首页 > 最新文献

Kragujevac Journal of Science最新文献

英文 中文
Ethnobotanical knowledge and traditional practice in the frame of urban ecosystem services on the example of the city of Kragujevac (Serbia) 城市生态系统服务框架下的民族植物学知识与传统实践——以塞尔维亚克拉古耶瓦茨市为例
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345315l
Milica Luković, Zora Dajić-Stevanović, Sonja Veljović
The ethnobotanical studies provide a generalized survey of ethnobotanical knowledge, traditional practices, and plant species utilization using by humans a range of provisioning ecosystem services, referring dominantly to rural and less to urban settlements. This study aims to answer the question of whether traditional ethnobotanical knowledge is applied in urban areas in the context of the selection and utilization of medicinal, aromatic, and wild edible plant species. The research was conducted in the urban area of the city of Kragujevac (central Serbia) in the period from May to October 2021. Data collection was performed "in situ" using semi-structured ethnobotanical face-to-face interviews with 43 respondents. The total number of finally selected plant species reported by respondents was 24. They were classified according to their purpose of use as medicinal, food, and ornamental. Herein, the analyzed urban population mostly utilized plant species for edible purposes.
民族植物学研究提供了对民族植物学知识、传统实践和人类利用一系列提供生态系统服务的植物物种的总体调查,主要涉及农村,较少涉及城市住区。本研究旨在回答传统民族植物学知识是否在药用、芳香和野生可食植物物种的选择和利用中应用于城市地区的问题。该研究于2021年5月至10月期间在克拉古耶瓦茨市(塞尔维亚中部)市区进行。数据收集是通过半结构化的民族植物学面对面访谈进行的,共有43名受访者。被调查者报告的最终选择的植物种类总数为24种。它们按照药用、食用和观赏的用途被分类。其中,所分析的城市人口主要利用可食用的植物物种。
{"title":"Ethnobotanical knowledge and traditional practice in the frame of urban ecosystem services on the example of the city of Kragujevac (Serbia)","authors":"Milica Luković, Zora Dajić-Stevanović, Sonja Veljović","doi":"10.5937/kgjsci2345315l","DOIUrl":"https://doi.org/10.5937/kgjsci2345315l","url":null,"abstract":"The ethnobotanical studies provide a generalized survey of ethnobotanical knowledge, traditional practices, and plant species utilization using by humans a range of provisioning ecosystem services, referring dominantly to rural and less to urban settlements. This study aims to answer the question of whether traditional ethnobotanical knowledge is applied in urban areas in the context of the selection and utilization of medicinal, aromatic, and wild edible plant species. The research was conducted in the urban area of the city of Kragujevac (central Serbia) in the period from May to October 2021. Data collection was performed \"in situ\" using semi-structured ethnobotanical face-to-face interviews with 43 respondents. The total number of finally selected plant species reported by respondents was 24. They were classified according to their purpose of use as medicinal, food, and ornamental. Herein, the analyzed urban population mostly utilized plant species for edible purposes.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrin-producing G cells of gastric mucosa in Dexamethasone-treated rats 地塞米松治疗大鼠胃黏膜分泌胃泌素的G细胞
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345195g
Radmila Glišić, Maja Čakić-Milošević, Mirela Ukropina, Stefan Marković, Marija Marin, Vesna Stanković
The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production.
