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Evaluation of the Antifertility Effect and Toxicity of Areca nut as Oral Contraceptive: Study on Male Rats 槟榔果口服避孕药对雄性大鼠的抗生育作用及毒性评价
Pub Date : 2022-04-11 DOI: 10.21776/ub.jkb.2022.032.01.3
A. Rahman, H. Dewi, Billi Brian Geniro, Easti Vishiara Amdely
Currently, very few male contraceptive methods are available. Areca nuts are known to have an antifertility effect, but the effective, safe dose is not certainly known. Data on its effectiveness and safety are needed to develop the potential of the areca nuts as an herbal contraceptive in men. This study determines the antifertility effect of areca nut administration at doses of 40, 30, and 20 mg/kgBW and their safety on the kidneys and liver. The green-colored raw areca nuts were used. The treatment groups were male rats whose fertility status was known before treatment. The control group were given distilled water. The treatment were given one dose a daily dissolved for 28 days of treatment, then male rats were bred again. Rats were terminated for histopathological examination of liver, kidneys, testes, and for analysis of spermatozoa. The administration of areca nuts caused a decreasing number of litters, but only the group given 40 mg/kgBW dose had a significant decrease (p<0.05). There were a damaged testes, a decreasing number and motility of spermatozoa as well as increasing spermatozoa abnormalities. There were no changes in liver tissue, but there was a mild grade cast in kidney tissue. Areca nut have antifertility effect in male rats with dose dependent manner, histopathological examination revealed cast nephotoxic but not hepatotoxic.
目前,很少有男性避孕方法可用。众所周知,槟榔果具有抗生育作用,但有效、安全的剂量还不确定。为了开发槟榔果作为男性草药避孕药的潜力,需要关于其有效性和安全性的数据。本研究确定40、30和20 mg/kgBW槟榔的抗生育作用及其对肾脏和肝脏的安全性。使用了绿色的生槟榔果。治疗组为治疗前已知生育状况的雄性大鼠。对照组给予蒸馏水。给药组每日一剂,连续28天,然后再饲养雄性大鼠。终止大鼠肝、肾、睾丸组织病理学检查和精子分析。槟榔给药使雏鸡凋落数减少,但只有40 mg/kgBW剂量组凋落数显著减少(p<0.05)。睾丸受损,精子数量和活力下降,精子异常增多。肝组织无改变,但肾组织有轻度铸型。槟榔对雄性大鼠有一定的抗生育作用,并呈剂量依赖性,组织病理学检查显示有一定的毒性,但无肝毒性。
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引用次数: 0
The Theory of Planned Behavior to Identify Out-of-Hospital Cardiac Arrest (OHCA) Bystanders' Intentions 院外心脏骤停旁观者意图的计划行为理论研究
Pub Date : 2022-04-11 DOI: 10.21776/ub.jkb.2022.032.01.11
Zenita Habibatul Ilmiyah, S. Andarini, Tony Suharsono
The theory of planned behavior states that intention is the best predictor of behavior. The intention to perform a behavior is determined by a person's attitude, subjective norms, and perceived behavioral control. As volunteers in the health sector, volunteers of the Indonesian Red Cross (PMI) have been equipped with knowledge and skills regarding the role of an OHCA bystander. Besides, the intentions of PMI volunteers greatly affect a person's tendency to be willing or unwilling to become an OHCA bystander. This study aims to apply the theory of planned behavior in identifying the factors that influence the intentions of PMI volunteers in acting as OHCA bystanders and the dominant factors that affect intentions. This study used an observational research type with a cross-sectional approach. The respondents in this study were 105 PMI volunteer members in Tuban Regency, which were conducted using the purposive sampling technique. In determining the most dominant factor that influenced intention, ordinal logistic regression analysis was used in which it was shown that the variable used in the last modeling analysis stage was the subjective norm (OR= 6.19). Based on the results of the analysis, it can be concluded that subjective norms are the most predictor factor that influences intentions.
