Pub Date : 2023-10-10DOI: 10.3329/kyamcj.v14i02.68533
None Md Faridul Islam Chowdhury
Several treatment options may help improve daily functioning in children with cerebral palsy (CP). However, these treatments cannot prevent early death or enable them to lead independent life without support. CP is a progressive disease, and even in its milder form, conditions such as Parkinson's disease, epilepsy, and stroke may develop even after 25 years. A new era of curable treatment has emerged for CP, utilizing bilateral cranioplasty and duraplasty (Tanfarid Procedure). This case report describes a successful case where this procedure was employed. During the surgery, after the removal of cranial bones through craniotomy, the absence of dural pulsation was observed, indicating elevated intracranial pressure. After duraplasty, normal brain pulsation was observed, indicating that intracranial pressure had normalized. In patients with CP, premature closure of sutures and thickening of skull bones lead to a reduced intracranial volume, which hinders proper brain growth and eventually results in brain atrophy, widened Sylvian issures, and widened sulci accompanied by the loss of brain parenchymal tissue. These findings were also evident in the patient's brain CT scan. In this case, cranioplasty and duraplasty provided adequate space for the brain to grow . The treatment of CP patients typically involves a multidisciplinary approach, which can be expensive. However, the procedure utilized in this case is affordable for economically disadvantaged individuals in this country. While a second cranial surgery may be required in some cases, the expenses associated with it are significantly lower compared to a lifetime of physiotherapy and other supportive treatments. Additionally, the outcomes are very promising.KYAMC Journal Vol. 14, No. 02, July 2023: 105-108.
{"title":"Satisfactory Improvement in Lifestyle of a Spastic Quadriplegic Cerebral Palsy Patient through Cranial Surgery","authors":"None Md Faridul Islam Chowdhury","doi":"10.3329/kyamcj.v14i02.68533","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i02.68533","url":null,"abstract":"Several treatment options may help improve daily functioning in children with cerebral palsy (CP). However, these treatments cannot prevent early death or enable them to lead independent life without support. CP is a progressive disease, and even in its milder form, conditions such as Parkinson's disease, epilepsy, and stroke may develop even after 25 years. A new era of curable treatment has emerged for CP, utilizing bilateral cranioplasty and duraplasty (Tanfarid Procedure). This case report describes a successful case where this procedure was employed. During the surgery, after the removal of cranial bones through craniotomy, the absence of dural pulsation was observed, indicating elevated intracranial pressure. After duraplasty, normal brain pulsation was observed, indicating that intracranial pressure had normalized. In patients with CP, premature closure of sutures and thickening of skull bones lead to a reduced intracranial volume, which hinders proper brain growth and eventually results in brain atrophy, widened Sylvian issures, and widened sulci accompanied by the loss of brain parenchymal tissue. These findings were also evident in the patient's brain CT scan. In this case, cranioplasty and duraplasty provided adequate space for the brain to grow . The treatment of CP patients typically involves a multidisciplinary approach, which can be expensive. However, the procedure utilized in this case is affordable for economically disadvantaged individuals in this country. While a second cranial surgery may be required in some cases, the expenses associated with it are significantly lower compared to a lifetime of physiotherapy and other supportive treatments. Additionally, the outcomes are very promising.KYAMC Journal Vol. 14, No. 02, July 2023: 105-108.","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GCTs (Granular Cell Tumors) are rare, uncommon STTs (Soft Tissue tumors) that may develop at any location in the human body. Though the initial one was identified first as a non-capsulated granular cell myoblastoma of the tongue, they are now identified immunohistochemically as principally of neural Schwann cell origin (S-100 marker positive). Still more rarely, non-neural GCTs are also described that are probably of mesenchymal origin (as evidenced by S-100 marker negativity and vimentin positivity). Though they are more common in females and black people in the third to sixth decades of life, no sex, no race, and no age group are immune to this disease. They are mostly benign and very rarely malignant. Exact history taking, physical examination and laboratory investigations, including histopathological, histochemical, and immunohistochemical examinations, are essential to arrive at a concrete diagnosis, as many other tumors (e.g., malignant melanoma, small cell lung cancer, etc.) in the body resemble GCTs both histologically (granularity) and by biological behavior (benign, malignancy, recurrency at primary and metastatic sites). Benign variants have clinical features depending on location and are universally cured by wide surgical excision. The malignant variant carries a worse prognosis. These rare GCTs are to be kept in mind always in the differential diagnosis of soft tissue swellings anywhere in the body. Their biological and pathological features, differential diagnosis, and therapeutic implications are discussed here, briefly reviewing the available literature.KYAMC Journal Vol. 14, No. 02, July 2023: 96-101.
