Abstrak
Preeklampsia merupakan sumber utama morbiditas dan mortalitas di dunia dan penyulit 3%-8% kehamilan di negara Barat. 10%-15% kematian maternal langsung berhubungan dengan preeklampsia dan eklampsia. Dari 20 kasus kematian ibu di Kota Padang pada tahun 2016, 50% penyebab langsungnya adalah eklampsia. Tujuan penelitian: 1) Mempelajari pengaruh preeklampsia pada kehamilan terhadap luaran persalinan maternal, 2) Mempelajari pengaruh preeklampsia pada kehamilan terhadap luaran persalinan perinatal. Jenis penelitian deskriptif dengan rancangan studi atau penelaahan kasus pada ibu hamil preeklampsia trimester II dan III diikuti sampai proses persalinan, diobservasi luaran persalinan ibu dan bayinya. Penelitian dilaksanankan pada bulan April-November 2017 di Wilayah Kerja Puskesmas dan Rumah Sakit Kota Padang. Populasi adalah seluruh ibu hamil terdeteksi preeklampsia pada kehamilan trimester II dan III, dengan sampel 72 orang yang diambil dengan teknik consecutive sampling. Analisis data univariat. Hasil luaran maternal ditemukan 91,7% bersalin dengan tindakan section caeraria (SC) dan 38,9% dialami oleh ibu dengan kehamilan pertama. sedangkan pada luaran perinatal ditemukan 40,2% bayi lahir dengan asfiksia, dan 23,6% dengan Berat Bayi Lahir Rendah. Diharapkan hasil penelitian dapat dijadikan bahan perbandingan untuk penelitian lebih lanjut mengenai komplikasi yang diakibatkan preeklampsia ibu hamil.
Kata Kunci: preeklampsia, luaran maternal, luaran perinatal
Abstract
Preeclampsia is a major source of morbidity and mortality in the world and complicates 3% -8% of pregnancies in Western countries. 10% -15% of maternal deaths are directly related to preeclampsia and eclampsia. Of the 20 cases of maternal deaths in Padang City by 2016, 50% of the direct causes are eclampsia. Objective: 1) Study the effect of preeclampsia on pregnancy on the outcome of maternal delivery, 2) study the effect of preeclampsia on pregnancy on perinatal delivery outcome. Type of descriptive study with study design or case study in pregnant women preeclampsia trimester II and III followed by labour, observed the delivery of mother and baby. The study was carried out in April-November 2017 in the Working Areas of Public Health Centre and Hospital in Padang City. The population was all pregnant women detected preeclampsia in second and third trimester pregnancies, with a sample of 72 people taken by consecutive sampling technique. Analysis of univariate data. Maternal outcomes were found to be 91.7% maternity with caeraria section (SC) and 38
The aim of this investigation was a clinical evaluation of the accelerating effect of Tithonia difersifolia extract on the burn wound healing in male Sprague-Dawley rats weighted 200-350. The sample then extracted using wet rendering (infusa) method using aqua-dest as extractor. The subjects were nine male Sprague-Dawley rats devided in to three group (negative control, positive control and experimental). Every group consist of three rats. Heated metal plat (d=2cm) used to get full thickness burn wound on dorsal rat part. Then, Tithonia difersifolia folium extract was given to wound healing(plannimetri method) for 14 days, negative control(aqua dest) 26 days and positive control (Bioplasenton) 20 days. The results with analysis Anova showed that Tithonia difersifolia folium extract have significant effect (p < 0,05) to wound healing of rat models.
The Comparative Zinc Levels in Preterm Labor and Normal Pregnancy
Preterm labor occurs between 20 weeks and before 37 weeks of pregnancy. It is indicated by regular contractions of the uterus and it may cause the thinning and flattening of the cervix. Preterm labor also causes the high rates of perinatal morbidity and mortality. Deficiency zinc during pregnancy can stimulate the preterm labor. The design of this reseacrh was a comparative cross sectional study. It was conducted in Rasidin District Hospital, Siti Rahmah Hospital and Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang on Februari 2017 to June 2018. There were 50 samples in this reseach. It was selected by consecutive sampling. The samples were divided into two groups: preterm labor and normal pregnancy. Zinc levels are examined by the ELISA method. Then, the data were analyzed by using the t test. The results of this reseach showed that the mean zinc level in the preterm labor group was 12.22 ± 0.41 μmol / L and 13.96 ± 0.64 μmol / L of the mean zinc level in the normal pregnancy group with P= 0.000. Moreover, statistical test inffered that there was significant difference between zinc levels in preterm labor and normal pregnancy. In short, it can be concluded that zinc levels group in the preterm labor were lower than the normal pregnancy group.
Keywords: Zinc, Preterm Labor
Perbandingan Kadar Zinc Pada Persalinan Preterm dan Kehamilan Normal
Persalinan preterm adalah persalinan yang terjadi antara 20 minggu dan sebelum 37 minggu kehamilan yang ditandai adanya kontraksi teratur dari uterus yang dapat menyebabkan penipisan dan pendataran serviks. Persalinan preterm menyebabkan tingginya angka morbiditas dan mortalitas perinatal. Defiseiensi zinc selama kehamilan dapat menstimulasi terjadinya persalinan preterm. Desain penelitian ini adalah cross sectional komparatif, penelitian dilakukan di RSUD Rasidin, RSI Siti Rahmah dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang pada bulan Februari 2017 – Juni 2018. Jumlah sampel sebanyak 50 yang dipilih secara consecutive sampling, yang dibagi menjadi dua kelompok yaitu persalinan preterm dan kehamilan normal. Kadar zinc diperiksa dengan metode ELISA. Data dianalisa menggunakan uji t test. Hasil penelitian rerata kadar zinc pada kelompok persalinan preterm 12,22 ± 0,41 µmol/L dan rerata kadar zinc pada kelompok kehamilan normal a