Pub Date : 2023-08-31DOI: 10.21776/ub.jkb.2023.032.04.8
Bunga Fardah Nahdiyah Achmada, D. Mutiasari, Abi Bakring Balyas, Lia Sasmithae, Helena Jelita
Hypertension is non-communicable and one of the main sources of premature death in the world, but the cause of this disease generally is still unknown. It is important to note that personality types are included among the suspected influencing factors due to being related to controlling behavior, emotions, and stress. According to Hippocrates-Galenus, they are divided into sanguine, melancholy, choleric, and phlegmatic. Therefore, this research aimed to determine respondents' characteristics, differences in blood pressure (BP) between personality types, and the effect of personality types on BP. The design employed was descriptive-analytic with a cross-sectional approach, and the sample used was 56 respondents, selected by purposive sampling technique. The data on personality types were collected by filling out a questionnaire, while BP data were obtained through BP measurement with a digital tensimeter, and the analysis was conducted with Fisher's Exact, Kruskal-Wallis, and one-way ANOVA tests. The results showed that most respondents, i.e. 62.5% were aged 17-29 years, 20% had BMI ≥27 or Obesity, 10.7% had SBP/DBP=140-149/90-99 or hypertension stage 1, 37.5% were married, 26.8% had birth control history, alcohol consumption history =0%, smoking history =1.8%, 35.7% had phlegmatic personality type, and 10.7% suffered hypertension. The results showed that there was a significant difference between personality types and systolic and diastolic blood pressure, respectively p=0,03 and 0,045. There is no effect of each personality type on blood pressure (p>0,05). In conclusion, despite the different SBP and DBP values of personality types, no effect is created on BP.
{"title":"The Effect of Personality Types on Blood Pressure in Female Patients Over 17 Years of Age","authors":"Bunga Fardah Nahdiyah Achmada, D. Mutiasari, Abi Bakring Balyas, Lia Sasmithae, Helena Jelita","doi":"10.21776/ub.jkb.2023.032.04.8","DOIUrl":"https://doi.org/10.21776/ub.jkb.2023.032.04.8","url":null,"abstract":"Hypertension is non-communicable and one of the main sources of premature death in the world, but the cause of this disease generally is still unknown. It is important to note that personality types are included among the suspected influencing factors due to being related to controlling behavior, emotions, and stress. According to Hippocrates-Galenus, they are divided into sanguine, melancholy, choleric, and phlegmatic. Therefore, this research aimed to determine respondents' characteristics, differences in blood pressure (BP) between personality types, and the effect of personality types on BP. The design employed was descriptive-analytic with a cross-sectional approach, and the sample used was 56 respondents, selected by purposive sampling technique. The data on personality types were collected by filling out a questionnaire, while BP data were obtained through BP measurement with a digital tensimeter, and the analysis was conducted with Fisher's Exact, Kruskal-Wallis, and one-way ANOVA tests. The results showed that most respondents, i.e. 62.5% were aged 17-29 years, 20% had BMI ≥27 or Obesity, 10.7% had SBP/DBP=140-149/90-99 or hypertension stage 1, 37.5% were married, 26.8% had birth control history, alcohol consumption history =0%, smoking history =1.8%, 35.7% had phlegmatic personality type, and 10.7% suffered hypertension. The results showed that there was a significant difference between personality types and systolic and diastolic blood pressure, respectively p=0,03 and 0,045. There is no effect of each personality type on blood pressure (p>0,05). In conclusion, despite the different SBP and DBP values of personality types, no effect is created on BP.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79925947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.21776/ub.jkb.2023.032.04.12
Muhammad Baihaqy Ibnu Hakim, Taufiq Nur Budaya, B. Daryanto
The circumcision clamp has been the primary alternative to the traditional surgical circumcision procedure since its invention in 1934. The circumcision clamp has the following advantages such as improved wound healing, shorter operation time, and no stitch removal pain. However, the clamp technique has a disadvantage where the operator cannot visualize the glans penis. Many studies have already reported the incidence of trauma or psychiatric disorders related to penile amputation, but the case of circumcision clamp-related penile amputation in Indonesia had never been reported. An eight-year-old boy was taken to the emergency department with post-circumcision bleeding. The patient had been circumcised using an Anastomat® circumcision device in the clinic, two hours prior and then referred to the emergency department. We perform penile exploration, and a defect in the ventral part of the glans penis was found, with the source of bleeding coming from the glans penis, and the urethra remained intact. Penile degloving with urethral spatulation and catheterization with a 10 Fr 2-way foley catheter was installed, continued with penile reconstruction and skin closure. The operation lasted for about sixty minutes. After six months of follow-up, the patient could urinate normally and spontaneously without any clinical complaint. Even though circumcision using a circumcision clamp is considered a safe procedure and preferable to surgical circumcision nowadays, it is necessary to emphasize that the use of a circumcision clamp still has a risk rate for penile amputation.
