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The practiced pattern of vascular access used in hemodialysis: A cross-sectional study 血液透析中血管通路的实践模式:一项横断面研究
Pub Date : 2022-04-01 DOI: 10.4103/ljms.ljms_56_21
Rodaba Bitrou, B. Shaibani, H. Ahmed, Khiri Ayad
Background: The incidence of end-stage renal disease (ESRD) is increasing considerably worldwide; moreover, most of the patients start their therapy by hemodialysis (HD). Arteriovenous fistula (AVF) is the best type of vascular access for use in such therapy, due to its decreased rate of complications, followed by arteriovenous graft (AVG) and finally, central venous catheters, which are associated with, increased mortality and morbidity. In this study, we aim to find out the proportion of the current to initial vascular access used, the timing of creating permanent access, and any complications experienced. Patients and Methods: A cross-sectional study was conducted on two hundred eighteen patients currently on regular hemodialysis program. Their records were reviewed and the data was analyzed for vascular accesses type used at the start of hemodialysis and at the current time, the timing of the creation of permanent access, and the complications occurred. Data collected were statistically analyzed using IBM-SPSS statistics software Inc. Chicago, IL, USA. Results: Out-of-the 218 patients on hemodialysis, 193 patients (88.5%) started hemodialysis via Central venous catheters (CVC), 23 patients (10.5%) had an arterio-venous fistula (AVF), and only two patients (0.9%) used tunneled CVC, while no one has AV-graft. Currently, 82.1% of patients have AVF, 7.8% have chronic CVC, 5.9% have acute CVC and only 4.1% have AV-Graft, Many complications are noted in all types of access with different percentages of occurrence. Conclusion: We concluded that although a high percentage of patients have AVF, still pre-emptive AVF counts very low percentage, serious complications are still happening and we recommend the establishment of joined pre-dialysis clinic with surgeons and psychologists in each dialysis center.
背景:终末期肾病(ESRD)的发病率在世界范围内显著增加;此外,大多数患者以血液透析(HD)开始治疗。动静脉瘘(AVF)是用于此类治疗的最佳血管通路类型,因为其并发症发生率较低,其次是动静脉移植物(AVG),最后是中心静脉导管,后者与死亡率和发病率增加有关。在这项研究中,我们的目的是找出当前使用的血管通道与初始通道的比例,创建永久通道的时间,以及所经历的任何并发症。患者和方法:一项横断面研究对218名目前正在进行常规血液透析计划的患者进行了研究。回顾了他们的记录,并分析了血液透析开始时和当前时间使用的血管通路类型、永久性通道创建的时间和发生的并发症的数据。收集的数据采用IBM-SPSS统计软件进行统计分析。芝加哥,伊利诺伊州,美国。结果:218例血液透析患者中,193例(88.5%)患者通过中心静脉导管(CVC)开始血液透析,23例(10.5%)患者有动静脉瘘(AVF),只有2例(0.9%)患者使用了隧道式CVC,没有一例患者移植过中心静脉导管。目前AVF发生率为82.1%,慢性CVC发生率为7.8%,急性CVC发生率为5.9%,AV-Graft发生率仅为4.1%。各种通路类型均存在多种并发症,发生率不同。结论:虽然AVF发生率较高,但先期AVF发生率极低,严重并发症仍时有发生,建议各透析中心建立联合透析前门诊,由外科医生和心理医生联合开展。
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引用次数: 0
Drug prescription practice and behavior: A narrative review with special emphasis on prescribing patterns in Libya 药物处方实践和行为:特别强调利比亚处方模式的叙述性回顾
Pub Date : 2022-04-01 DOI: 10.4103/ljms.ljms_42_22
Nouran Gzllal, Malak Gharibe, A. Atia
Counseling has evolved into an essential component of community pharmacy practice. Patient counseling and addressing drug-related problems are the pharmacist's key activities to ensure the safe and effective use of medicines. There are currently no solid theoretical foundations for research on physician prescribing choices. In fact, doctors' drug prescriptions are a complex phenomenon that are influenced by a number of factors. The majority of current studies in the field of drug prescription use an exploratory approach rather than a theoretical one to describe how doctors make decisions. In Libya, a prescription of medications can easily be obtained from community pharmacies without prescription, resulting in potential drug misuse and health hazard. It was stated previously that there was overprescribing of certain categories of drugs written by Libyan physicians which necessitating further improvement. This review aimed to describe the dispensing practice of prescribed medicines in daily community pharmacy practice in Libya, focusing on counseling, and rational prescription based on the World Health Organization prescribing indicators.
