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Urologic Oncology: Bladder, Penis, and Urethral Cancer, and Basic Principles of Oncology. 泌尿肿瘤学》:膀胱癌、阴茎癌和尿道癌》和《肿瘤学基本原理》。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1097/JU.0000000000004288
Sam S Chang
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引用次数: 0
Editorial Comment. 编辑评论。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1097/JU.0000000000004336
Matthieu Peycelon, Amane-Allah Lachkar
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引用次数: 0
Reply: Development of a Novel Prediction Tool for Response to First-Line Treatments of Monosymptomatic Nocturnal Enuresis: A Randomized, Controlled, International, Multicenter Study (DRYCHILD). 一项随机、对照、国际、多中心研究(DRYCHILD):开发一种新的预测单症状夜间遗尿症一线治疗反应的工具。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI: 10.1097/JU.0000000000004356
Cecilie Siggaard Jørgensen, Søren Rittig
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引用次数: 0
High 11-Ketotestosterone Linked to Shorter Time to Castration Resistance in Recurrent Nonmetastatic Prostate Cancer. 高11-酮睾酮与复发性非转移性前列腺癌患者出现阉割抵抗的时间缩短有关。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-11-15 DOI: 10.1097/JU.0000000000004333
Cylia Dahmani, Patrick Caron, David Simonyan, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Lévesque, Chantal Guillemette

Purpose: The contribution of 11-oxygenated androgens to the progression of lethal prostate cancer (PCa) remains unresolved. We hypothesized that evaluating circulating levels of 11-oxygenated androgens, such as the androgen receptor agonist 11-ketotestosterone (11KT), could serve as a potential predictor of the onset of castration-resistant PCa (CRPC).

Materials and methods: We used mass spectrometry to quantify 11-oxygenated androgens in postoperative plasma samples acquired from 145 patients who subsequently received androgen deprivation therapy for biochemical recurrence and achieved castrated testosterone levels. Kaplan-Meier survival analyses and multivariable Cox models were used to investigate relationships between steroids and CRPC.

Results: Of 145 patients, 31 developed CRPC with a median time to CRPC of 57 months. 11-Oxygenated androgen levels were unaffected by androgen deprivation therapy, which stands in contrast to the observed changes in testosterone and other steroids. 11KT was the most abundant androgen but was not linked to clinical features. Kaplan-Meier analysis revealed that 11KT levels above the median of 273 pg/mL were associated with a shorter time to CRPC (P = .03). In multivariable analyses, this was supported with an adjusted HR of 2.17 (95% CI, 0.99-4.71; P = .05).

Conclusions: 11KT is a key component of the hormonal profile predictive of earlier onset of CRPC. Enhancing our understanding of the specific role of 11KT in the progression to CRPC could help optimize hormonal therapy for castration-sensitive patients with PCa and CRPC.

背景11-氧合雄激素对致命性前列腺癌(PCa)进展的影响仍未解决。我们假设,评估11-氧合雄激素(如雄激素受体激动剂11-酮睾酮(11KT))的循环水平可作为预测阉割抵抗性前列腺癌(CRPC)发病的潜在指标:我们使用质谱法对145名患者的术后血浆样本中的11-氧合雄激素进行了定量分析,这些患者随后因生化复发(BCR)而接受了雄激素剥夺疗法(ADT),并达到了阉割睾酮(T)水平。采用卡普兰-梅耶生存分析和多变量考克斯模型研究类固醇与CRPC之间的关系:在145名患者中,31人发展为CRPC,中位CRPC时间为57个月。11-氧合雄激素水平不受ADT的影响,这与观察到的T和其他类固醇的变化形成鲜明对比。11KT是含量最高的雄激素,但与临床特征无关。Kaplan-Meier分析显示,11KT水平高于中位数273 pg/mL与CRPC发生时间较短有关(P = 0.03)。在多变量分析中,调整后的危险比为2.17(95%置信区间(CI)0.99-4.71;P = 0.05):11KT是预测早期CRPC发病的激素谱的关键组成部分。加强对11KT在CRPC进展过程中特定作用的了解有助于优化阉割敏感性PCa和CRPC患者的激素治疗。
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引用次数: 0
Reply: Development of a Novel Prediction Tool for Response to First-Line Treatments of Monosymptomatic Nocturnal Enuresis: A Randomized, Controlled, International, Multicenter Study (DRYCHILD). 回复:针对单症状夜间遗尿症一线治疗反应的新型预测工具的开发:国际多中心随机对照研究 (DRYCHILD)。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1097/JU.0000000000004330
Cecilie Siggaard Jørgensen, Søren Rittig
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引用次数: 0
Reply: Radiating for Two: Quantifying Radiation Exposure to Pregnant Urologists During Percutaneous Nephrolithotomy.
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1097/JU.0000000000004338
D Duane Baldwin, Zhamshid Okhunov
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引用次数: 0
Editorial Comment.
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1097/JU.0000000000004322
Carl Ceraolo, Scott Quarrier
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引用次数: 0
Letter: Radiating for Two: Quantifying Radiation Exposure to Pregnant Urologists During Percutaneous Nephrolithotomy. 信:两个人的辐射:量化怀孕泌尿科医生在经皮肾镜碎石术中的辐射暴露。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-11-21 DOI: 10.1097/JU.0000000000004325
David T Tzou
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引用次数: 0
Education and Simulation in Urology. 泌尿外科教育与模拟。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-12-09 DOI: 10.1097/JU.0000000000004344
Yash B Shah
{"title":"Education and Simulation in Urology.","authors":"Yash B Shah","doi":"10.1097/JU.0000000000004344","DOIUrl":"10.1097/JU.0000000000004344","url":null,"abstract":"","PeriodicalId":17471,"journal":{"name":"Journal of Urology","volume":" ","pages":"389-390"},"PeriodicalIF":5.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply by Authors. 作者回复。
IF 5.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1097/JU.0000000000004352
Cylia Dahmani, Patrick Caron, David Simonyan, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Lévesque, Chantal Guillemette
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引用次数: 0
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Journal of Urology
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