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High Prevalence of Vitamin D Deficiency in Women Presenting to Rheumatology Clinic in North of Iran: An Inverse Relation with Age 伊朗北部风湿病诊所妇女维生素D缺乏症高发:与年龄成反比
Pub Date : 2013-05-29 DOI: 10.4172/2167-0420.1000123
B. Heidari, P. Heidari, K. Tilaki
Background: Vitamin D deficiency is linked to bone mass attainment during adolescence period and to the development or progression of several rheumatic diseases that commonly appears in young females. There is a gap in the existing literature pertaining to vitamin D levels across the life-stages. This study was designed to investigate the status of serum vitamin D according to age in women presnting to rheumatology clinic in north of Iran. Methods: A total of 843 women were consecutively entered to study. Serum 25-hydroxyvitamin D (25-OHD) was measured by ELISA method and concentratins <20 ng/ml was considered as deficiency. Mean 25-OHD and proportions of 25-OHD deficiency was compared according to decades of age and between premenopausal (<50) and postmenpausal (≥ 50 years) women using Mann-Whitney and chi-square tests. Spearman’s test was used for correlation. Results: The median age was 50 (range 15-91) years. Overall 52.8% had 25-OHD deficiency and 24.6% had 25-OHD<10 ng/ml. Mean 25-OHD and proportion of deficiency diferred significantly across various decades of age (P=0.0001 for both).Mean 25-OHD positively correlated to age (r=0.300 P=0.0001) and proportion of 25-OHD deficiency inversely correlated with age (P=0.0001). Mean 25-OHD was lower and proportion of 25-OHD deficiency was higher in premenopausal versus postmenopausal women (P=0.001 for both). Conclusion: These findings indicate an inversly agerelated high prevalence of vitamin D deficiency particularly in premenopausal women presenting to rheumatology clinic. Regarding a link between vitamin D deficiency and development of several rheumatic diseases as well as bone mass impairment these findings suggest early recognition of vitamin D deficiency in young women. *Corresponding author: BehzadHeidari, Department of medicine, Rouhani hospital, Babol University of medical sciences, Babol, Iran, E-mail: heidaribeh@yahoo.com Received April 04, 2013; Accepted May 27, 2013; Published May 29, 2013 Citation: Heidari B, Heidari P, Tilaki KH (2013) High Prevalence of Vitamin D Deficiency in Women Presenting to Rheumatology Clinic in North of Iran: An Inverse Relation with Age. J Women’s Health Care 2: 123. doi:10.4172/21670420.1000123 Copyright: © 2013 Heidari B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
背景:维生素D缺乏症与青春期骨量的形成有关,也与年轻女性常见的几种风湿性疾病的发生或进展有关。现有文献中关于生命各阶段维生素D水平的研究存在空白。本研究旨在调查伊朗北部风湿病门诊就诊妇女血清维生素D的不同年龄状况。方法:对843名女性进行连续研究。ELISA法测定血清25-羟基维生素D (25-OHD),浓度<20 ng/ml为缺乏。采用Mann-Whitney检验和卡方检验比较绝经前(<50岁)和绝经后(≥50岁)妇女的平均25-OHD和25-OHD缺乏症的比例。采用Spearman检验进行相关性分析。结果:中位年龄50岁(15-91岁)。总体而言,52.8%的患者25-OHD缺乏,24.6%的患者25-OHD<10 ng/ml。平均25-OHD和缺乏比例在不同年龄层之间差异显著(两者P=0.0001)。平均25-OHD与年龄呈正相关(r=0.300 P=0.0001), 25-OHD缺乏率与年龄呈负相关(P=0.0001)。绝经前妇女的平均25-OHD较低,25-OHD缺乏的比例高于绝经后妇女(两者均P=0.001)。结论:这些发现表明维生素D缺乏症的高患病率呈负相关,特别是在风湿病诊所就诊的绝经前妇女中。关于维生素D缺乏与几种风湿性疾病的发展以及骨量损害之间的联系,这些研究结果表明,年轻女性应及早认识到维生素D缺乏。*通讯作者:BehzadHeidari,伊朗巴博勒医科大学鲁哈尼医院医学部,E-mail: heidaribeh@yahoo.com2013年5月27日录用;引文:Heidari B, Heidari P, Tilaki KH(2013)伊朗北部风湿病诊所女性维生素D缺乏症的高发率:与年龄成反比。[J]妇女保健杂志2:123。doi:10.4172/21670420.1000123版权所有:©2013 Heidari B等。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是要注明原作者和来源。