{"title":"Granular Cell Tumors","authors":"None ABM Moniruddin, None Halima Khatun Doly, None Shakila Jannat, None Tanvirul Hasan, None MA Rouf","doi":"10.3329/kyamcj.v14i02.68561","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i02.68561","url":null,"abstract":"GCTs (Granular Cell Tumors) are rare, uncommon STTs (Soft Tissue tumors) that may develop at any location in the human body. Though the initial one was identified first as a non-capsulated granular cell myoblastoma of the tongue, they are now identified immunohistochemically as principally of neural Schwann cell origin (S-100 marker positive). Still more rarely, non-neural GCTs are also described that are probably of mesenchymal origin (as evidenced by S-100 marker negativity and vimentin positivity). Though they are more common in females and black people in the third to sixth decades of life, no sex, no race, and no age group are immune to this disease. They are mostly benign and very rarely malignant. Exact history taking, physical examination and laboratory investigations, including histopathological, histochemical, and immunohistochemical examinations, are essential to arrive at a concrete diagnosis, as many other tumors (e.g., malignant melanoma, small cell lung cancer, etc.) in the body resemble GCTs both histologically (granularity) and by biological behavior (benign, malignancy, recurrency at primary and metastatic sites). Benign variants have clinical features depending on location and are universally cured by wide surgical excision. The malignant variant carries a worse prognosis. These rare GCTs are to be kept in mind always in the differential diagnosis of soft tissue swellings anywhere in the body. Their biological and pathological features, differential diagnosis, and therapeutic implications are discussed here, briefly reviewing the available literature.KYAMC Journal Vol. 14, No. 02, July 2023: 96-101.","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"65 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.3329/kyamcj.v14i02.64266
Razina Jubada, None Khaleda Parvin Rekha, None Md Mofazzal Sharif, None S M Aftab-E-Alam
Pulmonary atresia with ventricular septal defect is a severe form of congenital cyanotic heart disease (TOF) but its not very common form. Here main pulmonary does not arises from common arterial trunk. In pulmonary atresia there is no proper formation ofthe pulmonary valve which allows blood from the heart to thelung of patient. Instead of opening and closing of the valve,a solid sheet of tissue develops. Therefore blood cannot flow by its normal path to take oxygen from the lung. Instead, inadequate blood travels to the lung through other natural routes within the heart and its arteries and presenting degree of pulmonary atresia or discontinuity in arteries. MDCT gave structural details in this regard. So, role of MDCT play an important role to evaluate the details important information needed in preoperative evaluation for surgical policy in atretic patients. Here we discuss a case of pulmonary atresia (PA) with anomalous origin of the pulmonary artery.KYAMC Journal Vol. 14, No. 02, July 2023: 102-104.
{"title":"Pulmonary Atresia (PA) with Anomalous Origin of the Pulmonary Artery","authors":"Razina Jubada, None Khaleda Parvin Rekha, None Md Mofazzal Sharif, None S M Aftab-E-Alam","doi":"10.3329/kyamcj.v14i02.64266","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i02.64266","url":null,"abstract":"Pulmonary atresia with ventricular septal defect is a severe form of congenital cyanotic heart disease (TOF) but its not very common form. Here main pulmonary does not arises from common arterial trunk. In pulmonary atresia there is no proper formation ofthe pulmonary valve which allows blood from the heart to thelung of patient. Instead of opening and closing of the valve,a solid sheet of tissue develops. Therefore blood cannot flow by its normal path to take oxygen from the lung. Instead, inadequate blood travels to the lung through other natural routes within the heart and its arteries and presenting degree of pulmonary atresia or discontinuity in arteries. MDCT gave structural details in this regard. So, role of MDCT play an important role to evaluate the details important information needed in preoperative evaluation for surgical policy in atretic patients. Here we discuss a case of pulmonary atresia (PA) with anomalous origin of the pulmonary artery.KYAMC Journal Vol. 14, No. 02, July 2023: 102-104.","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.3329/kyamcj.v14i02.68523
A B M Moniruddin
Abstract not available KYAMC Journal Vol. 14, No. 02, July 2023: 62-63.
