Pub Date : 2022-09-17DOI: 10.14710/jksa.25.8.292-299
G. Gunawan, Sarahtrinita Glikeria Like Megawati, N. Prasetya, R. Wijaya
Synthesis of Ag2S from AgCl waste of argentometric titration with heating temperature variations as a temperature sensor has been done. This study aims to synthesize Ag2S and examine the effect of heating temperature on crystal quality and electrical characteristics as a temperature sensor based on the Negative Temperature Coefficient (NTC). Ag2S synthesis was carried out by precipitation in a water bath with various heating temperatures of 40°C, 60°C, and 80°C. The success of the synthesis was confirmed by X-Ray Diffraction (XRD) with a typical peak of 2θ from Ag2S standard at 29.07°, 31.60°, 36.97°, 37.81°, and the highest crystallinity was obtained at a heating temperature of 60°C. Meanwhile, UV-Vis Diffuse Reflectance Spectroscopy (DRS UV-Vis) showed a band gap corresponding to Ag2S (0.9-1.05 eV). Furthermore, the Ag2S powder was made into pellets and applied as a temperature sensor. Then the resistance value and the electrical characteristics of the resulting sensor were measured. The best resistance was obtained from Ag2S synthesized at a temperature of 60°C with constant (B) and sensitivity (α) values of 2974 K and −3.35%, respectively. This indicated that Ag2S had been successfully synthesized, and the best sensor quality was obtained from Ag2S heated at a temperature of 60°C.
{"title":"Synthesis, Characterization of Ag2s from AgCl Waste of Argentometry Titration with Heating Temperature Variations and Its Application as a Temperature Sensor Based on Negative Temperature Coefficient (NTC)","authors":"G. Gunawan, Sarahtrinita Glikeria Like Megawati, N. Prasetya, R. Wijaya","doi":"10.14710/jksa.25.8.292-299","DOIUrl":"https://doi.org/10.14710/jksa.25.8.292-299","url":null,"abstract":"Synthesis of Ag2S from AgCl waste of argentometric titration with heating temperature variations as a temperature sensor has been done. This study aims to synthesize Ag2S and examine the effect of heating temperature on crystal quality and electrical characteristics as a temperature sensor based on the Negative Temperature Coefficient (NTC). Ag2S synthesis was carried out by precipitation in a water bath with various heating temperatures of 40°C, 60°C, and 80°C. The success of the synthesis was confirmed by X-Ray Diffraction (XRD) with a typical peak of 2θ from Ag2S standard at 29.07°, 31.60°, 36.97°, 37.81°, and the highest crystallinity was obtained at a heating temperature of 60°C. Meanwhile, UV-Vis Diffuse Reflectance Spectroscopy (DRS UV-Vis) showed a band gap corresponding to Ag2S (0.9-1.05 eV). Furthermore, the Ag2S powder was made into pellets and applied as a temperature sensor. Then the resistance value and the electrical characteristics of the resulting sensor were measured. The best resistance was obtained from Ag2S synthesized at a temperature of 60°C with constant (B) and sensitivity (α) values of 2974 K and −3.35%, respectively. This indicated that Ag2S had been successfully synthesized, and the best sensor quality was obtained from Ag2S heated at a temperature of 60°C.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49409738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-09DOI: 10.14710/jksa.25.8.286-291
Samriani Samriani, M. Zakir, P. Taba, N. La Nafie, Iin Indriani
MCM-41 and Zn-MCM-41 were successfully synthesized using hydrothermal and impregnation methods. The synthesized silica mesoporous was confirmed by characterizing the material using XRD, SEM-EDS, and BET-BJH analyses. XRD results showed three main peaks at angles of 2θ = 2.40° (100), 3.87° (200), and 4.49° (210), which are characteristics of mesoporous materials with hexagonal structures. SEM analysis showed that the surface morphology of Zn-modified MCM-41 formed aggregates of smaller particles. The EDS results showed that the amount of Zn in MCM-41 was 1.25%. Modification with Zn metal also affected the surface area and porosity of MCM-41, where the surface area, pore volume, and pore diameter decreased. Based on the adsorption-desorption analysis of N2 gas, both materials exhibit a type IV isotherm typical for mesoporous materials with an H1 hysteresis loop.