计划行为理论指出,意图是行为的最佳预测者。执行行为的意图是由一个人的态度、主观规范和感知的行为控制决定的。作为卫生部门的志愿人员,印度尼西亚红十字会的志愿人员掌握了作为人道主义援助旁观者的知识和技能。此外,PMI志愿者的意向会极大地影响一个人愿意或不愿意成为OHCA旁观者的倾向。本研究旨在运用计划行为理论识别PMI志愿者作为OHCA旁观者的意图的影响因素和影响意图的主导因素。本研究采用横断面方法的观察性研究类型。本研究的调查对象为105名来自吐蕃县的PMI志愿者,采用目的抽样的方法。在确定影响意向的最主要因素时,使用了有序逻辑回归分析,结果表明,在最后一个建模分析阶段使用的变量是主观规范(OR= 6.19)。根据分析结果,可以得出主观规范是影响意图的最预测因素。
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引用次数: 1
Risk Factors for Mortality Due to Covid-19: A Case Study at a Distric Hospital in March-September 2020 2019冠状病毒病死率的危险因素:以2020年3月至9月某地区医院为例
Pub Date : 2022-04-11 DOI: 10.21776/ub.jkb.2022.032.01.14
Luthfiana Husnaini Utami, Dyah Yulia Ariani, Oskar Renagalih Amarta
The Covid-19 pandemic, which becomes a global health problem, has widely impacted not only health but also social, economic, and politics in Indonesia. Previous studies have indicated that the patient's prognosis is influenced by the degree of disease, age, gender, and comorbidities. District hospital in Bojonegoro is a Covid-19 referral hospital and 37,1 % of patients who died in march-september 2020. This study was conducted to identify risk factors for death in patients with Covid-19 in hospital so we can reduce casa fatality rate in district hospital in Bojonegoro. The independent variables in the study were age, gender, and comorbid status, while the dependent variable was the output status (recovered or deceased). The study was conducted at a private hospital in East Java in October 2020 on 104 patients as subjects. Data were analyzed using the chi-square test. The results show that all the factors studied, age p = 0.006, gender p = 0.050, and comorbid status p = 0.001, have a statistically significant relationship with mortality. In short, at this hospital, advanced age, male gender, and comorbidities are the risk factors for Covid-19 death.
新冠肺炎疫情已成为全球性健康问题,不仅对印度尼西亚的健康,而且对社会、经济、政治都产生了广泛影响。既往研究表明,患者的预后受疾病程度、年龄、性别和合并症的影响。Bojonegoro地区医院是一家Covid-19转诊医院,在2020年3月至9月期间死亡的患者中占37.1%。开展这项研究的目的是确定导致住院Covid-19患者死亡的危险因素,以便降低Bojonegoro地区医院的casa死亡率。研究中的自变量为年龄、性别和合并症状态,因变量为输出状态(康复或死亡)。该研究于2020年10月在东爪哇的一家私立医院进行,以104名患者为研究对象。数据分析采用卡方检验。结果显示,年龄p = 0.006、性别p = 0.050、合并症p = 0.001等因素与死亡率的关系均有统计学意义。简而言之,在这家医院,高龄、男性和合并症是Covid-19死亡的危险因素。
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引用次数: 0
Effectiveness of 0.1% Retinol Serum and Astaxanthin Gel on Skin Photoaging 0.1%视黄醇血清和虾青素凝胶对皮肤光老化的影响
Pub Date : 2022-04-09 DOI: 10.21776/ub.jkb.2022.032.01.12
Boedhy Setyanto, Sinta Murlistyarini, Dea Florensia
Skin photoaging is cumulative skin damage due to chronic environmental exposure, especially ultraviolet (UV) light, which interferes with the keratinocyte and fibroblast syntheses by matrix metalloproteinases (MMP). Retinol can improve wrinkles, pigmentation, elasticity, firmness, brightness, and various signs of photoaging on the skin. Astaxanthin is a powerful antioxidant that protects the skin from UV rays, inhibits MMP, and stimulates collagen production. This case report presents 2 cases of women complaining about deep skin wrinkles, dullness, and looseness. Physical examination in the facial region revealed wrinkles when resting in the first patient and wrinkles during motion in the second patient. The first patient was diagnosed Glogau III photoaging, while the second patient was diagnosed Glogau II photoaging. Both patients received astaxanthin gel therapy and SPF 33 sunscreen cream every morning, as well as 0.1% retinol serum every night. There was an improvement after six weeks. Astaxanthin and retinol 0.1% can be used as photoaging therapy. Adequate use of photoprotection is also necessary to prevent the worsening of photoaging.