《中华医学杂志》第14卷第02期，2023年7月:62-63。
{"title":"Alarming Trends of Dengue in 2023","authors":"A B M Moniruddin","doi":"10.3329/kyamcj.v14i02.68523","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i02.68523","url":null,"abstract":"Abstract not available KYAMC Journal Vol. 14, No. 02, July 2023: 62-63.","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Lateral pinch strength is a commonly employed indices of strength used in hand evaluations. For all handicrafts professionals, grip and pinch strength is an important criterion to be successful in their profession. The bead embroiderers are one of the major handicrafts worker groups of Bangladesh. Objectives: The study was planned to compare and correlate hand span and lateral pinch strength of the hand in bead embroiderers to establish baseline data of our own for further studies. Materials and Methods: There was a cross-sectional and analytical study conducted on 150 bead embroiderers in group B and 50 sedentary workers in group A, carried out in the Department of Anatomy, Dhaka Medical College, Dhaka between July 2016 and July 2017. The lateral pinch was measured by using a Pinch Gauge Dynamometer. The hand span was taken by using a ruler and unpaired student’s t-test and Pearson’s correlation coefficient were done to compare and correlate.Results: Lateral pinch strength showed a significant positive correlation with hand span in group B (r = +0.234, P<0.01) and non-significant positive correlation with hand span in group A (r = +0.275, P=0.053).Conclusion: The study findings may contribute significantly to current knowledge for designing machines and handheld devices.KYAMC Journal Vol. 14, No. 02, July 2023: 92-95.
{"title":"Correlation of Lateral Pinch Strength with Hand Span in Bead Embroiderers","authors":"None Irin Parven, None Satabdi Ghosh, None Segupta Kiswara, None Rehana Parveen, None Zeenatul Momena","doi":"10.3329/kyamcj.v14i02.68707","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i02.68707","url":null,"abstract":"Background: Lateral pinch strength is a commonly employed indices of strength used in hand evaluations. For all handicrafts professionals, grip and pinch strength is an important criterion to be successful in their profession. The bead embroiderers are one of the major handicrafts worker groups of Bangladesh. Objectives: The study was planned to compare and correlate hand span and lateral pinch strength of the hand in bead embroiderers to establish baseline data of our own for further studies. Materials and Methods: There was a cross-sectional and analytical study conducted on 150 bead embroiderers in group B and 50 sedentary workers in group A, carried out in the Department of Anatomy, Dhaka Medical College, Dhaka between July 2016 and July 2017. The lateral pinch was measured by using a Pinch Gauge Dynamometer. The hand span was taken by using a ruler and unpaired student’s t-test and Pearson’s correlation coefficient were done to compare and correlate.Results: Lateral pinch strength showed a significant positive correlation with hand span in group B (r = +0.234, P<0.01) and non-significant positive correlation with hand span in group A (r = +0.275, P=0.053).Conclusion: The study findings may contribute significantly to current knowledge for designing machines and handheld devices.KYAMC Journal Vol. 14, No. 02, July 2023: 92-95.","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-16DOI: 10.3329/kyamcj.v14i01.67510
Mohammed Mejbahuddin Mia, Muhammad Shahidul Islam, Rubaiyat Farzana Hussain, Samia Hoque
Background: Immune-mediated haemolytic disease of the newborn refers to a specific category of haemolytic anaemia that results from transplacental passage of IgG antibodies from a pre-sensitized mother to her fetus in utero. This occurs due to blood group incompatibility between the mother and the fetus. The clinical presentation covers a wide spectrum spanning from still births and erythroblastosis fetalis as well as infants born with only mild haemolysis to those having severe anaemia snd severe indirect hyperbilirubinaemia followed by hydrops.Objective: We describe the journey of a Rh-D negative mother who endured through six pregnancies in order to have a healthy baby.Conclusion: To highlight the importance of blood grouping and Rh typing during the first antenatal visit and subsequent monitoring of antibody titers, especially in a mother who is Rh-D negative. KYAMC Journal Vol. 14, No. 01, April 2023: 54-56
