Objective: COPD is characterized by exacerbation and may lead to intensive care unit admission in cases such as pneumonia and sepsis. While non-invasive mechanical ventilation is the first treatment option in intensive care units, it reduces mortality and hospitalization. In our study, we aimed to determine the factors affecting mortality in patients with COPD admitted to intensive care unit.
Materials and Methods: In our study, the data of patients admitted to the intensive care unit of Bolu Izzet Baysal State Hospital with COPD were evaluated retrospectively. Duration of intensive care unit stay, APACHE II score, comorbidities, need for noninvasive mechanical ventilation, CRP albumin ratio and leukocyte lymphocyte ratio were recorded.
Results: A total of 416 patients, including 177 (42.5%) women, were included in our study. Of the patients, 107 (25.7%) (Group 1) were admitted to ICU for COPD exacerbation, 183 (44%) (Group 2) for pneumonia and 126 (30.3%) (Group 3) for sepsis. Hypertension was the most common comorbidity in 112 patients (26.9%). Mortality was higher in patients with pneumonia and sepsis than in patients with COPD exacerbation. When all patients were compared according to prognosis, age, length of ICU stay, NLR, CAR and APACHE II scores were higher in patients who died. The duration of non-invasive mechanical ventilation was higher in patients with an episode of COPD, while mortality was higher in patients receiving invasive mechanical ventilation support.
CONCLUSION
While pneumonia and sepsis increase mortality in patients with COPD, NIMV has a favorable prognosis in these patients with encouraging results.
{"title":"Factors affecting mortality and patient outcome in patients with COPD followed in the intensive care unit","authors":"Mustafa DENİZ, Zerrin ÖZÇELİK, Pınar OZGUN","doi":"10.18521/ktd.1330530","DOIUrl":"https://doi.org/10.18521/ktd.1330530","url":null,"abstract":"Objective: COPD is characterized by exacerbation and may lead to intensive care unit admission in cases such as pneumonia and sepsis. While non-invasive mechanical ventilation is the first treatment option in intensive care units, it reduces mortality and hospitalization. In our study, we aimed to determine the factors affecting mortality in patients with COPD admitted to intensive care unit. 
 Materials and Methods: In our study, the data of patients admitted to the intensive care unit of Bolu Izzet Baysal State Hospital with COPD were evaluated retrospectively. Duration of intensive care unit stay, APACHE II score, comorbidities, need for noninvasive mechanical ventilation, CRP albumin ratio and leukocyte lymphocyte ratio were recorded. 
 Results: A total of 416 patients, including 177 (42.5%) women, were included in our study. Of the patients, 107 (25.7%) (Group 1) were admitted to ICU for COPD exacerbation, 183 (44%) (Group 2) for pneumonia and 126 (30.3%) (Group 3) for sepsis. Hypertension was the most common comorbidity in 112 patients (26.9%). Mortality was higher in patients with pneumonia and sepsis than in patients with COPD exacerbation. When all patients were compared according to prognosis, age, length of ICU stay, NLR, CAR and APACHE II scores were higher in patients who died. The duration of non-invasive mechanical ventilation was higher in patients with an episode of COPD, while mortality was higher in patients receiving invasive mechanical ventilation support. 
 CONCLUSION
 While pneumonia and sepsis increase mortality in patients with COPD, NIMV has a favorable prognosis in these patients with encouraging results.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135740699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Birgül ÖNEÇ, Durdu Mehmet KÖŞ, Gulsah ALTUN, Mehmet Ali SUNGUR
Objective: Multiple myeloma (MM) is a malignant hematological disease and anemia is observed in the majority of patients. Hepcidin, Growth differentiation factor-15 (GDF-15), soluble transferrin receptor (sTfR) have been investigated in many forms of anemia, especially in chronic diseases and cancers. However, there are few studies investigating their role in MM. We aimed to determine the relationship between hepcidin, sTfR and GDF-15 levels in MM patients and their clinical features such as anemia parameters, disease stage and overall survival.
Method: Hepcidin, sTfR and GDF-15 levels, as well as clinical and anemia-related parameters, were analyzed in newly diagnosed MM patients and healthy volunteers.