{"title":"Synthesis of MCM-41 Silica Mesoporous Modified with Zn Metal","authors":"Samriani Samriani, M. Zakir, P. Taba, N. La Nafie, Iin Indriani","doi":"10.14710/jksa.25.8.286-291","DOIUrl":"https://doi.org/10.14710/jksa.25.8.286-291","url":null,"abstract":"MCM-41 and Zn-MCM-41 were successfully synthesized using hydrothermal and impregnation methods. The synthesized silica mesoporous was confirmed by characterizing the material using XRD, SEM-EDS, and BET-BJH analyses. XRD results showed three main peaks at angles of 2θ = 2.40° (100), 3.87° (200), and 4.49° (210), which are characteristics of mesoporous materials with hexagonal structures. SEM analysis showed that the surface morphology of Zn-modified MCM-41 formed aggregates of smaller particles. The EDS results showed that the amount of Zn in MCM-41 was 1.25%. Modification with Zn metal also affected the surface area and porosity of MCM-41, where the surface area, pore volume, and pore diameter decreased. Based on the adsorption-desorption analysis of N2 gas, both materials exhibit a type IV isotherm typical for mesoporous materials with an H1 hysteresis loop.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44440943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.14710/jksa.25.8.280-285
M. Firdaus, T. Kusumaningsih, Ichsan Arifagama, Z. A. Amin
Alcohol oxidation plays an essential contribution to the chemical industry. Innovative green techniques, such as ultrasound irradiation, could be economically remarkable by enhancing reaction yield. In this research, the design and improvement of a new green ultrasound-assisted oxidation of alcohols procedure using CrO3 supported by Al2O3 with the addition of a small amount of t- butanol were reported. The oxidation of alcohols was also done without ultrasound irradiation to study the sonochemical effect. Based on FTIR and GC/MS analyses, the alcohols were effectively oxidized into their corresponding aldehydes in satisfactory yields (74–93%). The yield of the obtained aldehydes was increased by applying the ultrasonic irradiation technique, and no over-oxidation products were found. Overall, the innovative procedure offers several benefits, such as being easy to use, environmentally friendly, capable of improving yields, and having shorter oxidation times.
{"title":"Solvent-less Oxidation of Aromatic Alcohols Using CrO3/Al2O3 under Ultrasonic Irradiation","authors":"M. Firdaus, T. Kusumaningsih, Ichsan Arifagama, Z. A. Amin","doi":"10.14710/jksa.25.8.280-285","DOIUrl":"https://doi.org/10.14710/jksa.25.8.280-285","url":null,"abstract":"Alcohol oxidation plays an essential contribution to the chemical industry. Innovative green techniques, such as ultrasound irradiation, could be economically remarkable by enhancing reaction yield. In this research, the design and improvement of a new green ultrasound-assisted oxidation of alcohols procedure using CrO3 supported by Al2O3 with the addition of a small amount of t- butanol were reported. The oxidation of alcohols was also done without ultrasound irradiation to study the sonochemical effect. Based on FTIR and GC/MS analyses, the alcohols were effectively oxidized into their corresponding aldehydes in satisfactory yields (74–93%). The yield of the obtained aldehydes was increased by applying the ultrasonic irradiation technique, and no over-oxidation products were found. Overall, the innovative procedure offers several benefits, such as being easy to use, environmentally friendly, capable of improving yields, and having shorter oxidation times.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45456182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-09DOI: 10.14710/jksa.25.7.264-269
D. Basir, Jefri Liasta, Annisa Amelia, M. Miksusanti, S. Susilawati
This paper described the progress of phytochemical, especially alkaloids, work on Fagraea fragrans species (tembesu), Loganiaceae. A dimeric-pyridine alkaloid with molecular formula C20H20O4N2 has been successfully isolated from diethyl ether extracts from this plant’s barks. The alkaloid was explored from diethyl ether extracts using sulphuric acid (2%), then basified with ammonium hydroxide (25%) until the solution had a pH of 10.5. The later solution was extracted again with chloroform. The alkaloid residue was subjected to column chromatography and eluted with 10% acetone in chloroform. The chemical structure of the isolated dimeric-pyridine alkaloid was determined by LCMS/MS, 13C-NMR, and 1H-NMR spectroscopies. As a result, the isolated dimeric-pyridine alkaloid was closely similar to the oliveramine alkaloid, and this is also the first report about oliveramine from Fagraea fragrans (F. Fragrans).