{"title":"Iatrogenic Penile Amputation Due to Circumcision Clamp in an Eight-Year-Old Boy","authors":"Muhammad Baihaqy Ibnu Hakim, Taufiq Nur Budaya, B. Daryanto","doi":"10.21776/ub.jkb.2023.032.04.12","DOIUrl":"https://doi.org/10.21776/ub.jkb.2023.032.04.12","url":null,"abstract":"The circumcision clamp has been the primary alternative to the traditional surgical circumcision procedure since its invention in 1934. The circumcision clamp has the following advantages such as improved wound healing, shorter operation time, and no stitch removal pain. However, the clamp technique has a disadvantage where the operator cannot visualize the glans penis. Many studies have already reported the incidence of trauma or psychiatric disorders related to penile amputation, but the case of circumcision clamp-related penile amputation in Indonesia had never been reported. An eight-year-old boy was taken to the emergency department with post-circumcision bleeding. The patient had been circumcised using an Anastomat® circumcision device in the clinic, two hours prior and then referred to the emergency department. We perform penile exploration, and a defect in the ventral part of the glans penis was found, with the source of bleeding coming from the glans penis, and the urethra remained intact. Penile degloving with urethral spatulation and catheterization with a 10 Fr 2-way foley catheter was installed, continued with penile reconstruction and skin closure. The operation lasted for about sixty minutes. After six months of follow-up, the patient could urinate normally and spontaneously without any clinical complaint. Even though circumcision using a circumcision clamp is considered a safe procedure and preferable to surgical circumcision nowadays, it is necessary to emphasize that the use of a circumcision clamp still has a risk rate for penile amputation.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"211 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72832976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.21776/ub.jkb.2023.032.04.5
Oberson Nainggolan, Lia Sasmithae, R. Widayati
Human Immunodeficiency Virus (HIV) attacks white blood cells, thereby reducing the immunity of infected patients. It attacks Cluster of Differentiation 4 (CD4) lymphocyte cells which have a role in the immune system. It has killed 36.3 million people worldwide. There were reported 222 cases in Central Kalimantan Province in 2019. The therapy given to suppress HIV is antiretroviral (ARV) which gradually recover CD4 cells of the patients. This study aims to determine the effect of duration of the antiretroviral therapy (ART) duration on CD4 counts in patients with HIV at the VCT (Voluntary, Counselling, and Test) Polyclinic, dr. Doris Sylvanus Hospital during 2019-2020. It is a descriptive retrospective study, extracting data from patients medical record data. Following total sampling and selected based on inclusion and exclusion criteria i.e. aged ≥18 years and diagnosed with HIV during 2019-2020, with complete CD4 count records prior and after ART, there were 45 patients included. The results showed that CD4 counts increased in patients with fixed dose combination (FDC) Tenofovir, lamivudine and efavirenz, with average value of 190.36± 220.92 cells/mm3 prior ART, became 259.93± 203.74 cells/mm3 at 12 month ART, and 310.82± 22.,53 cells/mm3 at 24 month ART (p = 0.000). Thus, the longer ART duration the higher CD4 counts and recover the normal range.
