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Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of the Pharmacokinetic Properties Prediction of ADME. 将化合物与 DNA 螺旋酶 Q1 恶性疟原虫 3D7 相互螯合:药代动力学特性评估 ADME 预测。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_65_24
Afnan Shakoori, Zain Alhindi, Mohammad Alobaidy, Amna Moulana, Ayman Qashgari, Rehab M Bagadood, Ghadir Sindi, Banan Atwah, Anmar Anwar Khan

Background objectives: Quantum chemical & molecular docking practices to deliver new perceptions into how etoposide, novobiocin, nogalamycin and netropsin interact with the biological targets PF3D7_0918600 (Plasmodium falciparum 3D7). Further the pharmacokinetics of a drug candidate which influenced by a variety of factors, including P- glycoprotein (Pgp) transport, PBB (Plasma protein binding), & BBB (Blood-brain barrier) permeation help to forecast the pharmacological characteristics of acetyl-CoA reductase inhibitors (ADMEs) and their metabolites.

Methods: At this point, we have elevated four compounds such as etoposide, novobiocin, nogalamycin & netropsin. We have also studied molecular docking against the target protein of the Plasmodium falciparum (PF3D7_0918600) through exhausting the AutoDock Vina platform and AutoDock-Tools (ADT) and pharmacokinetic properties were carried out using the ADMET 2.0.

Results: The relative results of molecular docking recommended a greater binding affinity of novobiocin with the selected receptors among other compounds. In-silico ADME screening is a computational approach utilised to forecast the pharmacological characteristics of acetyl- CoA reductase inhibitors (ADMEs) and their metabolites.

Interpretation conclusion: The ADMEs are based on the adsorption-desorption kinetics and pharmacopoeia. Adsorption and distribution analysis are used to assess the potential of the drug candidate. In vitro ADME is exploited to expect the effect of Pgp transport on the drug candidates. ADME has been used to predict CYP1A2 inhibitors and to predict PPB and BBB penetration. This paper summarizes the current knowledge on molecular docking, ADME and identifies potential drug candidates for ADME in vitro and in vivo.

背景目标:通过量子化学和分子对接实践,对依托泊苷、新生物素、诺加霉素和奈托霉素如何与生物靶标PF3D7_0918600(恶性疟原虫3D7)相互作用有新的认识。此外,候选药物的药代动力学受多种因素的影响,包括 P-糖蛋白(Pgp)转运、PBB(血浆蛋白结合)和 BBB(血脑屏障)渗透,这有助于预测乙酰-CoA 还原酶抑制剂(ADMEs)及其代谢物的药理特性:目前,我们已将依托泊苷、新生物素、诺加霉素和奈托霉素等四种化合物升高。我们还通过 AutoDock Vina 平台和 AutoDock-Tools(ADT)研究了与恶性疟原虫靶蛋白(PF3D7_0918600)的分子对接,并使用 ADMET 2.0 进行了药代动力学特性研究:分子对接的相对结果表明,与其他化合物相比,新生物素与所选受体的结合亲和力更高。解释性结论:体内 ADME 筛选是一种用于预测乙酰辅酶还原酶抑制剂(ADMEs)及其代谢物药理特性的计算方法:ADMEs以吸附-解吸动力学和药典为基础。吸附和分布分析用于评估候选药物的潜力。体外 ADME 可用于预测 Pgp 转运对候选药物的影响。ADME 已被用于预测 CYP1A2 抑制剂以及预测 PPB 和 BBB 穿透性。本文总结了目前有关分子对接、ADME 的知识,并确定了体外和体内 ADME 的潜在候选药物。
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引用次数: 0
Embryonic dormancy in Aedes aegypti and Aedes albopictus (Diptera: Culicidae): a survival and dispersal mechanism. 埃及伊蚊和白纹伊蚊(双翅目:库蚊科)胚胎休眠:生存和传播机制。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_115_24
K O Germano, Laf De Souza, Amr Amaral, N A Honório, T Camara-Lima, McV Costa-Ribeiro