Result: Although MM patients had significantly lower Hb and Hct levels compared to the control group, none of the GDF-15, hepcidin and sTfR levels showed a significant difference between the groups. Among MM patients, we found that the anemic subgroup had significantly lower hepcidin levels than the non-anemic subgroup. GDF-15, hepcidin and sTfR levels showed weak or moderate positive correlation with each other, while GDF15 was positively correlated with creatinine and sTfR levels were correlated with many parameters such as LDH, CRP, ferritin, albumin, creatinine, Hb and ISS, all of which weak. None of the levels of GDF-15, hepcidin and sTfR had a significant effect on survival.
Conclusion: We suggested that these mediators may play a role in anemia of MM but there is not a clear relashionship as in chronic disease anemia, there may be different mechanisms according to the characteristics of the patient groups.
{"title":"The relationship of hepcidin, soluble transferrin receptor, growth differentiation factor-15 and anemia in multipl myeloma","authors":"Birgül ÖNEÇ, Durdu Mehmet KÖŞ, Gulsah ALTUN, Mehmet Ali SUNGUR","doi":"10.18521/ktd.1321364","DOIUrl":"https://doi.org/10.18521/ktd.1321364","url":null,"abstract":"Objective: Multiple myeloma (MM) is a malignant hematological disease and anemia is observed in the majority of patients. Hepcidin, Growth differentiation factor-15 (GDF-15), soluble transferrin receptor (sTfR) have been investigated in many forms of anemia, especially in chronic diseases and cancers. However, there are few studies investigating their role in MM. We aimed to determine the relationship between hepcidin, sTfR and GDF-15 levels in MM patients and their clinical features such as anemia parameters, disease stage and overall survival.
 Method: Hepcidin, sTfR and GDF-15 levels, as well as clinical and anemia-related parameters, were analyzed in newly diagnosed MM patients and healthy volunteers.
 Result: Although MM patients had significantly lower Hb and Hct levels compared to the control group, none of the GDF-15, hepcidin and sTfR levels showed a significant difference between the groups. Among MM patients, we found that the anemic subgroup had significantly lower hepcidin levels than the non-anemic subgroup. GDF-15, hepcidin and sTfR levels showed weak or moderate positive correlation with each other, while GDF15 was positively correlated with creatinine and sTfR levels were correlated with many parameters such as LDH, CRP, ferritin, albumin, creatinine, Hb and ISS, all of which weak. None of the levels of GDF-15, hepcidin and sTfR had a significant effect on survival. 
 Conclusion: We suggested that these mediators may play a role in anemia of MM but there is not a clear relashionship as in chronic disease anemia, there may be different mechanisms according to the characteristics of the patient groups.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135878619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet KÖDER, Saffet KILIÇASLAN, Abdullah BELADA, Arif Doğan HABİLOĞLU, Özlem ATAOĞLU, Mehmet Ali SUNGUR, Dursun ATİK
Objective: Our study aims to evaluate the nasal mucociliary clearance (NMC) in
Covid-19 patients who have been recently diagnosed and not been treated yet and
investigate how Covid-19 affects NMC.
Methods: A total of 120 participants, who applied to Düzce Atatürk State Hospital
between September and November 2020, were included in our study. 60 of them were
the participants, diagnosed with Covid-19. And 60 of them were the control group. The
age range was 18 to 66. 60 participants, diagnosed with Covid-19 and not yet treated,
were included in our study. Those with taste disorders were excluded from the study.
The control group consisted of 60 healthy volunteers. NMC was evaluated using a
saccharin test. The results were compared in the Statistical Package for Social Sciences
(SPSS).
Results: The study group, which consisted of 60 Covid-19 participants of whom
treatment was not yet started, and the 60-participant healthy control group were
evaluated in our study. The average age of the study group was 40,72±12,96 and 39,16
in the control group. The average NMC was 15,95±3,37 in the study group, and
8,38±1,03 in the control group. When evaluated statistically, it was found higher in the
study group (p
{"title":"Yeni Tanı Almış Kovid-19 Hastalarında Tedavi Öncesi Nazal Mukosiliyer Temizliğin Değerlendirilmesi","authors":"Ahmet KÖDER, Saffet KILIÇASLAN, Abdullah BELADA, Arif Doğan HABİLOĞLU, Özlem ATAOĞLU, Mehmet Ali SUNGUR, Dursun ATİK","doi":"10.18521/ktd.1217744","DOIUrl":"https://doi.org/10.18521/ktd.1217744","url":null,"abstract":"Objective: Our study aims to evaluate the nasal mucociliary clearance (NMC) in
 Covid-19 patients who have been recently diagnosed and not been treated yet and
 investigate how Covid-19 affects NMC.