{"title":"The Effect of Antiretroviral Therapy (ART) Duration on CD4 Counts in Human Immunodeficiency Virus (HIV) Patients in dr. Doris Sylvanus Regional Hospital","authors":"Oberson Nainggolan, Lia Sasmithae, R. Widayati","doi":"10.21776/ub.jkb.2023.032.04.5","DOIUrl":"https://doi.org/10.21776/ub.jkb.2023.032.04.5","url":null,"abstract":"Human Immunodeficiency Virus (HIV) attacks white blood cells, thereby reducing the immunity of infected patients. It attacks Cluster of Differentiation 4 (CD4) lymphocyte cells which have a role in the immune system. It has killed 36.3 million people worldwide. There were reported 222 cases in Central Kalimantan Province in 2019. The therapy given to suppress HIV is antiretroviral (ARV) which gradually recover CD4 cells of the patients. This study aims to determine the effect of duration of the antiretroviral therapy (ART) duration on CD4 counts in patients with HIV at the VCT (Voluntary, Counselling, and Test) Polyclinic, dr. Doris Sylvanus Hospital during 2019-2020. It is a descriptive retrospective study, extracting data from patients medical record data. Following total sampling and selected based on inclusion and exclusion criteria i.e. aged ≥18 years and diagnosed with HIV during 2019-2020, with complete CD4 count records prior and after ART, there were 45 patients included. The results showed that CD4 counts increased in patients with fixed dose combination (FDC) Tenofovir, lamivudine and efavirenz, with average value of 190.36± 220.92 cells/mm3 prior ART, became 259.93± 203.74 cells/mm3 at 12 month ART, and 310.82± 22.,53 cells/mm3 at 24 month ART (p = 0.000). Thus, the longer ART duration the higher CD4 counts and recover the normal range.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81929899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.21776/ub.jkb.2023.032.04.11
Taufiq Abdullah, A. Haedar, Budi Soenarto
Hypoglycemia is an emergency case that is caused by antidiabetic drugs from the sulfonylurea class. Prolonged and refractory hypoglycemia can increase mortality and morbidity. Renal impairment can result in recurrent hypoglycemic symptoms and require special treatment. In this study case, a 47-year-old woman with newly impaired renal function presented in a coma caused by hypoglycemia due to the use of glibenclamide (sulfonylurea drugs) that did not respond to standard hypoglycemic treatment. Treatment of refractory hypoglycemia is a challenge in itself. Octreotide may be considered in cases of refractory hypoglycemia that does not respond to standard glucose treatment, where in this case refractory hypoglycemia is caused by accumulating sulfonylurea because of impaired renal function.
{"title":"Octreotide Treatment for Hypoglycemic Refractory Case Caused by Sulfonylureas with Impaired Renal Function","authors":"Taufiq Abdullah, A. Haedar, Budi Soenarto","doi":"10.21776/ub.jkb.2023.032.04.11","DOIUrl":"https://doi.org/10.21776/ub.jkb.2023.032.04.11","url":null,"abstract":"Hypoglycemia is an emergency case that is caused by antidiabetic drugs from the sulfonylurea class. Prolonged and refractory hypoglycemia can increase mortality and morbidity. Renal impairment can result in recurrent hypoglycemic symptoms and require special treatment. In this study case, a 47-year-old woman with newly impaired renal function presented in a coma caused by hypoglycemia due to the use of glibenclamide (sulfonylurea drugs) that did not respond to standard hypoglycemic treatment. Treatment of refractory hypoglycemia is a challenge in itself. Octreotide may be considered in cases of refractory hypoglycemia that does not respond to standard glucose treatment, where in this case refractory hypoglycemia is caused by accumulating sulfonylurea because of impaired renal function.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84549850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.21776/ub.jkb.2023.032.04.10
Yosi Rizal, Eka Yudha Rahman
Emphysematous cystitis (EC) is a rare manifestation of a complicated urinary tract infection, and its pathognomonic feature is a gas appearance inside the bladder wall and lumen. Emphysematous cystitis with bladder mass is an extremely rare finding. In this case study, a 59-year-old female presented with dysuria and pneumaturia for two months before admission. Following history taking and physical examination, a CT scan was performed to establish the diagnosis, which revealed thickening bladder wall with free gas appearance, impressing emphysematous cystitis. Urine culture showed no bacterial growth, cystoscopy revealed posterosuperior bladder mass, a biopsy was done followed by fulguration of the bladder and showed no malignancy, and MRI implied emphysematous cystitis with bladder dome adhesions of colon mass with colovesical fistula. After resection of colon anastomosis, colitis was found as the etiology of the colovesical fistula. An accurate diagnosis of the disease and correct treatment would result in a good prognosis and outcome.