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引用次数: 10
Factors Influencing the Uptake of HIV Testing During Antenatal Care inRural Uganda 影响乌干达农村产前保健期间接受艾滋病毒检测的因素
Pub Date : 2013-02-03 DOI: 10.4172/2167-0420.1000121
Z. Mumtaz, N. Merchant, A. Levay
Despite critics of the ‘opt-out’ policy surrounding HIV testing during antenatal care visits in Uganda suggesting that women may be deterred from seeking antenatal care at facilities with on-site testing, empirical evidence suggests the acceptability of HIV testing during antenatal care has been significantly increasing over the last decade. Furthermore, there is a disconnect between high rates of antenatal care and low rates of facility births implying that there are other reasons women use antenatal care besides to prepare for a facility delivery. The aim of this paper is to investigate the role HIV testing has in the high rates of antenatal care uptake in Uganda. A focused ethnographic study was undertaken in two areas of Kabarole district between the period of September 2009 and January 2010. Data collection consisted of in-depth interviews, focus groups and participant observation.
尽管对乌干达产前保健期间艾滋病毒检测的“选择退出”政策的批评表明,妇女可能会被阻止在有现场检测的机构寻求产前保健,但经验证据表明,在过去十年中,产前保健期间艾滋病毒检测的可接受性已显著提高。此外,高产前保健率与低设施分娩率之间存在脱节,这意味着除了为设施分娩做准备外,妇女使用产前保健还有其他原因。本文的目的是调查艾滋病毒检测的作用,在乌干达产前保健的高吸收率。2009年9月至2010年1月期间,在卡巴罗尔区的两个地区开展了一项重点人种学研究。数据收集包括深度访谈、焦点小组和参与者观察。
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引用次数: 2
Incidence of Menstrual Disorders is Not Influenced by Nulliparity 月经紊乱的发生率不受未生育的影响
Pub Date : 2013-01-01 DOI: 10.4172/2167-0420.1000119
S. Pinzauti, N. Conti, I. D. Blasis, S. Vannuccini, Cinzia Orl, ini, L. Sabbioni, A. Testa, F. Petraglia
Background: Nulliparity is a condition that has been associated with some oncological gynecological diseases. Since religious community is a realistic example of nulliparous women, the present study aims to evidence if nulliparity is a risk factor for developing menstrual disorders and benign gynecological diseases. Materials and Methods: The present observational retrospective study enrolled 442 women divided in Group A (n=216; Catholic nuns) and Group B (n=226; parous women). All eligible women filled in standardized questionnaires, to obtain data on physiological and pathological aspects of menstrual cycle and related gynecological data. Statistical analysis was performed using univariate statistical analyses, Mann-Whitney U test or Fisher exact test. P<0.05 was considered statistically significant. Results: The results showed that nulliparity is not correlated with a different incidence of menstrual cycle disorders (in term of length or bleeding), or gynecological disorders (ovarian or uterine). Dysmenorrhea is more common in pluriparous women, with a higher use of painkillers in nulliparous women. Conclusion: Therefore, the present study suggests that nulliparity does not represent a risk factor for the development of menstrual irregularity and painful symptomatology, compared with pluriparous women.
