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Polymorphism of the proinflammatory and anti–inflammatory cytokines genes in patients with an acute pancreatitis in the Northern–Eastern region of Ukraine 乌克兰东北部地区急性胰腺炎患者的促炎和抗炎细胞因子基因多态性
Pub Date : 2022-12-30 DOI: 10.26779/2522-1396.2022.11-12.10
I. Duzhyi, O. Sytnik, V. Pak
Objective.To determine the influence of the genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines on course of an acute pancreatitis. Materials and methods. The genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines were studied in 83 patients with an acute pancreatitis, using the method of polymerase chain reaction (PCR). The control group have consisted of  60 healthy persons without an acute pancreatitis in anamnesis. Results. The rate of the genes polymorphism of interleukin–8 A–251T (rs 4073) and interleukin–10 C–592A (rs 1800872) was determined in oedematious and destructive forms of an acute pancreatitis, as well as in patients operated on. Conclusion. The acute pancreatitis transition into necrotic form was not connected with the kind of the genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines. Operative interventions  for an acute pancreatitis complications were performed statistically significantlymore frequently in carriers of the T/T gene genotype of interleukin–8 A–251T (rs 4073). The favorable, noncomplicated course of an acute pancreatitis was associated with polymorphism of the A/T gene interleukin–8 A–251T (rs 4073) and, possibly, – with polymorphism of the A/T gene interleukin–10 C–592A (rs 1800872).
目标。目的探讨促炎白介素- 8 A-251T (rs4073)和抗炎白介素- 10 C-592A (rs1800872)细胞因子基因多态性对急性胰腺炎病程的影响。材料和方法。采用聚合酶链反应(PCR)方法对83例急性胰腺炎患者的促炎-白细胞介素- 8 A-251T (rs4073)和抗炎-白细胞介素- 10 C-592A (rs1800872)细胞因子基因多态性进行了研究。对照组由60名无急性胰腺炎健忘症的健康人组成。结果。测定了急性胰腺炎水肿型、破坏性型及手术患者中白细胞介素- 8 A-251T (rs 4073)和白细胞介素- 10 C-592A (rs 1800872)基因多态性率。结论。急性胰腺炎向坏死的转变与促炎-白细胞介素- 8 A-251T (rs 4073)和抗炎-白细胞介素- 10 C-592A (rs 1800872)细胞因子的基因多态性无关。白细胞介素- 8 A-251T基因型T/T基因携带者对急性胰腺炎并发症进行手术干预的频率具有统计学意义(rs 4073)。急性胰腺炎的有利、无并发症病程与A/T基因白介素- 8 A - 251t多态性有关(rs 4073),也可能与A/T基因白介素- 10 C-592A多态性有关(rs 1800872)。
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引用次数: 0
Peculiarities of the induction immunosuppressive therapy in renal transplantation 肾移植诱导免疫抑制治疗的特点
Pub Date : 2022-12-30 DOI: 10.26779/2522-1396.2022.11-12.46
O. Voroniak, R. Zograbian, D. V. Kostiuk
Peculiarities of the induction immunosuppressive therapy in renal transplantation
肾移植诱导免疫抑制治疗的特点
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引用次数: 0
The ways to improve the ambulatory surgical service in environment of reformation in the health defense sphere of Ukraine 乌克兰卫生卫生领域改革环境下提高门诊外科服务的途径
Pub Date : 2022-12-30 DOI: 10.26779/2522-1396.2022.11-12.34
N. P. Korzhyk
The ways to improve the ambulatory surgical service in environment of reformation in the health defense sphere of Ukraine
乌克兰卫生卫生领域改革环境下提高门诊外科服务的途径
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引用次数: 0
Radiofrequency ablation in treatment of hepatic metastases of colorectal cancer 射频消融治疗结直肠癌肝转移
Pub Date : 2022-12-23 DOI: 10.26779/2522-1396.2022.7-8.62
T. A. Yusupov, N. M. Kostylieva
Radiofrequency ablation in treatment of hepatic metastases of colorectal cancer
射频消融治疗结直肠癌肝转移
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引用次数: 0
Impact of compression on velocity of venous and arterial main blood flow and cutaneous microcirculation of the lower extremity 压迫对下肢静脉、动脉主血流速度及皮肤微循环的影响
Pub Date : 2022-12-23 DOI: 10.26779/2522-1396.2022.7-8.19
V. I. Rusin, F. M. Pavuk, V. Y. Fedusyak
