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Prevalence and Related Risk Factors of Non-Alcoholic Fatty Liver Disease In HIV/AIDS Patients HIV/AIDS患者非酒精性脂肪肝患病率及相关危险因素
Pub Date : 2021-01-01 DOI: 10.36519/KD.2021.09
Figen Sarıgül, M. Deniz
Objective: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of fatty liver without inflammatory infiltration, excessive alcohol consumption, viral hepatitis, and other liver diseases. NAFLD is a major health problem as it can lead to cirrhosis, liver cancer and mortality. In HIV-positive patients, the prevalence of NAFLD ranges from 28 to 48%. Currently, there is no information about the prevalence and related factors related to NAFLD in those with HIV infection in our country. In this study, we aimed to investigate the prevalence of NAFLD and the related factors in newly diagnosed HIV-infected patients. Methods: The demographic data and ultrasonography of 558 HIV-infected patients newly diagnosed between June 2015 and September 2019 were analyzed retrospectively. In hepatic echogenicity, fatty liver was diagnosed with hyper echogenicity of liver compared with renal cortex and diffusion. Uni- and multi-variate logistic regression analyses were applied to estimate factors associated with NAFLD. Results: Of 358 patients who met the study criteria, 118 (33%) were diagnosed as NAFLD. Obesity was found in 10.2% of the patients with NAFLD and in 3.1% of the patients without NAFLD (p=0.021). NAFLD rate was significantly higher in patients with diabetes mellitus and hypertension (p<0.05). In the multivariate analysis, age, 1 mg/dl increase in glucose and triglyceride values and 1 unit increase in ALT/AST were associated with NAFLD. Conclusions: The results highlight the importance of early recognition and management of NAFLD and traditional factors associated with NAFLD in Turkish patients with HIV infection. Additionally, precautions and treatments should be a priority in the follow-up of patients in order to ensure the reduction of liver-related morbidity and mortality, which is one of the non-AIDS causes of these newly diagnosed HIV-infected patients.
目的:非酒精性脂肪肝(Non-alcoholic fatty liver disease, NAFLD)是脂肪肝最常见的病因,无炎症浸润、过度饮酒、病毒性肝炎等肝脏疾病。NAFLD是一个主要的健康问题,因为它会导致肝硬化、肝癌和死亡。在hiv阳性患者中,NAFLD的患病率从28%到48%不等。目前,我国HIV感染者中NAFLD的患病率及相关因素尚无相关资料。在本研究中,我们旨在调查新诊断的hiv感染者中NAFLD的患病率及其相关因素。方法:回顾性分析2015年6月至2019年9月新诊断的558例hiv感染者的人口学资料和超声检查结果。在肝脏回声方面,与肾皮质和弥散相比,脂肪肝诊断为肝脏高回声。应用单变量和多变量logistic回归分析估计与NAFLD相关的因素。结果:在358例符合研究标准的患者中,118例(33%)被诊断为NAFLD。肥胖发生率为10.2%的NAFLD患者和3.1%的非NAFLD患者(p=0.021)。糖尿病合并高血压患者NAFLD发生率明显高于糖尿病合并高血压患者(p<0.05)。在多因素分析中,年龄、葡萄糖和甘油三酯值升高1 mg/dl以及ALT/AST升高1单位与NAFLD相关。结论:研究结果强调了早期识别和管理土耳其HIV感染患者NAFLD以及与NAFLD相关的传统因素的重要性。此外,预防和治疗应是患者随访的重点,以确保降低肝脏相关发病率和死亡率,这是这些新诊断的艾滋病毒感染者的非艾滋病原因之一。
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引用次数: 0
Chronic Hepatitis C in the Pandemic 慢性丙型肝炎大流行
Pub Date : 2021-01-01 DOI: 10.36519/KD.2021.03
S. Tekin, Ş. Sümer, N. Demirtürk, B. Aygen
Corona virus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, affected all the world and has been a major cause for significant morbidity and mortality. COVID-19 represents with pulmonary manifestations, but in more than half of the cases, other organs, especially hepatic involvement, are observed. Chronic hepatitis C (CHC) is an important public health problem worldwide. Sustained virological response (SVR) can be achieved and HCV-related mortality and morbidity can be prevented with direct-acting antiviral agents (DAAs), which have been used in recent years. However, if CHC is not diagnosed, it can cause cirrhosis and liver cancer. Since the diagnosis and treatment of these patients require follow-up, they are among the most affected chronic diseases during the pandemic. It does not seem possible to predict when the COVID-19 outbreak will end. Diagnosis and treatment need of CHC patients should be met in special areas where protection measures are taken in health institutions. In patients who undergo DAA treatment, the follow-up should be carried out by health institutions that do not provide pandemic services, and if necessary, telemedicine should be used. © 2021, DOC Design and Informatics Co. Ltd.. All rights reserved.