全身给药糖皮质激素不仅具有强大的有益抗炎和免疫抑制作用,但也有许多不利的健康影响。因此,本研究旨在观察地塞米松(DEX)腹腔注射2 mg/kg后12 d大鼠胃窦黏膜产生胃泌素的G细胞的体视学和超微结构特征及分布。在两组大鼠(DEX和对照组)中,G细胞位于胃窦粘膜隐窝底部,但在DEX治疗的大鼠中,G细胞也位于胃腔附近,与基底细胞相比,G细胞的形态发生了改变。各组间胃窦粘膜单位面积和单位体积G细胞数差异有统计学意义。在dex处理的大鼠中,胃单位内胃窦G细胞的形态和位置的改变表明它们的活性被改变,胃酸产生的调节可能受损。
{"title":"Gastrin-producing G cells of gastric mucosa in Dexamethasone-treated rats","authors":"Radmila Glišić, Maja Čakić-Milošević, Mirela Ukropina, Stefan Marković, Marija Marin, Vesna Stanković","doi":"10.5937/kgjsci2345195g","DOIUrl":"https://doi.org/10.5937/kgjsci2345195g","url":null,"abstract":"The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Separation of propranolol enantiomers using chiral HPLC 心得安对映体的手性高效液相色谱分离
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345041t
Nemanja Turković, Jasna Savić, Branka Ivković, Aleksandar Ivković
Enantiomers of pharmaceuticals may exhibit different effects because the organism serves as a chiral selector. Enantiomers can now be identified and separated using analytical techniques such as gas chromatography and high-performance liquid chromatography. The nonselective b-adrenergic blocker propranolol is used as a racemate in therapy, but only the S(-) isomer has been shown to be active. The aim of this study was to determine the mobile phase composition that would achieve optimal retention and satisfactory resolution between enantiomers and to confirm the order of elution of the enantiomers. The enantioseparation was tested in the n-heptane/ethanol/ammonia, n-heptane/ethanol/diethylamine, n-heptane/isopropanol/ ammonia and n-heptane/isopropanol/diethylamine systems. Optimal separation of enantiomers (t1=4,708; t2=5.264; Rs=1.75) was achieved with the mobile phase n-heptane/ethanol/diethylamine 80/20/0.1. The elution order was based on the retention time of the pure S(-)isomer. It was confirmed that the R(+) isomer shows higher retention.
药物的对映体可能表现出不同的效果,因为生物体充当手性选择器。对映体现在可以用气相色谱和高效液相色谱等分析技术进行鉴定和分离。非选择性b-肾上腺素能阻滞剂普萘洛尔在治疗中被用作外消旋体,但只有S(-)异构体被证明是有效的。本研究的目的是确定流动相组成,以达到最佳的保留和对映体之间满意的分辨率,并确定对映体的洗脱顺序。在正庚烷/乙醇/氨、正庚烷/乙醇/二乙胺、正庚烷/异丙醇/氨和正庚烷/异丙醇/二乙胺体系中进行了对映体分离实验。对映体的最佳分离(t1=4,708;t2 = 5.264;Rs=1.75),流动相为正庚烷/乙醇/二乙胺80/20/0.1。洗脱顺序以纯S(-)异构体的保留时间为依据。结果表明,R(+)异构体具有较高的保留率。
{"title":"Separation of propranolol enantiomers using chiral HPLC","authors":"Nemanja Turković, Jasna Savić, Branka Ivković, Aleksandar Ivković","doi":"10.5937/kgjsci2345041t","DOIUrl":"https://doi.org/10.5937/kgjsci2345041t","url":null,"abstract":"Enantiomers of pharmaceuticals may exhibit different effects because the organism serves as a chiral selector. Enantiomers can now be identified and separated using analytical techniques such as gas chromatography and high-performance liquid chromatography. The nonselective b-adrenergic blocker propranolol is used as a racemate in therapy, but only the S(-) isomer has been shown to be active. The aim of this study was to determine the mobile phase composition that would achieve optimal retention and satisfactory resolution between enantiomers and to confirm the order of elution of the enantiomers. The enantioseparation was tested in the n-heptane/ethanol/ammonia, n-heptane/ethanol/diethylamine, n-heptane/isopropanol/ ammonia and n-heptane/isopropanol/diethylamine systems. Optimal separation of enantiomers (t1=4,708; t2=5.264; Rs=1.75) was achieved with the mobile phase n-heptane/ethanol/diethylamine 80/20/0.1. The elution order was based on the retention time of the pure S(-)isomer. It was confirmed that the R(+) isomer shows higher retention.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The physicochemical characteristics of honey and quantification of some anti-microbial agents in honey from different Serbian regions as a quality assessment tool 塞尔维亚不同地区蜂蜜的理化特性及抗菌成分的定量测定作为质量评价工具
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345093k
Vesna Kaljević, Kazimir Matović, Lidija Pejović, Brankica Kartalović, Zorka Stanić
Healthy, organic, high-calorie and very tasty - these attributes are often associated with natural products such as honey. The aim of this study is to characterize the 135 honey samples collected in seven regions of central Serbia in terms of their physicochemical parameters (electrical conductivity, moisture, free acids, insoluble matter and reducing sugars, hydroxymethylfurfural, and diastase activity), the possible presence of tetracycline, sulfonamide and pesticide residues, and finally to perform a quality assessment for consumer protection. Considering the physicochemical parameters, it was found that almost all honey samples complied with the European Legislation (EC Directive 2001/110: THE COUNCIL OF THE EUROPEAN UNION, 2001) for the parameters studied. From the point of view of antimicrobial agents, the commercial quality was considered good, and all samples were found to be free of harmful agents such as bacteriostatic, antibiotic and pesticide residues through analysis.