{"title":"Emphysematous Cystitis with Bladder Mass caused by Colovesical Fistula: A Rare Case Report","authors":"Yosi Rizal, Eka Yudha Rahman","doi":"10.21776/ub.jkb.2023.032.04.10","DOIUrl":"https://doi.org/10.21776/ub.jkb.2023.032.04.10","url":null,"abstract":"Emphysematous cystitis (EC) is a rare manifestation of a complicated urinary tract infection, and its pathognomonic feature is a gas appearance inside the bladder wall and lumen. Emphysematous cystitis with bladder mass is an extremely rare finding. In this case study, a 59-year-old female presented with dysuria and pneumaturia for two months before admission. Following history taking and physical examination, a CT scan was performed to establish the diagnosis, which revealed thickening bladder wall with free gas appearance, impressing emphysematous cystitis. Urine culture showed no bacterial growth, cystoscopy revealed posterosuperior bladder mass, a biopsy was done followed by fulguration of the bladder and showed no malignancy, and MRI implied emphysematous cystitis with bladder dome adhesions of colon mass with colovesical fistula. After resection of colon anastomosis, colitis was found as the etiology of the colovesical fistula. An accurate diagnosis of the disease and correct treatment would result in a good prognosis and outcome.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72742783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-08DOI: 10.21776/ub.jkb.2023.032.03.3
Azalia Ayu Rysaputri, Hery Susilo, D. Hidayati, I. Ratridewi
Pseudomonas aeruginosa is one of the most common pathogens that cause Healthcare-Associated Infections (HAIs). A previous study stated that Piper betle L. extract has antibacterial activity against certain bacteria, including Pseudomonas aeruginosa. This study has the objective of comparing antibacterial activity of the methanolic extract of Piper betle L. and amikacin on the growth of Pseudomonas aeruginosa. This study used the tube dilution method with a sample of Pseudomonas aeruginosa from Microbiology Laboratory Dr. Saiful Anwar General Hospital, Malang. The results of this study showed that the value of MIC and MBC from the methanolic extract of the Piper betle L. treatment was 4800μg/mL. Meanwhile, the amikacin treatment resulted in 0.4μg/mL for MIC and 0.45μg/mL for MBC. From linear regression, it was found that the methanolic extract of Piper betle L. had a β-coefficient value closer to -1 compared to amikacin. Therefore, it can be concluded that the methanolic extract of Piper betle L. has a greater inhibiting effect on the growth of Pseudomonas aeruginosa.
{"title":"Comparison of Methanolic Extract of Piper Betle to Amikacin against the Growth of Pseudomonas aeruginosa","authors":"Azalia Ayu Rysaputri, Hery Susilo, D. Hidayati, I. Ratridewi","doi":"10.21776/ub.jkb.2023.032.03.3","DOIUrl":"https://doi.org/10.21776/ub.jkb.2023.032.03.3","url":null,"abstract":"Pseudomonas aeruginosa is one of the most common pathogens that cause Healthcare-Associated Infections (HAIs). A previous study stated that Piper betle L. extract has antibacterial activity against certain bacteria, including Pseudomonas aeruginosa. This study has the objective of comparing antibacterial activity of the methanolic extract of Piper betle L. and amikacin on the growth of Pseudomonas aeruginosa. This study used the tube dilution method with a sample of Pseudomonas aeruginosa from Microbiology Laboratory Dr. Saiful Anwar General Hospital, Malang. The results of this study showed that the value of MIC and MBC from the methanolic extract of the Piper betle L. treatment was 4800μg/mL. Meanwhile, the amikacin treatment resulted in 0.4μg/mL for MIC and 0.45μg/mL for MBC. From linear regression, it was found that the methanolic extract of Piper betle L. had a β-coefficient value closer to -1 compared to amikacin. Therefore, it can be concluded that the methanolic extract of Piper betle L. has a greater inhibiting effect on the growth of Pseudomonas aeruginosa.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90626501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-08DOI: 10.21776/ub.jkb.2023.032.03.7
Hidajah Rachmawati, Muktamiroh Muktamiroh, D. Hasmono, Atika Putri Kusumaningtyas, Sendi Lia Yunita, Lilik Yusetyani
Infection is a condition caused by the propagation of harmful microorganisms with or without clinical symptoms. Improper use of antibiotics can lead to antibiotic resistance. The Ministry of Health of the Republic of Indonesia recommended a quantitative evaluation of the use of antibiotics using the Defined Daily Dose (DDD) method and a qualitative evaluation using the Gyssens method. This study evaluated antibiotics usage using DDD and Gyssens methods in ICU/HCU of the Muhammadiyah University General Hospital Malang. Employing retrospective observational method, data were collected from patient medical records hospitalized during January-December 2020. Results of the DDD quantitative analysis showed that the most widely used antibiotic was Ceftriaxone with a 35.79 DDD/100 patient-days. The Gyssenss qualitative analysis showed that the category VI (incomplete patient's medical record data) was 3%, category IVa (antibiotic use is more effective) (2%), category IIIb (duration of antibiotic use is too short) (3%), category IIb (antibiotic use is not at the right interval) (3%).
