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BK Nephropathy in the Modern Era: What Have We Learned? 现代BK肾病：我们学到了什么？
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-08-19 DOI: 10.34067/KID.0000000967
David Wojciechowski, Camille Nelson Kotton

BK polyomavirus (BKPyV) remains a significant cause of graft dysfunction and failure in kidney transplant recipients, with DNAemia affecting up to 30% and nephropathy contributing to approximately 7% of graft losses. This review synthesizes current understanding of BKPyV pathogenesis, risk factors, and management strategies. Screening protocols and immunosuppression reduction remain the cornerstone of care, although emerging therapies-including monoclonal antibodies and virus-specific T-cell therapies-offer promise. The role of mammalian target of rapamycin inhibitors and other agents is critically evaluated, with recent trials challenging their efficacy. Unique transplant-related factors, such as ureteral stent use and the kidney's role as a viral reservoir, may explain the predominance of BKPyV in renal transplantation. This review highlights the need for improved serologic and cellular immunity assays, targeted antiviral therapies, and individualized approaches to retransplantation. Continued research is essential to reduce the burden of BKPyV-associated nephropathy and improve long-term kidney transplant outcomes.

BK多瘤病毒（BKPyV）仍然是肾移植受者移植物功能障碍和衰竭的重要原因，dna血症影响高达30%，肾病约占移植物损失的7%。本文综述了目前对BKPyV发病机制、危险因素和治疗策略的了解。尽管包括单克隆抗体和病毒特异性t细胞疗法在内的新兴疗法带来了希望，但筛查方案和免疫抑制减少仍然是治疗的基石。mTOR抑制剂和其他药物的作用被严格评估，最近的试验挑战了它们的疗效。独特的移植相关因素，如输尿管支架的使用和肾脏作为病毒储存库的作用，可能解释了BKPyV在肾移植中的优势。该综述强调需要改进血清学和细胞免疫测定、靶向抗病毒治疗和个体化再移植方法。持续的研究对于减轻bkpyv相关肾病的负担和改善长期肾移植结果至关重要。
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引用次数: 0
Risk Factors for Suboptimal Dialysis Initiation: A Prospective Cohort Study. 透析起始次优的危险因素：一项前瞻性队列研究。
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-07-21 DOI: 10.34067/KID.0000000895
Amber O Molnar, K Scott Brimble, Sarah E Bota, Yuguang Kang, J P Harmon, Swapnil Hiremath, Pierre A Brown, Samuel A Silver, Ayub Akbari
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引用次数: 0
Urine Electrolyte to Predict Treatment Failure of Fluid Restriction in Syndrome of Inappropriate Antidiuresis: A Prospective Multicenter Study. 尿电解质预测不适当抗利尿综合征的限水治疗失败：一项前瞻性多中心研究。
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-07-25 DOI: 10.34067/KID.0000000912
Kittiphan Chienwichai, Sirin Jiwakanon, Kamonrat Chaiviriyawong, Jananya Wattanakul, Warat Rojnsaengroung, Soravit Manasuth, Sorawat Sangkaew, Arunchai Chang, Pannawat Mongkolrattanakul
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引用次数: 0
NF Erythroid 2-Related Factor 2 Peroxisome Proliferator-Activated Receptor-γ Crosstalk: Reprogramming Monocytic Myeloid-Derived Suppressor Cells in Kidney Disease. 红细胞2相关因子2过氧化物酶体增殖激活受体-γ串扰：肾脏疾病中单核髓源性抑制细胞的重编程
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-12-02 DOI: 10.34067/KID.0000001071
John D Imig
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引用次数: 0
Cardiovascular Autonomic Control in Normotensive Patients with Autosomal Dominant Polycystic Kidney Disease. 常染色体显性多囊肾病患者的心血管自主控制
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.34067/KID.0000000958
Daniel Ribeiro Rocha, Ana Carolina Anauate, Milene Subtil Ormanji, Cássia Toledo Bergamaschi, Ruy Ribeiro Campos, Bruno Moreira Silva, Ita Pfeferman Heilberg
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引用次数: 0
Should Kidney Transplantation be Offered to Patients with Body Mass Index >40?: Commentary. BMI指数为bb40的患者是否应该进行肾移植？:评论。
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-08-08 DOI: 10.34067/KID.0000000954
Phillipe Abreu, Jesse D Schold
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引用次数: 0
Should Kidney Transplantation be Offered to Patients with Body Mass Index >40?: PRO. 病态肥胖患者（BMI≥40 kg/m2）可进行肾移植：赞成。
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-08-08 DOI: 10.34067/KID.0000000624
Amanda J Vinson
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引用次数: 0
Compass Rose: Providing Direction and Automation of Glomerular Disease Drug Monitoring. 罗盘玫瑰™：提供肾小球疾病药物监测方向和自动化。
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-10-28 DOI: 10.34067/KID.0000001027
Shane A Bobart, Nabeel Aslam
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引用次数: 0
Cognitive Impairment: A Novel Risk Factor for Rapid Kidney Function Decline and Incident CKD in Middle-Aged Adults. 认知障碍：中年成年人肾功能快速下降和CKD发生的一个新的危险因素。
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-06-25 DOI: 10.34067/KID.0000000880
Ruqiyya Bano, Sean A P Clouston, Frank Mann, Babar A Khan, Melissa Carr, S Susan Hedayati, Benjamin J Luft, Farrukh M Koraishy
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引用次数: 0
NF Erythroid 2-Related Factor 2 Deficiency Enhances the Immunosuppressive Function of Monocytic Myeloid-Derived Suppressor Cells in a Peroxisome Proliferator-Activated Receptor- γ -Dependent Manner. Nrf2缺乏以PPARγ依赖的方式增强单核髓源性抑制细胞的免疫抑制功能。
IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360
Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.34067/KID.0000000947
Yichen Jia, Jiawei Li, Tianying Yang, Ruimin Li, Guowei Tu, Yue Qiu, Xuepeng Zhang, Ruirui Sang, Yi Shi, Shihao Xu, Yin Celeste Cheuk, Jingjing Liu, Ruiming Rong, Yi Zhang
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引用次数: 0
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