 Methods: A total of 120 participants, who applied to Düzce Atatürk State Hospital
 between September and November 2020, were included in our study. 60 of them were
 the participants, diagnosed with Covid-19. And 60 of them were the control group. The
 age range was 18 to 66. 60 participants, diagnosed with Covid-19 and not yet treated,
 were included in our study. Those with taste disorders were excluded from the study.
 The control group consisted of 60 healthy volunteers. NMC was evaluated using a
 saccharin test. The results were compared in the Statistical Package for Social Sciences
 (SPSS).
 Results: The study group, which consisted of 60 Covid-19 participants of whom
 treatment was not yet started, and the 60-participant healthy control group were
 evaluated in our study. The average age of the study group was 40,72±12,96 and 39,16
 in the control group. The average NMC was 15,95±3,37 in the study group, and
 8,38±1,03 in the control group. When evaluated statistically, it was found higher in the
 study group (p","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135826812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Şenay KOÇAKOĞLU, Dursun ÇADIRCI, Mehmet Şevki ÇADIRCI, Mehmet Ali EREN
Objective: Accurate management of hypothyroidism, which is one of the common reasons for referral to primary care, is critically important issue. This study aims to measure the knowledge and attitudes of family physicians (FPs) regarding the use of levothyroxine, which is the main pharmacological agent in the treatment of hypothyroidism.
Methods: This prospective and descriptive study was performed on 102 physicians from family health centers in Şanlıurfa province central districts. The researchers created a questionnaire consisting of eight questions; seven of which were multiple choices and one was open-ended, by scanning the guidelines and literature. Data were obtained by face-to-face interview technique.
Results: Of the participants, 21 (20.6%) were female and 81 (79.4%) male physicians, and the mean age of the participants was 36.9±8.0 (28-66) years. The work duration as a FP was 6.1±3.3 years. Sixteen (15.7%) of the participants reported that they had never prescribed levothyroxine. Two-thirds of them correctly answered the relationship between levothyroxine absorption and food intake, and 36.3% correctly answered that there would be a difference in absorption between different levothyroxine formulations. However, the rate of correct answers to the question of how to start hypothyroidism treatment in patients over 60 years of age or with coronary artery disease was quite low.
Conclusions: The results of this study revealed that FPs in Sanliurfa central districts do not have adequate knowledge about the use of levothyroxine for treatment of hypothyroidism, and they need effective training on this vital issue.
duyduklarını ortaya koymuştur.
目的:甲状腺功能减退症是转诊到初级保健的常见原因之一，准确的管理是一个至关重要的问题。本研究旨在了解家庭医生对治疗甲状腺功能减退的主要药物左旋甲状腺素的认知和态度。
方法:对Şanlıurfa省中心区家庭保健中心102名医师进行前瞻性和描述性研究。研究人员制作了一份由八个问题组成的问卷;其中七个是多项选择，一个是开放式的，通过浏览指南和文献。数据采用面对面访谈法获取。& # x0D;结果:女性21人(20.6%)，男性81人(79.4%)，平均年龄36.9±8.0(28-66)岁。工作时间为6.1±3.3年。16名(15.7%)参与者报告他们从未开过左甲状腺素。三分之二的人正确回答了左甲状腺素吸收与食物摄入量的关系，36.3%的人正确回答了不同左甲状腺素配方的吸收会有差异。然而，对于60岁以上或患有冠状动脉疾病的患者如何开始甲状腺功能减退治疗的问题，正确率相当低。
结论:本研究结果表明，三六法市中心地区的家庭护理人员对左旋甲状腺素治疗甲状腺功能减退的认识不足，需要对他们进行有效的培训。Duyduklarını ortaya koymutur。
{"title":"Birinci Basamak Uygulamaları İçin Kritik Bir Konu: Aile Hekimlerinin Levotiroksin Kullanımına İlişkin Bilgi ve Tutumları","authors":"Şenay KOÇAKOĞLU, Dursun ÇADIRCI, Mehmet Şevki ÇADIRCI, Mehmet Ali EREN","doi":"10.18521/ktd.1328697","DOIUrl":"https://doi.org/10.18521/ktd.1328697","url":null,"abstract":"Objective: Accurate management of hypothyroidism, which is one of the common reasons for referral to primary care, is critically important issue. This study aims to measure the knowledge and attitudes of family physicians (FPs) regarding the use of levothyroxine, which is the main pharmacological agent in the treatment of hypothyroidism.