{"title":"Antibiotic Use Evaluation in ICU/HCU of Muhammadiyah University General Hospital Malang using DDD and Gyssens Methods","authors":"Hidajah Rachmawati, Muktamiroh Muktamiroh, D. Hasmono, Atika Putri Kusumaningtyas, Sendi Lia Yunita, Lilik Yusetyani","doi":"10.21776/ub.jkb.2023.032.03.7","DOIUrl":"https://doi.org/10.21776/ub.jkb.2023.032.03.7","url":null,"abstract":"Infection is a condition caused by the propagation of harmful microorganisms with or without clinical symptoms. Improper use of antibiotics can lead to antibiotic resistance. The Ministry of Health of the Republic of Indonesia recommended a quantitative evaluation of the use of antibiotics using the Defined Daily Dose (DDD) method and a qualitative evaluation using the Gyssens method. This study evaluated antibiotics usage using DDD and Gyssens methods in ICU/HCU of the Muhammadiyah University General Hospital Malang. Employing retrospective observational method, data were collected from patient medical records hospitalized during January-December 2020. Results of the DDD quantitative analysis showed that the most widely used antibiotic was Ceftriaxone with a 35.79 DDD/100 patient-days. The Gyssenss qualitative analysis showed that the category VI (incomplete patient's medical record data) was 3%, category IVa (antibiotic use is more effective) (2%), category IIIb (duration of antibiotic use is too short) (3%), category IIb (antibiotic use is not at the right interval) (3%).","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88781251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-08DOI: 10.21776/ub.jkb.2022.032.03.1
Daffa Akrama Yuda, A. Rahman, Fathnur Sani Kasmadi, Humaryanto Humaryanto
Osteoarthritis (OA) is the most common form of arthritis. Meloxicam are one of NSAIDs commonly used that have many side effects. Areca nut (Areca catechu L), which contains flavonoids, can provide anti-inflammatory effects. This study aimed to determine the potential anti-inflammatory effect of ethyl acetate fraction from ripe areca nut in OA rat model. Twenty five of adults, male Rattus novergicus strain Wistar were induced to OA with Monosodium Iodoacetate (MIA), then divided into five groups that each group were given ethyl acetate fraction of ripe areca nut doses of 15mg/kgBW, 30mg/kgBW, and 60mg/kgBW, meloxicam 1.35mg/kgBW and aquadest as negative control for 14 days. Diameter of the knee joint is measured by digital metric kaliper to assess joint edema. The Histopathological examination with Haematoxyllin-Eosin stain to assess degree of inflammation on synovial. Among the areca groups, dose 30mg/kgBW had knee joint diameter reduced better and lower synovitis score. In conclusion, ethyl acetate fraction of the ripe areca nut group has anti inflammation effect in OA model but not dose-dependent.
{"title":"Anti-Inflammatory Effects of Ripe Areca Nut Ethyl Acetate Fraction in Wistar Rats with Knee Joints Osteoarthritis","authors":"Daffa Akrama Yuda, A. Rahman, Fathnur Sani Kasmadi, Humaryanto Humaryanto","doi":"10.21776/ub.jkb.2022.032.03.1","DOIUrl":"https://doi.org/10.21776/ub.jkb.2022.032.03.1","url":null,"abstract":"Osteoarthritis (OA) is the most common form of arthritis. Meloxicam are one of NSAIDs commonly used that have many side effects. Areca nut (Areca catechu L), which contains flavonoids, can provide anti-inflammatory effects. This study aimed to determine the potential anti-inflammatory effect of ethyl acetate fraction from ripe areca nut in OA rat model. Twenty five of adults, male Rattus novergicus strain Wistar were induced to OA with Monosodium Iodoacetate (MIA), then divided into five groups that each group were given ethyl acetate fraction of ripe areca nut doses of 15mg/kgBW, 30mg/kgBW, and 60mg/kgBW, meloxicam 1.35mg/kgBW and aquadest as negative control for 14 days. Diameter of the knee joint is measured by digital metric kaliper to assess joint edema. The Histopathological examination with Haematoxyllin-Eosin stain to assess degree of inflammation on synovial. Among the areca groups, dose 30mg/kgBW had knee joint diameter reduced better and lower synovitis score. In conclusion, ethyl acetate fraction of the ripe areca nut group has anti inflammation effect in OA model but not dose-dependent.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"28 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90523970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-08DOI: 10.21776/ub.jkb.2022.032.03.5
U. Setyawan, Rezki Tantular, Chaerani Bahar