由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)病毒引起的2019年冠状病毒病(COVID-19)影响了全世界,并已成为导致大量发病率和死亡率的主要原因。COVID-19以肺部表现为特征,但在一半以上的病例中,可观察到其他器官,特别是肝脏受累。慢性丙型肝炎(CHC)是世界范围内一个重要的公共卫生问题。使用近年来使用的直接作用抗病毒药物(DAAs)可以实现持续的病毒学应答(SVR),并预防hcv相关的死亡率和发病率。然而,如果CHC没有被诊断出来,它可能会导致肝硬化和肝癌。由于这些患者的诊断和治疗需要随访,因此它们属于大流行期间受影响最大的慢性病。预计新冠疫情何时结束似乎是不可能的。在卫生机构采取保护措施的特殊区域,应满足CHC患者的诊断和治疗需求。在接受DAA治疗的患者中,随访应由不提供大流行服务的卫生机构进行,必要时应使用远程医疗。©2021,DOC Design and Informatics Co. Ltd。版权所有。
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引用次数: 1
Comparison of Liver Safety of Favipiravir and Hydroxychloroquine in COVID-19 Treatment 法匹拉韦与羟氯喹治疗COVID-19的肝脏安全性比较
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.49
F. Cetinkaya, Hatice Karagoz, Orhan Yıldız, Ic Hastaliklari Klinigi Kayseri Turkiye Acibadem Kayseri Hastanesi
Objective: Since the first case from Wuhan, China in December 2019, COVID-19 has spread all over the world and a pandemic was declared by the World Health Organization on January 30, 2020 While there are no specific effective antiviral drugs or vaccines to treat or to prevent COVID-19;favipiravir, hydroxychloroquine and their combination are used in the treatment of COVID-19 in Turkey In this study, it was aimed to evaluate the demographic, clinical and laboratory findings, the treatments given and the effects of treatments on liver tests of the patients followed up with the diagnosis of COVID-19
摘要目的:自2019年12月中国武汉出现第一例病例以来,COVID-19已在全球蔓延,世界卫生组织于2020年1月30日宣布COVID-19大流行。尽管没有特定有效的抗病毒药物或疫苗来治疗或预防COVID-19,但法吡拉韦、羟氯喹及其复方在土耳其用于治疗COVID-19。诊断为COVID-19的患者所给予的治疗及治疗对随访患者肝脏检查的影响
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引用次数: 5
A Case of Herpes Simplex Virus Encephalitis Without Pleocytosis in Cerebrospinal Fluid and Complicated With Intracranial Hematoma 单纯疱疹病毒性脑炎无脑脊液多胞症合并颅内血肿1例
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.66
A. Tartar, Ş. Balın, A. Akbulut, M. Gonen, Kutbeddin Demirdağ, Tip Fakultesi Noroloji Anabilim Dali Elazig Turkiye Firat Universitesi
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引用次数: 1
Entecavir and Tenofovir Treatment in Patients With Hepatitis B Virus-Related Cirrhosis: A Comparison of Results of Two-Year Treatment 恩替卡韦和替诺福韦治疗乙型肝炎病毒相关性肝硬化患者:两年治疗结果的比较
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.54
Erhan Alkan, Gastroenteroloji Klinigi Antalya Turkiye Antalya Yasam Hastanesi, M. Akın, Y. Tuna, Gastroenteroloji Klinigi Antalya Turkiye Medical Park Antalya Hastanesi
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引用次数: 0
Time to Handover to the New Editor-in-Chief 是时候把工作交给新主编了
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.44
H. Eraksoy
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引用次数: 0
Evaluation of the Relationship Between Vitamin D Levels and Mortality and Morbidity in Intensive Care Unit Patients With Pneumonia 重症监护病房肺炎患者维生素D水平与死亡率和发病率关系的评价
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.56
A. Coşkun, Anesteziyoloji ve Reanimasyon Klinigi Antalya Turkiye Kepez Devlet Hastanesi, Senay Ozturk Durmaz
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引用次数: 0
Evaluation and Risk Mapping of Cutaneous Leishmaniasis Cases Between 2007 and 2017 in Sanliurfa, Turkey 土耳其Sanliurfa 2007 - 2017年皮肤利什曼病病例评估和风险制图
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.51
M. E. Gökler, Halk Sagligi Enstitusu Ankara Turkiye Ankara Yildirim Beyazit Universitesi, Hasan Durmuş, A. Atesoglu, Halk Sagligi Hizmetleri Baskanligi Hatay Turkiye Dortyol Ilce Saglik Mudurlugu
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引用次数: 0
Comparison of Antimicrobial Susceptibilities of Escherichia coli Isolated From Urinary Cultures of Different Patient Groups: A University Hospital Experience 不同患者组尿培养分离的大肠杆菌对抗菌药物的敏感性比较:一所大学医院的经验
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.55
H. Mirza, Tip Fakultesi Tibbi Mikrobiyoloji Anabilim Dali Ankara Baskent Universitesi, B. Sancak, Tip Fakultesi Tibbi Mikrobiyoloji Anabilim Dali Ankara Hacettepe Universitesi
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引用次数: 0
Multiple Pyogenic Liver Abscesses Due to Streptococcus intermedius 中间链球菌所致多发性化脓性肝脓肿
Pub Date : 2020-12-31 DOI: 10.5152/kd.2020.65
Merve Sarı, S. Cesur, Ç. Hatipoğlu, S. Kınıklı
Streptococcus intermedius is part of the normal oropharyngeal, genitourinary and gastrointestinal flora, and can cause purulent infections characterized by abscess formation involving the brain and the liver tissue In this report, multiple pyogenic liver abscesses due to S intermedius in a 46-year-old male admitted to the emergency department with complaints of fever, cough, and weakness, and hospitalized with a diagnosis of suspected COVID-19 with pneumonia, is presented The diagnosis was made by isolating the agent from the abscess After percutaneous abscess drainage and antimicrobial treatment, the patient fully healed
中间链球菌是正常口咽、泌尿生殖系统和胃肠道菌群的一部分,可引起化脓性感染,其特征是脓肿形成,累及脑和肝组织。本报告中,46岁男性患者因发烧、咳嗽、虚弱等主诉就诊于急诊科,诊断为疑似COVID-19合并肺炎住院。经经皮脓肿引流及抗菌药物治疗后,患者完全愈合
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引用次数: 0
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Klimik Dergisi/Klimik Journal
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