Objective. To study the impact of compression on velocity of venous and arterial main blood flow of the lower extremity, as well as cutaneous microcirculation in the back part of the foot in healthy individuals and patients with decompensated forms of varicose disease and postthrombophlebitis syndrome. Materials and methods. In the investigation 56 individuals took part and divided into three groups: Group I – 20 healthy persons; Group II – 15 patients with varicose disease in decompensated stage; Group III– 21 patients with decompensated stage of postthrombophlebitis syndrome. In all participants of the investigation the index of ankle–brachial pressure, deep–femoro–popliteal index, the regional perfusion index, transcutaneous partial pressure of oxygen and partial pressure of carbon dioxide, the arterial blood flow velocity in femoral artery and of venous blood flow distally from sapheno–femoral junction were measured before and after application of elastic medical knitwear of various Class of compression or the cuff pressure. Results. In the Class III compression in patients of Group III the transcutaneously registered indices crossing have occurred between partial pressure of oxygen and carbon dioxide, accompanied by domination of the carbon dioxide partial pressure over the oxygen partial pressure while further enhancement of the compression Class. In patients of Group II this tendency was observed while application of Class IV compression only. At the investigation beginning the values of partial pressure of carbon dioxide registered were higher in the Group III patients, than in the patients of Group II (p=0.0001). Conclusion. While application of the Class III compression the velocity of the hip venous blood flow, comparing with its initial values, have lowered at average by 78% in patients of Group II and at average in 7.4 times in the patients of |Group III (p=0.0001). It is affordable in patients, suffering decompensated postthrombophlebitic syndrome, to apply the elastic compression of Classes I–II, while in those, having varicose disease in decompensated stage, – the elastic compression of Classes III and iV as well.
目标。研究压迫对健康个体和失代偿型静脉曲张及血栓后静脉炎综合征患者下肢静脉和动脉主血流速度以及足后部皮肤微循环的影响。材料和方法。在调查中,56人被分为三组:第一组- 20名健康人;II组:失代偿期静脉曲张病患者15例;III组:21例失代偿期血栓后静脉炎综合征患者。在使用不同等级的医用弹性针织品或袖带压力前后,测量所有受试者的踝臂压力指数、股深腘窝指数、区域灌注指数、经皮氧分压和二氧化碳分压、股动脉动脉血流速度和隐股交界远端静脉血流量。结果。在III类压缩患者中,经皮记录的指标在氧气分压和二氧化碳分压之间发生交叉,并伴有二氧化碳分压超过氧气分压的优势,同时压缩等级进一步提高。在II组患者中,仅应用IV类压迫时观察到这种倾向。在调查开始时,III组患者的二氧化碳分压值高于II组患者(p=0.0001)。结论。当应用III类压缩时,与初始值相比,II组患者的髋关节静脉血流量平均降低了78%,III组患者的平均降低了7.4倍(p=0.0001)。对于失代偿的血栓后静脉综合征患者,应用I-II类弹性压迫是负担得起的,而对于失代偿期的静脉曲张患者,应用III类和iV类弹性压迫也是负担得起的。
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引用次数: 0
Modern tendencies in surgical treatment of cicatricial deformities of mammary gland 乳腺瘢痕性畸形手术治疗的现代趋势
Pub Date : 2022-12-23 DOI: 10.26779/2522-1396.2022.7-8.54
O. R. Feyta, O. Zhernov
Modern tendencies in surgical treatment of cicatricial deformities of mammary gland
乳腺瘢痕性畸形手术治疗的现代趋势
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引用次数: 0
Principal terms and modern classification of the battle surgical trauma 战斗外科创伤的主要术语和现代分类
Pub Date : 2022-12-23 DOI: 10.26779/2522-1396.2022.7-8.73
E. Khoroshun
Edited by E. M. Khoroshun
E. M. Khoroshun编辑
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引用次数: 0
Peculiarities of treatment of patients with complicated forms of the large bowel cancer in conditions of general clinical stationary 复杂形式大肠癌患者在一般临床稳定条件下的治疗特点
Pub Date : 2022-12-23 DOI: 10.26779/2522-1396.2022.7-8.09
M. Kubrak, S. M. Zavhorodnii, M. B. Danilyuk
Objective. To estimate the structure of complicated forms of colorectal cancer and surgical tactics of treatment in patients with this pathology in conditions of general surgery stationary. Materials and methods. Into the investigation 71 patients were included, treated for complicated forms of colorectal cancer. Results. Primary radical operative interventions were performed in 48 (67.61%) patients, palliative – 18 (25.35%), and symptomatic – 5 (7.04%). Conclusion. The treatment and diagnosis tactics, formatted in the general surgery stationary conditions,leads to certainly high level of morbidity – 45.07% (the complications have occurred in 32 patients),and lethality – 11.27% (8 patients died).