{"title":"Oliveramine: An Isolated Alkaloid from Fagraea fragrans (Tembesu) Bark","authors":"D. Basir, Jefri Liasta, Annisa Amelia, M. Miksusanti, S. Susilawati","doi":"10.14710/jksa.25.7.264-269","DOIUrl":"https://doi.org/10.14710/jksa.25.7.264-269","url":null,"abstract":"This paper described the progress of phytochemical, especially alkaloids, work on Fagraea fragrans species (tembesu), Loganiaceae. A dimeric-pyridine alkaloid with molecular formula C20H20O4N2 has been successfully isolated from diethyl ether extracts from this plant’s barks. The alkaloid was explored from diethyl ether extracts using sulphuric acid (2%), then basified with ammonium hydroxide (25%) until the solution had a pH of 10.5. The later solution was extracted again with chloroform. The alkaloid residue was subjected to column chromatography and eluted with 10% acetone in chloroform. The chemical structure of the isolated dimeric-pyridine alkaloid was determined by LCMS/MS, 13C-NMR, and 1H-NMR spectroscopies. As a result, the isolated dimeric-pyridine alkaloid was closely similar to the oliveramine alkaloid, and this is also the first report about oliveramine from Fagraea fragrans (F. Fragrans).","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43924239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-02DOI: 10.14710/jksa.25.7.245-252
H. Widiyandari, Hanaiyah Parasdila, A. S. Wijareni
Lithium-ion batteries using zinc oxide (ZnO) as anode material had a high theoretical capacity of about 987 mAh/g. Unfortunately, ZnO capacity can drop below 200 mAh/g after only a few cycles. For that reason, graphite was added in this study due to its stable theoretical capacity of around 348-374 mAh/g to maintain the stability of lithium-ion battery capacity. Zinc oxide/graphite (ZnO/Graphite) was prepared using a solid-state method, in which ZnO and graphite were mortared until homogeneous with the mass ratio of (2:1), (1:1), and (1:2). The SEM images of all samples showed the agglomerate morphology between ZnO and graphite which affect the results of the battery performance test. The final result of the ZnO/Graphite anode can be considered a continuous anode material due to the stable cycle performance obtained in the range of 219.72–371.27 mAh/g with a decreased value of 40% after 55 cycles.
{"title":"Preparation of Zinc Oxide/Graphite Composite Using Solid-State Method as an Anode Material for Lithium-Ion Battery","authors":"H. Widiyandari, Hanaiyah Parasdila, A. S. Wijareni","doi":"10.14710/jksa.25.7.245-252","DOIUrl":"https://doi.org/10.14710/jksa.25.7.245-252","url":null,"abstract":"Lithium-ion batteries using zinc oxide (ZnO) as anode material had a high theoretical capacity of about 987 mAh/g. Unfortunately, ZnO capacity can drop below 200 mAh/g after only a few cycles. For that reason, graphite was added in this study due to its stable theoretical capacity of around 348-374 mAh/g to maintain the stability of lithium-ion battery capacity. Zinc oxide/graphite (ZnO/Graphite) was prepared using a solid-state method, in which ZnO and graphite were mortared until homogeneous with the mass ratio of (2:1), (1:1), and (1:2). The SEM images of all samples showed the agglomerate morphology between ZnO and graphite which affect the results of the battery performance test. The final result of the ZnO/Graphite anode can be considered a continuous anode material due to the stable cycle performance obtained in the range of 219.72–371.27 mAh/g with a decreased value of 40% after 55 cycles.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47397118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-27DOI: 10.14710/jksa.25.7.235-244
Salni Salni, Muhammad Said, E. Eliza, Anggun Dita Dyah Gayatri, P. Hariani
This research reports the synthesized CoFe2O4/SiO2/Ag magnetic composite used as a photocatalyst to degrade Congo red dye and antibacterial agent against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The catalysts were characterized using XRD, SEM-EDS, VSM, UV-DRS, and pHpzc. The effects of photocatalyst dose (0.25, 0.5, 0.75, and 1.0 g/L), dye concentration (10, 20, 30, and 40 mg/L), and irradiation time (0–210 minutes) were all examined as photocatalytic degradation variables. The results showed that the CoFe2O4/SiO2/Ag composite was superparamagnetic with a saturation magnetization of 41.82 emu/g and had a band gap of 1.82 eV. The highest efficiency of decreasing the concentration of Congo red dye of 93.70% was obtained with an initial concentration of 10 mg/L, a catalyst dose of 0.5 g/L, and an irradiation time of 180 minutes. This study indicated that the composite had antibacterial properties against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria with the same MIC value of 1.25%. These results indicated that the CoFe2O4/SiO2/Ag composite has significant potential for applications in wastewater treatment.
