首页 > 最新文献

Kanzo最新文献

英文 中文
Update on systemic therapy for hepatocellular carcinoma 肝细胞癌全身治疗的最新进展
Kanzo
Pub Date : 2023-11-01 DOI: 10.2957/kanzo.64.540
Masafumi Ikeda, Taro Shibuki, Tomonao Taira, Kanae Inoue, Shota Yamaguchi, Ko Fukushi
肝細胞癌の薬物療法はソラフェニブ，レンバチニブなどの分子標的治療薬に代わり，アテゾリズマブ＋ベバシズマブやデュルバルマブ＋トレメリムマブといった免疫療法が主流となった．免疫療法が有効でない場合や免疫療法の適応がない場合に分子標的治療が選択される．年齢，Performance status，肝予備能，治療効果，有害事象などを考慮の上，治療法の選択が必要である．現在，Early stageでは根治治療の周術期治療，Intermediate stageでは肝動脈化学塞栓療法との併用療法，Advanced stageの一次治療，二次治療では新たな薬剤や併用療法などの開発が行われており，どのStageでも薬物療法が行われるようになった．これまで局所療法が主体だった肝細胞癌の治療も，薬物療法の併用療法が積極的に試みられるようになり，新たな治療開発は，薬物療法が中心となって行われている．
肝细胞癌的药物疗法已取代索拉非尼、连伐替尼等分子靶向治疗药，取而代之的是阿替唑单抗+贝伐西单抗和杜尔伐单抗+ tremerim单抗等免疫疗法。在免疫疗法无效或不适应免疫疗法的情况下选择分子靶向治疗。需要在考虑年龄、Performance status、肝储备能力、治疗效果、不良现象等因素的基础上选择治疗方法。目前Early stage是根治性的围手术期治疗，Intermediate stage是肝动脉化学栓塞疗法的联合治疗，Advanced stage的一线治疗，在二次治疗方面正在开发新的药物和联合疗法等，无论哪个Stage都可以使用药物疗法。过去以局部疗法为主体的肝细胞癌的治疗也开始积极尝试药物疗法的联合疗法，新的治疗开发以药物疗法为中心进行。
{"title":"Update on systemic therapy for hepatocellular carcinoma","authors":"Masafumi Ikeda, Taro Shibuki, Tomonao Taira, Kanae Inoue, Shota Yamaguchi, Ko Fukushi","doi":"10.2957/kanzo.64.540","DOIUrl":"https://doi.org/10.2957/kanzo.64.540","url":null,"abstract":"肝細胞癌の薬物療法はソラフェニブ，レンバチニブなどの分子標的治療薬に代わり，アテゾリズマブ＋ベバシズマブやデュルバルマブ＋トレメリムマブといった免疫療法が主流となった．免疫療法が有効でない場合や免疫療法の適応がない場合に分子標的治療が選択される．年齢，Performance status，肝予備能，治療効果，有害事象などを考慮の上，治療法の選択が必要である．現在，Early stageでは根治治療の周術期治療，Intermediate stageでは肝動脈化学塞栓療法との併用療法，Advanced stageの一次治療，二次治療では新たな薬剤や併用療法などの開発が行われており，どのStageでも薬物療法が行われるようになった．これまで局所療法が主体だった肝細胞癌の治療も，薬物療法の併用療法が積極的に試みられるようになり，新たな治療開発は，薬物療法が中心となって行われている．","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"120 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135565165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fontan術後に発症した切除不能肝細胞癌の1例 Fontan术后出现的无法切除肝细胞癌的1例
Kanzo
Pub Date : 2023-11-01 DOI: 10.2957/kanzo.64.567
Satoru Hagiwara, Kazuomi Ueshima, Naoshi Nishida, Hiroshi Ida, Kosuke Minaga, Yasunori Minami, Masahiro Takita, Tomoko Aoki, Masahiro Morita, Hirokazu Chishina, Takuya Matsubara, Naoya Omaru, Noboru Inamura, Masatoshi Kudo
症例は30代男性．幼少期に完全大血管転位III型に対してFontan手術が施行され，近医に定期的に通院していた．20XX年7月腹部USで多発肝腫瘤を指摘され当院紹介受診となった．造影CTにて最大13 cmの多発肝細胞癌と判明した（BCLC stage B）．画像上は門脈圧亢進所見や明らかな肝形態異常を認めなかったが，肝生検でCongestive Hepatic Fibrosis Score 3であり，実際には線維化の進展を認めていた．肝内多発のため外科手術やRFAの適応外であった．また最大径の腫瘍は肝外に突出しており，腹腔内破裂の危険性もあることから，まずTACEを施行した．再発に応じて各種抗癌剤治療を行い，生存中である．画像上は肝線維化を示唆する所見はなかったが，Fontan術後の特殊な循環動態では，肝線維化が進展している可能性があり，本症例を通して肝癌サーベイランスの重要性を再考する．
病例是30多岁的男性。幼年时期对完全大血管转位III型实施了Fontan手术，定期到附近的医生那里看诊。20xx年7月腹部US被指出多发肝肿块，在本院转诊就诊。造影CT发现是最大13cm的多发肝细胞癌(BCLC stage B)。图像上未发现门静脉高压症状或明显肝形态异常，但肝活检显示为Congestive Hepatic Fibrosis Score 3，实际上已证实纤维化进展。因为肝内多发，不适合外科手术和RFA。另外，最大直径的肿瘤向肝外突出，有腹腔破裂的危险，因此首先实施了TACE。根据复发进行各种抗癌剂治疗，维持生存。虽然影像上没有发现提示肝纤维化的迹象，但从Fontan术后特殊的循环动态来看，肝纤维化有进展的可能性，通过本病例再次考虑肝癌巡诊的重要性。