Aedes aegypti and Aedes albopictus are the main vectors of arboviruses such as dengue, Zika virus, and chikungunya. Ae. aegypti is a widely spread mosquito in tropical and subtropical regions, whereas Ae. albopictus is a culicid of Asian origin that shows exophilic behavior and can be found in subtropical and temperate areas. Climatic factors could influence the distribution of both species, making them use genetic and environmental resources to adapt to the environment, activating survival mechanisms (embryonic dormancy) that increase the developmental period and keep their offspring in the environment. From this perspective, this review aimed to compare the different physiological mechanisms of embryonic dormancy between Ae. aegypti and Ae. albopictus and their impact on the development and environmental adaptability of these two species. A total of 62 articles were identified in the PubMed, Scopus, and Web of Science databases corresponding to the period from 1981 to 2021. In diapause, the results mentioned above are indirectly linked to temperature and directly linked to photoperiod variations. With regard to quiescence, temperature and humidity are directly related to the activation of this mechanism. In conclusion, it is essential to highlight the expansion of arboviruses such as dengue, chikungunya, yellow fever, and Zika virus and their relationship with embryonic dormancy, diapause and quiescence, extremely important strategies for Ae. aegypti and Ae. albopictus to keep their offspring in the environment under adverse conditions.

埃及伊蚊和白纹伊蚊是登革热、寨卡病毒和基孔肯雅热等虫媒病毒的主要传播媒介。Ae。埃及伊蚊是热带和亚热带地区广泛分布的一种蚊子。白纹伊蚊是起源于亚洲的一种嗜外生境的扑蚊,可在亚热带和温带地区发现。气候因素可能影响这两个物种的分布,使它们利用遗传和环境资源来适应环境,激活生存机制(胚胎休眠),延长发育周期,使后代保持在环境中。从这一角度出发,本文旨在比较不同昆虫胚胎休眠的生理机制。埃及伊蚊和伊蚊。白纹伊蚊及其对这两个物种发育和环境适应性的影响。从1981年到2021年,PubMed、Scopus和Web of Science数据库共鉴定出62篇文章。在滞育中,上述结果与温度间接相关,与光周期变化直接相关。就静止而言,温度和湿度与这一机制的激活直接相关。总之,有必要强调登革热、基孔肯雅热、黄热病和寨卡病毒等虫媒病毒的扩展及其与胚胎休眠、滞育和静止的关系,这是伊蚊极其重要的策略。埃及伊蚊和伊蚊。使白纹伊蚊的后代保持在不利的环境条件下。
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引用次数: 0
Bridging the gaps: prioritizing research strategies for enhanced malaria control and elimination. 缩小差距:确定加强疟疾控制和消除的研究战略的优先次序。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_45_24
Rashed Alghamdi

Malaria continues to be a significant global health challenge, with millions of cases and hundreds of thousands of deaths reported annually. To combat this disease effectively, it is imperative to identify and address significant research gaps in malaria control and elimination efforts. This review synthesizes current knowledge and highlights critical gaps in several crucial areas of malaria research. Firstly, we discuss the complexities of vector biology and control, emphasizing the need for a deeper understanding of vector behavior, particularly in urban settings. Secondly, the study examines the challenges posed by drug resistance and the urgent need for alternative treatment strategies and novel drug targets. Thirdly, the review explores the ongoing quest for an effective malaria vaccine, underscoring the importance of understanding immunological correlates of protection. The study also explores medication resistance genes and genomic epidemiology, highlighting the need for more investigation into potential targets for drugs and vaccine candidates. Furthermore, it addresses the socioeconomic and environmental determinants of malaria transmission, highlighting the importance of integrating multidisciplinary approaches to address transmission dynamics. The study concludes with a discussion of how malaria transmission is impacted by climate change and the necessity of research to guide adaptation measures.

