Objective: To measure the quality of life by using the Standardized Pediatric Asthma Quality of Life Questionnaire(PAQLQ(S)) in children with asthma and to determine the association of the Childhood Asthma Control Test(c-ACT) and Global Initiative for Asthma(GINA) criteria of asthma control with the PAQLQ(S) domains. Methods: This study was planned in a cross-sectional design. All consecutive children between the ages 7-11 years who had been followed up at least one year with a diagnosis of asthma were enrolled. Children filled out PAQLQ(S). The levels of asthma control were defined by c-ACT and GINA criteria of asthma control. Results: Of the total 120 children, the median(%25-75) PAQLQ(S) and c-ACT scores were 4.90(1.3) and 17.9(4.8). All children had quality of life impairments except four. According to c-ACT, 41.7% of children were controlled; 58.3% of them were uncontrolled. PAQLQ(S) scores were found to be correlated with both c-ACT scores(p<0.001, r=0.612). The c-ACT score was more significantly correlated with the symptom domain of PAQLQ(S)(r=0,667, p<0,001). A more significant positive correlation was found between c-ACT and the duet score of activity and emotional function(r=0.930; p<0.001). Conclusion: Asthma affects the quality of life in children. PAQLQ(S) scores decrease significantly when asthma is out of control. PAQLQ(S) is more significantly associated with c-ACT than GINA criteria. It would be useful in clinical practice if c-ACT or GINA criteria can be improved to cover quality of life, at least the part of the quality of life related to the symptoms or the activity limitations and emotional functions.
{"title":"Is It Time to Add Domains of Quality of Life to the Childhood Asthma Control Test and the GINA Criteria?","authors":"Belgin Usta Güç, Özlem Yılmaz","doi":"10.18521/ktd.1251390","DOIUrl":"https://doi.org/10.18521/ktd.1251390","url":null,"abstract":"Objective: To measure the quality of life by using the Standardized Pediatric Asthma Quality of Life Questionnaire(PAQLQ(S)) in children with asthma and to determine the association of the Childhood Asthma Control Test(c-ACT) and Global Initiative for Asthma(GINA) criteria of asthma control with the PAQLQ(S) domains.\u0000Methods: This study was planned in a cross-sectional design. All consecutive children between the ages 7-11 years who had been followed up at least one year with a diagnosis of asthma were enrolled. Children filled out PAQLQ(S). The levels of asthma control were defined by c-ACT and GINA criteria of asthma control. \u0000Results: Of the total 120 children, the median(%25-75) PAQLQ(S) and c-ACT scores were 4.90(1.3) and 17.9(4.8). All children had quality of life impairments except four. According to c-ACT, 41.7% of children were controlled; 58.3% of them were uncontrolled. PAQLQ(S) scores were found to be correlated with both c-ACT scores(p<0.001, r=0.612). The c-ACT score was more significantly correlated with the symptom domain of PAQLQ(S)(r=0,667, p<0,001). A more significant positive correlation was found between c-ACT and the duet score of activity and emotional function(r=0.930; p<0.001).\u0000Conclusion: Asthma affects the quality of life in children. PAQLQ(S) scores decrease significantly when asthma is out of control. PAQLQ(S) is more significantly associated with c-ACT than GINA criteria. It would be useful in clinical practice if c-ACT or GINA criteria can be improved to cover quality of life, at least the part of the quality of life related to the symptoms or the activity limitations and emotional functions.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46577679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The production of normal blood cells in the bone marrow is interrupted in AML, which is characterized by the proliferation and accumulation of leukemic blasts. Therefore, patients experience anemia and thrombocytopenia. When gene expression of Aurora kinases, which is reported to be highly expressed in AML, decreases, it may be possible to alleviate the clinical findings in AML. In this study, it was aimed to examine the relationship of AURKB with important miRNAs that have the potential to regulate gene expression.
Method: HL60 and NB4 cells were transfected with important tumor suppressor miRNAs miR-34a-5p and let-7b-5p mimics. Then, its effects on proliferation were examined with WST-8 technique and its effects on AURKB gene expression were examined with qRT-PCR.
