Pub Date : 2024-10-01Epub Date: 2024-08-12DOI: 10.34067/KID.0000000000000542
Caroline R Sussman, Heather L Holmes, Alison Stiller, Ka Thao, Adriana V Gregory, Deema Anaam, Ryan Meloche, Yaman Mkhaimer, Harrison H Wells, Luiz D Vasconcelos, Matthew W Urban, Slobodan I Macura, Peter C Harris, Timothy L Kline, Michael F Romero
{"title":"Robotic Ultrasound and Novel Collagen Analyses for Polycystic Kidney Disease Research Using Mice.","authors":"Caroline R Sussman, Heather L Holmes, Alison Stiller, Ka Thao, Adriana V Gregory, Deema Anaam, Ryan Meloche, Yaman Mkhaimer, Harrison H Wells, Luiz D Vasconcelos, Matthew W Urban, Slobodan I Macura, Peter C Harris, Timothy L Kline, Michael F Romero","doi":"10.34067/KID.0000000000000542","DOIUrl":"10.34067/KID.0000000000000542","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1543-1552"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-05-15DOI: 10.34067/KID.0000000000000470
Robert W Steiner
{"title":"Screening of Living Kidney Donors for Genetic Diseases: Commentary.","authors":"Robert W Steiner","doi":"10.34067/KID.0000000000000470","DOIUrl":"10.34067/KID.0000000000000470","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1419-1421"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-05-15DOI: 10.34067/KID.0000000000000350
Yasar Caliskan, Krista L Lentine
{"title":"Screening of Living Kidney Donors for Genetic Diseases: PRO.","authors":"Yasar Caliskan, Krista L Lentine","doi":"10.34067/KID.0000000000000350","DOIUrl":"10.34067/KID.0000000000000350","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"5 10","pages":"1416-1418"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Think Kidney Function When Testing for and Treating Tuberculosis.","authors":"Nicola Wearne, Valerie A Luyckx","doi":"10.34067/KID.0000000578","DOIUrl":"10.34067/KID.0000000578","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"5 10","pages":"1405-1407"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-08-15DOI: 10.34067/KID.0000000000000552
Tessa K Novick, Deidra C Crews
{"title":"A Different Take on Precision Medicine in Nephrology.","authors":"Tessa K Novick, Deidra C Crews","doi":"10.34067/KID.0000000000000552","DOIUrl":"10.34067/KID.0000000000000552","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1566-1568"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.34067/KID.0000000000000545
Miguel Bigotte Vieira, Hiroyuki Arai, Carla Nicolau, Naoka Murakami
As the population ages and post-transplant survival improves, pretransplant and post-transplant malignancy are becoming increasingly common. In addition, rapid advances in cancer therapies and improving outcomes prompt us to rethink pretransplant cancer-free wait time and screening strategies. Although kidney transplant recipients (KTRs) are at higher risk of developing cancer, epidemiological data on how to best screen and treat cancers in KTRs are incomplete. Thus, current recommendations are still largely on the basis of studies in the general population, and their validity in KTRs is uncertain. Kidney transplant candidates without prior cancer should be evaluated for latent malignancies even in the absence of symptoms. Conversely, individuals with a history of malignancy require thorough monitoring to detect potential recurrences or de novo malignancies. When treating KTRs with cancer, reducing immunosuppression can enhance antitumor immunity, yet this also increases the risk of graft rejection. Optimal treatment and immunosuppression management remains undefined. As the emergence of novel cancer therapies adds complexity to this challenge, individualized risk-benefit assessment is crucial. In this review, we discuss up-to-date data on pretransplant screening and cancer-free wait time, as well as post-transplant cancer screening, prevention strategies, and treatment, including novel therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies.
