Pub Date : 2023-11-14DOI: 10.30629/0023-2149-2023-101-9-10-505-508
A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova
The article discusses the prevention of gastrointestinal bleeding in critically ill patients who are hospitalized in intensive care units (ICU). The main factors contributing to the occurrence of GIB in such patients are considered. The leading place among them is occupied by a stay on artificial ventilation of the lungs for > 48 hours and blood coagulopathy. Patients at high risk of developing GIB need prophylactic administration of proton pump inhibitors, H 2 -blockers, sucralfate, which allows to prevent the occurrence of GIB and improve the prognosis of patients.
{"title":"Modern possibilities of prevention of gastrointestinal bleeding in patients with gastric and duodenal stress ulcers","authors":"A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova","doi":"10.30629/0023-2149-2023-101-9-10-505-508","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-505-508","url":null,"abstract":"The article discusses the prevention of gastrointestinal bleeding in critically ill patients who are hospitalized in intensive care units (ICU). The main factors contributing to the occurrence of GIB in such patients are considered. The leading place among them is occupied by a stay on artificial ventilation of the lungs for > 48 hours and blood coagulopathy. Patients at high risk of developing GIB need prophylactic administration of proton pump inhibitors, H 2 -blockers, sucralfate, which allows to prevent the occurrence of GIB and improve the prognosis of patients.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.30629/0023-2149-2023-101-9-10-483-488
S. A. Sokotun, A. I. Simakova, N. G. Plekhova, A. O. Mikhailov, M. D. Barbashev, D. Yu. Barbasheva, A. V. Alexandrova, L. Ya. Hafizova
Objective: to provide a comparative analysis of clinical manifestations of the new coronavirus infection in vaccinated and unvaccinated patients. Materials and methods. А retrospective analysis of 160 medical histories of patients with laboratoryconfi rmed diagnosis of coronavirus infection (COVID-19) was presented, including 80 unvaccinated individuals and 80 vaccinated with “EpiVacCorona”, “CoviVac”, and “Gam-COVID-Vac” vaccines. Results. Vaccination against COVID-19 does not completely eliminate the possibility of infection with the virus, but there are a number of significant advantages and diff erences in the course of coronavirus infection among vaccinated patients. The duration of the disease on average was about 2 weeks, and for unvaccinated individuals — 18.1 ± 0.4 days. Vaccinated patients, regardless of the vaccine used, recovered significantly earlier. Signs of polysegmental pneumonia were not observed in 21.3% of vaccinated patients. Respiratory support lasted for 6.0 ± 0.3 days in unvaccinated patients, and for vaccinated individuals with “EpiVacCorona” — 4.4 ± 0.7 days, “CoviVac” — 3.5 ± 0.6 days, “Gam-COVID-Vac” — 3.2 ± 0.4 days, which was signifi cantly lower than the indicators for the control group (p <0.05). Conclusion. Сlinically, COVID-19 in vaccinated patients was milder compared to unvaccinated individuals, who most commonly experienced weakness, coughing, and extensive lung damage.
{"title":"Comparative characteristics of the clinical course of a new coronavirus infection depending on the vaccination status","authors":"S. A. Sokotun, A. I. Simakova, N. G. Plekhova, A. O. Mikhailov, M. D. Barbashev, D. Yu. Barbasheva, A. V. Alexandrova, L. Ya. Hafizova","doi":"10.30629/0023-2149-2023-101-9-10-483-488","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-483-488","url":null,"abstract":"Objective: to provide a comparative analysis of clinical manifestations of the new coronavirus infection in vaccinated and unvaccinated patients. Materials and methods. А retrospective analysis of 160 medical histories of patients with laboratoryconfi rmed diagnosis of coronavirus infection (COVID-19) was presented, including 80 unvaccinated individuals and 80 vaccinated with “EpiVacCorona”, “CoviVac”, and “Gam-COVID-Vac” vaccines. Results. Vaccination against COVID-19 does not completely eliminate the possibility of infection with the virus, but there are a number of significant advantages and diff erences in the course of coronavirus infection among vaccinated patients. The duration of the disease on average was about 2 weeks, and for unvaccinated individuals — 18.1 ± 0.4 days. Vaccinated patients, regardless of the vaccine used, recovered significantly earlier. Signs of polysegmental pneumonia were not observed in 21.3% of vaccinated patients. Respiratory support lasted for 6.0 ± 0.3 days in unvaccinated patients, and for vaccinated individuals with “EpiVacCorona” — 4.4 ± 0.7 days, “CoviVac” — 3.5 ± 0.6 days, “Gam-COVID-Vac” — 3.2 ± 0.4 days, which was signifi cantly lower than the indicators for the control group (p <0.05). Conclusion. Сlinically, COVID-19 in vaccinated patients was milder compared to unvaccinated individuals, who most commonly experienced weakness, coughing, and extensive lung damage.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"77 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134900600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.30629/0023-2149-2023-101-9-10-502-504
N. A. Zadorozhnaya, A. A. Domozhilova, N. V. Dubkova
This article deals with the relevant issue of using physical therapy methods in the comprehensive rehabilitation of women who have undergone surgery for transverse flat feet. The proposed treatment complex is of particular importance for differentiated strengthening of weakened ligaments, foot and calf muscles, shortening rehabilitation periods, consolidating the results achieved during surgical treatment (which excludes the development of relapses in the future), and preventing the formation of polymorbidity processes.