目标。目的:评估结直肠癌复杂形态的结构及在普通外科静止条件下对结直肠癌患者的手术治疗策略。材料和方法。在调查中,71名患者接受了复杂形式的结直肠癌治疗。结果。初步根治性手术干预48例(67.61%),姑息性手术18例(25.35%),症状性手术5例(7.04%)。结论。在普通外科静止状态下形成的治疗和诊断策略导致了较高的发病率(45.07%)(32例发生并发症)和致死率(11.27%)(8例死亡)。
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引用次数: 0
Intraoperative diagnosis of «sentinel» lymph nodes in the patients with mammary gland cancer 乳腺癌患者术中“前哨”淋巴结的诊断
Pub Date : 2022-12-23 DOI: 10.26779/2522-1396.2022.7-8.25
R. Nikitenko, V. Grubnik, Ye. A. Koichev, S. P. Degtyarenko
Objective. To improve intraoperative determination of «sentinel» lymph nodes in patients, suffering mammary gland cancer. Materials and methods. In the 2016 – 2021 yrs period on the base of the Odessa Regional Clinical Hospital 200 patients, suffering mammary gland cancer Stages Т1–Т3N0М0, were operated, using two dyes: the blue patented dye and fluorescent dye indocyanine green. All the patients were distributed into two groups. In Group I in 100 patients the "sentinel" lymph nodes biopsy was conducted. The blue patented dye was used for the lymph nodes staining. The same was conducted in 100 patients of Group II with the "sentinel" lymph nodes biopsy. For the lymph nodes staining there were applied the blue patented dye and fluorescent dye indocyanine green, which were introduced intravenously into the upper extremity on the side of the affected mammary gland along outflow from the upper extremity to mammary gland. Results. General five–year survival after axillary lympho–dissection and after biopsy of «sentinel» lymph nodes have constituted 91 and 92%, accordingly, while recurrence–free five–year survival – 82.2 and 83.9% accordingly. Only in 1.1% patient a regional recurrence in «sentinel» lymph nodes on the affected mammary gland side was revealed. In 57% patients the unaffected «sentinel» lymph nodes were diagnosed, that's why further lympho–dissection was accomplished. In 43% women–patients there was revealed metastatic affection of the lymph nodes. Recurrence was registered in 0.2% patients as an isolated metastases in axillary lymph nodes. Conclusion. The method of the «sentinel» lymph nodes diagnosis in mammary gland cancer, using the dyes, permits to escape the performance of traumatic operations in favor of organ–preserving interventions with biopsy of «sentinel» lymph nodes.