健康、有机、高热量和美味——这些特性通常与蜂蜜等天然产品联系在一起。本研究的目的是根据其物理化学参数(电导率、水分、游离酸、不溶性物质和还原糖、羟甲基糠醛和淀粉酶活性)、四环素、磺胺和农药残留的可能存在,对在塞尔维亚中部7个地区收集的135个蜂蜜样品进行表征,最后进行质量评估,以保护消费者。考虑到物理化学参数,发现几乎所有蜂蜜样品都符合欧洲立法(EC指令2001/110:the COUNCIL OF European UNION, 2001)所研究的参数。从抗菌药物的角度来看,认为商品质量良好,通过分析发现所有样品均不含抑菌剂、抗生素和农药残留等有害物质。
{"title":"The physicochemical characteristics of honey and quantification of some anti-microbial agents in honey from different Serbian regions as a quality assessment tool","authors":"Vesna Kaljević, Kazimir Matović, Lidija Pejović, Brankica Kartalović, Zorka Stanić","doi":"10.5937/kgjsci2345093k","DOIUrl":"https://doi.org/10.5937/kgjsci2345093k","url":null,"abstract":"Healthy, organic, high-calorie and very tasty - these attributes are often associated with natural products such as honey. The aim of this study is to characterize the 135 honey samples collected in seven regions of central Serbia in terms of their physicochemical parameters (electrical conductivity, moisture, free acids, insoluble matter and reducing sugars, hydroxymethylfurfural, and diastase activity), the possible presence of tetracycline, sulfonamide and pesticide residues, and finally to perform a quality assessment for consumer protection. Considering the physicochemical parameters, it was found that almost all honey samples complied with the European Legislation (EC Directive 2001/110: THE COUNCIL OF THE EUROPEAN UNION, 2001) for the parameters studied. From the point of view of antimicrobial agents, the commercial quality was considered good, and all samples were found to be free of harmful agents such as bacteriostatic, antibiotic and pesticide residues through analysis.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different extracts and isolated substances from the root of Onosma visianii Clem. as antifungal agents 不同提取液及分离物质的研究。作为抗真菌剂
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345257r
Ivana Radojević, Katarina Marković, Mirjana Grujović, Milena Vukić, Nenad Vuković
The aim of this study was to determine the antifungal activity of extracts and isolated substances from the root of Onosma visianii Clem. (Boraginaceae) by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The results show that antifungal activity depends on species of microorganism and the type of substances or extracts. All tested substances showed selective and moderate antifungal activity. MIC and MFC values for the extracts ranged from <0.015 to 15 mg/ml, while those for substances ranged from 0.04 to 5 mg/ml. Among all tested extracts, petroleum ether and methylene chloride in proportion 1:1 (against Penicillium expansum) and acetone extract (against Saccharomyces boulardii) showed the strongest antifungal activity. Among the isolated substances, the most significant was the effect of 5,8-O-dimethyl deoxyshikonin against P. expansum. The results of this study show that both extracts, and the isolated substances can be potentially used in pharmacology, biotechnology, or agriculture.