背景:不孕是一种与某些肿瘤性妇科疾病相关的疾病。由于宗教团体是无生育妇女的现实例子,本研究旨在证明无生育是否是发生月经紊乱和良性妇科疾病的危险因素。材料和方法:本观察性回顾性研究纳入442名妇女,分为A组(n=216;天主教修女)和B组(226例;怀孕的女性)。所有符合条件的妇女填写标准化问卷,获取月经周期的生理和病理方面的数据以及相关的妇科数据。统计分析采用单变量统计分析、Mann-Whitney U检验或Fisher精确检验。P<0.05为差异有统计学意义。结果:不孕与月经周期紊乱(长度或出血)或妇科紊乱(卵巢或子宫)的不同发生率无关。痛经在多产妇女中更为常见,未产妇女使用止痛药的比例较高。结论:因此,本研究表明,与多产妇女相比,未生育并不代表月经不规律和疼痛症状发展的危险因素。
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引用次数: 1
Development of a Cancer Treatment with Low-Intensity Ultrasound 低强度超声治疗癌症的研究进展
Pub Date : 2013-01-01 DOI: 10.4172/2167-0420.1000E113
M. Emoto
Copyright: © 2013 Emoto M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In recent years, research on the usage of ultrasound for cancer treatment has developed and while high intensity focused ultrasound (HIFU, FUS) has already been clinically applied to several types of cancers, it is not yet considered as an established treatment. On the other hand, studies using ultrasound energy for cancer treatment have advanced, thus revealing the enhancement of drug effects by employing low-intensity ultrasound. Furthermore, anti-angiogenesis against tumors is now attracting attention as a new cancer treatment. Therefore, our research focused on the biological effects and the enhancement of drug effects brought by this low-intensity ultrasound energy and reported on the efficacy against a uterine sarcoma model, by implementing the basic studies, for the first time, including the concomitant use of low-intensity ultrasound irradiation, as an expected new antiangiogenic therapy for cancer treatment. Furthermore, we have succeeded in simultaneously utilizing low-intensity ultrasound in both diagnosis and treatment, upon real time evaluation of the anti-tumor effects and anti-angiogenesis effects using color Doppler ultrasound imaging [1].
版权所有:©2013 Emoto M.这是一篇根据知识共享署名许可条款发布的开放获取文章,该许可允许在任何媒体上不受限制地使用、分发和复制,前提是注明原作者和来源。近年来,超声在癌症治疗中的应用研究有所发展,虽然高强度聚焦超声(HIFU, FUS)已经在临床上应用于几种类型的癌症,但尚未被认为是一种确定的治疗方法。另一方面,利用超声能量治疗癌症的研究取得了进展,揭示了利用低强度超声增强药物作用。此外,抗肿瘤血管生成作为一种新的癌症治疗方法正受到人们的关注。因此,我们的研究重点是这种低强度超声能量带来的生物效应和药物增强效应,并首次开展基础研究,报道了对子宫肉瘤模型的疗效,包括同时使用低强度超声照射,作为一种有望的抗癌新抗血管生成疗法。此外,我们利用彩色多普勒超声成像实时评估抗肿瘤作用和抗血管生成作用,成功地将低强度超声同时用于诊断和治疗[1]。
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引用次数: 0
Managing Costs in High Risk Obstetrics: The Value of Technology thatImproves Diagnostic Accuracy 高风险产科的成本管理:提高诊断准确性的技术价值
Pub Date : 2013-01-01 DOI: 10.4172/2167-0420.1000120
M. Lopes
In the USA, about 12.8% of babies (more than half a million a year) are born prematurely. The rate of premature birth has increased by 36% since the early 1980’s, [1] and is now responsible for an estimated $26 billion in costs to the American healthcare system annually [2]. Unfortunately, little progress has been made to decrease prevalence in so serious condition. From a managed care perspective, a premature birth constitutes a potential high cost episode of care and high-risk pregnancies constitute a major category of high-cost for payers. In Medicaid, 27% of all inpatient charges and 60% of all hospital procedures covered by Medicaid [3] are related to pregnancy and although only 10% of pregnancies are considered high risk, they account for 57% of total newborn costs [4]. A recent analysis found that overall, 4% of the Medicaid population was responsible for 48% of program spending in 2001 [5]. These high-cost members translate into highly concentrated spending on only a small fraction of the entire population. In this paper we will identify ways in which new technology can improve the diagnostic accuracy of pregnancy-related disorders and assist in managing the costs of high risk obstetrics.