{"title":"Haemolytic Disease of the Newborn","authors":"Mohammed Mejbahuddin Mia, Muhammad Shahidul Islam, Rubaiyat Farzana Hussain, Samia Hoque","doi":"10.3329/kyamcj.v14i01.67510","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i01.67510","url":null,"abstract":"Background: Immune-mediated haemolytic disease of the newborn refers to a specific category of haemolytic anaemia that results from transplacental passage of IgG antibodies from a pre-sensitized mother to her fetus in utero. This occurs due to blood group incompatibility between the mother and the fetus. The clinical presentation covers a wide spectrum spanning from still births and erythroblastosis fetalis as well as infants born with only mild haemolysis to those having severe anaemia snd severe indirect hyperbilirubinaemia followed by hydrops.Objective: We describe the journey of a Rh-D negative mother who endured through six pregnancies in order to have a healthy baby.Conclusion: To highlight the importance of blood grouping and Rh typing during the first antenatal visit and subsequent monitoring of antibody titers, especially in a mother who is Rh-D negative.\u0000KYAMC Journal Vol. 14, No. 01, April 2023: 54-56","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80973972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-16DOI: 10.3329/kyamcj.v14i01.64559
Halima Khatun Doly, Shakila Jannat, Sayeed Bin Sharif, Syeda Noorjahan Karim, Md Atiqur Rahman, ASM Akramul Islam
A 34-years-old married middle-class housewife without diabetes, hypertension or betel-nut- chewing hailing from Manikganj, Dhaka; came with the outside diagnosis as neuroendocrine tumor of the gallbladder to the Oncology Department of Khwaja Yunus Ali Medical College and Hospital (KYAMCH). She was admitted in the hospital with complaints of upper abdominal pain, abdominal bloating, weakness, anorexia, nausea and heartburn while taking fatty food. According to her Ultrasonography (USG) of the abdomen, a soft tissue mass was found in the gallbladder with unremarkable routine blood examination including tumor markers. She underwent open cholecystectomy with the suspicion of cancer. Grossly, gallbladder was measures 7.0x 5.0 cm with 0.3 cm wall thickness and on opening a polypoid nodule is found. Before treatment on request from the Oncology Department of KYAMCH, all slides were reviewed and a histopathological diagnosis of paraganglioma was made on the basis of organoid, nested or lobules (Zellballen pattern) of tumor cells in the lamina propria surrounded by a prominent fibrovascular stroma. Atypical mitoses, tumor necrosis, lymphovascular or perineural invasion was not found. The IHC reveals diffuse and strong positive reactions to NSE and CD56 for chief cells and strong positive reaction to S-100 protein for sustentacular cells. The epithelial tumor was ruled out by CK negative reaction. Therefore, the diagnosis of paraganglioma of the gallbladder was established. Because of the positive reaction to sustentacular cells, the neuroendocrine tumor has been excluded. To our knowledge, this type of case has not been reported in our country. On clinical follow-up the patient was found healthy. KYAMC Journal Vol. 14, No. 01, April 2023: 57-61
{"title":"Gallbladder Paraganglioma- A Rare Case Report","authors":"Halima Khatun Doly, Shakila Jannat, Sayeed Bin Sharif, Syeda Noorjahan Karim, Md Atiqur Rahman, ASM Akramul Islam","doi":"10.3329/kyamcj.v14i01.64559","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i01.64559","url":null,"abstract":"A 34-years-old married middle-class housewife without diabetes, hypertension or betel-nut- chewing hailing from Manikganj, Dhaka; came with the outside diagnosis as neuroendocrine tumor of the gallbladder to the Oncology Department of Khwaja Yunus Ali Medical College and Hospital (KYAMCH). She was admitted in the hospital with complaints of upper abdominal pain, abdominal bloating, weakness, anorexia, nausea