本研究的目的是测定香草根提取物和分离物的抗真菌活性。通过测定最小抑菌浓度(MIC)和最小杀菌剂浓度(MFC),对Boraginaceae病原菌进行鉴定。结果表明,其抗真菌活性与微生物种类、物质或提取物类型有关。所有被试物质均表现出选择性和适度的抗真菌活性。提取物的MIC和MFC值为0.015 ~ 15 mg/ml,物质的MIC和MFC值为0.04 ~ 5 mg/ml。其中,石油醚与二氯甲烷比例为1:1(对扩张青霉)和丙酮提取物(对博拉迪酵母菌)的抑菌活性最强。其中,5,8- o -二甲基脱氧紫草素的抗蚜效果最为显著。本研究结果表明,提取物和分离物质在药理学、生物技术或农业方面具有潜在的应用价值。
{"title":"Different extracts and isolated substances from the root of Onosma visianii Clem. as antifungal agents","authors":"Ivana Radojević, Katarina Marković, Mirjana Grujović, Milena Vukić, Nenad Vuković","doi":"10.5937/kgjsci2345257r","DOIUrl":"https://doi.org/10.5937/kgjsci2345257r","url":null,"abstract":"The aim of this study was to determine the antifungal activity of extracts and isolated substances from the root of Onosma visianii Clem. (Boraginaceae) by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The results show that antifungal activity depends on species of microorganism and the type of substances or extracts. All tested substances showed selective and moderate antifungal activity. MIC and MFC values for the extracts ranged from <0.015 to 15 mg/ml, while those for substances ranged from 0.04 to 5 mg/ml. Among all tested extracts, petroleum ether and methylene chloride in proportion 1:1 (against Penicillium expansum) and acetone extract (against Saccharomyces boulardii) showed the strongest antifungal activity. Among the isolated substances, the most significant was the effect of 5,8-O-dimethyl deoxyshikonin against P. expansum. The results of this study show that both extracts, and the isolated substances can be potentially used in pharmacology, biotechnology, or agriculture.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New record of marbled polecat Vormela peregusna (Mammalia: Carnivora: Mustelidae: Ictonychinae) out of its current distribution range 大理石纹鼬新记录(哺乳目:食肉目:鼬科:灰鼬科)
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345341s
Predrag Simonović, Radoslav Dekić, Vera Nikolić
This sighting record of marbled polecat Vormela peregusna is the westernmost for this globally vulnerable (VU) carnivore out of the native distribution range and the first one for Bosnia and Herzegovina. The current national conservational status is unknown. Hence, this species should be data deficient (DD) in the national legislative.
这一发现记录是这种全球脆弱食肉动物(VU)在本地分布范围之外的最西端,也是波斯尼亚和黑塞哥维那的第一次。目前全国的保护状况尚不清楚。因此,这一物种在国家立法中应该是数据不足的(DD)。
{"title":"New record of marbled polecat Vormela peregusna (Mammalia: Carnivora: Mustelidae: Ictonychinae) out of its current distribution range","authors":"Predrag Simonović, Radoslav Dekić, Vera Nikolić","doi":"10.5937/kgjsci2345341s","DOIUrl":"https://doi.org/10.5937/kgjsci2345341s","url":null,"abstract":"This sighting record of marbled polecat Vormela peregusna is the westernmost for this globally vulnerable (VU) carnivore out of the native distribution range and the first one for Bosnia and Herzegovina. The current national conservational status is unknown. Hence, this species should be data deficient (DD) in the national legislative.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological, ultrastructural and stereological analyses of pancreatic islets in glucocorticoid-treated rats 糖皮质激素治疗大鼠胰岛的组织学、超微结构和体视学分析
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345179g
Radmila Glišić, Maja Čakić-Milošević, Mirela Ukropina, Ana Mitrovski-Bogdanović, Vesna Stanković
Dexamethasone is a synthetic glucocorticoid commonly used in both human and veterinary medicine. Prolonged treatment with dexamethasone can lead to serious metabolic side effects such as insulin resistance and diabetes. In this study, the morphological, immunohistochemical, and ultrastructural changes in the rat pancreatic islets were investigated after dexamethasone treatment (2 mg/kg, intraperitoneally for 12 days). The results showed that the volume density, mean diameter and profile area of islets were significantly increased in dexamethasone-treated animals. The volume density, profile area and mass of B-cells increased, whereas the volume density of A-and D-cells decreased, as did the number of A-cells per mm 2 of islet. Mild insulin immunopositivity of the centrally located B-cells together with altered ultrastructural features indicated their loss of function. The results of the present study suggest adverse effects of dexamethasone on pancreatic endocrine function that may ultimately seriously affect glucose homeostasis.