在美国,大约12.8%的婴儿(每年超过50万)早产。自20世纪80年代初以来,早产率上升了36%,[1]并且现在每年给美国医疗保健系统造成约260亿美元的成本[2]。不幸的是,在如此严重的情况下,在降低患病率方面进展甚微。从管理式护理的角度来看,早产构成了潜在的高成本护理事件,高风险妊娠构成了支付者高成本的主要类别。在医疗补助中,27%的住院费用和60%的医疗程序[3]与怀孕有关,尽管只有10%的怀孕被认为是高风险的,但它们占新生儿总成本的57%[4]。最近的一项分析发现,2001年总体而言,4%的医疗补助人口承担了48%的项目支出[5]。这些高成本的成员意味着支出高度集中在整个人口的一小部分。在本文中,我们将确定新技术如何提高妊娠相关疾病的诊断准确性,并协助管理高风险产科的成本。
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引用次数: 3
The Role of Late Amniocentesis in the Management of PretermParturition 晚期羊膜穿刺术在早产管理中的作用
Pub Date : 2013-01-01 DOI: 10.4172/2167-0420.1000E109
O. Erez, M. Mazor
Copyright: © 2013 Erez O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Preterm labor and preterm PROM are both obstetrical syndromes leading to spontaneous preterm birth. This is one of the leading causes for maternal and neonatal morbidity and perinatal mortality [1-3]. Indeed, premature delivery has a lifelong effect on the neonates, ranging from severe morbidities near to the time of birth (i.e. respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and sepsis) to chronic morbidities later on in life (i.e. retinopathy of prematurity, bronchopulmonary dysplasia, cerebral palsy, and reduces mental and cognitive functions) [1-3]. The Institute of Medicine in the USA has estimated in 2005 that the annual cost of these obstetrical syndromes is about 25 billion US Dollars [4]. Thus, there is urgent need for tools that will assist in prevention and treatment of prematurity.
版权所有:©2013 Erez O, et al。这是一篇根据知识共享署名许可协议发布的开放获取文章,该协议允许在任何媒体上不受限制地使用、分发和复制,前提是要注明原作者和来源。早产和早PROM都是导致自发性早产的产科综合征。这是孕产妇和新生儿发病率和围产期死亡率的主要原因之一[1-3]。事实上,早产对新生儿有终身影响,从出生时的严重发病(如呼吸窘迫综合征、脑室内出血、坏死性小肠结肠炎和败血症)到生命后期的慢性发病(如早产儿视网膜病变、支气管肺发育不良、脑瘫、精神和认知功能下降)[1-3]。据美国医学研究所估计,2005年这些产科综合症的年度费用约为250亿美元。因此,迫切需要有助于预防和治疗早产的工具。
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引用次数: 2
Female Genital Mutilation (FGM) is Still a Challenge in DevelopingCountries 女性生殖器切割(FGM)在发展中国家仍然是一个挑战
Pub Date : 2012-11-05 DOI: 10.4172/2167-0420.1000E107
A. Ali
I am honored to have been invited to write an editorial to the Journal of Woman’s Health Care. I would like in this article to discuss one of the harmful practice to woman’s health. Female Genital Mutilation (FGM) or Female Genital Cutting represents a violation of human and child rights and outlawed in many countries [1]. Female Genital Mutilation (FGM) or cutting is defined as “all procedures involving partial or total removal of the external female genitalia or other injury to the female organs whether for cultural or other non-therapeutic reasons” [2]. Even to date, the governments of many developing countries where the practice is highly prevalent are not taking strong stand against female genital cutting, this might be explained by the fear of the government from the society which accept circumcision as necessary, natural and adopt the rationale for its existence [3]. In Sudan, where I am working there is a very high prevalence rate of FGM (ranged between 87%-100%) [4]. It is little bit of low prevalence (50.3%) in neighboring Egypt and ranged between 23.3%-45.2% in Nigeria. In some African and Asian countries for example Eritrea, Djibouti, Mali and Somalia, the prevalence rate of FGM is more than 90% [5]. Generally the girls undergo the procedures between the age of 6 and 12 year old before they become decisive persons, thus the practice is against the child and human rights. Female genital cutting always performed by midwives without anesthesia, moreover it is practiced without precaution concerning the septic conditions is putting the girls at a greater risk of complications. FGM is a public health issue with recognized complications such as hemorrhage, shock, infection, necrotizing fasciitis, pain and psychological morbidities [6].
