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Concerns of non-hodgkin's lymphoma in open-heart surgery for rheumatic heart disease: A case report and review of literature 风湿性心脏病心内直视手术对非霍奇金淋巴瘤的关注:一例报告及文献回顾
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_79_22
Anish Gupta, Anshuman Darbari, U. Nath, R. Abisho
There are concerns regarding safe conduct of open-heart surgery in a patient with hematological malignancy, both in intraoperative and postoperative management of the patient. There is a paucity of literature regarding this problem and limited data have been published regarding the conduct of coronary artery bypass surgery on pump in a patient with hematological malignancies. We describe our experience in a patient with rheumatic heart disease with non-Hodgkin's lymphoma requiring mitral valve replacement.
对于恶性血液病患者进行心内直视手术的安全性,无论是术中还是术后的管理,都值得关注。关于这个问题的文献很少,关于血液系统恶性肿瘤患者在泵上进行冠状动脉搭桥手术的数据也有限。我们描述我们的经验,病人风湿性心脏病与非霍奇金淋巴瘤需要二尖瓣置换术。
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引用次数: 0
Role of yoga in prehypertension and hypertension 瑜伽在高血压前期和高血压中的作用
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_39_22
Abhay Kumar, G. Keshavamurthy, Navreet Singh, Balwinder Singh, R. Vaidya, Tanmoy Roy, S. Singh, Ankush Gupta, N. Bajaj, P. Barwad, Ekambir Singh
Background: The high prevalence of hypertension in India necessitates both pharmacological and nonpharmacological measures to control it. Here, we report the findings of a study to investigate the effectiveness of yoga therapy in lowering blood pressure (BP) in prehypertensive and hypertensive individuals. Methods: This was a single center, nonrandomized controlled clinical trial, of 200 hypertensives and 100 prehypertensives patients. The control group received the prescribed antihypertensive and lifestyle modification while the yoga group was additionally taught simple yogic exercise by a trained yoga teacher. This training included intensive supervised phase 2-h training sessions in Ujjayi breathing, Bhastrika Pranayama and chanting of “Om” for 10 lessons, followed by self-performed yogic exercise at home for 1 h till the end of study at 1 year. Results: The systolic BP (SBP) in the hypertensive yoga group was significantly lower (t = 3.04, P < 0.01) than the control group at 6 months, but not so at 1 year (SBP t = 0.53, P > 0.05). In the prehypertensive participants, at 6 months (t = 5.85, P = 0.00), and 1 year (t = 6.385, P < 0.05) a significant difference was observed between SBP of the two groups However, no significant difference was observed between the diastolic BP among hypertensives or prehypertensives at 6 months and 1 year. Conclusion: Our present study indicates that yoga therapy is a viable adjunct to pharmacological intervention to reduce SBP in the management of hypertension and prehypertension and that yoga should be incorporated in the treatment regime of such patients, specifically for individuals who have prehypertension.
背景:印度高血压的高患病率需要采取药物和非药物措施来控制它。在此,我们报道了一项研究结果,该研究旨在调查瑜伽疗法在高血压前期和高血压患者中降低血压(BP)的有效性。方法:这是一项单中心、非随机对照的临床试验,共有200名高血压患者和100名高血压前期患者。对照组接受了规定的降压药和生活方式的改变,而瑜伽组则由受过训练的瑜伽老师教授简单的瑜伽运动。这项训练包括在Ujjayi呼吸、Bhastrika Pranayama的强化监督下进行2小时的训练,并念10节“Om”,然后在家进行1小时的瑜伽练习,直到1年的学习结束。结果:高血压瑜伽组的收缩压(SBP)在6个月时显著低于对照组(t=3.04,P<0.01),但在1年时没有显著降低(SBP t=0.53,P>0.05),高血压患者和高血压前期患者在6个月和1年时的舒张压之间没有观察到显著差异。结论:我们目前的研究表明,在高血压和高血压前期的治疗中,瑜伽疗法是药物干预的一种可行的辅助手段,可以降低SBP,并且瑜伽应该纳入此类患者的治疗方案中,特别是对于患有高血压前期的患者。
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引用次数: 0