{"title":"Rehabilitation of patients who underwent surgery for transverse flatfoot using exercise therapy","authors":"N. A. Zadorozhnaya, A. A. Domozhilova, N. V. Dubkova","doi":"10.30629/0023-2149-2023-101-9-10-502-504","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-502-504","url":null,"abstract":"This article deals with the relevant issue of using physical therapy methods in the comprehensive rehabilitation of women who have undergone surgery for transverse flat feet. The proposed treatment complex is of particular importance for differentiated strengthening of weakened ligaments, foot and calf muscles, shortening rehabilitation periods, consolidating the results achieved during surgical treatment (which excludes the development of relapses in the future), and preventing the formation of polymorbidity processes.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"32 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.30629/0023-2149-2023-101-9-10-496-501
S. I. Remizov, A. V. Andreev, V. M. Durleshter, S. A. Gabriel, O. V. Zasyadko
Objective. To evaluate the treatment outcomes of acute necrotizing pancreatitis using drains of different diameters in patients with acute necrotic accumulations. Materials and methods. From 2013 to 2018, 124 patients with acute necrotizing pancreatitis were treated using minimally invasive surgical techniques. Group 1 consisted of 56 patients who were initially given drains with a diameter of 8–16 Fr, while Group 2 consisted of 68 patients who were given drains with a diameter of 28–32 Fr. The patient groups were comparable in terms of main indicators (p > 0.05). Results. In Group 1, replacement with larger diameter drains was needed in 100% of cases, while in Group 2 it was needed in 18.7% of patients (p < 0.05). As a final treatment method, puncture-drainage technology was used in Group 1 for 31 (55.4%) patients, and in Group 2 for 57 (83.8%) (p < 0.05). The incidence of perioperative complications was 51.7% in Group 1 and 16.1% in Group 2 (p < 0.05). The duration of hospitalization in Group 1 was on average 16 ± 7.3 days longer. Mortality rate was 30.4% in Group 1 and 11.8% in Group 2 (p < 0.05). Conclusion. The use of wide-bore drains at the initial stage increases the effectiveness of puncture-drainage treatment of acute necrotizing pancreatitis and allows for a reduction in mortality rate.
{"title":"Selection of drain diameter in initial drainage of patients with acute necrotizing pancreatitis","authors":"S. I. Remizov, A. V. Andreev, V. M. Durleshter, S. A. Gabriel, O. V. Zasyadko","doi":"10.30629/0023-2149-2023-101-9-10-496-501","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-496-501","url":null,"abstract":"Objective. To evaluate the treatment outcomes of acute necrotizing pancreatitis using drains of different diameters in patients with acute necrotic accumulations. Materials and methods. From 2013 to 2018, 124 patients with acute necrotizing pancreatitis were treated using minimally invasive surgical techniques. Group 1 consisted of 56 patients who were initially given drains with a diameter of 8–16 Fr, while Group 2 consisted of 68 patients who were given drains with a diameter of 28–32 Fr. The patient groups were comparable in terms of main indicators (p > 0.05). Results. In Group 1, replacement with larger diameter drains was needed in 100% of cases, while in Group 2 it was needed in 18.7% of patients (p < 0.05). As a final treatment method, puncture-drainage technology was used in Group 1 for 31 (55.4%) patients, and in Group 2 for 57 (83.8%) (p < 0.05). The incidence of perioperative complications was 51.7% in Group 1 and 16.1% in Group 2 (p < 0.05). The duration of hospitalization in Group 1 was on average 16 ± 7.3 days longer. Mortality rate was 30.4% in Group 1 and 11.8% in Group 2 (p < 0.05). Conclusion. The use of wide-bore drains at the initial stage increases the effectiveness of puncture-drainage treatment of acute necrotizing pancreatitis and allows for a reduction in mortality rate.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"30 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.30629/0023-2149-2023-101-9-10-513-516
M. Sh. Knopov
The article presents the life and creative path of an outstanding Russian hematologist, an excellent clinician, a talented healthcare organizer, a well-known public figure, the founder of one of the largest hematology schools in our country, academician of the Academy of Medical Sciences of the USSR, Honored Scientist of the Uzbek SSR Professor Alexander Nikolaevich Kryukov.