疟疾仍然是全球健康面临的重大挑战,每年都有数百万病例和数十万人死亡的报告。为了有效防治这一疾病,必须找出并解决疟疾控制和消除工作中的重大研究缺口。本综述综合了当前的知识,并强调了在疟疾研究的几个关键领域中存在的重大差距。首先,我们讨论了病媒生物学和控制的复杂性,强调需要更深入地了解病媒的行为,尤其是在城市环境中。其次,研究探讨了抗药性带来的挑战,以及对替代治疗策略和新型药物靶点的迫切需求。第三,综述探讨了目前对有效疟疾疫苗的探索,强调了了解免疫保护相关因素的重要性。研究还探讨了抗药性基因和基因组流行病学,强调需要对药物和候选疫苗的潜在靶点进行更多调查。此外,研究还探讨了疟疾传播的社会经济和环境决定因素,强调了整合多学科方法解决传播动态问题的重要性。研究最后讨论了疟疾传播如何受到气候变化的影响,以及开展研究以指导适应措施的必要性。
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引用次数: 0
Susceptibility of temephos against Aedes aegypti and Anopheles stephensi mosquito larvae in Dehradun of Uttarakhand, India. 印度北阿坎德邦德拉敦地区双硫磷对埃及伊蚊和斯氏按蚊幼虫的敏感性分析。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_98_24
R K Singh, Gaurav Kumar, Subhash Joshi, Anup R Anvikar

Background objectives: Temephos is being used regularly to control immature of vector borne diseases in various states in India.

Methods: World Health Organization method was used to evaluate larval susceptibility status of Aedes aegypti and Anopheles stephensi against temephos in Dehradun of Uttarakhand.

Results: The results of the study revealed that the larval mortality in different localities ranged from 67.11% to 98.22%, the-lowest mortality was recorded from Kedarpuram (67.11%) and highest larval was recorded from Vikash Nagar (98.88%). The study revealed that most of larval populations of Ae. aegypti were resistant or under verification required category against temephos at diagnostic concentrations collected from six different localities of study area of Dehradun while only one larval population of Ae. aegypti was found susceptible. However, Anopheles stephensi larvae collected from all sites were susceptible at diagnostic concentration of temephos.

Interpretation conclusion: The study highlights the potential development of resistance to temephos in Ae. aegypti across most of the study areas in Dehradun.

背景目标:双硫磷在印度各邦被定期用于控制未成熟的病媒传播疾病。方法:采用世界卫生组织方法评价北阿坎德邦德拉顿地区埃及伊蚊和斯氏按蚊幼虫对双硫磷的敏感性。结果:不同地区的幼虫死亡率在67.11% ~ 98.22%之间,凯达普兰地区最低(67.11%),维卡什纳加尔地区最高(98.88%)。研究表明,伊蚊的大部分幼虫种群。在德拉敦研究区6个不同地点采集的双硫磷诊断浓度下,埃及伊蚊对双硫磷呈抗性或处于鉴定需要的类别;埃及伊蚊易受感染。所有地点采集的斯氏按蚊幼虫均对双硫磷诊断浓度敏感。解读结论:本研究突出了双硫磷对伊蚊抗药性的发展潜力。在德拉敦的大部分研究区域都发现了埃及伊蚊。
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引用次数: 0
Japanese encephalitis virus: An overview. 日本脑炎病毒:概述。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_49_24
Qiuyang Li, Xiaoling Cheng, Min Luo, Jinrong Shi

Japanese encephalitis (JE) is a mosquito-borne infectious disease caused by the Japanese encephalitis virus (JEV), posing a substantial threat to human health and property safety. Until now, there has been a lack of specific therapeutic options for treating JEV infections. In this review article, we provide a comprehensive discussion of JEV's characteristics, diagnostic methodologies, vaccine development efforts, and potential anti-JEV pharmaceuticals to provide insights and references that could be used to inform and enhance strategies for the prevention and control of Japanese encephalitis.

日本脑炎(JE)是由日本脑炎病毒(JEV)引起的蚊媒传染病,对人类健康和财产安全构成严重威胁。迄今为止,治疗 JEV 感染的特异性疗法一直缺乏。在这篇综述文章中,我们全面讨论了 JEV 的特征、诊断方法、疫苗开发工作以及潜在的抗 JEV 药物,从而提供一些见解和参考,为预防和控制日本脑炎的策略提供信息和帮助。
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引用次数: 0
Application of Artificial Intelligence for quantifying Plasmodium berghei in blood samples from infected mice. 应用人工智能定量检测感染小鼠血液中的伯氏疟原虫。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_86_24
Noha Talal Zelai

Background objectives: In malaria infection, quantifying blood parasitemia is a critical step for evaluating the severity of the disease. This has generally been conducted manually, and thus, its accuracy depends on the expertise of technicians. There is an urgent need for an automated technique to overcome manual errors. The aim of the study is to find an alternative method for counting malaria blood parasitemia.