{"title":"Preparation of CoFe2O4/SiO2/Ag Magnetic Composite as Photocatalyst for Congo Red Dye and Antibacterial Potential","authors":"Salni Salni, Muhammad Said, E. Eliza, Anggun Dita Dyah Gayatri, P. Hariani","doi":"10.14710/jksa.25.7.235-244","DOIUrl":"https://doi.org/10.14710/jksa.25.7.235-244","url":null,"abstract":"This research reports the synthesized CoFe2O4/SiO2/Ag magnetic composite used as a photocatalyst to degrade Congo red dye and antibacterial agent against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The catalysts were characterized using XRD, SEM-EDS, VSM, UV-DRS, and pHpzc. The effects of photocatalyst dose (0.25, 0.5, 0.75, and 1.0 g/L), dye concentration (10, 20, 30, and 40 mg/L), and irradiation time (0–210 minutes) were all examined as photocatalytic degradation variables. The results showed that the CoFe2O4/SiO2/Ag composite was superparamagnetic with a saturation magnetization of 41.82 emu/g and had a band gap of 1.82 eV. The highest efficiency of decreasing the concentration of Congo red dye of 93.70% was obtained with an initial concentration of 10 mg/L, a catalyst dose of 0.5 g/L, and an irradiation time of 180 minutes. This study indicated that the composite had antibacterial properties against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria with the same MIC value of 1.25%. These results indicated that the CoFe2O4/SiO2/Ag composite has significant potential for applications in wastewater treatment.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49056763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-27DOI: 10.14710/jksa.25.6.224-230
N. Azis, A. Wahab, A. Karim, N. La Nafie, Triana Febrianti
In this present study, silver nanoparticles (AgNPs) were synthesized through an easy, rapid, and eco-friendly pathway using Lannea coromandelica aqueous bark extract. The obtained AgNPs were characterized using Ultraviolet-Visible (UV-Vis) spectrophotometer, Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The results indicated that the pH of colloidal AgNPs played a vital role in forming AgNPs. The pH ranges used in this study were 6, 8, 10, and 12. The formation of AgNPs was confirmed by observing the surface plasmon resonance (SPR) band at each pH and obtaining a wavelength of 430.50, 419.50, 418.50, and 410.00 nm. A comparison of the FTIR spectra of Lannea coromandelica aqueous bark extract and AgNPs showed the contribution of the O-H group in reducing silver ions. XRD diffractogram showed that AgNPs formed at 2θ = 37.8056o (1 1 1), 44.0345o (2 0 0), 64.3942o (2 2 0), dan 77.5003o (3 1 1) with face-centered cubic (FCC) crystal structure, and the average particle size was 22.5047 nm. SEM results showed that the nanoparticles have a non-uniform and irregular shape.
