Yaoxin Ao, Jiangfeng Lyv, Fangjun Xiao, Junxing Yang
<p>We read with great interest the article by Hansson et al., “Knee hyperextension is not associated with anterior knee laxity, subjective knee function or revision surgery after anterior cruciate ligament reconstruction in children and adolescents,” published in <i>KSSTA</i> [<span>5</span>]. This large-scale cohort study provides important evidence supporting the safe use of hamstring tendon autografts in pediatric ACL reconstruction (ACLR), suggesting that preoperative passive knee hyperextension (KHE, ≤−5°) does not negatively impact surgical outcomes.</p><p>While the findings are valuable, we would like to raise two methodological considerations that may help refine the interpretation of the results and inform future research. First, the use of the adult threshold (≤−5°) to define KHE in a pediatric cohort may not fully account for developmental norms. Passive knee hyperextension is age- and sex-dependent, with values in adolescents—particularly females—often exceeding −5° physiologically [<span>7, 9, 11, 14</span>]. In this study, 53% of patients were categorized as hyperextenders, a proportion consistent with normal variation, raising the possibility that physiological hyperextension was misclassified as pathological. This may have diluted subgroup effects, especially in those with more pronounced hyperextension (e.g., ≤−10°), for whom no outcome gradient was observed. To address this, we suggest incorporating age- and sex-stratified analyses or applying receiver operating characteristic (ROC) curves to determine pediatric-specific thresholds. Such refinements may help clarify whether the observed null association applies across all developmental stages or only within physiological ranges.</p><p>Second, although the authors acknowledge the absence of rotational stability assessment, its clinical relevance merits further discussion. KHE has been shown to increase ACL stress under rotational loads due to compounded valgus and internal rotation torques [<span>6, 10, 13</span>]. A multicenter cohort study by Ueki et al. confirmed that preoperative knee hyperextension and high-grade pivot shift were significant risk factors for residual pivot shift 1 year after surgery [<span>15</span>]. Importantly, growing evidence indicates that rotational laxity (particularly pivot shift) appears inherently higher in pediatric populations compared to adults. Kamada et al. [<span>8</span>] identified patients <20 years as having 6.1 times greater risk of residual pivot shift after ACL reconstruction, while Dejour et al. [<span>1</span>] demonstrated that high-grade pivot shift prevalence decreases significantly with age (odds ratio [OR] 0.94/year, <i>p</i> < 0.001). Rotational instability is a key contributor to functional knee deficits yet is not captured by anterior laxity measurements alone [<span>3, 16</span>]. Previous studies have demonstrated its clinical importance. High-grade pivot shifts have been associated with worse functional outcomes, re
{"title":"Letter to the Editor on “Knee hyperextension is not associated with anterior knee laxity subjective knee function or revision surgery after anterior cruciate ligament reconstruction in children and adolescents”","authors":"Yaoxin Ao, Jiangfeng Lyv, Fangjun Xiao, Junxing Yang","doi":"10.1002/ksa.70063","DOIUrl":"10.1002/ksa.70063","url":null,"abstract":"<p>We read with great interest the article by Hansson et al., “Knee hyperextension is not associated with anterior knee laxity, subjective knee function or revision surgery after anterior cruciate ligament reconstruction in children and adolescents,” published in <i>KSSTA</i> [<span>5</span>]. This large-scale cohort study provides important evidence supporting the safe use of hamstring tendon autografts in pediatric ACL reconstruction (ACLR), suggesting that preoperative passive knee hyperextension (KHE, ≤−5°) does not negatively impact surgical outcomes.</p><p>While the findings are valuable, we would like to raise two methodological considerations that may help refine the interpretation of the results and inform future research. First, the use of the adult threshold (≤−5°) to define KHE in a pediatric cohort may not fully account for developmental norms. Passive knee hyperextension is age- and sex-dependent, with values in adolescents—particularly females—often exceeding −5° physiologically [<span>7, 9, 11, 14</span>]. In this study, 53% of patients were categorized as hyperextenders, a proportion consistent with normal variation, raising the possibility that physiological hyperextension was misclassified as pathological. This may have diluted subgroup effects, especially in those with more pronounced hyperextension (e.g., ≤−10°), for whom no outcome gradient was observed. To address this, we suggest incorporating age- and sex-stratified analyses or applying receiver operating characteristic (ROC) curves to determine pediatric-specific thresholds. Such refinements may help clarify whether the observed null association applies across all developmental stages or only within physiological ranges.</p><p>Second, although the authors acknowledge the absence of rotational stability assessment, its clinical relevance merits further discussion. KHE has been shown to increase ACL stress under rotational loads due to compounded valgus and internal rotation torques [<span>6, 10, 13</span>]. A multicenter cohort study by Ueki et al. confirmed that preoperative knee hyperextension and high-grade pivot shift were significant risk factors for residual pivot shift 1 year after surgery [<span>15</span>]. Importantly, growing evidence indicates that rotational laxity (particularly pivot shift) appears inherently higher in pediatric populations compared to adults. Kamada et al. [<span>8</span>] identified patients <20 years as having 6.1 times greater risk of residual pivot shift after ACL reconstruction, while Dejour et al. [<span>1</span>] demonstrated that high-grade pivot shift prevalence decreases significantly with age (odds ratio [OR] 0.94/year, <i>p</i> < 0.001). Rotational instability is a key contributor to functional knee deficits yet is not captured by anterior laxity measurements alone [<span>3, 16</span>]. Previous studies have demonstrated its clinical importance. High-grade pivot shifts have been associated with worse functional outcomes, re","PeriodicalId":17880,"journal":{"name":"Knee Surgery, Sports Traumatology, Arthroscopy","volume":"33 11","pages":"4103-4104"},"PeriodicalIF":5.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/ksa.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}