Globally, lung cancer is by far the leading cause of death by cancer-which contribute to 2.094 million death-with the highest toll from cancer being 1.8 million. Currently, lung cancer therapy has developed from chemotherapy to targeted therapy, such as Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI). This study aimed to assess the survival rate of adenocarcinoma cell lung cancer patients who received EGFR-TKI therapy at the Pulmonary Clinic of Dr. Saiful Anwar General Hospital Malang. This study was a retrospective study using patient medical records between 2017 and 2020. The data were processed and analyzed using the Chi-Square test. The number of samples was 117 patients consisting of 63 patients receiving Gefitinib therapy, 36 patients receiving Afatinib therapy, and 18 patients receiving Erlotinib therapy. There were no significant differences between variables of age, sex, smoking history, stage, and exon mutations with 1-year survival. Gefitinib therapy has a higher average survival time than Afatinib and Erlotinib. However, the 1-year survival rate (YSR) was highest on Afatinib. The Middle Survival (MS) of the three regimens is almost the same, about 300 days. Statistical data showed no relationship between survival and the treatment regimen given (p=0.187). The most common side effect of TKI is skin rash. This research should be carried out with a larger sample to minimize bias.
{"title":"Survival Rate of Lung Adenocarcinoma Patients Receiving EGFR - Tyrosine Kinase Inhibitor Targeted Therapy","authors":"U. Setyawan, Rezki Tantular, Chaerani Bahar","doi":"10.21776/ub.jkb.2022.032.03.5","DOIUrl":"https://doi.org/10.21776/ub.jkb.2022.032.03.5","url":null,"abstract":"Globally, lung cancer is by far the leading cause of death by cancer-which contribute to 2.094 million death-with the highest toll from cancer being 1.8 million. Currently, lung cancer therapy has developed from chemotherapy to targeted therapy, such as Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI). This study aimed to assess the survival rate of adenocarcinoma cell lung cancer patients who received EGFR-TKI therapy at the Pulmonary Clinic of Dr. Saiful Anwar General Hospital Malang. This study was a retrospective study using patient medical records between 2017 and 2020. The data were processed and analyzed using the Chi-Square test. The number of samples was 117 patients consisting of 63 patients receiving Gefitinib therapy, 36 patients receiving Afatinib therapy, and 18 patients receiving Erlotinib therapy. There were no significant differences between variables of age, sex, smoking history, stage, and exon mutations with 1-year survival. Gefitinib therapy has a higher average survival time than Afatinib and Erlotinib. However, the 1-year survival rate (YSR) was highest on Afatinib. The Middle Survival (MS) of the three regimens is almost the same, about 300 days. Statistical data showed no relationship between survival and the treatment regimen given (p=0.187). The most common side effect of TKI is skin rash. This research should be carried out with a larger sample to minimize bias.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73548455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-08DOI: 10.21776/ub.jkb.2022.032.03.10
Aditya Airlangga Ekaputra, B. Daryanto, Kurnia Penta Seputra
Infected urachal cyst is one of urachal spectrum abnormalities. It usually presents in children because obliteration normally happened at early infancy. Rare case occurs in adult either can be small incidence or unrecognized symptoms until adulthood. Only small numbers of literature reported. The urachus is a tube extending from the anterior roof of the vesica urinaria to the umbilicus along the midline. The urachus is a vestigial fibromuscular structure located anterior to the fascia transversalis and posterior to the peritoneum. The presence of an embryonic urachal remnant can result in a variety of clinical complications. Due to the rarity of urachal residual disorders and the possibility of vague stomach or urinary symptoms, it is difficult to make a firm preoperative diagnosis. A 32-year-old female was referred to Saiful Anwar General Hospital after suffering abdominal pain for two months; the perineum felt the pain. There was a history of dysuria and nausea since the previous month, but no history of fever or change in bowel habits. Abdominal ultrasound showed an abscess at the anterior bladder and MRI showed an infected cyst mass in the suprapubic pointing to the left umbilical. Partial cystectomy and uterus biopsy were performed. The histopathologic result showed chronic inflammation tissue, and no malignancy was found. Misdiagnosis may lead to many complications such as progressive infection until malignancy therefore early detection of this case is important.
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