and heartburn while taking fatty food. According to her Ultrasonography (USG) of the abdomen, a soft tissue mass was found in the gallbladder with unremarkable routine blood examination including tumor markers. She underwent open cholecystectomy with the suspicion of cancer. Grossly, gallbladder was measures 7.0x 5.0 cm with 0.3 cm wall thickness and on opening a polypoid nodule is found. Before treatment on request from the Oncology Department of KYAMCH, all slides were reviewed and a histopathological diagnosis of paraganglioma was made on the basis of organoid, nested or lobules (Zellballen pattern) of tumor cells in the lamina propria surrounded by a prominent fibrovascular stroma. Atypical mitoses, tumor necrosis, lymphovascular or perineural invasion was not found. The IHC reveals diffuse and strong positive reactions to NSE and CD56 for chief cells and strong positive reaction to S-100 protein for sustentacular cells. The epithelial tumor was ruled out by CK negative reaction. Therefore, the diagnosis of paraganglioma of the gallbladder was established. Because of the positive reaction to sustentacular cells, the neuroendocrine tumor has been excluded. To our knowledge, this type of case has not been reported in our country. On clinical follow-up the patient was found healthy.\u0000KYAMC Journal Vol. 14, No. 01, April 2023: 57-61","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74463264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Febrile neutropenia (FN) is a serious event in children with cancer; associated with various complications and mentionable adverse outcome.Objective: To identify the outcome of febrile neutropenia in children with cancer.Materials and methods: This prospective observational study was conducted from October 2017 to November 2018 in the Department of Pediatric Hematology and Oncology, BSMMU. Children (age<18years) with malignancy who were admitted with febrile neutropenia or admitted patients who had developed febrile neutropenia onward were enrolled in this study. Finally, the outcome of each episode of FN was analyzed.Results: Total of 61 patients with 68 febrile neutropenic episodes were studied. Male patients were 62.29% and female patients were 37.70% with a mean age of 7 years. Majority were ALL (50.8%) followed by AML (29.5%), NHL (11.4 %) and solid tumor (8.1%). Bacterial infection was confirmed by culture in 14.7% episodes, 11.7% episodes had positive blood culture. Most of the isolated organisms were gram-negative (90%). Cough (39.7%), bleeding (19%) and diarrhea (17.64%) were the common clinical manifestations in those febrile neutropenic episodes. The mean duration of neutropenia was 9 days, 55.88% of episodes had prolonged neutropenia. Profound neutropenia was recorded in 47 % episodes and significantly associated with adverse outcome. Age ≥10 years also significantly associated with adverse outcome. The treatment success rate was achieved in76.4 % of episodes. A composite adverse event was observed in 23.52% of episodes; with mortality in 11.76%.Conclusion: Febrile neutropenia was a common complication in hematological malignancy. Although 76.4% episodes of febrile neutropenia had been treated successfully, mortality was significantly higher 11.76%. Profound neutropenia and age ≥10 were significant risk factors for dreadful outcome. KYAMC Journal Vol. 14, No. 01, April 2023: 07-10
{"title":"Outcome of Febrile Neutropenia in Children with Cancer: Experience from a Tertiary Health Care Center","authors":"Md Imrul Kaes, Afiqul Islam, Chowdhury Yakub Jamal, Mousumi Saha, Indira Chowdhury","doi":"10.3329/kyamcj.v14i01.65304","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i01.65304","url":null,"abstract":"Background: Febrile neutropenia (FN) is a serious event in children with cancer; associated with various complications and mentionable adverse outcome.Objective: To identify the outcome of febrile neutropenia in children with cancer.Materials and methods: This prospective observational study was conducted from October 2017 to November 2018 in the Department of Pediatric Hematology and Oncology, BSMMU. Children (age<18years) with malignancy who were admitted