 Methods: This prospective and descriptive study was performed on 102 physicians from family health centers in Şanlıurfa province central districts. The researchers created a questionnaire consisting of eight questions; seven of which were multiple choices and one was open-ended, by scanning the guidelines and literature. Data were obtained by face-to-face interview technique. 
 Results: Of the participants, 21 (20.6%) were female and 81 (79.4%) male physicians, and the mean age of the participants was 36.9±8.0 (28-66) years. The work duration as a FP was 6.1±3.3 years. Sixteen (15.7%) of the participants reported that they had never prescribed levothyroxine. Two-thirds of them correctly answered the relationship between levothyroxine absorption and food intake, and 36.3% correctly answered that there would be a difference in absorption between different levothyroxine formulations. However, the rate of correct answers to the question of how to start hypothyroidism treatment in patients over 60 years of age or with coronary artery disease was quite low.
 Conclusions: The results of this study revealed that FPs in Sanliurfa central districts do not have adequate knowledge about the use of levothyroxine for treatment of hypothyroidism, and they need effective training on this vital issue.
 duyduklarını ortaya koymuştur.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136071895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ozden GOKDEMIR, Sudip BHATTACHARYA, Maria BAKOLA, Halime Seda KÜÇÜKERDEM, Gazmend BOJAJ, Kyle HOEDBECKE, Eleni JELASTOPULU
Objective: After the increased number of COVID-19-positive patients, a plateau phase and a decrease in the numbers were expected, followed by a second phase which could lead to an increased health system workload. The importance of training well-educated and qualified healthcare professionals (HPs) has been reconsidered. The rapid spread of the epidemic revealed the limitations of traditional method education. Massive online courses (MOOCs) were offered as a solution to keep the information up-to-date and accessible. The aim of our study was to evaluate the perceptions and experiences of healthcare professionals on strengthening the health system during the COVID-19 pandemic.
Methods: In this descriptive cross-sectional multi-centered study, an online survey was applied to HPs between February-May 2021. There were 28 participating countries. Due to international participation, the survey was conducted in English.
Results: There were 88 female and 87 male participants. Most of the participants were from Europe and Euroasia. Most of them reported their income as $501-$1500 US Dollars). The duration of job experience was between 5-15 years. 111 of them have completed a postdoctoral degree.
Conclusion: According to the survey, all the groups reported as the effect of strengthening primary care by MOOC was positive.
{"title":"STRENGTHENING PRIMARY HEALTH CARE THROUGH MOOC- A CROSS-SECTIONAL STUDY","authors":"Ozden GOKDEMIR, Sudip BHATTACHARYA, Maria BAKOLA, Halime Seda KÜÇÜKERDEM, Gazmend BOJAJ, Kyle HOEDBECKE, Eleni JELASTOPULU","doi":"10.18521/ktd.1285324","DOIUrl":"https://doi.org/10.18521/ktd.1285324","url":null,"abstract":"Objective: After the increased number of COVID-19-positive patients, a plateau phase and a decrease in the numbers were expected, followed by a second phase which could lead to an increased health system workload. The importance of training well-educated and qualified healthcare professionals (HPs) has been reconsidered. The rapid spread of the epidemic revealed the limitations of traditional method education. Massive online courses (MOOCs) were offered as a solution to keep the information up-to-date and accessible. The aim of our study was to evaluate the perceptions and experiences of healthcare professionals on strengthening the health system during the COVID-19 pandemic.
 Methods: In this descriptive cross-sectional multi-centered study, an online survey was applied to HPs between February-May 2021. There were 28 participating countries. Due to international participation, the survey was conducted in English. 
 Results: There were 88 female and 87 male participants. Most of the participants were from Europe and Euroasia. Most of them reported their income as $501-$1500 US Dollars). The duration of job experience was between 5-15 years. 111 of them have completed a postdoctoral degree. 