{"title":"Synthesis of Silver Nanoparticles in an Eco-friendly Way using Lannea coromandelica Aqueous Bark Extract","authors":"N. Azis, A. Wahab, A. Karim, N. La Nafie, Triana Febrianti","doi":"10.14710/jksa.25.6.224-230","DOIUrl":"https://doi.org/10.14710/jksa.25.6.224-230","url":null,"abstract":"In this present study, silver nanoparticles (AgNPs) were synthesized through an easy, rapid, and eco-friendly pathway using Lannea coromandelica aqueous bark extract. The obtained AgNPs were characterized using Ultraviolet-Visible (UV-Vis) spectrophotometer, Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The results indicated that the pH of colloidal AgNPs played a vital role in forming AgNPs. The pH ranges used in this study were 6, 8, 10, and 12. The formation of AgNPs was confirmed by observing the surface plasmon resonance (SPR) band at each pH and obtaining a wavelength of 430.50, 419.50, 418.50, and 410.00 nm. A comparison of the FTIR spectra of Lannea coromandelica aqueous bark extract and AgNPs showed the contribution of the O-H group in reducing silver ions. XRD diffractogram showed that AgNPs formed at 2θ = 37.8056o (1 1 1), 44.0345o (2 0 0), 64.3942o (2 2 0), dan 77.5003o (3 1 1) with face-centered cubic (FCC) crystal structure, and the average particle size was 22.5047 nm. SEM results showed that the nanoparticles have a non-uniform and irregular shape.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45725132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-27DOI: 10.14710/jksa.25.7.253-263
A. Lestari, Irmanida Batubara, S. T. Wahyudi, A. Ilmiawati
Phenolics, including flavonoids, are bioactive components in garlic in relatively abundant amounts and are present 2–4 times more in black garlic. Both of these compounds are reported to have biological activity, with one of them acting as an antioxidant. However, its ability as an antigout is still not widely reported. Xanthine oxidase, adenine deaminase, guanine deaminase, purine nucleoside phosphorylase, and 5-Nucleotidase II are involved during the production of uric acid and causes gout. This study predicted the potential of the phenolic and flavonoid compounds in garlic and black garlic as antigout in inhibiting five target receptors through a molecular docking approach. Utilizing AutoDock Tools v.1.5.7 for receptor and ligand preparation, AutoDock Vina and AutoDock4 for molecular docking, and LigPlot+ and PyMOL for visualization. About 21 compounds from the phenolic and flavonoid groups were used as test ligands and 16 reference ligands (substrate and commercial). SwissADME predicted the pharmacokinetic parameters. The results showed that apigenin, morin, resveratrol, kaempferol, (+)-catechin, isorhamnetin, and (-)-epicatechin were predicted to have good interactions at each target receptor and had the potential to be developed as candidates for multi-target antigout. Based on the pharmacokinetic parameters, all these compounds had good scores in each, making them feasible to continue in vitro or in vivo trials.
{"title":"Phenolic Compound in Garlic (Allium sativum) and Black Garlic Potency as Antigout Using Molecular Docking Approach","authors":"A. Lestari, Irmanida Batubara, S. T. Wahyudi, A. Ilmiawati","doi":"10.14710/jksa.25.7.253-263","DOIUrl":"https://doi.org/10.14710/jksa.25.7.253-263","url":null,"abstract":"Phenolics, including flavonoids, are bioactive components in garlic in relatively abundant amounts and are present 2–4 times more in black garlic. Both of these compounds are reported to have biological activity, with one of them acting as an antioxidant. However, its ability as an antigout is still not widely reported. Xanthine oxidase, adenine deaminase, guanine deaminase, purine nucleoside phosphorylase, and 5-Nucleotidase II are involved during the production of uric acid and causes gout. This study predicted the potential of the phenolic and flavonoid compounds in garlic and black garlic as antigout in inhibiting five target receptors through a molecular docking approach. Utilizing AutoDock Tools v.1.5.7 for receptor and ligand preparation, AutoDock Vina and AutoDock4 for molecular docking, and LigPlot+ and PyMOL for visualization. About 21 compounds from the phenolic and flavonoid groups were used as test ligands and 16 reference ligands (substrate and commercial). SwissADME predicted the pharmacokinetic parameters. The results showed that apigenin, morin, resveratrol, kaempferol, (+)-catechin, isorhamnetin, and (-)-epicatechin were predicted to have good interactions at each target receptor and had the potential to be developed as candidates for multi-target antigout. Based on the pharmacokinetic parameters, all these compounds had good scores in each, making them feasible to continue in vitro or in vivo trials.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49024245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-18DOI: 10.14710/jksa.25.6.218-223
Irmanida Batubara, Arnold Patogi Siahaan, E. Rohaeti, A. Muddathir
Jojoba (Simmondsia chinensis) (Link) C.K. is a shrub plant widely used in cosmetics, especially jojoba oil. The residue will remain when producing jojoba oil and become waste. This study aimed to determine the antibacterial activity of Jojoba seed residue (JSR) and its possible active antibacterial compounds. JSR was collected from Sudan and extracted by maceration with n-hexane, ethyl acetate, and 70% ethanol. The antibacterial activity was determined with the microdilution method against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The 70% ethanol extract showed the value of MIC and MBC against E. coli, which was 7.8 mg/ml; meanwhile, against S. aureus was 3.9 mg/mL and 7.8 mg/mL, respectively. Fractionation of 70% ethanol extract using silica gel column chromatography with gradient elution produced ten fractions. Fraction 3 showed the MIC and MBC values in E. coli which were 3.1 mg/mL and 12 mg/ml, and in S. aureus, which were 3.1 mg/mL and 6.2 mg/mL. The fractionation continued to Fraction 3 using preparative thin layer chromatography to collect subfraction 3.2 at an Rf value of 0.76, actively based on contact autobiography against E. coli and S. aureus. Embelin was detected in Subfraction 3.2 using liquid chromatography-mass spectrometry (UHPLC-Q-Orbitrap HRMS) and suggested as the active antibacterial component in JSR.