皮肤光老化是由于长期环境暴露,特别是紫外线(UV)光,干扰角质形成细胞和成纤维细胞合成基质金属蛋白酶(MMP)造成的累积皮肤损伤。视黄醇可以改善皮肤上的皱纹、色素沉着、弹性、紧致度、亮度和各种光老化迹象。虾青素是一种强大的抗氧化剂,可以保护皮肤免受紫外线的伤害,抑制MMP,刺激胶原蛋白的产生。本病例报告提出2例女性主诉皮肤深皱纹、暗沉、松弛。在面部区域的体格检查显示,第一个病人在休息时出现皱纹,第二个病人在运动时出现皱纹。第1例诊断为Glogau III型光老化,第2例诊断为Glogau II型光老化。两名患者每天早上接受虾青素凝胶治疗和SPF 33的防晒霜,每晚接受0.1%视黄醇血清。六周后情况有所改善。0.1%虾青素和视黄醇可用于光老化治疗。充分使用光防护也是防止光老化恶化的必要条件。
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引用次数: 0
Relationship of Depression and Sleep Quality among North Jakarta Medical Students during the COVID-19 Pandemic 新冠肺炎大流行期间北雅加达医科学生抑郁与睡眠质量的关系
Pub Date : 2022-04-09 DOI: 10.21776/ub.jkb.2022.032.01.9
Annabella Naida Tanusetiawan, Surilena Surilena, Nelly Tina Widjaja, Dharmady Agus
Medical students with high academic load have had elevated baseline rates of depression and poor sleep quality. During the COVID-19 pandemic, medical students are more susceptible to depression and poor sleep quality. This study aimed to analyze depression and sleep quality among medical students at the School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia (FKIK UAJ) during the COVID-19 pandemic. A cross-sectional study was conducted among pre-clinical and clinical students of FKIK UAJ academic year 2020/2021. Respondents were selected through proportional systematic random sampling to fulfill the Patient Health Questionnaire-9 (PHQ-9) and Pittsburgh Sleep Quality Index (PSQI) for depression and sleep quality. The data were analyzed using Mann Whitney U-Test. There were 63.3% of 635 respondents with depression, in which 39.4% respondents had mild depression, 14.2% respondents with moderate depression, and 9.8% respondents with severe depression. There were 59,2% of respondents with poor sleep quality. Depression was highest in females (67.2%) and pre-clinical stage of 2020 intake year (74.6%), and among clinical level students of 2018 (56%) and 2019 (53.9%) intake year. Poor sleep quality was also highest in females (62.8%) and pre-clinical 2020 intake year (69.8%), and among clinical level students of 2018 (53%) and 2019 (51.9%) intake year. The Mann-Whitney U-test showed a significant difference between depression level and sleep quality in pre-clinical and clinical students of FKIK UAJ during the COVID-19 pandemic (p value=0.000). Depression and sleep quality among medical students of FKIK UAJ during the COVID-19 pandemic were significantly associated.
