{"title":"Coinfection of Crimean-Congo Haemorrhagic Fever and Brucellosis: A Case Report","authors":"Alper Tahmaz, M. Deniz, Veli Gunay, N. Oztoprak","doi":"10.5152/kd.2019.87","DOIUrl":"https://doi.org/10.5152/kd.2019.87","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74993661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biliary Tract Infections: Causative Agents and Analysis of Risk Factors for Infections With Drug-Resistant Bacteria","authors":"S. Başaran, Halit Ozsut, A. Çağatay, H. Eraksoy","doi":"10.5152/kd.2019.84","DOIUrl":"https://doi.org/10.5152/kd.2019.84","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76528202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Audit of Antimicrobial Prophylaxis for the Prevention of Surgical Infections: A Call to Action for Antimicrobial Stewardship","authors":"Z. Khan, Junaid Khan, F. Khan, M. Kamran","doi":"10.5152/kd.2019.88","DOIUrl":"https://doi.org/10.5152/kd.2019.88","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78810145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Measurement of Bone Mineral Density in HIV-Infected Individuals Who Are Not Considered as a Specific Risk Group for Bone Mineral Densitometry Screening","authors":"C. Cimen, Ozden Aksu-Sayman, Muzaffer Fincancı","doi":"10.5152/kd.2019.82","DOIUrl":"https://doi.org/10.5152/kd.2019.82","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79045046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyit Ali Büyüktuna, Caner Oksuz, M. Hasbek, Tip Fakultesi Tibbi Mikrobiyoloji Anabilim Dali Sivas Cumhuriyet Universitesi
{"title":"Concurrent Brucellosis and Crimean-Congo Haemorrhagic Fever: A Case Report","authors":"Seyit Ali Büyüktuna, Caner Oksuz, M. Hasbek, Tip Fakultesi Tibbi Mikrobiyoloji Anabilim Dali Sivas Cumhuriyet Universitesi","doi":"10.5152/kd.2019.86","DOIUrl":"https://doi.org/10.5152/kd.2019.86","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86623400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dilek Karamanlıoğlu, P. Aysert-Yildiz, Melek Kaya, N. Sarı, Tibbi Mikrobiyoloji Laboratuvari Ankara Turkiye Nafiz Korez Sincan Devlet Hastanesi
Objective: The aim of this study was to investigate the distribution of pathogens in urine cultures with significant bacteriuria from inpatients and outpatients, and to detect extended-spectrum beta-lactamase (ESBL) production rates among Enterobacteriaceae and their antimicrobial susceptibilities in our hospital. Methods: Urine specimens sent from various units to micro-biology laboratory between January 2016 and December 2017 were examined, and urines with pyuria and yielding a significant bacteriuria were included in the study. The identification, susceptibility tests , and ESBL production of the bacteria were determined by the VITEK ® 2 automated system. Results: A total of 4352 urine specimens showed significant bacteriuria. The most commonly isolated microorganisms were Escherichia coli, Klebsiella spp. and Enterococcus spp. ESBL positivity was found in 17.9% of Enterobacteriaceae , and it was detected more frequently in bacteria isolated from males, inpatients and patients over 65 years of age ( p <0.001). In the presence of ESBL positivity, sensitivity rates of nearly all antibiotics except fosfomycin and nitrofurantoin were significantly low. When antibiotic sensitivity rates of E. coli and Klebsiella spp. were compared between the outpatients and inpatients, antibiotic sensitivity rates in inpatients were low. Nitrofurantoin and fosfomycin were the most active antibiotics for both E. coli and Klebsiella spp. in outpatients; whereas amoxicillin-clavulanate, trimethoprim-sulfamethoxazole and ciprofloxacin were the less active ones. The most active parenteral antibiotics against E. coli and Klebsiella spp. were piperacillin-tazobactam, carbapen-ems and aminoglycosides.