A narrative review on serum biomarkers of cardiac fibrosis 心脏纤维化血清生物标志物综述
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_19_23
S. Kumari, U. Sharma, Deepika Jindal, Traymbak Basak
Myocardial fibrosis is the excessive deposition of extracellular matrix (ECM) proteins in the cardiac interstitium leading to pathological conditions of the heart. The objective is to understand the pathophysiology of cardiac fibrosis and the quest for serum biomarkers that will assist in early diagnosis before the occurrence of major cardiac events. There are many serum biomarkers that get elevated highlighting ECM remodeling during cardiac fibrosis. Lysyl oxidase like -2 is one such ECM protein, plays a crucial role in the up-regulation of TGF - β, the transformation of cardiac fibroblast to myoblast, the migration of collagen, and cross-linking of collagen and elastin. However, assessment of lysyl oxidase like-2 (LOXL-2) in different pathologically driven cardiac fibrosis is limited. Also, none of the serum biomarkers has proved to be the most accurate diagnostic tool for assessing fibrosis independently; hence, meticulous, less invasive, and cost-effective serum biomarkers need to be scrutinized. Hence lysyl oxidase Like-2 (LOXL-2) in combination with other serum biomarkers like PICP/PINP/TIMP-1/ST-2, or Galectin-3 can be combined to assess the presence of fibrosis in the heart. This review includes the journal, articles, and research paper on cardiac fibrosis which was published in the last 10–15 years to highlight the huge gap in the treatment of cardiac fibrosis and the need for a new combination of biomarkers with better prognostic and diagnostic value.
心肌纤维化是指细胞外基质(ECM)蛋白在心脏间质中过度沉积,导致心脏病理状况。目的是了解心脏纤维化的病理生理学,并寻求有助于重大心脏事件发生前早期诊断的血清生物标志物。有许多血清生物标志物升高,突出了心脏纤维化期间ECM的重塑。赖氨酰氧化酶样-2就是这样一种ECM蛋白,在TGF-β的上调、心脏成纤维细胞向成肌细胞的转化、胶原的迁移以及胶原和弹性蛋白的交联中起着至关重要的作用。然而,赖氨酰氧化酶样-2(LOXL-2)在不同病理驱动的心脏纤维化中的评估是有限的。此外,没有一种血清生物标志物被证明是独立评估纤维化的最准确的诊断工具;因此,需要仔细检查细致、侵入性小、成本效益高的血清生物标志物。因此,赖氨酰氧化酶Like-2(LOXL-2)与其他血清生物标志物(如PICP/PINP/TIMP-1/ST-2或半乳糖凝集素-3)的组合可以用于评估心脏中纤维化的存在。这篇综述包括过去10-15年发表的关于心脏纤维化的期刊、文章和研究论文,以强调心脏纤维化治疗方面的巨大差距,以及对具有更好预后和诊断价值的生物标志物新组合的需求。
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引用次数: 0
Immature mediastinal teratoma mimicking as pulmonary stenosis – A rare presentation 未成熟纵隔畸胎瘤类似肺狭窄-罕见的表现
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_82_22
S. Sarkar, B. Majumder, Debasish Mohapatra, R. Ghosh
Anterior mediastinal teratoma can externally compress the pulmonary artery, which can present with symptoms of pulmonary stenosis rarely. We have reported a case of a 47-year-old male with immature mediastinal teratoma presenting as pulmonary stenosis. Initial physical examination revealed an ejection systolic murmur in the pulmonary area. With suspicion of valvular heart disease, the patient was referred to our cardiology department. Chest X-ray shows mass just above the left hilar zone. Two-dimensional echocardiography shows a mediastinal mass compressing the pulmonary trunk causing an obstruction. Contrast-enhanced computed tomography of thorax and magnetic resonance study confirmed the mediastinal mass. Fine-needle aspiration cytology of the mass suggestive of immature teratoma. The patient was transferred to the cardiothoracic vascular surgery department for further management. Mediastinal mass can mimic valvular heart disease with symptoms of cardiovascular pathology. Proper investigations for diagnostic clarity and prompt management are crucial in these conditions.