学业负担高的医学生抑郁基线率高,睡眠质量差。在2019冠状病毒病大流行期间,医学生更容易患抑郁症和睡眠质量差。本研究旨在分析2019冠状病毒病大流行期间印度尼西亚阿特马查亚天主教大学医学与健康科学学院(FKIK UAJ)医学生的抑郁和睡眠质量。在2020/2021学年FKIK UAJ的临床前和临床学生中进行了横断面研究。采用比例系统随机抽样的方法抽取调查对象完成患者健康问卷-9 (PHQ-9)和匹兹堡睡眠质量指数(PSQI)的抑郁和睡眠质量评估。采用Mann Whitney U-Test对数据进行分析。635名被调查者中有抑郁症的占63.3%,其中轻度抑郁症占39.4%,中度抑郁症占14.2%,重度抑郁症占9.8%。59.2%的受访者睡眠质量较差。女性(67.2%)和临床前阶段(74.6%)以及2018年和2019年临床阶段(53.9%)的学生中抑郁症比例最高。女性(62.8%)和临床前2020学年(69.8%)以及2018年(53%)和2019年(51.9%)学年的临床级学生的睡眠质量也最高。Mann-Whitney u检验显示,2019冠状病毒病大流行期间,FKIK UAJ临床前和临床学生的抑郁水平和睡眠质量存在显著差异(p值=0.000)。2019冠状病毒病大流行期间,FKIK UAJ医学生抑郁与睡眠质量显著相关。
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引用次数: 0
Validation of TWIST (Testicular Workup for Ischemia and Suspected Torsion) Score System for Differential Diagnosis in Acute Scrotum in Tertiary Teaching Hospital 三级教学医院急性阴囊鉴别诊断TWIST(睾丸缺血及疑似扭转检查)评分系统的验证
Pub Date : 2022-04-09 DOI: 10.21776/ub.jkb.2022.032.01.4
Nyoman Gede Prayudi, B. Daryanto, Taufiq Nur Budaya
The acute scrotum is a common urological emergency and has a broad differential diagnosis. There is no clear consensus on a particular algorithm to follow in the diagnosis of testicular torsion. Testicular Workup for Ischemia and Suspected Torsion (TWIST) Score, a risk scoring system based on signs and symptoms, can be invaluable in managing patients with the acute scrotum, specifically testicular torsion. This study aimed to evaluate the effectiveness of the TWIST scoring system for differential diagnosis of acute scrotal patients. The study was conducted using secondary data, medical records from 111 male patients diagnosed with acute scrotum in Saiful Anwar General Hospital Malang between January 2015 and December 2018. Data about the onset of pain, first contact, history, physical examination findings, any adjunct test performed, and intra-operative findings were collected. The effectiveness of the TWIST score in diagnosing testicular torsion was determined by calculating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Of the 111 patients, 43 patients (38.7%) had testicular torsion. The mean age was 17.49 (6.69) years. A total of 39 patients were classified as high risk as per the TWIST Score with cut point 5 had 83.7% sensitivity, 95.6% specificity, 92.3% positive predictive value (PPV), and 90.3% negative predictive value (NPV). The area under the curve was 0.93. The use of the TWIST Score in clinical practice can accurately determine high-risk patients who can proceed straight to the operating theatre without the need for an ultrasound.
急性阴囊是泌尿外科常见的急症,有广泛的鉴别诊断。目前还没有明确的共识,一个特定的算法遵循诊断睾丸扭转。睾丸缺血和疑似扭转检查(TWIST)评分是一种基于体征和症状的风险评分系统,对治疗急性阴囊,特别是睾丸扭转患者具有宝贵的价值。本研究旨在评估TWIST评分系统对急性阴囊患者鉴别诊断的有效性。该研究使用了二手数据,即2015年1月至2018年12月期间在玛琅赛弗安瓦尔综合医院诊断为急性阴囊的111名男性患者的医疗记录。收集有关疼痛发作、首次接触、病史、体格检查结果、任何辅助检查以及术中发现的数据。通过计算TWIST评分的敏感性、特异性、阳性预测值(positive predictive value, PPV)和阴性预测值(negative predictive value, NPV)来确定TWIST评分诊断睾丸扭转的有效性。111例患者中43例(38.7%)有睾丸扭转。平均年龄17.49岁(6.69岁)。根据TWIST评分,39例患者被归为高风险,切点5的敏感性为83.7%,特异性为95.6%,阳性预测值(PPV)为92.3%,阴性预测值(NPV)为90.3%。曲线下面积为0.93。在临床实践中使用TWIST评分可以准确地确定哪些高危患者可以直接进入手术室,而不需要超声检查。
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引用次数: 1
Baseline Stroke Severity as a Predictor of 30-Day Post-Ischemic Stroke Disability Outcome 基线脑卒中严重程度作为缺血性脑卒中后30天残疾结局的预测因子
Pub Date : 2022-04-09 DOI: 10.21776/ub.jkb.2022.032.01.6
Diana Teresa, R. Pinzon, Sugianto Adisaputro