with febrile neutropenia or admitted patients who had developed febrile neutropenia onward were enrolled in this study. Finally, the outcome of each episode of FN was analyzed.Results: Total of 61 patients with 68 febrile neutropenic episodes were studied. Male patients were 62.29% and female patients were 37.70% with a mean age of 7 years. Majority were ALL (50.8%) followed by AML (29.5%), NHL (11.4 %) and solid tumor (8.1%). Bacterial infection was confirmed by culture in 14.7% episodes, 11.7% episodes had positive blood culture. Most of the isolated organisms were gram-negative (90%). Cough (39.7%), bleeding (19%) and diarrhea (17.64%) were the common clinical manifestations in those febrile neutropenic episodes. The mean duration of neutropenia was 9 days, 55.88% of episodes had prolonged neutropenia. Profound neutropenia was recorded in 47 % episodes and significantly associated with adverse outcome. Age ≥10 years also significantly associated with adverse outcome. The treatment success rate was achieved in76.4 % of episodes. A composite adverse event was observed in 23.52% of episodes; with mortality in 11.76%.Conclusion: Febrile neutropenia was a common complication in hematological malignancy. Although 76.4% episodes of febrile neutropenia had been treated successfully, mortality was significantly higher 11.76%. Profound neutropenia and age ≥10 were significant risk factors for dreadful outcome.\u0000KYAMC Journal Vol. 14, No. 01, April 2023: 07-10","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79110444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-16DOI: 10.3329/kyamcj.v14i01.45711
A. Moniruddin
Abstract not availableKYAMC Journal Vol. 14, No. 01, April 2023: 01-03
《中华医学杂志》第14卷第01期，2023年4月:01-03
{"title":"Human Health Benefits From Probiotics","authors":"A. Moniruddin","doi":"10.3329/kyamcj.v14i01.45711","DOIUrl":"https://doi.org/10.3329/kyamcj.v14i01.45711","url":null,"abstract":"Abstract not availableKYAMC Journal Vol. 14, No. 01, April 2023: 01-03","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72786899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-16DOI: 10.3329/kyamcj.v14i01.65136
Most Nasrin Nigger, Sheuly Akhter, Ummul Nusrat Jahan, Aeysha Begum
Background: In women of reproductive age, polycystic ovarian syndrome (PCOS) is a prevalent endocrine condition. Menstrual irregularities (oligomenorrhea or amenorrhea), hirsutism, persistent acne, androgen-dependent alopecia, abdominal obesity, hypertension, and infertility are all clinical signs of PCOS.Objective: To assess the success of pregnancy in patients with polycystic ovary syndrome.Materials and Methods: This observational cross-sectional study was carried out in the Department of Obstetrics and Gynaecology at Khwaja Yunus Ali Medical College and Hospital, Enayetpur, Sirajganj, Bangladesh from June 2020 to May 2022 for a period of two years. Women diagnosed with PCOS were willing to participate in our study were recruited from obstetrics Out patient Department (OPD) and antenatal ward of Department of Obstetrics and Gynaecology at Khwaja Yunus Ali Medical College and Hospital. After obtaining an informed consent from them, a detailed interview schedule containing socio- demographic details, menstrual/marital/ obstetric/past/personal/ family history was taken.Results: Concerning complications Preeclampsia was found in 5 (9.1%) of the PCOS patients but not in the non-PCOS patients. The differences in gestational age and mode of birth between the two groups were not statistically significant (p>0.05). Perinatal outcome: 21 (39.6%) PCOS patients were admitted to the Neonatal Intensive Care Unit (NICU), compared to 11 (20.0%) non-PCOS patients. Which of the two groups was statistically significant (p<0.05).Conclusion: The present study suggested that preeclampsia is a relatively common condition, and complications such gestational hyperglycemia, gestational hypertension, and preeclampsia were frequent in the PCOS group. In comparison to the non-PCOS group, the PCOS group had considerably greater rates of low birth weight and NICU admission. KYAMC Journal Vol. 14, No. 01, April 2023: 30-34
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