{"title":"Extended-Spectrum β-Lactamase Production Rates and Antibiotic Susceptibilities Among Enterobacteriaceae Isolated From Urine Cultures","authors":"Dilek Karamanlıoğlu, P. Aysert-Yildiz, Melek Kaya, N. Sarı, Tibbi Mikrobiyoloji Laboratuvari Ankara Turkiye Nafiz Korez Sincan Devlet Hastanesi","doi":"10.5152/kd.2019.68","DOIUrl":"https://doi.org/10.5152/kd.2019.68","url":null,"abstract":"Objective: The aim of this study was to investigate the distribution of pathogens in urine cultures with significant bacteriuria from inpatients and outpatients, and to detect extended-spectrum beta-lactamase (ESBL) production rates among Enterobacteriaceae and their antimicrobial susceptibilities in our hospital. Methods: Urine specimens sent from various units to micro-biology laboratory between January 2016 and December 2017 were examined, and urines with pyuria and yielding a significant bacteriuria were included in the study. The identification, susceptibility tests , and ESBL production of the bacteria were determined by the VITEK ® 2 automated system. Results: A total of 4352 urine specimens showed significant bacteriuria. The most commonly isolated microorganisms were Escherichia coli, Klebsiella spp. and Enterococcus spp. ESBL positivity was found in 17.9% of Enterobacteriaceae , and it was detected more frequently in bacteria isolated from males, inpatients and patients over 65 years of age ( p <0.001). In the presence of ESBL positivity, sensitivity rates of nearly all antibiotics except fosfomycin and nitrofurantoin were significantly low. When antibiotic sensitivity rates of E. coli and Klebsiella spp. were compared between the outpatients and inpatients, antibiotic sensitivity rates in inpatients were low. Nitrofurantoin and fosfomycin were the most active antibiotics for both E. coli and Klebsiella spp. in outpatients; whereas amoxicillin-clavulanate, trimethoprim-sulfamethoxazole and ciprofloxacin were the less active ones. The most active parenteral antibiotics against E. coli and Klebsiella spp. were piperacillin-tazobactam, carbapen-ems and aminoglycosides.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91369241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular Risk Assessment and Relationship of Risk With Triglyceride/High Density Lipoprotein Cholesterol Ratio in HIV-Infected Patients","authors":"Ezgi Gulten, B. Dokuzoğuz","doi":"10.5152/kd.2019.76","DOIUrl":"https://doi.org/10.5152/kd.2019.76","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87019165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cigdem Cicek-Kolak, Aylin Erman-Daloglu, Betil Özhak, D. Ogunc, F. Gunseren
{"title":"Epidemiology of Candidemia, Antifungal Susceptibilities of Candida Species and Their Impact on Mortality in Adult Patients Admitted to Akdeniz University Hospital","authors":"Cigdem Cicek-Kolak, Aylin Erman-Daloglu, Betil Özhak, D. Ogunc, F. Gunseren","doi":"10.5152/kd.2019.71","DOIUrl":"https://doi.org/10.5152/kd.2019.71","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77544312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nazlım Aktug-Demir, S. Sumer, Gizem Çimen, B. Ozturk, O. Ural
{"title":"A Case of Neurosyphilis Presenting With Uveitis","authors":"Nazlım Aktug-Demir, S. Sumer, Gizem Çimen, B. Ozturk, O. Ural","doi":"10.5152/kd.2019.85","DOIUrl":"https://doi.org/10.5152/kd.2019.85","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77758708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Korkmaz, N. Demirturk, A. Batırel, N. Tulek, M. Ozguler, R. Harman, G. Cınar, O. Toka, Gulsen Yoruk, C. Ataman-Hatipoglu, Figen Sarigul, F. Sırmatel, Ayfer İmre, Duru Mistanoğlu-Ozatag, F. Karakeçili, O. Ural, S. Sumer, Nazlım Aktug-Demir, A. Kadanalı, Ş. Çomoğlu, S. Ucer, N. Saltoğlu, Ö. Günal, H. D. Ozkaya, E. Yenilmez, R. Çetinkaya, E. Yüksel, I. Hakyemez, M. Meriç-Koç, Gunay Tuncer-Ertem, Zehra Bestepe-Dursun, I. Çelik, E. Yılmaz, Güliz Evik, A. Kaya, K. Suer, Tip Fakultesi Biyoistatistik Anabilim Dali Ankara Turk Hacettepe Universitesi
Objective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48th week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results. Klimik Dergisi 2019; 32(3): 265-74.
目的:慢性乙型肝炎(CHB)和肝骨赘病均可导致肝脏坏死性炎症。因此，肝骨赘病的存在可能会对抗病毒治疗的效果产生负面影响。我们的目的是确定肝细胞增生对接受恩替卡韦(ETV)和替诺福韦(TDF)治疗的慢性乙型肝炎患者病毒学反应的影响。方法:采用回顾性设计。通过查阅病历，检索了2012年1月至2017年6月29家不同医院感染性疾病和临床微生物科因CHB接受抗病毒治疗的所有患者。结果:共纳入1069例患者。650例患者接受TDF治疗，419例接受ETV治疗。脂肪变性患者在TDF治疗第48周获得的病毒学应答率更高(p=0.029)。未发生脂肪变性的患者在ETV第24周和第48周的病毒学应答较高(p=0.001)。比较TDF和ETV治疗肝纤维化患者，发现TDF组48周病毒学应答更高。结论:虽然脂肪变性对核苷治疗的短期结果的病毒学应答有影响，但对长期结果的病毒学应答没有任何影响。Klimik Dergisi 2019;32(3): 265 - 74。
{"title":"Effect of Hepatosteatosis on the Virological Response in Entecavir and Tenofovir Therapies","authors":"P. Korkmaz, N. Demirturk, A. Batırel, N. Tulek, M. Ozguler, R. Harman, G. Cınar, O. Toka, Gulsen Yoruk, C. Ataman-Hatipoglu, Figen Sarigul, F. Sırmatel, Ayfer İmre, Duru Mistanoğlu-Ozatag, F. Karakeçili, O. Ural, S. Sumer, Nazlım Aktug-Demir, A. Kadanalı, Ş. Çomoğlu, S. Ucer, N. Saltoğlu, Ö. Günal, H. D. Ozkaya, E. Yenilmez, R. Çetinkaya, E. Yüksel, I. Hakyemez, M. Meriç-Koç, Gunay Tuncer-Ertem, Zehra Bestepe-Dursun, I. Çelik, E. Yılmaz, Güliz Evik, A. Kaya, K. Suer, Tip Fakultesi Biyoistatistik Anabilim Dali Ankara Turk Hacettepe Universitesi","doi":"10.5152/kd.2019.73","DOIUrl":"https://doi.org/10.5152/kd.2019.73","url":null,"abstract":"Objective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48th week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results. Klimik Dergisi 2019; 32(3): 265-74.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85139425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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