Results: It was determined that these miRNAs negatively regulated proliferation in both AML cell lines and downregulated the expression level of the Aurora kinase B (AURKB) gene in the miRNA transfected group compared to the control group.
Conclusion: In conclusion, it was determined that miR-34a-5p and let-7b-5p could regulate AURKB expression in AML cells. Therefore, it was thought that these miRNAs may have an important potential as a therapeutic biomarker in preventing excessive cell division and poor prognosis in AML.
{"title":"AURKB Geni miR-34a-5p ve let-7b-5p Tarafından Hedeflendiğinden AML Hücre Proliferasyonunda Rol Oynar mı?","authors":"Ilknur SUER, Murat KAYA","doi":"10.18521/ktd.1171549","DOIUrl":"https://doi.org/10.18521/ktd.1171549","url":null,"abstract":"Objective: The production of normal blood cells in the bone marrow is interrupted in AML, which is characterized by the proliferation and accumulation of leukemic blasts. Therefore, patients experience anemia and thrombocytopenia. When gene expression of Aurora kinases, which is reported to be highly expressed in AML, decreases, it may be possible to alleviate the clinical findings in AML. In this study, it was aimed to examine the relationship of AURKB with important miRNAs that have the potential to regulate gene expression. 
 Method: HL60 and NB4 cells were transfected with important tumor suppressor miRNAs miR-34a-5p and let-7b-5p mimics. Then, its effects on proliferation were examined with WST-8 technique and its effects on AURKB gene expression were examined with qRT-PCR.
 Results: It was determined that these miRNAs negatively regulated proliferation in both AML cell lines and downregulated the expression level of the Aurora kinase B (AURKB) gene in the miRNA transfected group compared to the control group.
 Conclusion: In conclusion, it was determined that miR-34a-5p and let-7b-5p could regulate AURKB expression in AML cells. Therefore, it was thought that these miRNAs may have an important potential as a therapeutic biomarker in preventing excessive cell division and poor prognosis in AML.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Assessment of the Orthorexia Nervosa Tendencies among Postpartum Women","authors":"D. A. Başer","doi":"10.18521/KTD.777632","DOIUrl":"https://doi.org/10.18521/KTD.777632","url":null,"abstract":"","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44609041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self‐medication patterns among Turkish university students","authors":"Gamze Gursul, C. Fidan, E. Oksuz, A. Kut","doi":"10.18521/KTD.773128","DOIUrl":"https://doi.org/10.18521/KTD.773128","url":null,"abstract":"","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42722708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Çetinkaya, Esra Fidan, Selim Göksu, Bihter Gökçe Bozat, Ş. Demir
Objective: Cup therapy has an important place in traditional and complementary medicine applications. The purpose of our study, this is the first time to investigate the protective effect of cup therapy in rats on experimentally generated epileptic seizures in new rat modeling created by different anatomic regions. Methods: A total of 42 Wistar albino rats were randomly divided into 6 groups (n:7). The "new dry cup" was applied to the G1 group, and the "new wet cup" model was applied to the G2. In the G3 group, an "epilepsy model" (PTZ, 35 mg / kg) was created and ''diazepam'' (2.5 mg / kg) was given to G4. "Dry cup" and "wet cup" models were applied to the G5 and G6 groups, respectively. 24 hours after the cupping therapies, the rats were injected with PTZ and the epilepsy behavior scores of the rats in all groups were recorded for 20-30 minutes. Results: In the 'Open Area' and 'Elevated Plus Maze' tests, there was no behavioral difference between the cup therapy group and the control group (p > 0.05). Given all the parameters, the G4 group significantly reduces the seizure compared to other groups (p < 0.05). There is a significant difference in G2, G5 and G6 groups compared to G3 in the phases parameter (p < 0.05). Conclusions: In this study, the new wet cup therapy (G2), which was applied for the first time, had a protective effect on seizures. G2, G5 and G6 groups are observed to suppress seizures compared to G3. Our findings are expected to contribute greatly to animal model analysis in the future.