Methods: This study evaluated the accuracy of automated counting using QuPath compared to manual counting. GraphPad Kappa evaluated agreement between high and low parasitemia in both counting methods using Cohen's test.

Results: QuPath was revealed to be a promising method that has fair agreement and no statistically significant differences compared to manual counting.

Interpretation conclusion: In conclusion, automated quantification is suggested to be a time- and effort-saving technique and, therefore, a worthwhile alternative to manual counting.

背景目的:在疟疾感染中,量化血液寄生虫血症是评估疾病严重程度的关键步骤。这通常是手工进行的,因此,其准确性取决于技术人员的专业知识。迫切需要一种自动化技术来克服人工错误。这项研究的目的是找到一种计算疟疾血液寄生虫病的替代方法。方法:本研究评估了使用QuPath自动计数与人工计数的准确性。GraphPad Kappa使用Cohen的测试评估了两种计数方法中高寄生虫血症和低寄生虫血症的一致性。结果:与人工计数相比,QuPath是一种有前景的方法,具有公平的一致性,没有统计学上的显著差异。解释结论:总而言之,建议自动定量是一种省时省力的技术,因此是一种值得替代人工计数的方法。
{"title":"Application of Artificial Intelligence for quantifying Plasmodium berghei in blood samples from infected mice.","authors":"Noha Talal Zelai","doi":"10.4103/JVBD.JVBD_86_24","DOIUrl":"https://doi.org/10.4103/JVBD.JVBD_86_24","url":null,"abstract":"<p><strong>Background objectives: </strong>In malaria infection, quantifying blood parasitemia is a critical step for evaluating the severity of the disease. This has generally been conducted manually, and thus, its accuracy depends on the expertise of technicians. There is an urgent need for an automated technique to overcome manual errors. The aim of the study is to find an alternative method for counting malaria blood parasitemia.</p><p><strong>Methods: </strong>This study evaluated the accuracy of automated counting using QuPath compared to manual counting. GraphPad Kappa evaluated agreement between high and low parasitemia in both counting methods using Cohen's test.</p><p><strong>Results: </strong>QuPath was revealed to be a promising method that has fair agreement and no statistically significant differences compared to manual counting.</p><p><strong>Interpretation conclusion: </strong>In conclusion, automated quantification is suggested to be a time- and effort-saving technique and, therefore, a worthwhile alternative to manual counting.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerating the fight towards malaria elimination: bridging gaps to achieve health equity in India. 加快消除疟疾的斗争:弥合差距,实现印度的卫生公平。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_92_24
Vani H Chalageri, B M Shrinivasa, N Sujith Nath, Prerana Nandish, Anup Anvikar

Malaria continues to remain a serious threat to public health, especially in regions with socio-economic and healthcare disparities. The paper attempts to contextualise the current scenario of malaria transmission, the advancement made towards its elimination and the multi-dimensional strategies that may be required to overcome cultural and regional barriers; with a focus on India's goal to eliminate malaria by 2030.

疟疾仍然是对公共健康的严重威胁,尤其是在社会经济和医疗保健存在差异的地区。本文试图介绍疟疾传播的现状、在消除疟疾方面取得的进展以及克服文化和地区障碍所需的多维战略;重点介绍印度到 2030 年消除疟疾的目标。
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引用次数: 0
Characterization of Anopheles mosquito breeding habitats for malaria vector control in Mazowe and Shamva districts, Zimbabwe. 津巴布韦 Mazowe 和 Shamva 地区疟蚊孳生地的特征,以控制疟疾病媒。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_85_24
S Nyasvisvo David, Nhiwatiwa Tamuka, Sithole Rudo, Sande Shadreck

Background objectives: Area-specific identification and studies of Anopheles breeding habitat diversity, distribution, and productivity in different seasons are important in designing and advancing effective malaria vector control according to the local context and needs. This study identified and characterized Anopheles breeding habitats for targeted control of malaria vectors in Mazowe and Shamva districts.

Methods: Repeated cross-sectional surveys were conducted in Mazowe and Shamva districts between April and December 2023. Habitat productivity and physicochemical parameters were measured. Anopheles larvae were collected, reared to adults, and identified using morphological keys. SPSS software was used for data analysis. One-way ANOVA, Fisher's exact, Pearson's correlation, and simple linear regression tests were conducted.