咨询已经发展成为社区药房实践的重要组成部分。患者咨询和解决药物相关问题是药剂师确保安全有效使用药物的关键活动。目前还没有坚实的理论基础来研究医生的处方选择。事实上,医生的药物处方是一个复杂的现象,受许多因素的影响。目前在药物处方领域的大多数研究使用探索性方法而不是理论方法来描述医生如何做出决定。在利比亚,在没有处方的情况下很容易从社区药房获得药物处方,造成潜在的药物滥用和健康危害。以前曾指出,利比亚医生开出的某些类别的药物处方过多,这需要进一步改进。本综述旨在描述利比亚日常社区药房处方药的配药实践,重点关注咨询和基于世界卫生组织处方指标的合理处方。
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引用次数: 0
An overview evaluation of bacterial infection and bacterial contamination at the hospital environment and antibiogram for the isolated pathogens at Al Kufra Teaching Hospital, Libya 利比亚Al Kufra教学医院细菌感染和医院环境细菌污染的总体评估和分离病原体的抗生素谱
Pub Date : 2022-04-01 DOI: 10.4103/ljms.ljms_25_22
Ismaeel H. Bozakouk, Alabirsh Hussein, Iain L. Kean, Mohammed Bumadian, Abubaker S. Toboli
Background/Aims: Infectious diseases are the major public health problem worldwide. The medical services into the Southern Libyan sub-Saharan hospitals do not receive much attention in knowing the infection rates of pathogenic bacteria coming to the hospital, as well as there is not much information available about the hospital infection control application system. This study was performed to evaluate the infectious disease received to Al Kufra teaching hospital and determination the hospital risk factors involved in hospital-acquired infection. Materials and Methods: The screening was performed to investigate the distribution of potential pathogens among 157 samples collected from the four hospital wards including intensive care unit, the pediatric ward, male and female surgical ward from the hospitalizes patients, medical staff and hospital workers, and across different hospital facilities. Results: The bedsores swabs and urine samples showed 100% of infection, followed by sputum, stool, surgical wounds, and cerebrospinal fluid (85.8%, 67%, 62.5%, and 42.9%), respectively. Most of the hospital facilities showed 100% of contamination. The results showed Staphylococcus aureus colonized 40 (77%) of the total nasal swabs, other samples detected Bacillus cereus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli 0157. The sensitivity of Gram-positive organisms to the antibiotics showed resistance to Penicillin G (90.1%) and Amoxicillin + Clavulanic acid (82.7%), Methicillin (65.5%) and Vancomycin (65.5%). For Gram-negative organisms, the isolates showed resistance to tetracycline and colistin (62.5%) for each. Conclusion: The bacterial outbreak in the clinical and environmental samples of Al Kufra Teaching Hospital was relatively high. To control bacterial infection and hospital contamination, several instructions need to be carried out to protect the hospital staff and patients from being infected.