 Conclusion: According to the survey, all the groups reported as the effect of strengthening primary care by MOOC was positive.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Patient adaptation, particularly in the management of chronic diseases, is an often overlooked but crucial aspect that is more important than medication treatment itself. It is also one of the major problems contributing to treatment failures. Our study aims to evaluate the adaptation levels of elderly hypertensive individuals residing in the city center of Edirne, as well as the factors influencing adaptation levels.
Materials and Methods: The study sample consists of 421 elderly hypertensive individuals registered with 52 primary healthcare units in the city center of Edirne. Data were collected using a questionnaire comprising 75 questions. The questionnaire included socio-demographic characteristics, factors that may affect patient adaptation, and the Chronic Disease Adaptation Scale consisting of 25 questions.
Results: Of the participants, 226 (53.7%) were female and 195 (46.3%) were male. The participants had an average adaptation score of 87.04±9.77, with a minimum score of 62 and a maximum score of 116. Younger elderly individuals had higher adaptation scores. Adaptation scores were lower for widowed individuals, illiterate individuals, and those living alone. Participants who were informed about their illness and treatment, involved their families, and had family support had higher adaptation scores.
Conclusion: The adaptation levels of the elderly participants in our study were found to be below the expected level. Existing studies in the literature predominantly focus on medication adaptation. Conducting studies that specifically target disease adaptation would enable a better understanding of patients and the development of new strategies to improve adaptation levels.
{"title":"Edirne Merkezindeki Hipertansif Yaşlıların Kronik Hastalıklarına Uyum Düzeyleri ve İlişkili Faktörler: Kesitsel Bir Çalışma","authors":"Önder SEZER, Ezgi Sezin CEZİK, Hamdi Nezih DAĞDEVİREN","doi":"10.18521/ktd.1332494","DOIUrl":"https://doi.org/10.18521/ktd.1332494","url":null,"abstract":"Objective: Patient adaptation, particularly in the management of chronic diseases, is an often overlooked but crucial aspect that is more important than medication treatment itself. It is also one of the major problems contributing to treatment failures. Our study aims to evaluate the adaptation levels of elderly hypertensive individuals residing in the city center of Edirne, as well as the factors influencing adaptation levels.
 Materials and Methods: The study sample consists of 421 elderly hypertensive individuals registered with 52 primary healthcare units in the city center of Edirne. Data were collected using a questionnaire comprising 75 questions. The questionnaire included socio-demographic characteristics, factors that may affect patient adaptation, and the Chronic Disease Adaptation Scale consisting of 25 questions.
 Results: Of the participants, 226 (53.7%) were female and 195 (46.3%) were male. The participants had an average adaptation score of 87.04±9.77, with a minimum score of 62 and a maximum score of 116. Younger elderly individuals had higher adaptation scores. Adaptation scores were lower for widowed individuals, illiterate individuals, and those living alone. Participants who were informed about their illness and treatment, involved their families, and had family support had higher adaptation scores.
 Conclusion: The adaptation levels of the elderly participants in our study were found to be below the expected level. Existing studies in the literature predominantly focus on medication adaptation. Conducting studies that specifically target disease adaptation would enable a better understanding of patients and the development of new strategies to improve adaptation levels.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Genetic testing for male infertility is rarely performed in our country. Male infertility is caused by chromosome number or structural problems, Y chromosome deletions and gene alterations. Infertility is a problem seen in 15% of couples. Genetic causes are responsible for the etiology of 3-10% of those diagnosed with male infertility due to oligozoospermia and azoospermia. In this retrospective study, we aimed to determine both the chromosomal structure and the microdeletion of the azoospermic factor (AZF) region on the Y chromosome in infertile men admitted to our center before the application of assisted reproductive techniques. Method: We studied 327 patients who applied to our laboratory for routine analysis. Chromosome analysis was performed from peripheral blood by conventional cytogenetic method. DNA was isolated from peripheral blood and Y chromosome microdeletion was analyzed by fragment analysis method with Y chromosome microdeletion detection kit. Results: Out of 327 patients, 32 had cytogenetic and 18 had molecular abnormalities and 4 had both cytogenetic and molecular abnormalities. Numerical and structural anomalies were detected in patients with anomalous karyotype. Among the patients with Y microdeletions, 1 patient had AZFa, 2 patient had AZFb, 6 patients had AZFc, 3 patients had AZFc+d, 2 patients had AZFb+c+d, 1 patient had AZFb+c+sY160, 1 patient had AZFa+b+d+c+sY90, and 2 patient had AZFb+d+c+sY90. Conclusion: Our study shows that chromosomal abnormalities and Y chromosome microdeletions are important causes of male infertility and that chromosome analysis and Y chromosome microdeletion tests should be performed to explain these abnormalities. It also emphasizes the importance of genetic counseling in explaining male infertility.
