The Lancet最新文献

{"title":"A just transition for antimicrobial resistance: planning for an equitable and sustainable future with antimicrobial resistance.","authors":"","doi":"10.1016/S0140-6736(23)01687-2","DOIUrl":"10.1016/S0140-6736(23)01687-2","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"2766-2767"},"PeriodicalIF":98.4,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10215489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of engaging patients and families for patient safety.","authors":"Jane K O'Hara, Carolyn Canfield","doi":"10.1016/S0140-6736(23)01908-6","DOIUrl":"10.1016/S0140-6736(23)01908-6","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"791-793"},"PeriodicalIF":98.4,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10361533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards an equitable people-centred health system for Spain.","authors":"Helena Legido-Quigley, Itxaso Berrojalbiz, Manuel Franco, Montserrat Gea-Sánchez, Sara Jaurrieta, Muriel Larrea, Sergio Minue, Javier Padilla, Jose Maria Valderas, Tomas Zapata","doi":"10.1016/S0140-6736(23)01858-5","DOIUrl":"10.1016/S0140-6736(23)01858-5","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"335-337"},"PeriodicalIF":98.4,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10557457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transferable exclusivity voucher: a flawed incentive to stimulate antibiotic innovation.","authors":"Christine Årdal, Enrico Baraldi, Reinhard Busse, Rosa Castro, Francesco Ciabuschi, José Miguel Cisneros, Inge C Gyssens, Stephan Harbarth, Tomislav Kostyanev, Yohann Lacotte, Nicola Magrini, Anthony McDonnell, Annelie A Monnier, Suerie Moon, Elias Mossialos, Germán Peñalva, Marie-Cécile Ploy, Momir Radulović, Adrián Alonso Ruiz, John-Arne Røttingen, Michael Sharland, Evelina Tacconelli, Ursula Theuretzbacher, Sabine Vogler, Ute Wolff Sönksen, Kerstin Åkerfeldt, Otto Cars, Jim O'Neill","doi":"10.1016/S0140-6736(23)00282-9","DOIUrl":"10.1016/S0140-6736(23)00282-9","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"e2-e4"},"PeriodicalIF":98.4,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10685290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging fentanyl-xylazine syndemic in the USA: challenges and future directions.","authors":"David T Zhu, Joseph Friedman, Philippe Bourgois, Fernando Montero, Suzanne Tamang","doi":"10.1016/S0140-6736(23)01686-0","DOIUrl":"10.1016/S0140-6736(23)01686-0","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"1949-1952"},"PeriodicalIF":168.9,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10439141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El Niño and health in an era of unprecedented climate change.","authors":"Andy Haines, Holly C Y Lam","doi":"10.1016/S0140-6736(23)01664-1","DOIUrl":"10.1016/S0140-6736(23)01664-1","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"1811-1813"},"PeriodicalIF":168.9,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health can contribute to peace in the Eastern Mediterranean Region-what should be done to make it happen?","authors":"Wasiq Khan, Mohamed Jama, Arturo Pesigan, Akihiro Seita, Maha El-Adawy, Richard Brennan, Sania Nishtar","doi":"10.1016/S0140-6736(23)01795-6","DOIUrl":"10.1016/S0140-6736(23)01795-6","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"1601-1603"},"PeriodicalIF":168.9,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10188706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming women's, children's, and adolescents' health and wellbeing through primary health care.","authors":"","doi":"10.1016/S0140-6736(23)01909-8","DOIUrl":"10.1016/S0140-6736(23)01909-8","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"1606-1608"},"PeriodicalIF":168.9,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lancet Commission on peaceful societies through health equity and gender equality.","authors":"Valerie Percival, Oskar T Thoms, Ben Oppenheim, Dane Rowlands, Carolyn Chisadza, Sara Fewer, Gavin Yamey, Amy C Alexander, Chloe L Allaham, Sara Causevic, François Daudelin, Siri Gloppen, Debarati Guha-Sapir, Maseh Hadaf, Samuel Henderson, Steven J Hoffman, Ana Langer, Toni Joe Lebbos, Luiz Leomil, Minna Lyytikäinen, Anju Malhotra, Paul