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Inflammatory Cytokine Levels in Patients with Autosomal Dominant Polycystic Kidney Disease. 常染色体显性多囊肾病患者的炎性细胞因子水平。
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.34067/KID.0000000000000525
Sita Arjune, Katharina Lettenmeier, Polina Todorova, Martin Richard Späth, Mohamed Majjouti, Esther Mahabir, Franziska Grundmann, Roman-Ulrich Müller
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引用次数: 0
Cullin 3/with No Lysine [K] Kinase/Ste20/SPS-Related Proline Alanine Rich Kinase Signaling: Impact on NaCl Cotransporter Activity in BP Regulation. Cullin3/WNK/SPAK 信号：对血压调节中 NaCl 共转运体活性的影响
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 Epub Date: 2024-08-09 DOI: 10.34067/KID.0000000000000527
Kingsley Omage, James A McCormick

The sodium chloride cotransporter (NCC) fine-tunes Na + balance and indirectly affects the homeostasis of other ions including K + , Mg 2+ , and Ca 2+ . Owing to its effects on Na + balance, BP is significantly affected by alterations in NCC activity. Several factors have been reported to influence the expression and activity of NCC. One critical factor is NCC phosphorylation/dephosphorylation that occurs at key serine-threonine amino acid residues of the protein. Phosphorylation, which results in increased NCC activity, is mediated by the with no lysine [K] (WNK)-SPS-related proline alanine rich kinase (SPAK)/OSR1 kinases. NCC activation stimulates reabsorption of Na + , increasing extracellular fluid volume and hence BP. On the other hand, proteasomal degradation of WNK kinases after ubiquitination by the Cullin 3-Kelch-like 3 E3 ubiquitin ligase complex and dephosphorylation pathways oppose WNK-SPAK/OSR1-mediated NCC activation. Components of the Cullin 3/Kelch-like 3-WNK-SPAK/OSR1 regulatory pathway may be targets for novel antihypertensive drugs. In this review, we outline the impact of these regulators on the activity of NCC and the consequent effect on BP.

氯化钠协同转运体（NCC）可调节 Na+ 平衡，并间接影响其他离子（包括 K+、Mg2+ 和 Ca2+）的平衡。由于其对 Na+ 平衡的影响，NCC 活性的改变会对血压产生重大影响。据报道，NCC 的表达和活性受多种因素影响。其中一个关键因素是发生在蛋白质关键丝氨酸-苏氨酸氨基酸残基上的 NCC 磷酸化/去磷酸化。磷酸化导致 NCC 活性增加，由 WNK-SPAK/OSR1 激酶介导。NCC 激活会刺激 Na+ 的重吸收，增加细胞外液容量，从而提高血压。另一方面，WNK 激酶被 CUL3-KLHL3 E3 泛素连接酶复合物泛素化后的蛋白酶体降解以及去磷酸化途径会抑制 WNK-SPAK/OSR1 介导的 NCC 激活。CUL3/KLHL3-WNK-SPAK/OSR1调节途径的组成成分可能是新型抗高血压药物的靶点。在本综述中，我们将概述这些调节因子对 NCC 活性的影响以及由此对血压产生的影响。
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引用次数: 0
Aryl Hydrocarbon Receptor Pathway Augments Peritoneal Fibrosis in a Murine CKD Model Exposed to Peritoneal Dialysate. 芳基烃受体通路促进暴露于腹膜透析液的小鼠慢性肾脏病模型的腹膜纤维化
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 Epub Date: 2024-09-05 DOI: 10.34067/KID.0000000000000516
Saran Lotfollahzadeh, Aniket Vazirani, Isaac E Sellinger, Janelle Clovie, Isaac Hoekstra, Arjun Patel, Abbas Brahim Malloum, Wenqing Yin, Herreet Paul, Pranav Yadati, Jeffrey Siracus, Marina Malikova, Luise I Pernar, Jean Francis, Lauren Stern, Vipul C Chitalia
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引用次数: 0
Prognostication from Kidney Transplant Biopsies: 90 Years of Dynamic Alien Landscape Forward and Back. 肾移植活检的预后：90 年动态异形景观的前世今生
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 DOI: 10.34067/KID.0000000000000534
Kim Solez
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引用次数: 0