{"title":"Evaluation of Y Chromosome Microdeletion and Chromosome Analysis Results in Infertile Male Patients","authors":"Cüneyd Yavaş, Mustafa Doğan, R. Eröz, H. Canat","doi":"10.18521/ktd.1299776","DOIUrl":"https://doi.org/10.18521/ktd.1299776","url":null,"abstract":"Objective: Genetic testing for male infertility is rarely performed in our country. Male infertility is caused by chromosome number or structural problems, Y chromosome deletions and gene alterations. Infertility is a problem seen in 15% of couples. Genetic causes are responsible for the etiology of 3-10% of those diagnosed with male infertility due to oligozoospermia and azoospermia. In this retrospective study, we aimed to determine both the chromosomal structure and the microdeletion of the azoospermic factor (AZF) region on the Y chromosome in infertile men admitted to our center before the application of assisted reproductive techniques. \u0000Method: We studied 327 patients who applied to our laboratory for routine analysis. Chromosome analysis was performed from peripheral blood by conventional cytogenetic method. DNA was isolated from peripheral blood and Y chromosome microdeletion was analyzed by fragment analysis method with Y chromosome microdeletion detection kit. \u0000Results: Out of 327 patients, 32 had cytogenetic and 18 had molecular abnormalities and 4 had both cytogenetic and molecular abnormalities. Numerical and structural anomalies were detected in patients with anomalous karyotype. Among the patients with Y microdeletions, 1 patient had AZFa, 2 patient had AZFb, 6 patients had AZFc, 3 patients had AZFc+d, 2 patients had AZFb+c+d, 1 patient had AZFb+c+sY160, 1 patient had AZFa+b+d+c+sY90, and 2 patient had AZFb+d+c+sY90. \u0000Conclusion: Our study shows that chromosomal abnormalities and Y chromosome microdeletions are important causes of male infertility and that chromosome analysis and Y chromosome microdeletion tests should be performed to explain these abnormalities. It also emphasizes the importance of genetic counseling in explaining male infertility.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44907961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Şenoğlu, Ali Teki̇n, O. Yildirim, D. Baba, Alpaslan Yüksel
Objective: Transurethral resection of the prostate (TURP) is considered the standard in the surgical therapy of lower urinary tract symptoms related to benign prostate hyperplasia (BPH). However, there is no consensus on the timing of catheter removal. In this study, we aimed to compare the long-term effects of early and delayed removal of urethral catheters who underwent TURP. Methods: We prospectively analyzed a total of 91 patients who underwent TURP. Patients were randomized into two groups; the early (postop 1st-2nd days) and delayed (7th day) removal of the urethral catheter. After the surgery in 1, 3, and 6th months, we evaluated all patients regarding treatment success. In addition, international prostate symptom score (IPSS), quality of life (QoL), maximum flow rate, postvoid residual urine volume, and morbidities (hematuria, infection, urethral stricture, irritative symptoms, need for re-operation) were assessed at all visits. Results: After TURP, there was no statistical difference in urodynamic parameters, complications, IPSS, and QoL in both groups. Only in the 3rd-month, the maximum flow rate was higher in favor of the early group. Despite similar results in both groups, strictures occurred earlier in the early group than delayed group (respectively 1 and 3 months). Conclusion: These results suggest that there are no differences in efficacy and complications in groups of early or delayed urethral catheter removal after TURP. The results of long-term studies with large series should be awaited to reach a more definite conclusion. We have tried to shed light on a topic without consensus on the time of urethral catheterization after TURP.