{"title":"Academician A.N. Kryukov is one of the founders of Russian hematology (on the 145th anniversary of his birth)","authors":"M. Sh. Knopov","doi":"10.30629/0023-2149-2023-101-9-10-513-516","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-513-516","url":null,"abstract":"The article presents the life and creative path of an outstanding Russian hematologist, an excellent clinician, a talented healthcare organizer, a well-known public figure, the founder of one of the largest hematology schools in our country, academician of the Academy of Medical Sciences of the USSR, Honored Scientist of the Uzbek SSR Professor Alexander Nikolaevich Kryukov.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"25 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.30629/0023-2149-2023-101-9-10-509-512
V. V. Krivetsky, A. A. Zavyalov, M. V. Strutsenko, V. A. Antipov, V. S. Fomin
Multiple aneurysms of the cerebral vessels, previously considered a rare pathology, are increasingly being diagnosed due to the development of neurovisualization methods. The proportion of patients with multiple aneurysms of the cerebral vessels ranges from 15 to 45% among all patients with aneurysms. Multiple aneurysms are detected in 25–30% of patients with subarachnoid hemorrhage. Surgical treatment of patients in this group is a relevant problem that requires a comprehensive approach. This article presents a clinical observation of successful treatment of a 58-year-old patient with multiple aneurysms in the acute period of rupture, using microsurgical clipping and endovascular embolization.
{"title":"Hybrid approach in the surgical treatment of multiple cerebral aneurysm in the acute period of rupture","authors":"V. V. Krivetsky, A. A. Zavyalov, M. V. Strutsenko, V. A. Antipov, V. S. Fomin","doi":"10.30629/0023-2149-2023-101-9-10-509-512","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-509-512","url":null,"abstract":"Multiple aneurysms of the cerebral vessels, previously considered a rare pathology, are increasingly being diagnosed due to the development of neurovisualization methods. The proportion of patients with multiple aneurysms of the cerebral vessels ranges from 15 to 45% among all patients with aneurysms. Multiple aneurysms are detected in 25–30% of patients with subarachnoid hemorrhage. Surgical treatment of patients in this group is a relevant problem that requires a comprehensive approach. This article presents a clinical observation of successful treatment of a 58-year-old patient with multiple aneurysms in the acute period of rupture, using microsurgical clipping and endovascular embolization.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"32 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.30629/0023-2149-2023-101-9-10-489-495
I. V. Samorodskaya, T. E. Afanasenkova
Objective: to assess the variability and dynamics of mortality from liver and bile duct diseases in the regions of Russia for the period of 2019–2021. Materials and methods. Rosstat data on the number of deaths according to form C51 and on the average annual population by one-year age groups by gender and age were used. Standardized mortality rates (SMRs) were calculated for 12 causes of death related to liver and bile duct diseases and included in the Brief Nomenclature of Causes of Death of Rosstat (BNCD) for 82 regions of the Russian Federation. Results. The mean SMRs from all liver and bile duct diseases in 2020 (42.4 ± 11.9 per 100,000 population) and 2021 (42.8 ± 13.2) were higher than in 2019 (39.4 ± 11.4), with annual increases observed in 38 regions, decreases in 7, and mixed trends in 37. The contribution of liver diseases to all-cause mortality was 3.95 ± 0.91% in 2019, 3.65 ± 0.85% in 2020, and 3.26 ± 0.92% in 2021. The highest SMRs were registered for liver fibrosis and cirrhosis, while the lowest SMRs were for acute hepatitis. Considerable variability in SMRs was observed between regions in 2021: the maximum SMR for liver cancer was more than 14 times higher than the minimum, while for liver fibrosis and cirrhosis it was 25 times higher. Hypotheses explaining the reasons for these differences are discussed. Conclusions. Significant regional variability in SMRs does not allow for a stable trend towards reducing mortality from these causes to be identified.