地塞米松是一种合成糖皮质激素,通常用于人类和兽药。长期使用地塞米松治疗可导致严重的代谢副作用,如胰岛素抵抗和糖尿病。本研究采用地塞米松(2mg /kg,腹腔注射12 d)治疗大鼠胰岛,观察其形态学、免疫组化和超微结构变化。结果表明,地塞米松处理后大鼠胰岛的体积密度、平均直径和剖面面积均显著增加。b细胞的体积密度、剖面面积和质量增加,而a细胞和d细胞的体积密度下降,每mm2胰岛a细胞数量减少。位于中心位置的b细胞轻度胰岛素免疫阳性,并伴有超微结构特征的改变,表明其功能丧失。本研究结果提示地塞米松对胰腺内分泌功能的不良影响可能最终严重影响葡萄糖稳态。
{"title":"Histological, ultrastructural and stereological analyses of pancreatic islets in glucocorticoid-treated rats","authors":"Radmila Glišić, Maja Čakić-Milošević, Mirela Ukropina, Ana Mitrovski-Bogdanović, Vesna Stanković","doi":"10.5937/kgjsci2345179g","DOIUrl":"https://doi.org/10.5937/kgjsci2345179g","url":null,"abstract":"Dexamethasone is a synthetic glucocorticoid commonly used in both human and veterinary medicine. Prolonged treatment with dexamethasone can lead to serious metabolic side effects such as insulin resistance and diabetes. In this study, the morphological, immunohistochemical, and ultrastructural changes in the rat pancreatic islets were investigated after dexamethasone treatment (2 mg/kg, intraperitoneally for 12 days). The results showed that the volume density, mean diameter and profile area of islets were significantly increased in dexamethasone-treated animals. The volume density, profile area and mass of B-cells increased, whereas the volume density of A-and D-cells decreased, as did the number of A-cells per mm 2 of islet. Mild insulin immunopositivity of the centrally located B-cells together with altered ultrastructural features indicated their loss of function. The results of the present study suggest adverse effects of dexamethasone on pancreatic endocrine function that may ultimately seriously affect glucose homeostasis.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136116590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus 妊娠期药物治疗及其与母体和胎儿基因组不稳定性的关系
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345129d
Katarina Đorđević, Slobodan Arsenijević, Olivera Milošević-Đorđević, Dragoslav Marinković, Darko Grujičić
Pregnancy is a special physiological condition, where drug treatment presents a special concern. The use of drugs during pregnancy is increasing. Micronuclei, chromosomal aberrations, and sister chromatid exchanges are biomarkers of early biological effects which play an important role in assessing the genetic integrity of both individuals and populations. The aim of this review is to make a cross-section of previously conducted studies on the detections of genotoxic effects of drugs on human peripheral blood lymphocytes, after therapeutic exposure during the second and third trimester of pregnancy, as well as in umbilical blood lymphocytes of newborns whose mothers received the same therapy. Previous studies have shown that the cells of pregnant women and newborns are very sensitive to the effects of genotoxins, and cytogenetic biomarkers are associated with the risk of developing numerous diseases, including cancer in adults. Altogether, the administration of various doses and times of use of medications should be performed with caution.