{"title":"Comparison of Early Versus Late Urethral Catheter Removal After Transurethral Resection of The Prostate In Patients with Benign Prostate Hyperplasia.","authors":"Y. Şenoğlu, Ali Teki̇n, O. Yildirim, D. Baba, Alpaslan Yüksel","doi":"10.18521/ktd.1326542","DOIUrl":"https://doi.org/10.18521/ktd.1326542","url":null,"abstract":"Objective: Transurethral resection of the prostate (TURP) is considered the standard in the surgical therapy of lower urinary tract symptoms related to benign prostate hyperplasia (BPH). However, there is no consensus on the timing of catheter removal. In this study, we aimed to compare the long-term effects of early and delayed removal of urethral catheters who underwent TURP. \u0000Methods: We prospectively analyzed a total of 91 patients who underwent TURP. Patients were randomized into two groups; the early (postop 1st-2nd days) and delayed (7th day) removal of the urethral catheter. After the surgery in 1, 3, and 6th months, we evaluated all patients regarding treatment success. In addition, international prostate symptom score (IPSS), quality of life (QoL), maximum flow rate, postvoid residual urine volume, and morbidities (hematuria, infection, urethral stricture, irritative symptoms, need for re-operation) were assessed at all visits. \u0000Results: After TURP, there was no statistical difference in urodynamic parameters, complications, IPSS, and QoL in both groups. Only in the 3rd-month, the maximum flow rate was higher in favor of the early group. Despite similar results in both groups, strictures occurred earlier in the early group than delayed group (respectively 1 and 3 months). \u0000Conclusion: These results suggest that there are no differences in efficacy and complications in groups of early or delayed urethral catheter removal after TURP. The results of long-term studies with large series should be awaited to reach a more definite conclusion. We have tried to shed light on a topic without consensus on the time of urethral catheterization after TURP.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49536540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Cihan Dağli, S. Öner, Beyza YAZGAN DAĞLI, Zülal Öner
Özet Amaç: Bu çalışmada lomber lordoz açısı ve lomber kas kalınlığı ile non-spesifik bel ağrısı arasındaki ilişkinin manyetik rezonans görüntüleme (MRG) görüntüleri aracılığıyla incelenmesi amaçlanmıştır. Metod: Çalışmaya bel ağrısı şikayetiyle ilgili Eğitim ve Araştırma Hastanesine başvuran, MRG’de disk patolojisi saptanmayan, 18-65 yaş aralığındaki, 96 non-spesifik bel ağrılı birey (43 erkek/53 kadın) dahil edildi. Sosyodemografik bilgiler bel ağrısı değerlendirme formu kullanılarak kaydedildi. Bel ağrısı engellilik düzeyi, Oswestry Bel Ağrısı Engellilik Anketi (ODI) ile değerlendirildi. L3-L4 vertebra seviyesine karşılık gelen (m.) psoas major, m. multifidus, m. quadratus lumborum ve m. erector spinae kaslarının kalınlıkları ölçüldü. Lomber lordoz açısının belirlenmesinde Cobb açı ölçme yöntemi kullanıldı. Tüm ölçümler Radiant DICOM görüntüleme programı kullanılarak üç tekrarlı olarak yapıldı. Bulgular: Elde edilen sonuçlar, ODI ile m. psoas major kalınlığı arasında ters bir ilişki bulunduğunu gösterdi (p
具体目标：在这项研究中，该角色旨在通过磁共振成像（MRG）测试隆伯肌的宽度和厚度之间的关系。梅托德：Çalışmaya bel ağrısıšikayetiyle ilgili Eğitim ve Araştırma Hastanesine başvuran，MRG'de磁盘patolojisi saptanmayan，18-65 yaşaralığındaki，96个非规范的bel ağrılıbirey（43 erkek/53 kadın）dahil edildi。使用反向疼痛评估的形式记录了社会人口统计信息。疼痛阻塞程度通过Oswestry-Bell疾病分析（ODI）进行评估。腰大肌的残余，例如多裂肌，例如腰方肌和竖脊肌，对应于L3-L4的脊椎水平。在确定Lomber光合作用角度时使用Cobb开放测量方法。所有测量均使用Radiant DICOM可视化程序进行了三次。结果表明：ODI与腰大肌密度（p）呈相反关系