我很荣幸被邀请为《妇女保健杂志》写一篇社论。我想在这篇文章中讨论一种对妇女健康有害的做法。女性生殖器切割(FGM)或女性生殖器切割是对人权和儿童权利的侵犯,在许多国家是非法的[1]。女性生殖器切割(FGM)或切割被定义为“所有涉及部分或全部切除女性外生殖器或其他女性器官损伤的手术,无论是出于文化原因还是其他非治疗原因”[2]。即使到目前为止,许多发展中国家的政府在这种做法非常普遍的情况下,并没有对女性生殖器切割采取强硬立场,这可能是由于政府对社会的恐惧,社会认为割礼是必要的,自然的,并采用了其存在的理由[3]。在我工作的苏丹,女性生殖器切割的流行率非常高(87%-100%)[4]。邻国埃及的流行率略低(50.3%),尼日利亚的流行率在23.3%-45.2%之间。在一些非洲和亚洲国家,如厄立特里亚、吉布提、马里和索马里,女性生殖器切割的流行率超过90%[5]。一般来说,女孩在成为有决定意义的人之前在6至12岁之间接受手术,因此这种做法是违反儿童和人权的。女性生殖器切割通常是由助产士在没有麻醉的情况下进行的,而且在没有预防措施的情况下进行,这使女孩面临更大的并发症风险。女性生殖器切割是一个公共卫生问题,具有公认的并发症,如出血、休克、感染、坏死性筋膜炎、疼痛和心理疾病[6]。
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引用次数: 0
Survey of Correlation between Preeclampsia and Season & Some of itsRisk Factor In Pregnant Women 孕妇子痫前期与季节及部分危险因素的相关性调查
Pub Date : 2012-07-21 DOI: 10.4172/2167-0420.1000114
F. Khojasteh, A. Safarzadeh, Burayri
Background: Preeclampsia, is a multisystem disorder unique to human pregnancy. It is one of the main complications during pregnancy and one of the three major causes of matenal mortality. The aim of this study was to evaluate the preeclampsia correlation with season and its risk factors in 15-45 year old women. Methods: The hospital records of consecutive patients (July 2004 - June2007) with preeclampsia were used for this study. This case - control study, the patients of the case group were 2488 persons who had the requirements of the study (age: 15- 45 year, gravid: 1-3), and then other 2488 pregnant women without preeclampsia were selected as the control group. Data achieved through filling questionnaires through the patients file. The SPSS info software program was used for statistical analysis. Results: The results showed that there is an inverse correlation between preeclampsia and seasons. At the start of spring it gradually began to increase and reached to a sudden peak in Autumn and then it suddenly decreased in the winter.The most important factors of the prevalenee of preeclampsia were hypertension, diabetes and previous preeclampsia, respectively.
