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A SINGLE CELL ATLAS OF T CELL LYMPHOMA REVEALS INSIGHTS INTO DISEASE PATHOGENESIS t细胞淋巴瘤的单细胞图谱揭示了疾病发病机制的见解
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 DOI: 10.1016/j.leukres.2025.107942
Ruoyan Li, Jamie D. Matthews, Emily R. James, Carla Vázquez Amos, Christopher Steel, Shuang Li, Olli Duvfa, Egor Volchkcov, Myrisini Tzioni, Chenqu Suo, Ekaterina Shelomentseva, Lorenz Kretschmer, Dmitry Abramov, Philip Turton, Ruth F. Jarrett, Michaela Schlederer, Lukas Kenner, G. A. Amos Burke, Ming-Qing Du, Sarah Teichmann, Suzanne D. Turner
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引用次数: 0
SINGLE INSTITUTION TREATMENT RESULTS FOR PEDIATRIC ANAPLASTIC LYMPHOMA KINASE (ALK)-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA (ALCL) BETWEEN 2000 AND 2023 2000年至2023年儿童间变性淋巴瘤激酶（alk）阳性间变性大细胞淋巴瘤（alcl）的单机构治疗结果
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 DOI: 10.1016/j.leukres.2025.108027
Ifenna Amaefuna, Gabriela Gheorghe, Ruth Wang’ondu, Guangjin Luo, Alexa Rodriguez, Yiwang Zhou, Hiroto Inaba, Raul C. Ribeiro, Stephanie B. Dixon, Mathew J. Ehrhardt
{"title":"SINGLE INSTITUTION TREATMENT RESULTS FOR PEDIATRIC ANAPLASTIC LYMPHOMA KINASE (ALK)-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA (ALCL) BETWEEN 2000 AND 2023","authors":"Ifenna Amaefuna, Gabriela Gheorghe, Ruth Wang’ondu, Guangjin Luo, Alexa Rodriguez, Yiwang Zhou, Hiroto Inaba, Raul C. Ribeiro, Stephanie B. Dixon, Mathew J. Ehrhardt","doi":"10.1016/j.leukres.2025.108027","DOIUrl":"10.1016/j.leukres.2025.108027","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UTILIZING TARGETED IMMUNOTHERAPY TO REDUCE ONCOLOGIC CHEMORADIOTHERAPY IN CAYA WITH ADVANCED MB-NHL 利用靶向免疫治疗减少晚期mb-nhl患者的肿瘤放化疗
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 DOI: 10.1016/j.leukres.2025.107956
Anthony Audino, Kayleigh Clark, Aliza Gardenswartz, Jessica Hochberg, Jaclyn Basso, Ana C. Xavier, Rodney R. Miles, Stephan D. Voss, Samir Kahwash, Suzanne Braniecki, Megan Lim, Lauren Harrison, Stanton Goldman, Mitchell S. Cairo
{"title":"UTILIZING TARGETED IMMUNOTHERAPY TO REDUCE ONCOLOGIC CHEMORADIOTHERAPY IN CAYA WITH ADVANCED MB-NHL","authors":"Anthony Audino, Kayleigh Clark, Aliza Gardenswartz, Jessica Hochberg, Jaclyn Basso, Ana C. Xavier, Rodney R. Miles, Stephan D. Voss, Samir Kahwash, Suzanne Braniecki, Megan Lim, Lauren Harrison, Stanton Goldman, Mitchell S. Cairo","doi":"10.1016/j.leukres.2025.107956","DOIUrl":"10.1016/j.leukres.2025.107956","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INVESTIGATING THE ‘ENIGMA OF THE MISSING T CELL RECEPTOR’ IN ANAPLASTIC LARGE CELL LYMPHOMA 研究间变性大细胞淋巴瘤中“缺失t细胞受体之谜”
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 DOI: 10.1016/j.leukres.2025.107998
Carla Vazquez Amos, Camilla J Fairbairn, Timothy I M Malcom, Lukas Kenner, G.A. Amos Burke, Jamie D Matthews, Suzanne D Turner
{"title":"INVESTIGATING THE ‘ENIGMA OF THE MISSING T CELL RECEPTOR’ IN ANAPLASTIC LARGE CELL LYMPHOMA","authors":"Carla Vazquez Amos, Camilla J Fairbairn, Timothy I M Malcom, Lukas Kenner, G.A. Amos Burke, Jamie D Matthews, Suzanne D Turner","doi":"10.1016/j.leukres.2025.107998","DOIUrl":"10.1016/j.leukres.2025.107998","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HGBCL-11q: THE DARKEST LYMPHOMA MICROENVIRONMENT? HGBCL-11q：最黑暗的淋巴瘤微环境？
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 DOI: 10.1016/j.leukres.2025.108000
MC. Siciliano, S. Mazzara, G. Bertolazzi, R. Boccacci, C. Lori, M. Vannucchi, R. Guazzo, M. Granai, A. Fischer, H. Horn, G. Ott, C. Tripodo, S. Lazzi, C. Bellan, R. Siebert, L. Leoncini
{"title":"HGBCL-11q: THE DARKEST LYMPHOMA MICROENVIRONMENT?","authors":"MC. Siciliano, S. Mazzara, G. Bertolazzi, R. Boccacci, C. Lori, M. Vannucchi, R. Guazzo, M. Granai, A. Fischer, H. Horn, G. Ott, C. Tripodo, S. Lazzi, C. Bellan, R. Siebert, L. Leoncini","doi":"10.1016/j.leukres.2025.108000","DOIUrl":"10.1016/j.leukres.2025.108000","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHK1-S, a splicing variant of CHK1, suppresses chronic myeloid leukemia CHK1- s， CHK1的剪接变体，抑制慢性髓性白血病
IF 2.1 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 Epub Date: 2025-07-22 DOI: 10.1016/j.leukres.2025.107922
Hu Lei, Hanzhang Xu, Yingying Wang, Yingli Wu
Checkpoint kinase 1 (CHK1) is a crucial protein involved in the cell cycle checkpoint during the DNA damage response and is essential for sustaining leukemia cell activity. CHK1-S (excluded exon 3) is an alternative splice variant of CHK1. Here, we demonstrate that CHK1-S is highly expressed in wild-type mouse bone marrow, and the ratio of CHK1-S to CHK1 is significantly higher compared to other tissues. The BCR-ABL protein reduces the expression of CHK1-S while increasing CHK1 levels in vitro and in vivo. Furthermore, the expression of CHK1-S is significantly reduced in the bone marrow mononuclear cells of newly diagnosed chronic myeloid leukemia (CML) patients. Inhibition of BCR-ABL activity with imatinib or knockdown of BCR-ABL can restore the expression of CHK1-S in K562 cells. Additionally, restoring CHK1-S can inhibit the proliferation of K562 cells and increase the proportion of cells in the G2/M phase. Mechanistically, the splicing factors transformer 2α (TRA2A) and TRA2B are associated with the selective splicing of CHK1-S in K562 cells. Our findings demonstrate that CHK1-S functions in opposition to CHK1, acting as a suppressor of CML.