怀孕是一种特殊的生理状况,药物治疗需要特别关注。怀孕期间药物的使用正在增加。微核、染色体畸变和姐妹染色单体交换是早期生物效应的生物标志物,在评估个体和群体的遗传完整性方面发挥着重要作用。本综述的目的是对先前进行的药物对妊娠中期和晚期治疗性暴露后的人类外周血淋巴细胞以及母亲接受相同治疗的新生儿脐血淋巴细胞的遗传毒性检测的研究进行横断面分析。先前的研究表明,孕妇和新生儿的细胞对基因毒素的影响非常敏感,细胞遗传学生物标志物与发生多种疾病的风险有关,包括成人癌症。总之,各种剂量和使用药物的时间都应谨慎进行。
{"title":"Pharmacotherapy during pregnancy and its association with genome instability in mother and fetus","authors":"Katarina Đorđević, Slobodan Arsenijević, Olivera Milošević-Đorđević, Dragoslav Marinković, Darko Grujičić","doi":"10.5937/kgjsci2345129d","DOIUrl":"https://doi.org/10.5937/kgjsci2345129d","url":null,"abstract":"Pregnancy is a special physiological condition, where drug treatment presents a special concern. The use of drugs during pregnancy is increasing. Micronuclei, chromosomal aberrations, and sister chromatid exchanges are biomarkers of early biological effects which play an important role in assessing the genetic integrity of both individuals and populations. The aim of this review is to make a cross-section of previously conducted studies on the detections of genotoxic effects of drugs on human peripheral blood lymphocytes, after therapeutic exposure during the second and third trimester of pregnancy, as well as in umbilical blood lymphocytes of newborns whose mothers received the same therapy. Previous studies have shown that the cells of pregnant women and newborns are very sensitive to the effects of genotoxins, and cytogenetic biomarkers are associated with the risk of developing numerous diseases, including cancer in adults. Altogether, the administration of various doses and times of use of medications should be performed with caution.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allelopathic potential of Codiaeum variegatum L. Rumph. Ex A. Juss. On germination, early growth and biochemical characteristics of Lolium perenne L 黄菖蒲的化感作用。例A. Juss。黑麦草的萌发、早期生长及生化特性研究
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345287k
Milica Kanjevac, Marija Todorović, Milan Stanković, Biljana Bojović
In this study, the allelopathic potential of aqueous extracts of Codiaeum variegatum L. Rumph. Ex A. Juss. (40%, 20%, 10%, 5%, 2.5%, and 1.25%) on germination, early growth, and physiological activity of the selected plant recipient Lolium perenne L. was investigated. The obtained results confirmed the existence of allelopathic potential, which differed in its possibilities of adverse effects on the morphological and physiological characteristics of the recipient plant. The monitoring of the germination characteristics of the recipient plant showed that the tested extracts exhibited a concentration-dependent effect, i.e., stronger concentrations had a stronger inhibitory effect. A weaker negative effect on the growth of the selected species was observed, and it was shown that the root length of the seedling was usually under the stronger inhibitory effect of higher concentrations of extracts, in contrast to the length of the shoot, where all the applied extracts had a significant stimulatory effects. Moreover, allelochemicals of C. variegatum were shown to interfere with the synthesis of phenolic compounds and antioxidant capacity of L. perenne seedlings, the values of which decreased with increasing concentration of test extracts.