前纵隔畸胎瘤可压迫肺动脉,很少出现肺动脉狭窄的症状。我们报告了一例47岁男性纵隔畸胎瘤,表现为肺动脉狭窄。初步体格检查显示肺部有射血收缩杂音。由于怀疑有瓣膜性心脏病,患者被转诊到我们的心脏科。胸部X光片显示左肺门区上方有肿块。二维超声心动图显示纵隔肿块压迫肺干,导致阻塞。胸部对比增强计算机断层扫描和磁共振研究证实了纵隔肿块。肿块的细针抽吸细胞学检查提示为未成熟畸胎瘤。患者被转移到心胸血管外科接受进一步治疗。纵隔肿块可模拟心脏瓣膜病,伴有心血管病理症状。在这些情况下,为了诊断的清晰性和及时的管理进行适当的调查是至关重要的。
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引用次数: 0
LMCA aneurysm and a fistula resulting with a giant extracardiac aneurysm LMCA动脉瘤和由巨大心外动脉瘤引起的瘘管
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_13_23
K. Atilgan, B. Onuk, E. Zafer Cengiz, F. Yesil, A. Çolak, T. Aybek
A 54-year-old, asymptomatic, disease-free female patient was operated for an incidentally detected left main coronary artery aneurysm (CAA) associated with fistula to a giant aneurysm associated with the right atrium (RA). The patient had an extremely rare left main CAA and a fistula connection of a giant aneurysm connecting to the RA.
一名54岁、无症状、无疾病的女性患者因偶然发现的左主冠状动脉瘤(CAA)合并右心房巨大动脉瘤(RA)瘘接受了手术。该患者患有极为罕见的左主干CAA和与RA相连的巨大动脉瘤瘘管连接。
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引用次数: 0
Tuberculosis with new onset of diabetes and hypertension following recovery from coronavirus disease 2019 infection: A case series 2019冠状病毒病感染康复后新发糖尿病和高血压的结核病:一系列病例
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_14_23
R. Chatterjee, Aitihya Chakraborty, K. Sarkar, N. Pramanik, Shatavisa Mukherjee
The sign and symptoms of coronavirus disease 2019 (COVID-19) and infectious disease caused by severe acute respiratory syndrome coronavirus 2 are not only restricted to the respiratory system but includes a myriad of clinical manifestations involving various systems. There are various sequelae of COVID-19 reported. Here, we report a series of three cases of tuberculosis along with new onset of diabetes mellitus and hypertension in previously euglycemic, normotensive patients following recovery from COVID-19.
2019冠状病毒病(新冠肺炎)和严重急性呼吸综合征冠状病毒2引起的传染病的体征和症状不仅限于呼吸系统,还包括涉及各种系统的无数临床表现。报道了新冠肺炎的各种后遗症。在此,我们报告了一系列三例结核病病例,以及新冠肺炎康复后血糖正常、血压正常的患者新发的糖尿病和高血压。
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引用次数: 0
Comparative analysis of different prognostic markers in predicting outcome in advanced heart failure 不同预后标志物预测晚期心力衰竭预后的比较分析
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_17_23
Parth Godhiwala, S. Sushanth Kumar, S. Acharya, M. Patel
Introduction: Heart failure (HF) is a debilitating condition with an adverse outcome, especially during the advanced stage having higher morbidity and mortality rates. Various parameters have been used as prognostic markers in advanced HF. This study highlights about the comparative analysis of different prognostic markers in predicting mortality in advanced HF. Methods: This prospective observational study was conducted in patients of advanced HF admitted to the department of medicine intensive care unit in a rural tertiary care hospital from 2018 to 2020. Advanced HF was diagnosed using the updated HF Association-European Society of Cardiology criteria. The serum N-terminal pro-B-type natriuretic peptide (NT-proBNP), six-minute walk test (6MWT), left ventricular ejection fraction (LVEF), estimated glomerular filtration rate, and glycosylated hemoglobin type A1c levels were measured on admission. Receiver operating characteristic (ROC) curve was also studied for the above-mentioned variables, and the area under ROC curve (AUROC) was also determined. Results: Seventy-five patients with an average age of 60.55 ± 14.04 years were evaluated. Out of 75, 48 (64%) were male and 27 (36%) were female. There was inhospital mortality in 20 (26.67%) patients. The mean NT-proBNP levels among the mortality group was 9826.95 ± 3485.10 pg/mL, while in nonmortality group, it was 6135.40 ± 2342.77 pg/mL (P = 0.001). The cutoff range in this study for on-admission serum NT-proBNP levels was 8990 pg/mL, with AUROC of 0.81, the sensitivity of 70.0%, and specificity of 90.9%. In multiple regression analysis keeping mortality as the dependent variable, it was seen that variables NT-proBNP, 6MWT (<300 m), and LVEF were significantly associated with mortality. Conclusion: Serum NT-proBNP and 6MWT (<300 m) were important predictors of mortality in advanced HF.