背景/目的:传染病是世界范围内主要的公共卫生问题。进入利比亚南部撒哈拉以南地区医院的医疗服务在了解医院病原菌感染率方面不受重视,医院感染控制应用系统的信息也不多。本研究旨在评估Al Kufra教学医院接收的感染性疾病,并确定涉及医院获得性感染的医院危险因素。材料与方法:从重症监护病房、儿科病房、男女外科病房、住院患者、医务人员和医院工作人员以及不同医院机构采集157份样本,调查潜在病原体的分布情况。结果:褥疮拭子和尿液感染检出率为100%,其次为痰液(85.8%)、粪便(67%)、手术伤口(62.5%)和脑脊液(42.9%)。大部分医院设施100%被污染。结果:金黄色葡萄球菌定植40株(77%),其余标本检出蜡样芽孢杆菌、肺炎链球菌、铜绿假单胞菌、粪肠球菌、大肠杆菌0157。革兰氏阳性菌对抗生素的敏感性表现为:青霉素G(90.1%)、阿莫西林+克拉维酸(82.7%)、甲氧西林(65.5%)、万古霉素(65.5%)耐药;革兰氏阴性菌对四环素和粘菌素均有耐药性(62.5%)。结论:库夫拉教学医院临床及环境样本细菌暴发率较高。为了控制细菌感染和医院污染,需要执行一些指示,以保护医院工作人员和患者免受感染。
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引用次数: 0
Mineral bone disorders in hemodialysis patients in the West of Libya 利比亚西部血液透析患者的矿物质骨紊乱
Pub Date : 2022-01-01 DOI: 10.4103/ljms.ljms_38_21
K. Ayad, B. Shaibani, Zaynab Rahouma, Yousef AL-Adawi, Fatma Malool, Amina Smaida, Samiha Shamli, Reema Gattusa
Background and Objectives: Chronic kidney disease (CKD) is affecting 5%–10% of the world population. As kidney function declines, there is progressive deterioration in minerals homeostasis manifesting as disruption of serum and tissue concentrations of phosphorus, calcium (Ca), and parathyroid hormone (PTH). CKD-mineral bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism manifested by any or a combination of the following: abnormalities of Ca, phosphorus, PTH, Vitamin D metabolism, abnormalities of bone turnover, and vascular or soft-tissue calcification, associated with fractures, cardiovascular disease, and mortality in CKD patients. The study aims to identify the prevalence and pattern of CKD-MBD among hemodialysis patients in the west of Libya. Patients and Methods: A cross-sectional study was carried out on 186 regular hemodialysis patients from five hemodialysis centers in the west of Tripoli-Libya District. All patients were investigated for complete blood count, blood sugar, serum albumin, blood urea, serum creatinine, total Ca level, serum phosphate, serum alkaline phosphatase, and serum intact PTH (iPTH) level. Results: According to the Kidney Disease Outcomes Quality (KDOQ) iPTH level guideline, 88.10% of the studied patients had metabolic bone disorders, and 39.80% showed low bone turnover. About 48.40% were high bone turnover; only 11.80% of studied patients were within the target range according to the KDOQ Initiative guidelines. About 40.36% of studied patients had low calcium levels (below 8.5 mg%), and 35.48% had high phosphorus levels (more than 5.5 mg%). About 61.10% of high bone turnover patients complain of bone pain and 50.50% complain of muscle weakness. Among low bone turnover patients, 36.48% had no symptoms, and 28.38% were complaining of both muscle weakness and bone pain. Conclusions: The prevalence of MBDs among studied patients with abnormal PTH levels is 87.6%, distributed as 39.2% in abnormal low PTH (low bone turnover), and 48.4% in abnormal high PTH (high bone turnover).