检查点激酶1 （CHK1）是DNA损伤反应过程中参与细胞周期检查点的关键蛋白，对维持白血病细胞活性至关重要。CHK1- s（排除外显子3）是CHK1的另一种剪接变体。本研究证明CHK1- s在野生型小鼠骨髓中高表达，且CHK1- s与CHK1的比例明显高于其他组织。BCR-ABL蛋白在体外和体内均可降低CHK1- s的表达，同时提高CHK1的水平。此外，CHK1-S在新诊断的慢性髓性白血病（CML）患者骨髓单个核细胞中的表达显著降低。用伊马替尼抑制BCR-ABL活性或敲低BCR-ABL可恢复K562细胞中CHK1-S的表达。此外，恢复CHK1-S可以抑制K562细胞的增殖，增加G2/M期细胞的比例。在机制上，剪接因子transformer 2α (TRA2A)和TRA2B与K562细胞中CHK1-S的选择性剪接有关。我们的研究结果表明，CHK1- s的功能与CHK1相反，作为CML的抑制因子。
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引用次数: 0
GUIDED POSTER VIEWING SESSION 2: FUNDAMENTAL 引导海报观看环节2：基础
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1016/j.leukres.2025.107826
Lorea Chaparro-González , Andrés Durán Adame , Julia Mestre , Raúl Azibeiro , Lucía Ruiz Perez-Hita , Josgrey Navas , Blanca Xicoy , Neus Torres-Hernández , Oriol Calvete , Miguel Perera , Marta Salido , Teresa Bernal , Esperanza Such , Maria Diez-Campelo , Mar Mallo , Mónica Del Rey , Francesc Sole
{"title":"GUIDED POSTER VIEWING SESSION 2: FUNDAMENTAL","authors":"Lorea Chaparro-González ,&nbsp;Andrés Durán Adame ,&nbsp;Julia Mestre ,&nbsp;Raúl Azibeiro ,&nbsp;Lucía Ruiz Perez-Hita ,&nbsp;Josgrey Navas ,&nbsp;Blanca Xicoy ,&nbsp;Neus Torres-Hernández ,&nbsp;Oriol Calvete ,&nbsp;Miguel Perera ,&nbsp;Marta Salido ,&nbsp;Teresa Bernal ,&nbsp;Esperanza Such ,&nbsp;Maria Diez-Campelo ,&nbsp;Mar Mallo ,&nbsp;Mónica Del Rey ,&nbsp;Francesc Sole","doi":"10.1016/j.leukres.2025.107826","DOIUrl":"10.1016/j.leukres.2025.107826","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":"Article 107826"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PARALLEL SESSION 01: TP53 IN MDS 平行会议01:tp53在MDS
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1016/j.leukres.2025.107749
Peter Valk
{"title":"PARALLEL SESSION 01: TP53 IN MDS","authors":"Peter Valk","doi":"10.1016/j.leukres.2025.107749","DOIUrl":"10.1016/j.leukres.2025.107749","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":"Article 107749"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RAPID FIRE SESSION 02 快速射击阶段02
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1016/j.leukres.2025.107806
Roi Gat , Ariel Israel , Howard Oster , Noa Goldschmidt , Itamar Raz , Eugene Merzon , Moshe Mittelman
{"title":"RAPID FIRE SESSION 02","authors":"Roi Gat ,&nbsp;Ariel Israel ,&nbsp;Howard Oster ,&nbsp;Noa Goldschmidt ,&nbsp;Itamar Raz ,&nbsp;Eugene Merzon ,&nbsp;Moshe Mittelman","doi":"10.1016/j.leukres.2025.107806","DOIUrl":"10.1016/j.leukres.2025.107806","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":"Article 107806"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PARALLEL SESSION 02: CLONAL DISORDERS CLOSELY RELATED MDS 平行会议02：与MDS密切相关的克隆性疾病
IF 2.2 4区 医学 Q3 HEMATOLOGY
Leukemia research
Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1016/j.leukres.2025.107753
Michael Savona
{"title":"PARALLEL SESSION 02: CLONAL DISORDERS CLOSELY RELATED MDS","authors":"Michael Savona","doi":"10.1016/j.leukres.2025.107753","DOIUrl":"10.1016/j.leukres.2025.107753","url":null,"abstract":"","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":"156 ","pages":"Article 107753"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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