{"title":"Kommentar zu „Hörerhalt nach Cochlea-Implantat-Operation mit Hilfe von KI prognostizieren“.","authors":"","doi":"10.1055/a-2299-1723","DOIUrl":"https://doi.org/10.1055/a-2299-1723","url":null,"abstract":"","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eingriffe an Larynx, Hypopharynx und Trachea.","authors":"J A Werner, J P Windfuhr","doi":"10.1055/a-2304-9134","DOIUrl":"https://doi.org/10.1055/a-2304-9134","url":null,"abstract":"","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-03-12DOI: 10.1055/a-2249-4201
Yen-Tran Ly, Franca Arndt, Alessa L Boschert, Bruno Pavletić, Florian Webner, Andreas Kohl, Henrik Grübbel, Julian Soltau, Iman Talai, Mohamed Diaoulé Diallo, Andreas Westhoff, Andreas Schreiber, Tobias Hecking, Frank Duschek, Karin Grünewald, Frank Meller, Jörn Biedermann, Frank Rinderknecht, Werner Kraft, Daniel Schmeling, Jens Jordan, Ralf Moeller
Aviation is among the social sectors most impacted by the COVID-19 pandemic, and at the same time has contributed to the rapid global spread of the SARS-CoV-2 virus. SARS-CoV-2 is one of the coronaviruses that have led to outbreaks such as MERS-CoV in the past. This group of pathogens, as well as others that may be unknown at this time, will continue to challenge our society in the future. In order to be able to react better, a research training group was established at DLR in cooperation with 6 institutes, which will develop interdisciplinary approaches to researching and combating current and future pandemics. Engineers, physicists, software developers, biologists and physicians are working closely together on new concepts and the development of interdisciplinary knowledge in order to better control and contain future pandemics and to be able to react in a more targeted manner. One focus is the reduction of germ contamination in airplanes but also in other means of public transport such as buses and trains. In this review, we provide an overview of the baseline situation and possible approaches to address future pandemic challenges.
{"title":"[After the pandemic is before the pandemic: And how interdisciplinary research can help here].","authors":"Yen-Tran Ly, Franca Arndt, Alessa L Boschert, Bruno Pavletić, Florian Webner, Andreas Kohl, Henrik Grübbel, Julian Soltau, Iman Talai, Mohamed Diaoulé Diallo, Andreas Westhoff, Andreas Schreiber, Tobias Hecking, Frank Duschek, Karin Grünewald, Frank Meller, Jörn Biedermann, Frank Rinderknecht, Werner Kraft, Daniel Schmeling, Jens Jordan, Ralf Moeller","doi":"10.1055/a-2249-4201","DOIUrl":"10.1055/a-2249-4201","url":null,"abstract":"<p><p>Aviation is among the social sectors most impacted by the COVID-19 pandemic, and at the same time has contributed to the rapid global spread of the SARS-CoV-2 virus. SARS-CoV-2 is one of the coronaviruses that have led to outbreaks such as MERS-CoV in the past. This group of pathogens, as well as others that may be unknown at this time, will continue to challenge our society in the future. In order to be able to react better, a research training group was established at DLR in cooperation with 6 institutes, which will develop interdisciplinary approaches to researching and combating current and future pandemics. Engineers, physicists, software developers, biologists and physicians are working closely together on new concepts and the development of interdisciplinary knowledge in order to better control and contain future pandemics and to be able to react in a more targeted manner. One focus is the reduction of germ contamination in airplanes but also in other means of public transport such as buses and trains. In this review, we provide an overview of the baseline situation and possible approaches to address future pandemic challenges.</p>","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-06-20DOI: 10.1055/a-2251-0620
Veronika Innerhofer, Timo Gottfried, Helen Heppt, Verena Strasser, Charles Schmit, Benedikt Hofauer Mhba, Daniel Dejaco
{"title":"[Ultrasound - part 2: closer look at sonography of the thyroid gland].","authors":"Veronika Innerhofer, Timo Gottfried, Helen Heppt, Verena Strasser, Charles Schmit, Benedikt Hofauer Mhba, Daniel Dejaco","doi":"10.1055/a-2251-0620","DOIUrl":"10.1055/a-2251-0620","url":null,"abstract":"","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas Dietz, Markus Pirlich, Matthäus Stöhr, Veit Zebralla, Susanne Wiegand
In general, a trend towards transoral resection (as opposed to classic open approaches) + neck dissection + adjuvant radio- (chemo-) therapy has been observed for oropharyngeal carcinoma over the last 20 years. Techniques of transoral surgery (TOS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS) have been propagated in retrospective comparisons with conventional surgery or primary radiochemotherapy as gentle, minimally invasive procedures with good late functional results. Meta-analyses of mostly uncontrolled retrospective analyses suggest that TORS may have better disease-free survival (DFS) and a reduced risk of free flap reconstruction compared with open surgery. TORS (TOS) was associated with fewer tumor-positive resection margins (R1), a lower number of recurrences, fewer intraoperative tracheostomies, a shorter inpatient stay and a shorter duration of postoperative nasal tube feeding compared to open surgery. In principle, based on the best evidence currently available from registry studies, stage I-II oropharyngeal carcinomas can be treated either with primary surgery or radiochemotherapy with a comparable chance of survival. With comparable evidence for stage III and IVa, p16neg. oropharyngeal carcinomas, the majority of authors advocate primary surgery followed by adjuvant radiotherapy or radiochemotherapy as the treatment of first choice. For p16pos. patients the results of registry studies are inconsistent, although the largest registry study on 450 HPV-positive stage III patients shows a significant superiority of primary surgery + adjuvant radiochemotherapy. Since all registry studies did not adjust for smoking status, among other factors, the current data situation should be evaluated with the necessary caution.
