significance of clinical findings in the trauma bay, regardless of laboratory findings, when deciding to order abdominal CT imaging for pediatric BAT patients.

Level of evidence: Therapeutic/Care Management; Level III.

Abstract: Blunt cerebrovascular injuries are not as rare as they were once thought to be-but they still have the same potential for disastrous outcomes. They may occur following any trauma, but more common with higher energy transfer mechanisms. If stroke occurs, prompt recognition and treatment offers the best chance for optimal outcome. Early diagnosis and provision of antithrombotic therapy may prevent strokes, so screening of asymptomatic patients is recommended. Herein we will present what you need to know to diagnose and manage blunt cerebrovascular injury.

Abstract: There have been numerous changes in resuscitation strategies for severely injured patients over the last several decades. Certain strategies, such as aggressive crystalloid resuscitation, have largely been abandoned because of the high incidence of complications and worsening of trauma-induced coagulopathy. Significant emphasis has been placed on restoring a normal coagulation profile with plasma or whole blood transfusion. In addition, the importance of the lethal consequences of trauma-induced coagulopathy, such as hyperfibrinolysis, has been easily recognized by the use of viscoelastic testing, and its treatment with tranexamic acid has been extensively studied. Furthermore, the critical role of early intravenous calcium administration, even before blood transfusion administration, has been emphasized. Other adjuncts, such as fibrinogen supplementation with fibrinogen concentrate or cryoprecipitate and prothrombin complex concentrate, are being studied and incorporated in some of the institutional massive transfusion protocols. Finally, balanced blood component transfusion (1:1:1 or 1:1:2) and whole blood have become commonplace in trauma centers in North America. This review provides a description of recent developments in resuscitation and a discussion of recent innovations and areas for future investigation.

Background: Patients with severe traumatic brain injury (TBI) are at an increased risk of respiratory failure refractory to traditional therapies. The safety of extracorporeal membrane oxygenation (ECMO) in this population remains unclear. We aimed to examine outcomes following ECMO compared with traditional management in severe TBI patients.

Methods: We performed a retrospective cohort study using the Trauma Quality Improvement Program (2017-2020). We identified patients 18 years or older with severe TBI (Abbreviated Injury Score head, ≥3) who underwent ECMO or had either in-hospital cardiac or acute respiratory distress syndrome during their hospitalization. The study excluded pPatients who arrived without signs of life, had a prehospital cardiac arrest, had an unsurvivable injury, were transferred out within 48 hours of arrival, or were received as a transfer and died within 12 hours of arrival Patients with missing information regarding in-hospital mortality were also excluded. Outcomes included mortality, in-hospital complications, and intensive care unit length of stay. To account for patient and injury characteristics, we used 1:1 propensity matching. We performed a subgroup analysis among ECMO patients, comparing patients who received anticoagulants with those who did not.

Results: We identified 10,065 patients, of whom 221 (2.2%) underwent ECMO. In the propensity-matched sample of 134 pairs, there was no difference in mortality. Extracorporeal membrane oxygenation was associated with a higher incidence of cerebrovascular accidents (9% vs. 1%, p = 0.006) and a lower incidence of ventilator-associated pneumonia. In the subgroup analysis of 64 matched pairs, patients receiving anticoagulation had lower mortality, higher unplanned return to the operating room, and longer duration of ventilation and intensive care unit length of stay.

Conclusion: Extracorporeal membrane oxygenation use in severe TBI patients was not associated with higher mortality and should be considered a potential intervention in this patient population. Systemic anticoagulation showed mortality benefit, but further work is required to elucidate the impact on neurological outcomes, and the appropriate dosing and timing of anticoagulation.

Level of evidence: Therapeutic/Care Management; Level III.

Background: Both healthy plasma and cytoprotective aPC (3K3A-aPC) have been shown to mitigate the endotheliopathy of trauma (EoT), but optimal therapeutics remain unknown. Our aim was therefore to determine optimal therapies to mitigate EoT by investigating the effectiveness of 3K3A-aPC with and without plasma-based resuscitation strategies.

Methods: Electric cell-substrate impedance sensing (ECIS) was used to measure real-time permeability changes in endothelial cells. Cells were treated with a 2-μg/mL solution of aPC 30 minutes prior to stimulation with plasma taken from severely injured trauma patients (ISS > 15 and BD < -6) (TP). Healthy plasma, or plasma frozen within 24 hours (FP24), was added concomitantly with TP. Cells treated with thrombin and untreated cells were included in this study as control groups.