{"title":"Dynamics and variability of regional mortality rates from liver and biliary tract diseases in the period from 2019 to 2021","authors":"I. V. Samorodskaya, T. E. Afanasenkova","doi":"10.30629/0023-2149-2023-101-9-10-489-495","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-489-495","url":null,"abstract":"Objective: to assess the variability and dynamics of mortality from liver and bile duct diseases in the regions of Russia for the period of 2019–2021. Materials and methods. Rosstat data on the number of deaths according to form C51 and on the average annual population by one-year age groups by gender and age were used. Standardized mortality rates (SMRs) were calculated for 12 causes of death related to liver and bile duct diseases and included in the Brief Nomenclature of Causes of Death of Rosstat (BNCD) for 82 regions of the Russian Federation. Results. The mean SMRs from all liver and bile duct diseases in 2020 (42.4 ± 11.9 per 100,000 population) and 2021 (42.8 ± 13.2) were higher than in 2019 (39.4 ± 11.4), with annual increases observed in 38 regions, decreases in 7, and mixed trends in 37. The contribution of liver diseases to all-cause mortality was 3.95 ± 0.91% in 2019, 3.65 ± 0.85% in 2020, and 3.26 ± 0.92% in 2021. The highest SMRs were registered for liver fibrosis and cirrhosis, while the lowest SMRs were for acute hepatitis. Considerable variability in SMRs was observed between regions in 2021: the maximum SMR for liver cancer was more than 14 times higher than the minimum, while for liver fibrosis and cirrhosis it was 25 times higher. Hypotheses explaining the reasons for these differences are discussed. Conclusions. Significant regional variability in SMRs does not allow for a stable trend towards reducing mortality from these causes to be identified.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"77 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134900601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.30629/0023-2149-2023-101-9-10-474-482
G. O. Gaisina, Yu. A. Luchnikova, A. V. Khrushcheva, L. H. Rufullayeva, R. R. Tagirova, S. E. Mamedli, M. Yu. Lyashok, S. Yu. Smorodova, P. A. Boriskina, D. A. Vatulin, A. S. Lazarenko, V. A. Magafurova, N. E. Kosinskaya
Vision is essential for everyday activities, yet the most common eye diseases — cataracts, diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma — lead to vision loss with age. Cataract surgery is one of the most frequently performed operations and results are usually excellent in the absence of accompanying eye pathology. However, patients with DR, AMD, and glaucoma often develop significant visual impairments. The pathogenesis of these multifactorial diseases often involves genetic and hereditary components, with recent data confirming the role of DNA damage and repair as important pathogenic factors. In this review, we describe in detail the main mechanisms of DNA damage and repair, including base excision repair, nucleotide excision repair, double-strand break repair, and discuss their role in the development of DR, AMD, and glaucoma.
{"title":"Role of DNA damage and repair in chronic eye diseases","authors":"G. O. Gaisina, Yu. A. Luchnikova, A. V. Khrushcheva, L. H. Rufullayeva, R. R. Tagirova, S. E. Mamedli, M. Yu. Lyashok, S. Yu. Smorodova, P. A. Boriskina, D. A. Vatulin, A. S. Lazarenko, V. A. Magafurova, N. E. Kosinskaya","doi":"10.30629/0023-2149-2023-101-9-10-474-482","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-474-482","url":null,"abstract":"Vision is essential for everyday activities, yet the most common eye diseases — cataracts, diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma — lead to vision loss with age. Cataract surgery is one of the most frequently performed operations and results are usually excellent in the absence of accompanying eye pathology. However, patients with DR, AMD, and glaucoma often develop significant visual impairments. The pathogenesis of these multifactorial diseases often involves genetic and hereditary components, with recent data confirming the role of DNA damage and repair as important pathogenic factors. In this review, we describe in detail the main mechanisms of DNA damage and repair, including base excision repair, nucleotide excision repair, double-strand break repair, and discuss their role in the development of DR, AMD, and glaucoma.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"120 31","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.30629/0023-2149-2023-101-9-10-467-473
Ya. Т. Vardanyan
Research over the past decade indicates that some psychotropic drugs increase the risk of developing arrhythmias and sudden cardiac death. Many antidepressants and antipsychotic drugs have arrhythmogenic potential and are associated with QT interval prolongation and development of ventricular arrhythmia of the “torsades de pointes” type, while some psychotropic drugs are associated with changes in ECG phenotype of Brugada syndrome and development of polymorphic ventricular arrhythmias.