随着人口老龄化和移植后存活率的提高，移植前和移植后恶性肿瘤越来越常见。此外，癌症疗法的快速发展和治疗效果的不断改善也促使我们重新思考移植前无癌症等待时间和筛查策略。尽管肾移植受者（KTR）罹患癌症的风险较高，但有关如何对肾移植受者进行最佳癌症筛查和治疗的流行病学数据并不完整。因此，目前的建议仍主要基于对普通人群的研究，其在肾移植受者中的有效性尚不确定。没有癌症病史的肾移植候选者即使没有症状，也应接受潜伏恶性肿瘤的评估。相反，有恶性肿瘤病史的患者则需要进行全面监测，以发现潜在的复发或新发恶性肿瘤。在治疗患有癌症的 KTR 时，减少免疫抑制可增强抗肿瘤免疫力，但这也会增加移植物排斥反应的风险。最佳治疗和免疫抑制管理仍未确定。新型癌症疗法的出现增加了这一挑战的复杂性，因此个体化的风险效益评估至关重要。在这篇综述中，我们将讨论移植前筛查和无癌症等待时间的最新数据，以及移植后癌症筛查、预防策略和治疗，包括免疫检查点抑制剂和嵌合抗原受体 T 细胞疗法等新型疗法。
{"title":"Cancer Screening and Cancer Treatment in Kidney Transplant Recipients.","authors":"Miguel Bigotte Vieira, Hiroyuki Arai, Carla Nicolau, Naoka Murakami","doi":"10.34067/KID.0000000000000545","DOIUrl":"10.34067/KID.0000000000000545","url":null,"abstract":"<p><p>As the population ages and post-transplant survival improves, pretransplant and post-transplant malignancy are becoming increasingly common. In addition, rapid advances in cancer therapies and improving outcomes prompt us to rethink pretransplant cancer-free wait time and screening strategies. Although kidney transplant recipients (KTRs) are at higher risk of developing cancer, epidemiological data on how to best screen and treat cancers in KTRs are incomplete. Thus, current recommendations are still largely on the basis of studies in the general population, and their validity in KTRs is uncertain. Kidney transplant candidates without prior cancer should be evaluated for latent malignancies even in the absence of symptoms. Conversely, individuals with a history of malignancy require thorough monitoring to detect potential recurrences or de novo malignancies. When treating KTRs with cancer, reducing immunosuppression can enhance antitumor immunity, yet this also increases the risk of graft rejection. Optimal treatment and immunosuppression management remains undefined. As the emergence of novel cancer therapies adds complexity to this challenge, individualized risk-benefit assessment is crucial. In this review, we discuss up-to-date data on pretransplant screening and cancer-free wait time, as well as post-transplant cancer screening, prevention strategies, and treatment, including novel therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies.</p>","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":"5 10","pages":"1569-1583"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-07-18DOI: 10.34067/KID.0000000000000517
Kevin Lu, Kun-Yuan Chiu, I-Chieh Chen, Guan-Cheng Lin
{"title":"Identification of GTF2I Polymorphisms as Potential Biomarkers for CKD in the Han Chinese Population : Multicentric Collaborative Cross-Sectional Cohort Study.","authors":"Kevin Lu, Kun-Yuan Chiu, I-Chieh Chen, Guan-Cheng Lin","doi":"10.34067/KID.0000000000000517","DOIUrl":"10.34067/KID.0000000000000517","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1466-1476"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01Epub Date: 2024-08-06DOI: 10.34067/KID.0000000000000539
Guilherme Palhares Aversa Santos, Ricardo Sesso, Jocemir Ronaldo Lugon, Precil Diego Miranda de Menezes Neves, Abner Mácola Pacheco Barbosa, Naila Camila da Rocha, Luis Gustavo Modelli de Andrade
{"title":"KRT in Brazil: A Retrospective Cohort Study Based on Analysis of the Brazilian Public Health System.","authors":"Guilherme Palhares Aversa Santos, Ricardo Sesso, Jocemir Ronaldo Lugon, Precil Diego Miranda de Menezes Neves, Abner Mácola Pacheco Barbosa, Naila Camila da Rocha, Luis Gustavo Modelli de Andrade","doi":"10.34067/KID.0000000000000539","DOIUrl":"10.34067/KID.0000000000000539","url":null,"abstract":"","PeriodicalId":17882,"journal":{"name":"Kidney360","volume":" ","pages":"1477-1489"},"PeriodicalIF":3.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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