{"title":"Evaluation of the Protective Effect of The Cup Therapy on the Epileptic Seizure in Rats","authors":"A. Çetinkaya, Esra Fidan, Selim Göksu, Bihter Gökçe Bozat, Ş. Demir","doi":"10.18521/KTD.777484","DOIUrl":"https://doi.org/10.18521/KTD.777484","url":null,"abstract":"Objective: Cup therapy has an important place in traditional and complementary medicine applications. The purpose of our study, this is the first time to investigate the protective effect of cup therapy in rats on experimentally generated epileptic seizures in new rat modeling created by different anatomic regions. Methods: A total of 42 Wistar albino rats were randomly divided into 6 groups (n:7). The \"new dry cup\" was applied to the G1 group, and the \"new wet cup\" model was applied to the G2. In the G3 group, an \"epilepsy model\" (PTZ, 35 mg / kg) was created and ''diazepam'' (2.5 mg / kg) was given to G4. \"Dry cup\" and \"wet cup\" models were applied to the G5 and G6 groups, respectively. 24 hours after the cupping therapies, the rats were injected with PTZ and the epilepsy behavior scores of the rats in all groups were recorded for 20-30 minutes. Results: In the 'Open Area' and 'Elevated Plus Maze' tests, there was no behavioral difference between the cup therapy group and the control group (p > 0.05). Given all the parameters, the G4 group significantly reduces the seizure compared to other groups (p < 0.05). There is a significant difference in G2, G5 and G6 groups compared to G3 in the phases parameter (p < 0.05). Conclusions: In this study, the new wet cup therapy (G2), which was applied for the first time, had a protective effect on seizures. G2, G5 and G6 groups are observed to suppress seizures compared to G3. Our findings are expected to contribute greatly to animal model analysis in the future.","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48787465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adenotonsiller Hipertrofili Hastalarda Efüzyonlu Otitis Media Gelişiminde Etkili Risk Faktörlerinin Araştırılması","authors":"F. Akcan, A. Belada","doi":"10.18521/KTD.804397","DOIUrl":"https://doi.org/10.18521/KTD.804397","url":null,"abstract":"","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44667568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automated classification of brain tumors by deep learning-based models on magnetic resonance images using a developed web-based interface","authors":"B. Tetik, Hasan Ucuzal, Şeyma Yaşar, C. Colak","doi":"10.18521/KTD.889777","DOIUrl":"https://doi.org/10.18521/KTD.889777","url":null,"abstract":"","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45680444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of tetanus immunoglobulin G levels according to age and sociodemographic characteristics: A community-based study","authors":"R. Kutlu, M. Doğan, Ali Rıza Çapa, M. Baykan","doi":"10.18521/KTD.765027","DOIUrl":"https://doi.org/10.18521/KTD.765027","url":null,"abstract":"","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42195994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Unlu, H. B. Altınsoy, E. Balbay, M. Sungur, M. Boran, B. Onal
{"title":"Shear Wave Ultrasound Elastography And Dıffusıon-Weıghted Magnetıc Resonance Imagıng Fındıngs Of Pleural-Based Masses Wıth Hıstopathologıc Correlatıon","authors":"E. Unlu, H. B. Altınsoy, E. Balbay, M. Sungur, M. Boran, B. Onal","doi":"10.18521/KTD.880329","DOIUrl":"https://doi.org/10.18521/KTD.880329","url":null,"abstract":"","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46827080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can Low Magnesium be A Rısk Factor for the Development of Polyneuropathy in Patıents With Diabetes?","authors":"Mehmet Mühürdaroğlu, Ezgi Agadayi, Arzu Kösem","doi":"10.18521/KTD.874172","DOIUrl":"https://doi.org/10.18521/KTD.874172","url":null,"abstract":"","PeriodicalId":17884,"journal":{"name":"Konuralp Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45939892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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