Acute Kidney Injury in a Young Woman after Dilation and Curettage. 一名年轻女性在扩张和刮宫术后出现急性肾损伤。
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 DOI: 10.34067/KID.0000000000000519
Sandipan Shringi, Boris Sinayuk, Eric Kerns
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引用次数: 0
The COVID-19 Vaccination and IgA Nephropathy: Further Cause for Reassurance. COVID-19 疫苗接种与 IgA 肾病：更多保证
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 DOI: 10.34067/KID.0000000000000530
Haresh Selvaskandan, Jonathan Barratt
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引用次数: 0
Cell Catcher: A New Method to Extract and Preserve Live Renal Cells from Urine. 细胞捕捉器：从尿液中提取和保存肾脏活细胞的新方法。
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 DOI: 10.34067/KID.0000000000000503
Katia Nazmutdinova, Cheuk Yan Man, Martyn Carter, Philip L Beales, Paul J D Winyard, Stephen B Walsh, Karen L Price, David A Long
{"title":"Cell Catcher: A New Method to Extract and Preserve Live Renal Cells from Urine.","authors":"Katia Nazmutdinova, Cheuk Yan Man, Martyn Carter, Philip L Beales, Paul J D Winyard, Stephen B Walsh, Karen L Price, David A Long","doi":"10.34067/KID.0000000000000503","DOIUrl":"10.34067/KID.0000000000000503","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"5 9","pages":"1359-1363"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Second Opinions after Adverse Determination of Kidney Transplant Evaluation. 肾移植评估结果不佳后的第二意见结果。
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 Epub Date: 2024-08-02 DOI: 10.34067/KID.0000000000000529
Danielle S Kroll, Kyle J Woodward, Adarsh Ramakrishnan, Miko Yu, Heather K Morris, Joel T Adler, Lloyd E Ratner, Sumit Mohan, Syed Ali Husain
{"title":"Outcomes of Second Opinions after Adverse Determination of Kidney Transplant Evaluation.","authors":"Danielle S Kroll, Kyle J Woodward, Adarsh Ramakrishnan, Miko Yu, Heather K Morris, Joel T Adler, Lloyd E Ratner, Sumit Mohan, Syed Ali Husain","doi":"10.34067/KID.0000000000000529","DOIUrl":"10.34067/KID.0000000000000529","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1367-1369"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Present and Imagining the Future Landscape of Onconephrology. 探索肿瘤肾脏病学的现状并畅想未来。
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 Epub Date: 2024-08-26 DOI: 10.34067/KID.0000000000000544
Abinet M Aklilu, Anushree C Shirali
{"title":"Exploring the Present and Imagining the Future Landscape of Onconephrology.","authors":"Abinet M Aklilu, Anushree C Shirali","doi":"10.34067/KID.0000000000000544","DOIUrl":"10.34067/KID.0000000000000544","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1377-1379"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Access to Expensive Therapies and Diagnostics for Kidney Care in Switzerland. 在瑞士，肾脏护理可获得昂贵的治疗和诊断。
IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI: 10.34067/KID.0000000000000522
Valerie A Luyckx, Paul de Zwart, Giuseppina Spartà, Thomas F Mueller
{"title":"Access to Expensive Therapies and Diagnostics for Kidney Care in Switzerland.","authors":"Valerie A Luyckx, Paul de Zwart, Giuseppina Spartà, Thomas F Mueller","doi":"10.34067/KID.0000000000000522","DOIUrl":"10.34067/KID.0000000000000522","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1281-1288"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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