Results: Seven different types of Anopheles breeding habitats were identified from 56 sites. The highest mean density of larvae was recorded in stream edge pools during the post-rainfall period. Anophelespretoriensis (67.4%), An. gambiae s.l. (23.1%), An. rufipes (9.2%) and An. coustani (0.38%) were breeding in the study area. Anopheles pretoriensis bred in all habitat types, An. coustani in swamps only while An. gambiae s.l. and An. rufipes preferred stream edge pools, roadside pools, and hoof prints. There was a significant positive correlation between larval density and dissolved oxygen (r = 0.535; p < 0.001) and conductivity (r = 0.288; p = 0.032).

Interpretation conclusion: Size, origin, and type of breeding habitat were positive indicators for different Anopheles species in the study area. Potential malaria vector breeding habitats should be targeted for larval control under the current malaria control and elimination phases in the two districts.

背景目标:针对特定地区确定和研究按蚊在不同季节的繁殖栖息地多样性、分布和生产力,对于根据当地情况和需求设计和推进有效的疟疾病媒控制非常重要。这项研究确定并描述了按蚊繁殖栖息地的特征,以便有针对性地控制马佐威和沙姆瓦地区的疟疾病媒:方法:2023 年 4 月至 12 月期间,在马佐韦和沙姆瓦地区进行了重复横断面调查。测量了栖息地的生产力和理化参数。收集按蚊幼虫,将其饲养成成虫,并使用形态学钥匙进行鉴定。使用 SPSS 软件进行数据分析。进行了单因素方差分析、费雪精确检验、皮尔逊相关检验和简单线性回归检验:结果:从 56 个地点发现了七种不同类型的按蚊繁殖生境。在降雨后的溪流边缘水池中,幼虫的平均密度最高。在研究区域繁殖的按蚊有:Anophelespretoriensis(67.4%)、An. gambiae s.l.(23.1%)、An. rufipes(9.2%)和 An. coustani(0.38%)。pretoriensis 按蚊在所有生境类型中繁殖,coustani 按蚊只在沼泽中繁殖,而冈比亚按蚊和 rufipes 按蚊则喜欢溪边水池、路边水池和蹄印。幼虫密度与溶解氧(r = 0.535; p < 0.001)和电导率(r = 0.288; p = 0.032)之间存在明显的正相关:繁殖栖息地的大小、来源和类型是研究区域不同按蚊物种的积极指标。在这两个地区目前的疟疾控制和消除阶段,应针对潜在的疟疾病媒繁殖栖息地进行幼虫控制。
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引用次数: 0
Coverage and evaluation survey of post-mass drug administration for lymphatic filariasis in four endemic districts of Uttar Pradesh: are we on the track? 北方邦四个淋巴丝虫病流行区大规模用药后的覆盖面和评估调查:我们是否已步入正轨?
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_102_24
Sourabh Paul, Aswani Kumar Seth, Neeraj Pawar, Abhay Singh, Mukesh Shukla, Bhola Nath

Background objectives: There is a persistent high microfilaria rate and variable reporting of coverage of Mass Drug Administration (MDA). The study aims to estimate the coverage, effective coverage, and compliance of drugs administered under MDA and to determine the predictors affecting the effective coverage.

Methods: A community-based cross-sectional study was conducted in Amethi, Lucknow, Raebareli and Sultanpur districts of Uttar Pradesh, India. The study participants were selected using multi-stage random sampling using Probability Proportional to Estimated Size (PPES). The coverage, effective coverage and compliance of drugs were presented as proportion. The multivariable logistic regression model was applied to identify the significant predictors for effective coverage.

Results: Of 4151 participants, 997 (24.0%), 340 (8.2%), 1158 (27.9%) and 1656 (39.9%) belonged to Amethi, Lucknow, Raebareli and Sultanpur districts respectively. The coverage ranged from 49.8% to 87.9% and effective coverage ranged from 51.8% to 73.2% across districts. The compliance was the poorest (70.7%) in Sultanpur. The source of information about MDA, the sex of the study participants and the area of residence emerged as predictors for effective coverage in the districts.