总体而言，在过去的 20 年中，口咽癌的治疗趋势是经口切除术（而不是传统的开放式方法）+ 颈部切除术+ 放射（化疗）辅助治疗。经口手术（TOS）技术，包括经口激光显微手术（TLM）和经口机器人手术（TORS），已在与传统手术或原发性放化疗的回顾性比较中得到推广，它们是温和的微创手术，具有良好的后期功能效果。对大部分无对照回顾性分析进行的 Meta 分析表明，与开放手术相比，TORS 的无病生存率（DFS）可能更高，游离皮瓣重建的风险也更低。与开放手术相比，TORS（TOS）与较少的肿瘤阳性切除边缘（R1）、较少的复发次数、较少的术中气管造口、较短的住院时间和较短的术后鼻饲管喂养时间相关。原则上，根据目前登记研究中获得的最佳证据，I-II期口咽癌可采用原发手术或放射化学治疗，且生存几率相当。对于 III 期和 IVa 期的 p16 阴性口咽癌，大多数作者主张首选原发手术，然后辅以放疗或放射化疗。对于 p16 阴性患者，登记研究的结果并不一致，不过对 450 名 HPV 阳性 III 期患者进行的最大登记研究显示，初次手术+辅助放化疗的疗效显著。由于所有登记研究都没有对吸烟状况等因素进行调整，因此在评估目前的数据情况时应保持必要的谨慎。
{"title":"[Surgical Treatment of Oropharyngeal Cancer - Recommendations of the Current German S3 Guideline, Part I].","authors":"Andreas Dietz, Markus Pirlich, Matthäus Stöhr, Veit Zebralla, Susanne Wiegand","doi":"10.1055/a-2223-4083","DOIUrl":"https://doi.org/10.1055/a-2223-4083","url":null,"abstract":"<p><p>In general, a trend towards transoral resection (as opposed to classic open approaches) + neck dissection + adjuvant radio- (chemo-) therapy has been observed for oropharyngeal carcinoma over the last 20 years. Techniques of transoral surgery (TOS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS) have been propagated in retrospective comparisons with conventional surgery or primary radiochemotherapy as gentle, minimally invasive procedures with good late functional results. Meta-analyses of mostly uncontrolled retrospective analyses suggest that TORS may have better disease-free survival (DFS) and a reduced risk of free flap reconstruction compared with open surgery. TORS (TOS) was associated with fewer tumor-positive resection margins (R1), a lower number of recurrences, fewer intraoperative tracheostomies, a shorter inpatient stay and a shorter duration of postoperative nasal tube feeding compared to open surgery. In principle, based on the best evidence currently available from registry studies, stage I-II oropharyngeal carcinomas can be treated either with primary surgery or radiochemotherapy with a comparable chance of survival. With comparable evidence for stage III and IVa, p16neg. oropharyngeal carcinomas, the majority of authors advocate primary surgery followed by adjuvant radiotherapy or radiochemotherapy as the treatment of first choice. For p16pos. patients the results of registry studies are inconsistent, although the largest registry study on 450 HPV-positive stage III patients shows a significant superiority of primary surgery + adjuvant radiochemotherapy. Since all registry studies did not adjust for smoking status, among other factors, the current data situation should be evaluated with the necessary caution.</p>","PeriodicalId":17965,"journal":{"name":"Laryngo-rhino-otologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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