Mkandawire, Holly A Norris, Ole Petter Ottersen, Jason Phillips, Sigrún Rawet, Alexa Salikova, Idil Shekh Mohamed, Ghazal Zazai, Tarja Halonen, Catherine Kyobutungi, Zulfiqar A Bhutta, Peter Friberg","doi":"10.1016/S0140-6736(23)01348-X","DOIUrl":"10.1016/S0140-6736(23)01348-X","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"1661-1722"},"PeriodicalIF":168.9,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10188702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial.","authors":"David Conen, Michael Ke Wang, Ekaterine Popova, Matthew T V Chan, Giovanni Landoni, Juan P Cata, Cara Reimer, Sean R McLean, Sadeesh K Srinathan, Juan Carlos Trujillo Reyes, Ascension Martín Grande, Anna Gonzalez Tallada, Daniel I Sessler, Edith Fleischmann, Barbara Kabon, Luca Voltolini, Patrícia Cruz, Donna E Maziak, Laura Gutiérrez-Soriano, William F McIntyre, Vikas Tandon, Elisabeth Martínez-Téllez, Juan Jose Guerra-Londono, Deborah DuMerton, Randolph H L Wong, Anna L McGuire, Biniam Kidane, Diego Parise Roux, Yaron Shargall, Jennifer R Wells, Sandra N Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, John W Eikelboom, Sanjit S Jolly, Jeff S Healey, P J Devereaux","doi":"10.1016/S0140-6736(23)01689-6","DOIUrl":"10.1016/S0140-6736(23)01689-6","url":null,"abstract":"<p><strong>Background: </strong>Higher levels of inflammatory biomarkers are associated with an increased risk of perioperative atrial fibrillation and myocardial injury after non-cardiac surgery (MINS). Colchicine is an anti-inflammatory drug that might reduce the incidence of these complications.</p><p><strong>Methods: </strong>COP-AF was a randomised trial conducted at 45 sites in 11 countries. Patients aged 55 years or older and undergoing major non-cardiac thoracic surgery were randomly assigned (1:1) to receive oral colchicine 0·5 mg twice daily or matching placebo, starting within 4 h before surgery and continuing for 10 days. Randomisation was done with use of a computerised, web-based system, and was stratified by centre. Health-care providers, patients, data collectors, and adjudicators were masked to treatment assignment. The coprimary outcomes were clinically important perioperative atrial fibrillation and MINS during 14 days of follow-up. The main safety outcomes were a composite of sepsis or infection, and non-infectious diarrhoea. The intention-to-treat principle was used for all analyses. This trial is registered with ClinicalTrials.gov, NCT03310125.</p><p><strong>Findings: </strong>Between Feb 14, 2018, and June 27, 2023, we enrolled 3209 patients (mean age 68 years [SD 7], 1656 [51·6%] male). Clinically important atrial fibrillation occurred in 103 (6·4%) of 1608 patients assigned to colchicine, and 120 (7·5%) of 1601 patients assigned to placebo (hazard ratio [HR] 0·85, 95% CI 0·65 to 1·10; absolute risk reduction [ARR] 1·1%, 95% CI -0·7 to 2·8; p=0·22). MINS occurred in 295 (18·3%) patients assigned to colchicine and 325 (20·3%) patients assigned to placebo (HR 0·89, 0·76 to 1·05; ARR 2·0%, -0·8 to 4·7; p=0·16). The composite outcome of sepsis or infection occurred in 103 (6·4%) patients in the colchicine group and 83 (5·2%) patients in the placebo group (HR 1·24, 0·93-1·66). Non-infectious diarrhoea was more common in the colchicine group (134 [8·3%] events) than the placebo group (38 [2·4%]; HR 3·64, 2·54-5·22).</p><p><strong>Interpretation: </strong>In patients undergoing major non-cardiac thoracic surgery, administration of colchicine did not significantly reduce the incidence of clinically important atrial fibrillation or MINS but increased the risk of mostly benign non-infectious diarrhoea.</p><p><strong>Funding: </strong>Canadian Institutes of Health Research, Accelerating Clinical Trials Consortium, Innovation Fund of the Alternative Funding Plan for the Academic Health Sciences Centres of Ontario, Population Health Research Institute, Hamilton Health Sciences, Division of Cardiology at McMaster University, Canada; Hanela Foundation, Switzerland; and General Research Fund, Research Grants Council, Hong Kong.</p>","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"1627-1635"},"PeriodicalIF":168.9,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10166081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}