Results: A dose-dependent difference was found between the 5% and 10% plasma-treated groups when human umbilical vein endothelial cells were simultaneously stimulated with TP (μd, 7.346; 95% confidence interval [CI], 4.574-10.12). There was no difference when compared with TP alone in the 5% (μd, 5.713; 95% CI, -1.751 to 13.18) or 10% group (μd, -1.633; 95% CI, -9.097 to 5.832). When 3K3A-aPC was added to plasma and TP, the 5% group showed improvement in permeability compared with TP alone (μd, 10.11; 95% CI, 2.642 to 17.57), but there was no difference in the 10% group (μd -1.394; 95% CI, -8.859 to 6.070). The combination of 3K3A-aPC, plasma, and TP at both the 5% plasma (μd, -28.52; 95% CI, -34.72 to -22.32) and 10% plasma concentrations (μd, -40.02; 95% CI, -46.22 to -33.82) had higher intercellular permeability than the 3K3A-aPC preincubation group.

Conclusion: Our data show that FP24, in a posttrauma environment, pretreatment with 3K3A-aPC can potentially mitigate the EoT to a greater degree than FP24 with or without 3K3A-aPC. Although further exploration is needed, this represents a potentially ideal and perhaps superior therapeutic treatment for the dysregulated thromboinflammation of injured patients.

Background: Contrast extravasation ("blush") on contrast-enhanced computed tomography (CECT) indicates active bleeding, but diagnostic angiography (AG) following CECT sometimes differs from the CECT findings in patients with pelvic fractures. This study aimed to evaluate the concordance rate between blush on CECT and AG based on pelvic anatomical location.

Methods: This retrospective single-center study included patients (18 years or older) with pelvic fractures between 2015 and 2023 who had AG after CECT. Angiography was performed in patients with blush or hematoma on CECT, or unstable hemodynamics due to pelvic fracture. Pelvic bleeding regions were categorized separately into left and right as anterior internal iliac artery and posterior internal iliac artery based on pelvic arterial anatomy. The concordance rate between blush on CECT and AG was assessed using the k statistic.

Results: A total of 87 patients with pelvic fractures were included. Among these, 75 (86%) had blush on CECT, and 12 (14%) had no blush on CECT. The concordance rate was 83% (95% confidence interval, 0.03-0.57; k = 0.30) when assessed on an individual patient basis and 53% (95% confidence interval, 0.24-0.44; k = 0.34) when evaluated by anatomical regions on a unilateral half of the pelvis. The concordance rate for the anatomical hemipelvis evaluation was significantly lower compared with the individual evaluation ( p < 0.001). Thirty-three percent of patients with unilateral blush on CECT showed new contralateral blushes during AG.

Conclusion: The location of active bleeding often differs between CECT and AG, indicating that bleeding may change intermittently and at various sites over time. This suggests the importance of evaluating both sides of the pelvic arteries during AG rather than solely relying on CECT findings.

Level of evidence: Prognostic and Epidemiological; Level IV.

Background: Lung contusion (LC) complicated by pneumonia is associated with a higher risk of acute lung injury (ALI) mediated by activation of immune cells and injury to the lung epithelium. Small extracellular vesicles (sEVs) are essential mediators of cellular crosstalk; however, their role in the development of postinjury ALI remains unclear. We hypothesized that LC complicated by pneumonia increases the pro-inflammatory effect of alveolar sEVs on macrophages and the cytotoxicity of alveolar sEVs to pulmonary epithelial cells, worsening the severity of ALI.

Methods: Studies in C57BL/6 mice were designed with four groups: sham, LC, Pneumonia (Pneu), and LC + Pneu. Lung contusion was induced by a cortical controlled impactor, while pneumonia was conducted by intratracheal injection of 10 5 cfu Pseudomonas aeruginosa . Bronchoalveolar lavage fluid (BAL) was harvested 24 hours postinfection, and sEVs were purified by centrifugation and size exclusion chromatography. To evaluate the effect of alveolar sEV on cells, sEVs from each group were cocultured with macrophages (RAW 264.7) to assess cytokine release and lung epithelial cells (MLE 12) to assess epithelial cytotoxicity.

Results: The LC + Pneu group severely injured lungs histologically and increased the susceptibility to the bacteria. The LC + Pneu group showed higher concentrations of proteins, macrophage inflammatory protein 1-alpha (MIP1α), and intercellular adhesion molecule 1 (ICAM-1) in BAL. MIP1α and ICAM-1 expression in the macrophages increased after incubation with sEVs from the LC + Pneu group. Moreover, the sEVs demonstrated higher cytotoxicity to epithelial cells and increased apoptosis in epithelial cells after incubation with sEVs from the LC + Pneu group.

Conclusion: Lung contusion complicated by pneumonia increased the pro-inflammatory effect of alveolar sEVs on macrophages and the cytotoxicity of alveolar sEVs to pulmonary epithelial cells, worsening the severity of ALI. These results demonstrate the potential importance of alveolar sEVs in lung inflammation following a bacterial infection after trauma.