目标。目的:提高乳腺癌患者术中“前哨”淋巴结的检测水平。材料和方法。2016年至2021年期间,在敖德萨地区临床医院的基础上,200名患有Т1 -Т3N0М0期乳腺癌的患者接受了手术,使用了两种染料:蓝色专利染料和吲哚菁绿荧光染料。所有患者分为两组。第一组100例患者行前哨淋巴结活检。采用蓝色专利染料对淋巴结进行染色。对100例II组患者进行“前哨”淋巴结活检。淋巴结染色采用蓝色专利染料和吲哚菁绿荧光染料,沿上肢向乳腺流出静脉注入患乳腺一侧上肢。结果。腋窝淋巴清扫和前哨淋巴结活检后的五年生存率分别为91%和92%,而无复发的五年生存率分别为82.2%和83.9%。只有1.1%的患者在受影响的乳腺侧的“前哨”淋巴结中发现了局部复发。在57%的患者中,未受影响的“前哨”淋巴结被诊断出来,这就是为什么要进行进一步的淋巴清扫。在43%的女性患者中发现淋巴结转移。0.2%的患者复发为腋窝淋巴结的孤立转移。结论。使用染料对乳腺癌的“前哨”淋巴结进行诊断,可以避免创伤性手术的实施,有利于“前哨”淋巴结活检的器官保存干预。
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引用次数: 0
Application of surgical magnet instruments for diagnosis and pulling out of ferromagnetic foreign bodies of abdominal cavity in the battle gun–shot trauma 外科磁铁器械在战斗枪伤中腹腔铁磁异物诊断与取出中的应用
Pub Date : 2022-12-23 DOI: 10.26779/2522-1396.2022.7-8.30
O. Usenko, І. A. Lurin, K. V. Gumenuk, V. Nehoduiko, P. M. Mikhaylusov, A. Ryzhenko, R. Saliutin
Objective. To determine the possibility and expediency of application of ferromagnetic instruments for diagnosis and pulling out of the abdominal cavity foreign bodies in the battle gun–shot trauma, including application of miniinvasive technologies. Materials and methods. In the investigation 154 patients took part, including 110 (71.4%) with application of open laparotomy access, аnd 44 (28.6%) – using laparoscopic technologies. While doing open laparotomy interventions magnet surgical instruments were applied. Results. The magnet instruments were used in 2.5 times more frequently in open laparotomy accesses, than in the laparoscopic.There was established, that the average duration of search and pulling out of foreign bodies without application of special instruments have constituted (21 ± 2.2) min, while with it – (10 ± 1.2) min only, what is in 2 times lesser (p˂0.05). When special instruments were used, 98% of foreign ferromagnetic bodies were pulled out from abdominal cavity, while without it – 34% only, causing necessity to perform the staged interventions for their pulling out. Conclusion. Practical introduction of the magnet instruments proposed permits to reveal the majority of the ferromagnetic foreign body quantity with lesser time loss for their search, localization and pulling out, what is very important in conditions of military–field surgery. Foreign body of the gun–shot origin in patients, suffering penetrating abdominal wounding, demonstrated visually, palpatory or instrumentally, must be pulled out.
目标。探讨应用铁磁仪器诊断和取出腹腔异物在战斗枪伤中的可行性和方便性,包括微创技术的应用。材料和方法。调查共154例患者,其中110例(71.4%)采用开腹手术,44例(28.6%)采用腹腔镜技术。在开腹手术干预时应用磁铁手术器械。结果。在开腹手术中使用磁铁器械的频率是腹腔镜手术的2.5倍。经证实,在不使用特殊仪器的情况下,搜寻和取出异物的平均时间为(21±2.2)分钟,而使用特殊仪器时,平均时间为(10±1.2)分钟,缩短了2倍(p小于0.05)。当使用特殊器械时,98%的异物铁磁体从腹腔中取出,而没有特殊器械时,只有34%的异物铁磁体从腹腔中取出,这就需要对其进行分阶段的干预。结论。实用的磁体仪器的引入,可以在较小的时间损失下揭示大部分铁磁异物的数量,从而进行查找、定位和拔出,这在军事野战条件下是非常重要的。患者腹部穿透性损伤,经目视、触诊或器械检查证实,必须拔出枪击源异物。
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引用次数: 1
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Klinicheskaia khirurgiia
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