本研究对黄菖蒲水提液的化感作用进行了研究。例A. Juss。研究了不同浓度(40%、20%、10%、5%、2.5%和1.25%)对植物受体黑麦草(Lolium perenne L.)萌发、早期生长和生理活性的影响。结果证实了化感电位的存在,但其对受体植物形态和生理特性产生不良影响的可能性不同。对受体植株发芽特性的监测表明,所测提取物具有浓度依赖性,即浓度越高,抑制作用越强。对所选树种生长的负面影响较弱,且较高浓度提取物对幼苗根长的抑制作用较强,而对茎长的刺激作用则较强。此外,化感化学物质对白羊草幼苗酚类化合物的合成和抗氧化能力有干扰作用,且随提取物浓度的增加而降低。
{"title":"Allelopathic potential of Codiaeum variegatum L. Rumph. Ex A. Juss. On germination, early growth and biochemical characteristics of Lolium perenne L","authors":"Milica Kanjevac, Marija Todorović, Milan Stanković, Biljana Bojović","doi":"10.5937/kgjsci2345287k","DOIUrl":"https://doi.org/10.5937/kgjsci2345287k","url":null,"abstract":"In this study, the allelopathic potential of aqueous extracts of Codiaeum variegatum L. Rumph. Ex A. Juss. (40%, 20%, 10%, 5%, 2.5%, and 1.25%) on germination, early growth, and physiological activity of the selected plant recipient Lolium perenne L. was investigated. The obtained results confirmed the existence of allelopathic potential, which differed in its possibilities of adverse effects on the morphological and physiological characteristics of the recipient plant. The monitoring of the germination characteristics of the recipient plant showed that the tested extracts exhibited a concentration-dependent effect, i.e., stronger concentrations had a stronger inhibitory effect. A weaker negative effect on the growth of the selected species was observed, and it was shown that the root length of the seedling was usually under the stronger inhibitory effect of higher concentrations of extracts, in contrast to the length of the shoot, where all the applied extracts had a significant stimulatory effects. Moreover, allelochemicals of C. variegatum were shown to interfere with the synthesis of phenolic compounds and antioxidant capacity of L. perenne seedlings, the values of which decreased with increasing concentration of test extracts.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The composition and structure of the microcrustacean zooplankton of the artificial reservoir Grliško in Eastern Serbia 塞尔维亚东部Grliško人工水库浮游动物的组成和结构
Pub Date : 2023-01-01 DOI: 10.5937/kgjsci2345345n
Ljiljana Ninić, Vera Nikolić, Vesna Đikanović, Dragana Miličić
This paper provides an overview of the qualitative composition and structure of the microcrustacean of the Grliško reservoir based on field research conducted from 11 June 2019 to 9 July 2019. Sampling was carried out every seven days at sub-sites with different macrofauna, using the standard hydrobiological methodology. A total of 18 zooplankton taxa were recorded, belonging to the following groups: Rotifera (1 taxon), Cladocera (12 taxa), and Copepoda (5 taxa). The largest number of taxa was found in June. The total number of taxa was almost the same in the sub-areas with a lot of macrovegetation and without vegetation but differed in the qualitative composition of zooplankton species, spatially and temporally. Since the main purpose of the Grliško reservoir is to provide water for the population, it is necessary to constantly monitor the zooplankton, as it can be an important indicator of the state of this aquatic ecosystem.
本文基于2019年6月11日至2019年7月9日的野外研究,对Grliško储层微甲壳类动物的定性组成和结构进行了概述。采用标准的水生生物学方法,每7天在不同大型动物群的子站点进行采样。共记录到浮游动物18个类群,分属轮虫目(1个类群)、枝虫目(12个类群)和桡足目(5个类群)。6月份发现的分类群最多。大植被和无植被分区的分类群总数基本相同,但浮游动物种类的定性组成在时空上存在差异。由于Grliško水库的主要目的是为种群提供水,因此有必要不断监测浮游动物,因为它可以作为该水生生态系统状态的重要指标。
{"title":"The composition and structure of the microcrustacean zooplankton of the artificial reservoir Grliško in Eastern Serbia","authors":"Ljiljana Ninić, Vera Nikolić, Vesna Đikanović, Dragana Miličić","doi":"10.5937/kgjsci2345345n","DOIUrl":"https://doi.org/10.5937/kgjsci2345345n","url":null,"abstract":"This paper provides an overview of the qualitative composition and structure of the microcrustacean of the Grliško reservoir based on field research conducted from 11 June 2019 to 9 July 2019. Sampling was carried out every seven days at sub-sites with different macrofauna, using the standard hydrobiological methodology. A total of 18 zooplankton taxa were recorded, belonging to the following groups: Rotifera (1 taxon), Cladocera (12 taxa), and Copepoda (5 taxa). The largest number of taxa was found in June. The total number of taxa was almost the same in the sub-areas with a lot of macrovegetation and without vegetation but differed in the qualitative composition of zooplankton species, spatially and temporally. Since the main purpose of the Grliško reservoir is to provide water for the population, it is necessary to constantly monitor the zooplankton, as it can be an important indicator of the state of this aquatic ecosystem.","PeriodicalId":17829,"journal":{"name":"Kragujevac Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Kragujevac Journal of Science
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1