{"title":"Antibacterial Activity of Jojoba Seed residue and Its Possible Active Compound","authors":"Irmanida Batubara, Arnold Patogi Siahaan, E. Rohaeti, A. Muddathir","doi":"10.14710/jksa.25.6.218-223","DOIUrl":"https://doi.org/10.14710/jksa.25.6.218-223","url":null,"abstract":"Jojoba (Simmondsia chinensis) (Link) C.K. is a shrub plant widely used in cosmetics, especially jojoba oil. The residue will remain when producing jojoba oil and become waste. This study aimed to determine the antibacterial activity of Jojoba seed residue (JSR) and its possible active antibacterial compounds. JSR was collected from Sudan and extracted by maceration with n-hexane, ethyl acetate, and 70% ethanol. The antibacterial activity was determined with the microdilution method against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The 70% ethanol extract showed the value of MIC and MBC against E. coli, which was 7.8 mg/ml; meanwhile, against S. aureus was 3.9 mg/mL and 7.8 mg/mL, respectively. Fractionation of 70% ethanol extract using silica gel column chromatography with gradient elution produced ten fractions. Fraction 3 showed the MIC and MBC values in E. coli which were 3.1 mg/mL and 12 mg/ml, and in S. aureus, which were 3.1 mg/mL and 6.2 mg/mL. The fractionation continued to Fraction 3 using preparative thin layer chromatography to collect subfraction 3.2 at an Rf value of 0.76, actively based on contact autobiography against E. coli and S. aureus. Embelin was detected in Subfraction 3.2 using liquid chromatography-mass spectrometry (UHPLC-Q-Orbitrap HRMS) and suggested as the active antibacterial component in JSR.","PeriodicalId":17811,"journal":{"name":"Jurnal Kimia Sains dan Aplikasi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48710748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-11DOI: 10.14710/jksa.25.6.212-217
I. W. T. Aryasa
Metal nanoparticles and exploration of green synthesis can be applied to lung tissue therapy, cancer, and even vaccines. Additionally, due to the rise in microbial resistance or the demand for novel antibiotics, the use of NPs as an antibacterial agent has expanded. Meanwhile, using methods to produce metal nanoparticles based on the abundance of biodiversity as a green-reducing agent will be safer. In the present study, Kayu tulak leaves extract served as the green-reducing agent. The synthesized silver nanoparticles were characterized using a UV-Vis spectrophotometer, PSA (Particle Size Analyzer), and TEM (Transmission Electron Microscope). The results showed that the silver nanoparticles synthesized using Kayu tulak leaf extract at concentrations of AgNO3 1 and 2 mM had absorbance peaks at 436.5 nm and 467 nm, respectively. The average particle size distributions of the two silver nanoparticles were 88.2 and 16.9 nm, respectively. The characterization of silver nanoparticles using TEM obtained a mixture of spherical, hexagonal, and triangular shapes. The silver nanoparticles synthesized using Kayu tulak as a bio-reductant exhibited antibacterial activity. At AgNO3 solutions of 1 and 2 mM, silver nanoparticles showed antibacterial activity against Escherichia coli with inhibition zone diameters of 6.39 ± 0.30 mm and 8.28 ± 0.19 mm (moderate inhibition), while against Staphylococcus aureus were 4.30 ± 0.24 mm (weak inhibition) and 6.39 ± 0.27 mm (moderate inhibition).
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