{"title":"Fontan術後に発症した切除不能肝細胞癌の1例","authors":"Satoru Hagiwara, Kazuomi Ueshima, Naoshi Nishida, Hiroshi Ida, Kosuke Minaga, Yasunori Minami, Masahiro Takita, Tomoko Aoki, Masahiro Morita, Hirokazu Chishina, Takuya Matsubara, Naoya Omaru, Noboru Inamura, Masatoshi Kudo","doi":"10.2957/kanzo.64.567","DOIUrl":"https://doi.org/10.2957/kanzo.64.567","url":null,"abstract":"症例は30代男性．幼少期に完全大血管転位III型に対してFontan手術が施行され，近医に定期的に通院していた．20XX年7月腹部USで多発肝腫瘤を指摘され当院紹介受診となった．造影CTにて最大13 cmの多発肝細胞癌と判明した（BCLC stage B）．画像上は門脈圧亢進所見や明らかな肝形態異常を認めなかったが，肝生検でCongestive Hepatic Fibrosis Score 3であり，実際には線維化の進展を認めていた．肝内多発のため外科手術やRFAの適応外であった．また最大径の腫瘍は肝外に突出しており，腹腔内破裂の危険性もあることから，まずTACEを施行した．再発に応じて各種抗癌剤治療を行い，生存中である．画像上は肝線維化を示唆する所見はなかったが，Fontan術後の特殊な循環動態では，肝線維化が進展している可能性があり，本症例を通して肝癌サーベイランスの重要性を再考する．","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135565590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
シンポジウム 研讨会
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.a687
{"title":"シンポジウム","authors":"","doi":"10.2957/kanzo.64.a687","DOIUrl":"https://doi.org/10.2957/kanzo.64.a687","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139314054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ワークショップ 工作坊
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.a765
{"title":"ワークショップ","authors":"","doi":"10.2957/kanzo.64.a765","DOIUrl":"https://doi.org/10.2957/kanzo.64.a765","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139314176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
若手セッション 青年会议
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.a898
{"title":"若手セッション","authors":"","doi":"10.2957/kanzo.64.a898","DOIUrl":"https://doi.org/10.2957/kanzo.64.a898","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"196 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
人名索引 人名索引
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.i3_1
{"title":"人名索引","authors":"","doi":"10.2957/kanzo.64.i3_1","DOIUrl":"https://doi.org/10.2957/kanzo.64.i3_1","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139314184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
一般演題 一般演題
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.a819
{"title":"一般演題","authors":"","doi":"10.2957/kanzo.64.a819","DOIUrl":"https://doi.org/10.2957/kanzo.64.a819","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
プログラム 计划
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.s3_1
{"title":"プログラム","authors":"","doi":"10.2957/kanzo.64.s3_1","DOIUrl":"https://doi.org/10.2957/kanzo.64.s3_1","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139314085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
特別講演 特別講演
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.a675
{"title":"特別講演","authors":"","doi":"10.2957/kanzo.64.a675","DOIUrl":"https://doi.org/10.2957/kanzo.64.a675","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139314030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
特別企画 特别企画
Kanzo
Pub Date : 2023-10-25 DOI: 10.2957/kanzo.64.a793
{"title":"特別企画","authors":"","doi":"10.2957/kanzo.64.a793","DOIUrl":"https://doi.org/10.2957/kanzo.64.a793","url":null,"abstract":"","PeriodicalId":17925,"journal":{"name":"Kanzo","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
类型
全部 化学•材料 生命科学 医学 物理 工程技术 环境•农林 材料科学 地球科学 法学 管理学 化学 环境科学与生态学 计算机科学 教育学 经济学 农林科学 人文科学 生物学 数学 物理与天体物理 心理学 综合性期刊 其他 工业工程 理学 历史学 农学 文学 信息工程
数据库
全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley
期刊
Kanzo
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1