More than 50% of patients who survived stroke have a chronic disability. The National Institute of Health Stroke Scale (NIHSS) is a scoring system to determine the neurologic deficit of a stroke patient. This study analyzed stroke severity based on baseline NIHSS score as a determinant for 30-day post-ischemic stroke disability. This study method uses a retrospective cohort design based on medical records and stroke registry of ischemic stroke patients in Bethesda Hospital Yogyakarta. During admission, the predictive factors for the disability of the study subjects were evaluated. The baseline NIHSS assessment score was measured at 1x24 hours after admission. Disability was measured using a simplified modified Rankin Scale questionnaire (smRSq) Indonesian version at 30-day post-ischemic stroke. Statistical analysis includes univariate, bivariate, and logistic regression multivariate data analysis. The subjects were 84 patients with ischemic stroke. Disability at 30-day post-ischemic stroke occurred in 22 patients (26.2%). Logistic regression multivariate analysis show that Neutrophil to Lymphocyte Ratio (NLR) (RR: 4.488, CI: 1.873–10.756, p: 0.001) and baseline NIHSS score (RR: 28.563, CI: 2.891–282.181, p: 0.004) together significantly affect the mRS of 30-day post-ischemic stroke. Patients admitted with a higher baseline NIHSS score have a 28.5 fold risk for a worse functional outcome than those with lower baseline NIHSS scores. Stroke severity based on baseline NIHSS score is a determinant factor for disability in patients at 30-day post-ischemic stroke.
超过50%的中风幸存者患有慢性残疾。美国国立卫生研究院卒中量表(NIHSS)是一种用于确定卒中患者神经功能缺陷的评分系统。本研究基于基线NIHSS评分分析脑卒中严重程度,作为缺血性脑卒中后30天残疾的决定因素。本研究方法采用回顾性队列设计,基于日惹Bethesda医院缺血性脑卒中患者的医疗记录和卒中登记。入院时,对研究对象残疾的预测因素进行评估。入院后1x24小时测量基线NIHSS评估评分。在缺血性卒中后30天,使用简化的修正兰金量表(smRSq)印度尼西亚版进行残疾测量。统计分析包括单变量、双变量和逻辑回归多变量数据分析。研究对象为84例缺血性脑卒中患者。22例(26.2%)发生缺血性卒中后30天残疾。多因素Logistic回归分析显示,中性粒细胞与淋巴细胞比值(NLR) (RR: 4.488, CI: 1.873-10.756, p: 0.001)和基线NIHSS评分(RR: 28.563, CI: 2.891-282.181, p: 0.004)共同显著影响缺血性卒中后30 d的mRS。入院时NIHSS基线评分较高的患者功能预后差的风险是NIHSS基线评分较低患者的28.5倍。基于基线NIHSS评分的脑卒中严重程度是缺血性脑卒中后30天患者残疾的决定因素。
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引用次数: 0
Relationship between Assertive Communication and Cyber-​​bullying in Adolescents 青少年自信沟通与网络欺凌的关系
Pub Date : 2021-08-31 DOI: 10.21776/ub.jkb.2021.031.04.7
Ira Kusumawaty, Yunike Yunike, Sujati Ni Ketut
The mandatory use of online facilities during the Covid-19 period has a great opportunity to increase the problem of cyber bullying at all levels of education. The concept of assertiveness cannot be separated from cyber bullying and it is known that communicating assertively can prevent cyber bullying even though it is difficult to implement. The complexity of the psychological problems of victims of cyber bullying requires comprehensive management. This analytical descriptive study with a cross sectional approach aims to analyze the relationship between assertive communication and cyber bullying by involving 151 student participants and high school students in Palembang. The data was collected using an assertive scale and a cyber-bullying scale, which was distributed online using a Google form.  From Kendall's tau-b statistical test, it is known that there is a relationship between assertive communication and cyber bullying (p=0.026). It is recommended that the education sector implement self-awareness, empathy, assertive communication and conflict resolution training to prevent the increasing number of cyber bullying's victim. The academic and managerial sectors are expected to facilitate promotion through educational media about using online facilities intelligently by respecting human dignity.