心力衰竭(HF)是一种具有不良后果的衰弱性疾病,特别是在晚期,具有较高的发病率和死亡率。各种参数已被用作晚期心衰的预后指标。本研究强调了不同预后指标在预测晚期心衰死亡率方面的比较分析。方法:对某农村三级医院内科重症监护室2018 - 2020年收治的晚期心衰患者进行前瞻性观察研究。晚期心衰诊断采用最新的心衰协会-欧洲心脏病学会标准。入院时测定血清n端前b型利钠肽(NT-proBNP)、6分钟步行试验(6MWT)、左心室射血分数(LVEF)、肾小球滤过率和糖化血红蛋白A1c水平。研究了上述变量的受试者工作特征(ROC)曲线,并确定了受试者工作特征曲线下面积(AUROC)。结果:患者75例,平均年龄60.55±14.04岁。75人中,男性48人(64%),女性27人(36%)。住院死亡20例(26.67%)。死亡组NT-proBNP均值为9826.95±3485.10 pg/mL,非死亡组NT-proBNP均值为6135.40±2342.77 pg/mL (P = 0.001)。本研究入院时血清NT-proBNP水平的截止范围为8990 pg/mL, AUROC为0.81,敏感性为70.0%,特异性为90.9%。在以死亡率为因变量的多元回归分析中,NT-proBNP、6MWT (<300 m)和LVEF与死亡率显著相关。结论:血清NT-proBNP和6MWT (<300 m)是晚期心衰患者死亡率的重要预测指标。
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引用次数: 1
Hybrid approach for postclassical blalock–Taussig shunt tetralogy 后古典blallock - taussig分流四联症的混合方法
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_57_22
Vishal Agrawal, P. Garg, P. Vyas, Joshi Hasit, Amit Mishra
In developing countries, we still come across occasional patients who have undergone classic Blalock–Taussig shunt (CBTS) previously. We present a case of 23-year-old female with tetralogy of Fallot who had undergone CBTS operation at the age of 1 year and is now presented for total correction. Takedown of CBTS during surgery has catastrophic complications during looping and ligation of shunt due to extensive collateralization. We, therefore, took a hybrid approach for the patient. The CBTS was first blocked with the balloon, followed by surgical intracardiac repair, and finally, by device closure of CBTS.
在发展中国家,我们仍然偶尔会遇到以前接受过经典Blalock-Taussig分流术(CBTS)的患者。我们报告了一例23岁的法洛四联症女性患者,她在1岁时接受了cbt手术,现在正在进行全面矫正。手术中CBTS的拆除由于广泛的侧支,在分流术的环和结扎过程中会产生灾难性的并发症。因此,我们对病人采取了一种混合的方法。首先用球囊阻断CBTS,然后进行心内手术修复,最后通过装置关闭CBTS。
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引用次数: 1
Successful surgical extraction of an entrapped intra-aortic balloon pump 手术成功取出夹住的主动脉内球囊泵
IF 0.1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_84_22
Jayarama Pai, S. Mukkannavar, Bharat Siddharth, R. Geethika, D. Shriram
Intra-aortic balloon pump use is an approach for the provision of mechanical support to improve cardiac output and perfusion in the perioperative period in patients undergoing coronary intervention. Despite its beneficial use, rupture of the balloon and entrapment of blood clots in the lumen may occur in very rare cases. We discuss a postoperative presentation, plan, and operative management for the removal of an entrapped balloon catheter.
