Pub Date : 2024-10-22DOI: 10.1097/hep.0000000000001132
Che C. Colpitts, Thomas F. Baumert
{"title":"Fine-tuning of hepatitis C virus immune evasion through hypervariable region 1 insertions","authors":"Che C. Colpitts, Thomas F. Baumert","doi":"10.1097/hep.0000000000001132","DOIUrl":"https://doi.org/10.1097/hep.0000000000001132","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"46 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-18DOI: 10.1097/hep.0000000000001112
Vincent L Chen,Timothy R Morgan,Yaron Rotman,Heather M Patton,Kenneth Cusi,Fasiha Kanwal,W Ray Kim
{"title":"Resmetirom therapy for metabolic dysfunction-associated steatotic liver disease: October 2024 updates to AASLD Practice Guidance.","authors":"Vincent L Chen,Timothy R Morgan,Yaron Rotman,Heather M Patton,Kenneth Cusi,Fasiha Kanwal,W Ray Kim","doi":"10.1097/hep.0000000000001112","DOIUrl":"https://doi.org/10.1097/hep.0000000000001112","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"8 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-18DOI: 10.1097/hep.0000000000001121
Monica A. Tincopa, Luis Antonio Díaz, Daniel Q. Huang, Juan Pablo Arab, Marco Arrese, Adrian Gadano, Claudia P. Oliveira, Richele Bettencourt, Egbert Madamba, Susy Kim, Harris Siddqi, Fernando Javier Barreyro, Sebastián Marciano, Jorge Martínez Morales, Cristiane Villela-Nogueira, Nathalie Leite, Claudia Alves Couto, Rafael Theodoro, Mísia Joyner de Sousa Dias Monteiro, Mario G. Pessoa, Mario Reis Alvares-da-Silva, Fatima Higuera de la Tijera, Constanza D. Sabate, Manuel Mendizabal, Lisa Richards, Claude B. Sirlin, Rohit Loomba
Background & Aims: Cut-points for non-invasive tests (NITs) for risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) were derived from predominantly non-Hispanic populations. It is unknown if these cut-points perform adequately in Hispanic individuals. We assessed the performance characteristics of current NIT cut-points among Hispanic patients and determined whether they could be further optimized. Approach & Results: We prospectively enrolled 244 adults with biopsy-proven MASLD. Participants underwent a research visit with magnetic resonance elastography (MRE) and vibration controlled transient elastography (VCTE). Histology and imaging assessments were conducted centrally. Diagnostic performance was evaluated by area under the receiver-operating curve (AUROC) and optimal cut-points were identified by Youden J analysis. The mean (±SD) age and body mass index were 52.6 (±13) and 31.6 (±4.6) kg/m2. Overall, 40% had diabetes, 31% (N=75) were Hispanic. 40% of Hispanic and 28.4% of non-Hispanic patients had significant fibrosis. To detect significant fibrosis, MRE and VCTE exhibited significantly lower accuracy in Hispanic versus non-Hispanic participants (AUROC: MRE, 0.87 vs. 0.98, p=0.01; VCTE, 0.78 vs. 0.92, p=0.02). Clinical care algorithms yielded high false-negative rates among Hispanic participants (14% with low-risk FIB-4 and 21% with low-risk VCTE had advanced fibrosis on biopsy). Cut-points of 2.73 kPa for MRE and 6.9 kPa for VCTE were optimal to detect significant fibrosis in Hispanic individuals. Findings were validated in a Latin American cohort. Conclusions: Lower NIT cut-points may be needed to optimize surveillance for significant fibrosis due to MASLD in Hispanic populations commensurate with their higher burden and severity of disease.
{"title":"Disparities in screening and risk stratification for hispanic adults with metabolic dysfunction-associated steatotic liver disease","authors":"Monica A. Tincopa, Luis Antonio Díaz, Daniel Q. Huang, Juan Pablo Arab, Marco Arrese, Adrian Gadano, Claudia P. Oliveira, Richele Bettencourt, Egbert Madamba, Susy Kim, Harris Siddqi, Fernando Javier Barreyro, Sebastián Marciano, Jorge Martínez Morales, Cristiane Villela-Nogueira, Nathalie Leite, Claudia Alves Couto, Rafael Theodoro, Mísia Joyner de Sousa Dias Monteiro, Mario G. Pessoa, Mario Reis Alvares-da-Silva, Fatima Higuera de la Tijera, Constanza D. Sabate, Manuel Mendizabal, Lisa Richards, Claude B. Sirlin, Rohit Loomba","doi":"10.1097/hep.0000000000001121","DOIUrl":"https://doi.org/10.1097/hep.0000000000001121","url":null,"abstract":"Background & Aims: Cut-points for non-invasive tests (NITs) for risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) were derived from predominantly non-Hispanic populations. It is unknown if these cut-points perform adequately in Hispanic individuals. We assessed the performance characteristics of current NIT cut-points among Hispanic patients and determined whether they could be further optimized. Approach & Results: We prospectively enrolled 244 adults with biopsy-proven MASLD. Participants underwent a research visit with magnetic resonance elastography (MRE) and vibration controlled transient elastography (VCTE). Histology and imaging assessments were conducted centrally. Diagnostic performance was evaluated by area under the receiver-operating curve (AUROC) and optimal cut-points were identified by Youden J analysis. The mean (±SD) age and body mass index were 52.6 (±13) and 31.6 (±4.6) kg/m<jats:sup>2</jats:sup>. Overall, 40% had diabetes, 31% (N=75) were Hispanic. 40% of Hispanic and 28.4% of non-Hispanic patients had significant fibrosis. To detect significant fibrosis, MRE and VCTE exhibited significantly lower accuracy in Hispanic versus non-Hispanic participants (AUROC: MRE, 0.87 vs. 0.98, <jats:italic toggle=\"yes\">p</jats:italic>=0.01; VCTE, 0.78 vs. 0.92, <jats:italic toggle=\"yes\">p</jats:italic>=0.02). Clinical care algorithms yielded high false-negative rates among Hispanic participants (14% with low-risk FIB-4 and 21% with low-risk VCTE had advanced fibrosis on biopsy). Cut-points of 2.73 kPa for MRE and 6.9 kPa for VCTE were optimal to detect significant fibrosis in Hispanic individuals. Findings were validated in a Latin American cohort. Conclusions: Lower NIT cut-points may be needed to optimize surveillance for significant fibrosis due to MASLD in Hispanic populations commensurate with their higher burden and severity of disease.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"67 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1097/hep.0000000000000982
{"title":"Erratum: Protection and antibody levels 35 years after primary series with hepatitis B vaccine and response to a booster dose","authors":"","doi":"10.1097/hep.0000000000000982","DOIUrl":"https://doi.org/10.1097/hep.0000000000000982","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"17 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1097/hep.0000000000001123
Liqin Zhu
{"title":"Reply: HKDC1 promotes liver cancer stemness under hypoxia via stabilizing β-catenin","authors":"Liqin Zhu","doi":"10.1097/hep.0000000000001123","DOIUrl":"https://doi.org/10.1097/hep.0000000000001123","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"45 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1097/hep.0000000000001102
{"title":"Erratum: JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in the evaluation of virus neutralization","authors":"","doi":"10.1097/hep.0000000000001102","DOIUrl":"https://doi.org/10.1097/hep.0000000000001102","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"9 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-17DOI: 10.1097/hep.0000000000000983
{"title":"Erratum: Diagnosis, Evaluation, and Management of Ascites and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases","authors":"","doi":"10.1097/hep.0000000000000983","DOIUrl":"https://doi.org/10.1097/hep.0000000000000983","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"124 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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