{"title":"An MRI Analysis of The Lumbar Lordosis Angle and Lumbar Muscle Thicknesses in Patients with Non-Specific Low Back Pain","authors":"Ali Cihan Dağli, S. Öner, Beyza YAZGAN DAĞLI, Zülal Öner","doi":"10.18521/ktd.1210087","DOIUrl":"https://doi.org/10.18521/ktd.1210087","url":null,"abstract":"Özet \u0000Amaç: Bu çalışmada lomber lordoz açısı ve lomber kas kalınlığı ile non-spesifik bel ağrısı arasındaki ilişkinin manyetik rezonans görüntüleme (MRG) görüntüleri aracılığıyla incelenmesi amaçlanmıştır. \u0000Metod: Çalışmaya bel ağrısı şikayetiyle ilgili Eğitim ve Araştırma Hastanesine başvuran, MRG’de disk patolojisi saptanmayan, 18-65 yaş aralığındaki, 96 non-spesifik bel ağrılı birey (43 erkek/53 kadın) dahil edildi. Sosyodemografik bilgiler bel ağrısı değerlendirme formu kullanılarak kaydedildi. Bel ağrısı engellilik düzeyi, Oswestry Bel Ağrısı Engellilik Anketi (ODI) ile değerlendirildi. L3-L4 vertebra seviyesine karşılık gelen (m.) psoas major, m. multifidus, m. quadratus lumborum ve m. erector spinae kaslarının kalınlıkları ölçüldü. Lomber lordoz açısının belirlenmesinde Cobb açı ölçme yöntemi kullanıldı. Tüm ölçümler Radiant DICOM görüntüleme programı kullanılarak üç tekrarlı olarak yapıldı. \u0000Bulgular: Elde edilen sonuçlar, ODI ile m. psoas major kalınlığı arasında ters bir ilişki bulunduğunu gösterdi (p","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48894482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Ercan, F. Gümüş, T. Acar, Mahmudul Islam, H. Dheir
ABSTRACT OBJECTIVES: Youtube is one of the most popular video-sharing websites and can be a powerful tool for disseminating health information. We examined dialysis catheter application videos' characteristics, usefulness, and scientific accuracy. METHODS: We performed a Youtube search with the keywords of "dialysis catheter" without selecting any filter in the English language in April 2022. The content of the videos, video sources, type of catheter mentioned in the video, presence of animation, and the accuracy of the information was evaluated. mDISCERN score was also determined to clarify the power of the accuracy. RESULTS: The evaluation showed that the number of videos with accurate information was 171 (83.4%) with a significantly higher mDISCERN score (2.85±0.59). Among the targeted videos, the mDISCERN score of the videos uploaded by healthcare professionals and the official institution was significantly higher. The average usefulness score was 1.96±0.23, and there was no significant difference between the sources. Conclusions: It would be more appropriate to present the videos selected in terms of education and reliability under a sub-title such as "YouTube Medical Education" for use by medical professionals.
{"title":"Educational Value of Youtube Videos In Dialysis Catheter Application","authors":"Z. Ercan, F. Gümüş, T. Acar, Mahmudul Islam, H. Dheir","doi":"10.18521/ktd.1267307","DOIUrl":"https://doi.org/10.18521/ktd.1267307","url":null,"abstract":"ABSTRACT \u0000OBJECTIVES: Youtube is one of the most popular video-sharing websites and can be a powerful tool for disseminating health information. We examined dialysis catheter application videos' characteristics, usefulness, and scientific accuracy. \u0000METHODS: We performed a Youtube search with the keywords of \"dialysis catheter\" without selecting any filter in the English language in April 2022. The content of the videos, video sources, type of catheter mentioned in the video, presence of animation, and the accuracy of the information was evaluated. mDISCERN score was also determined to clarify the power of the accuracy. \u0000RESULTS: The evaluation showed that the number of videos with accurate information was 171 (83.4%) with a significantly higher mDISCERN score (2.85±0.59). Among the targeted videos, the mDISCERN score of the videos uploaded by healthcare professionals and the official institution was significantly higher. The average usefulness score was 1.96±0.23, and there was no significant difference between the sources. \u0000Conclusions: It would be more appropriate to present the videos selected in terms of education and reliability under a sub-title such as \"YouTube Medical Education\" for use by medical professionals.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44447715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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