Interpretation conclusion: The effective coverage was poor with good drug complianceacross the districts. There is a need for a well-designed pre-MDA campaign addressing the fear of side effects of drugs and emphasising the presence of the community during the MDA round along with monitoring and evaluation of the round.

背景目标:微丝蚴感染率居高不下,大规模药物管理(MDA)的覆盖范围报告不一。本研究旨在估算大规模药物管理的覆盖率、有效覆盖率和用药依从性,并确定影响有效覆盖率的预测因素:在印度北方邦的阿梅提、勒克瑙、雷巴里和苏丹普尔地区开展了一项基于社区的横断面研究。参与研究的人员是通过多阶段随机抽样,使用概率与估计人数成比例(PPES)的方法选出的。药物的覆盖率、有效覆盖率和依从性以比例表示。采用多变量逻辑回归模型确定有效覆盖率的重要预测因素:在 4151 名参与者中,997 人(24.0%)、340 人(8.2%)、1158 人(27.9%)和 1656 人(39.9%)分别属于阿梅提、勒克瑙、雷巴里和苏丹普尔地区。各地区的覆盖率从 49.8%到 87.9%不等,有效覆盖率从 51.8%到 73.2%不等。苏尔坦布尔的依从性最差(70.7%)。关于 MDA 的信息来源、研究参与者的性别和居住地区成为各地区有效覆盖率的预测因素:各地区的有效覆盖率较低,但服药依从性良好。有必要开展精心设计的 MDA 前宣传活动,以消除对药物副作用的恐惧,并强调社区在 MDA 期间的参与以及对该轮活动的监测和评估。
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引用次数: 0
Persistence of West Nile Virus circulation in North-East region of India: A prospective facility-based study spanning over a decade. 印度东北部地区西尼罗河病毒传播的持续性:一项基于设施的前瞻性研究,历时十年。
IF 0.8 4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2024-10-05 DOI: 10.4103/JVBD.JVBD_168_23
Siraj Ahmed Khan, Pritom Chowdhury, Anisha Shah, Himanshu Medhi, Parveena Choudhury, Purvita Chowdhury, Pramit Ghosh

Background objectives: To understand the distribution and presence of West Nile (WN) among the acute encephalitis syndrome (AES) patients, a prospective facility-based study was conducted over 13 years (2007-2019).

Methods: During the period, 8957 patients hospitalized with AES in northeastern India were tested for the evidence of WN virus infection by IgM ELISA followed by Plaque reduction neutralization test (PRNT).

Results: Of the samples tested 324 (3.62%) were found positive for WN IgM antibodies and 73 paired sera showed a fourfold rise in neutralizing antibody titre by PRNT. The study establishes WN as a noteworthy cause of encephalitis in an erstwhile endemic area for Japanese encephalitis (JE).

Interpretation conclusion: Therefore, it is important that WN is recognized as an important acute encephalitis syndrome (AES) causing aetiology in this region and the National centre for vector borne disease control (NCVBDC) guidelines for detection of AES may be modified accordingly. Thus, inclusion of WN in routine diagnosis, along with establishment of an integrative surveillance network with one-health approach will be important.

背景目标:为了解西尼罗河病毒(WN)在急性脑炎综合征(AES)患者中的分布和存在情况,我们开展了一项为期13年(2007-2019年)的基于医疗机构的前瞻性研究:在此期间,对印度东北部 8957 名急性脑炎综合征住院患者进行了西尼罗河病毒感染证据检测,检测方法为 IgM 酶联免疫吸附试验(ELISA)和斑块缩小中和试验(PRNT):结果:在检测的样本中有 324 份(3.62%)发现 WN IgM 抗体呈阳性,73 份配对血清的 PRNT 中和抗体滴度上升了四倍。这项研究证实,在日本脑炎(JE)曾经流行的地区,WN 是一种值得注意的脑炎病因:因此,必须将 WN 视为该地区重要的急性脑炎综合征(AES)病因,并相应修改国家病媒传染病控制中心(NCVBDC)的急性脑炎综合征检测指南。因此,将 WN 纳入常规诊断,同时建立一个采用单一保健方法的综合监测网络将非常重要。
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引用次数: 0
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Journal of Vector Borne Diseases
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