背景:子痫前期是一种人类妊娠特有的多系统疾病。它是怀孕期间的主要并发症之一,也是造成产妇死亡的三大原因之一。本研究的目的是评估15-45岁女性子痫前期与季节及其危险因素的相关性。方法:采用2004年7月- 2007年6月连续收治的先兆子痫患者的住院记录进行研究。本病例对照研究,病例组患者为符合研究要求的2488例(年龄:15- 45岁,孕龄:1-3岁),另选取2488例无子痫前期孕妇作为对照组。通过患者档案填写问卷获得数据。采用SPSS info软件进行统计分析。结果:子痫前期与季节呈负相关。在春季开始时逐渐增加,在秋季达到一个突然的高峰,然后在冬季突然减少。影响子痫前期患病率的最重要因素分别是高血压、糖尿病和既往子痫前期。
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引用次数: 8
Focal Placenta Accreta and Spontaneous Uterus Rupture in the Post-Partum 产后局灶性胎盘增生和自发性子宫破裂
Pub Date : 2012-02-28 DOI: 10.4172/2167-0420.1000105
C. Pafumi, Leanza, A. Carbonaro, M. Stracquadanio, G. Leanza, A. Iemmola, A. D. Agati
Introduction: Uterine rupture occurs when the integrity of the myometrial wall is compromised. It could interest the uterine body (prior to labour) or the lower segment (during labour). The main causes of uterine rupture are obstetric anamnestic factors and/or the administration of oxytocin. Case presentation:The authors report the case of a 42 years old patient without risk factors for uterine rupture. After the expulsion of the placenta the mother had continuous blood loss, for this reason she was subjected to subtotal hysterectomy. Histological examination revealed the absence of decidua in the uterine fundus and thinning of the myometrium. Histological examination of the lesion at the site commented that there was infiltration of the chorionic villi into the endometrium and this is undoubtedly the features of placenta accreta. Conclusion: The authors emphasize the importance of careful observation of the placenta after delivery for the absence of even small placental cotyledons in order to eliminate a rare risk factor for silent uterine rupture.
子宫破裂发生在子宫肌壁完整性受损的时候。它可以引起子宫体(分娩前)或下段(分娩时)的兴趣。子宫破裂的主要原因是产科遗忘因素和/或催产素的施用。病例介绍:作者报告了一例42岁无子宫破裂危险因素的患者。胎盘排出后,母亲持续失血,因此她接受了子宫次全切除术。组织学检查显示子宫底无蜕膜,子宫肌层变薄。病变部位的组织学检查显示,绒毛膜绒毛浸润到子宫内膜,这无疑是胎盘增生的特征。结论:作者强调分娩后仔细观察胎盘的重要性,即使没有小的胎盘子叶,以消除沉默子宫破裂的一个罕见的危险因素。
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引用次数: 0
Obstetric and Non-Obstetric Indications for Admission in the Antepartum and Postpartum Periods of Pregnancy 产前和产后住院的产科和非产科指征
Pub Date : 2012-02-21 DOI: 10.4172/2167-0420.1000104
T. Waters, J. Bailit
Objective: To determine the most common non-obstetric indications for admission during the antepartum and postpartum period of pregnancy. Methods: This is a population-based investigation of the primary diagnoses for admission in the antepartum and postpartum periods of pregnancy. Data was obtained from the Healthcare Cost and Utilization Project’s State Inpatient Database for the state of California for 2005. The frequency of each primary diagnosis was determined. Diagnoses were classified as obstetric or non-obstetric and compared for differences in maternal race, age and insurance provider. Results: 576,846 total maternal admissions were identified with 35,158 antepartum (6.1%), 536,415 intrapartum (93.0%) and 5273 postpartum (0.9%). Overall, 26.6% of admissions were non-obstetric in nature. The most common non-obstetric indication for antenatal admission was urinary tract infections. The most common postpartum non-obstetric indication for admission was psychiatric/substance abuse disorders. Conclusions: Many admissions during pregnancy are non-obstetric in nature and may be amenable to outpatient screening.
目的:探讨妊娠产前和产后住院最常见的非产科指征。方法:这是一项基于人群的调查,主要诊断入院在产前和产后期间的妊娠。数据来自2005年加利福尼亚州医疗保健成本和利用项目的州住院患者数据库。确定每一种原发性诊断的频率。诊断分为产科或非产科,并比较产妇种族、年龄和保险提供者的差异。结果:共入院产妇576,846例,其中产前35,158例(占6.1%),分娩536,415例(占93.0%),产后5273例(占0.9%)。总体而言,26.6%的住院患者是非产科患者。产前入院最常见的非产科指征是尿路感染。最常见的产后非产科入院指征是精神疾病/药物滥用障碍。结论:许多怀孕期间入院是非产科性质的,可能适合门诊筛查。
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引用次数: 6
期刊
Journal of Womens Health Care
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