新冠肺炎疫情期间强制使用网络设施,很有可能加剧各级教育中的网络欺凌问题。自信的概念不能与网络欺凌分开,众所周知,自信的沟通可以防止网络欺凌,尽管很难实施。网络欺凌受害者心理问题的复杂性需要综合治理。本研究采用横断面分析方法,通过对巨港市151名学生和高中生的调查,旨在分析自信沟通与网络欺凌之间的关系。数据是通过自信量表和网络欺凌量表收集的,这些量表通过谷歌表格在网上分发。从Kendall的tau-b统计检验可知,自信沟通与网络欺凌之间存在关系(p=0.026)。建议教育部门实施自我意识、同理心、自信沟通和冲突解决培训,以防止越来越多的网络欺凌受害者。学界和企业界希望通过教育媒体宣传,尊重人的尊严,明智地使用网络设施。
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引用次数: 2
Factors Associated with Fatigue in Chronic Kidney Disease Patients Undergoing Hemodialysis: A Systematic Review 慢性肾脏病血液透析患者疲劳相关因素:系统综述
Pub Date : 2021-08-31 DOI: 10.21776/ub.jkb.2021.031.04.12
F. Prastiwi, T. A. Wihastuti, D. D. S. L. Ismail
Fatigue is the primary complaint most frequently reported by patients on hemodialysis. The importance of knowing the factors related to fatigue is a strategy that can be carried out by health workers in optimally applying interventions to reduce patient fatigue problems. This systematic review aimed to determine the factors associated with fatigue in patients undergoing hemodialysis. The systematic review method began by identifying research articles in the Pubmed, ProQuest, Ebsco, and ScienceDirect databases in 2011–2020. Review protocol was using PRISMA. Based on the results of the analysis, it was obtained 23 articles that discussed demographic factors, physiological factors, socioeconomic factors, situational factors, and psychological factors that could be associated with fatigue in hemodialysis patients. There is much to learn about fatigue in patients undergoing hemodialysis, including causative factors, assessment of severity, and effective management of fatigue so that it can be used as a benchmark for determining appropriate interventions.
疲劳是血液透析患者最常见的主诉。了解与疲劳有关的因素的重要性是卫生工作者在最佳地应用干预措施以减少患者疲劳问题时可执行的一项战略。本系统综述旨在确定与血液透析患者疲劳相关的因素。系统评价方法首先确定2011-2020年在Pubmed、ProQuest、Ebsco和ScienceDirect数据库中的研究文章。审查方案使用PRISMA。根据分析结果,获得了23篇文章,讨论了可能与血液透析患者疲劳相关的人口因素、生理因素、社会经济因素、情境因素和心理因素。关于血液透析患者的疲劳,包括致病因素、严重程度评估和疲劳的有效管理,还有很多需要了解的,以便它可以作为确定适当干预措施的基准。
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引用次数: 0
Clinical Response of Convalescent Plasma Therapy in COVID-19 Patients in Dr. Saiful Anwar General Hospital 安华总医院新冠肺炎恢复期血浆治疗临床疗效观察
Pub Date : 2021-08-31 DOI: 10.21776/ub.jkb.2021.031.04.5
Niniek Burhan, H. P. Brahmantyo, Djoko Heri Hermanto, P. Arsana
The use of convalescent plasma has been beneficial for more than a century to treat various infections.  The lack of effective treatment currently available for COVID-19 has reemerged the use of convalescent plasma as a potential therapeutic option. This is an observational descriptive study in 13 COVID-19 patient who got convalescent Plasma. Consist of 11 (84%) male patient, 2 (16%) female patient. Divided into two groups based on severity, and outcome. 38% patient included in severe disesase and 62% patient in critically Ill condition. 30% patient who got convalescent plasma deceased, and 70% had a resolve condition.
一个多世纪以来,使用恢复期血浆治疗各种感染一直是有益的。由于目前缺乏有效的COVID-19治疗方法,恢复期血浆再次成为一种潜在的治疗选择。本研究是对13例接受恢复期血浆治疗的COVID-19患者进行观察性描述性研究。男性11例(84%),女性2例(16%)。根据严重程度和结果分为两组。重症患者38%,危重患者62%。恢复期血浆患者死亡30%,病情缓解70%。
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引用次数: 0
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