主动脉内球囊泵是冠状动脉介入治疗患者围手术期提供机械支持以改善心输出量和灌注的一种方法。尽管它的有益用途,破裂的球囊和困住的血凝块在管内可能发生在非常罕见的情况下。我们讨论一个术后的表现,计划,和手术管理去除夹持球囊导管。
{"title":"Successful surgical extraction of an entrapped intra-aortic balloon pump","authors":"Jayarama Pai, S. Mukkannavar, Bharat Siddharth, R. Geethika, D. Shriram","doi":"10.4103/jpcs.jpcs_84_22","DOIUrl":"https://doi.org/10.4103/jpcs.jpcs_84_22","url":null,"abstract":"Intra-aortic balloon pump use is an approach for the provision of mechanical support to improve cardiac output and perfusion in the perioperative period in patients undergoing coronary intervention. Despite its beneficial use, rupture of the balloon and entrapment of blood clots in the lumen may occur in very rare cases. We discuss a postoperative presentation, plan, and operative management for the removal of an entrapped balloon catheter.","PeriodicalId":17503,"journal":{"name":"Journal of the Practice of Cardiovascular Sciences","volume":"9 1","pages":"73 - 75"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47880046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A quasi-experimental study to assess the effectiveness of structured counseling among caregivers of heart failure patients on selected outcomes 一项准实验研究,评估结构化咨询在心衰患者护理人员中对选定结果的有效性
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/jpcs.jpcs_1_23
Lakshmanan Gopichandran, Shivani Chauhan, Milan Tirwa, Sandeep Seth, Sujata Satapathy, PayalKahol Hote
Background: In India, heart failure (HF) is one of the most prevalent chronic diseases. Caregivers are essential and play an important role in bridging the gap in providing care to HF patients. Caregivers' demanding and difficult roles can result in a significant burden, which may lead to stress and symptoms of depression. Aim and Objectives: The objective of the study is to assess the effectiveness of structured counseling on caregiver burden, stress, and depression among caregivers of HF patients. Materials and Methods: Sixty caregivers of patients with HF were selected using consecutive sampling and divided into control and experimental groups. A one-on-one, 30-min structured counseling session was delivered telephonically to caregivers of HF patients. A pretest was taken before the intervention and posttest 1 month later, through telephone, on caregiver burden, stress, and depression using the caregiver burden interview, Perceived Stress Scale, and Patient Health Questionnaire-9. Results: The experimental group showed a significant reduction in caregiver burden (P = 0.001), stress (P = 0.001), and depression (P = 0.001) scores at 1 month. Female caregivers showed a significantly higher caregiver burden (P = 0.046) and depression (P = 0.019), and nuclear families showed a significantly higher caregiver burden (P = 0.016) and depression (P = 0.027). There was a significant positive correlation between stress and the presence of comorbidities (P = 0.021) and depression and the presence of comorbidities (P = 0.042). Conclusions: Structured counseling was effective in reducing caregiver burden and decreasing stress and depression in caregivers of HF patients.
{"title":"A quasi-experimental study to assess the effectiveness of structured counseling among caregivers of heart failure patients on selected outcomes","authors":"Lakshmanan Gopichandran, Shivani Chauhan, Milan Tirwa, Sandeep Seth, Sujata Satapathy, PayalKahol Hote","doi":"10.4103/jpcs.jpcs_1_23","DOIUrl":"https://doi.org/10.4103/jpcs.jpcs_1_23","url":null,"abstract":"Background: In India, heart failure (HF) is one of the most prevalent chronic diseases. Caregivers are essential and play an important role in bridging the gap in providing care to HF patients. Caregivers' demanding and difficult roles can result in a significant burden, which may lead to stress and symptoms of depression. Aim and Objectives: The objective of the study is to assess the effectiveness of structured counseling on caregiver burden, stress, and depression among caregivers of HF patients. Materials and Methods: Sixty caregivers of patients with HF were selected using consecutive sampling and divided into control and experimental groups. A one-on-one, 30-min structured counseling session was delivered telephonically to caregivers of HF patients. A pretest was taken before the intervention and posttest 1 month later, through telephone, on caregiver burden, stress, and depression using the caregiver burden interview, Perceived Stress Scale, and Patient Health Questionnaire-9. Results: The experimental group showed a significant reduction in caregiver burden (P = 0.001), stress (P = 0.001), and depression (P = 0.001) scores at 1 month. Female caregivers showed a significantly higher caregiver burden (P = 0.046) and depression (P = 0.019), and nuclear families showed a significantly higher caregiver burden (P = 0.016) and depression (P = 0.027). There was a significant positive correlation between stress and the presence of comorbidities (P = 0.021) and depression and the presence of comorbidities (P = 0.042). Conclusions: Structured counseling was effective in reducing caregiver burden and decreasing stress and depression in caregivers of HF patients.","PeriodicalId":17503,"journal":{"name":"Journal of the Practice of Cardiovascular Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136217715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of the Practice of Cardiovascular Sciences
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