{"title":"Cardiovascular eff ects of psychotropic drugs","authors":"Ya. Т. Vardanyan","doi":"10.30629/0023-2149-2023-101-9-10-467-473","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-467-473","url":null,"abstract":"Research over the past decade indicates that some psychotropic drugs increase the risk of developing arrhythmias and sudden cardiac death. Many antidepressants and antipsychotic drugs have arrhythmogenic potential and are associated with QT interval prolongation and development of ventricular arrhythmia of the “torsades de pointes” type, while some psychotropic drugs are associated with changes in ECG phenotype of Brugada syndrome and development of polymorphic ventricular arrhythmias.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"142 33","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-12DOI: 10.30629/0023-2149-2023-101-9-10-454-466
V. A. Kidenko, M. M. Metova, E. Yu. Gabrielyan, Yu. A. Trusov, A. D. Melikhova, E. P. Muslimova, Ya. V. Sedmova, K. R. Khabibullina, E. V. Malikova, L. A. Valiullina, D. D. Bagautdinova, A. V. Petrakova, K. S. Terekhina
Myocardial infarction (MI) is the leading cause of death worldwide. The loss of cardiomyocytes resulting from injuries such as acute MI often leads to fibrotic scarring and depressed cardiac function. The use of targeted drug delivery systems is always necessary as they provide unique advantages for increasing efficacy and reducing undesirable effects. Nanoparticles (NPs) are the most common means of delivering therapeutic agents to target tissues. NPs for drug delivery can be composed of various nanomaterials and structures, including lipids, polymers, dendrimers, carbon nanotubes, and metal nanoparticles. We have reviewed approaches to cardio-specific drug delivery based on NPs for the treatment of ischemic heart disease in preclinical and clinical studies. Drug delivery based on NPs has the potential for specific targeting of tissues and cells, as well as for prolonged release of multiple therapeutic agents. However, the use of NPs in the therapy of cardiovascular diseases is relatively limited compared to other areas such as oncology and neurology. One of the main obstacles is the lack of specificity in current targeting systems for the heart. Future research is needed to identify specific ligands/receptors in cardiomyocytes and develop new NPs with high affinity and specificity.
{"title":"Nanoparticles for targeted drug delivery in modern cardiology","authors":"V. A. Kidenko, M. M. Metova, E. Yu. Gabrielyan, Yu. A. Trusov, A. D. Melikhova, E. P. Muslimova, Ya. V. Sedmova, K. R. Khabibullina, E. V. Malikova, L. A. Valiullina, D. D. Bagautdinova, A. V. Petrakova, K. S. Terekhina","doi":"10.30629/0023-2149-2023-101-9-10-454-466","DOIUrl":"https://doi.org/10.30629/0023-2149-2023-101-9-10-454-466","url":null,"abstract":"Myocardial infarction (MI) is the leading cause of death worldwide. The loss of cardiomyocytes resulting from injuries such as acute MI often leads to fibrotic scarring and depressed cardiac function. The use of targeted drug delivery systems is always necessary as they provide unique advantages for increasing efficacy and reducing undesirable effects. Nanoparticles (NPs) are the most common means of delivering therapeutic agents to target tissues. NPs for drug delivery can be composed of various nanomaterials and structures, including lipids, polymers, dendrimers, carbon nanotubes, and metal nanoparticles. We have reviewed approaches to cardio-specific drug delivery based on NPs for the treatment of ischemic heart disease in preclinical and clinical studies. Drug delivery based on NPs has the potential for specific targeting of tissues and cells, as well as for prolonged release of multiple therapeutic agents. However, the use of NPs in the therapy of cardiovascular diseases is relatively limited compared to other areas such as oncology and neurology. One of the main obstacles is the lack of specificity in current targeting systems for the heart. Future research is needed to identify specific ligands/receptors in cardiomyocytes and develop new NPs with high affinity and specificity.","PeriodicalId":17856,"journal":{"name":"Klinicheskaia meditsina","volume":"35 36","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135037999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：