背景和目的:慢性肾脏疾病(CKD)影响着世界人口的5%-10%。随着肾功能下降,矿物质体内平衡逐渐恶化,表现为血清和组织中磷、钙(Ca)和甲状旁腺激素(PTH)浓度的破坏。CKD-矿物质骨障碍(CKD- mbd)是一种全身性矿物质和骨代谢紊乱,表现为以下任何或组合:钙、磷、甲状旁腺激素、维生素D代谢异常、骨转换异常、血管或软组织钙化,与CKD患者骨折、心血管疾病和死亡率相关。该研究旨在确定利比亚西部血液透析患者中CKD-MBD的患病率和模式。患者和方法:对来自的黎波里-利比亚区西部五个血液透析中心的186名常规血液透析患者进行了横断面研究。对所有患者进行全血细胞计数、血糖、血清白蛋白、尿素、血清肌酐、总钙水平、血清磷酸盐、血清碱性磷酸酶、血清完整甲状旁腺激素(iPTH)水平的检测。结果:根据肾脏病结局质量(KDOQ) iPTH水平指南,88.10%的患者存在代谢性骨紊乱,39.80%的患者存在低骨转换。高骨转换约占48.40%;根据KDOQ倡议指南,只有11.80%的研究患者在目标范围内。约40.36%的患者钙水平低(低于8.5 mg%), 35.48%的患者磷水平高(超过5.5 mg%)。61.10%的高骨转换患者表现为骨痛,50.50%的患者表现为肌肉无力。在低骨转换患者中,36.48%的患者无症状,28.38%的患者有肌无力和骨痛的主诉。结论:所研究的PTH异常患者MBDs患病率为87.6%,其中PTH异常低(低骨转换)患者患病率为39.2%,PTH异常高(高骨转换)患者患病率为48.4%。
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引用次数: 0
Transverse sinus aneurysm presented as fetal intracranial hemorrhage: A new case report 横窦动脉瘤表现为胎儿颅内出血1例
Pub Date : 2022-01-01 DOI: 10.4103/ljms.ljms_7_22
F. Taleb, Seraj Ajaj, Abdussalam Abograra
A transverse sinus aneurysm is a very rare vascular pathology. Limited cases were reported in the literature. Here, we report a new case of a transverse sinus aneurysm presented as fetal intracranial hemorrhage of third-trimester pregnant women.
横窦动脉瘤是一种非常罕见的血管病变。文献报道的病例有限。在这里,我们报告一个新的病例横贯窦动脉瘤表现为胎儿颅内出血的晚期妊娠妇女。
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引用次数: 0
Neuroendocrine tumor in a patient living with human immunodeficiency virus 人类免疫缺陷病毒患者的神经内分泌肿瘤
Pub Date : 2022-01-01 DOI: 10.4103/ljms.ljms_10_22
Khalid Albsheer, Shahda Alhassan Ahmed, Rayan M Sibira, Elmukhtar B. Habas
Neuroendocrine tumors (NETs) are epithelial neoplasms with predominant neuroendocrine differentiation, potentially arising from anywhere along the alimentary tract. We report a case of NET in a patient living with human immunodeficiency virus (HIV) (PLWH). A 58-year-old gentleman presented to the emergency department with a 2-week history of dry cough, loose motions, and fatigue; he had unintended weight loss ongoing during the past 4 months. Examination is significant for hepatomegaly (20 cm). On evaluation, a diagnosis of both HIV/AIDS and metastatic NET of gastrointestinal origin was confirmed. The chronic antigenic stimulation, cytokine dysregulation, and inflammation observed in PLWH are believed to influence the development of variety of malignancy. Hence, a high index of suspicion for neoplasms in HIV/AIDS (PLWH) regardless of their viral load or immunosuppression status is necessity when presented with red flag malignancies, especially with the overlapping symptoms of AIDS and the constitutional symptoms of cancers.
神经内分泌肿瘤(NETs)是一种以神经内分泌分化为主的上皮性肿瘤,可能发生在消化道的任何地方。我们报告一例NET患者生活与人类免疫缺陷病毒(HIV) (PLWH)。一位58岁的男士因干咳、运动松散和疲劳2周就诊于急诊科;在过去的4个月里,他的体重意外地持续下降。检查发现肝肿大(20厘米)。经评估,诊断为HIV/AIDS和胃肠道起源的转移性NET。在PLWH中观察到的慢性抗原刺激、细胞因子失调和炎症被认为影响各种恶性肿瘤的发展。因此,无论其病毒载量或免疫抑制状态如何,当出现危险恶性肿瘤时,特别是艾滋病症状和癌症的体质症状重叠时,必须高度怀疑艾滋病毒/艾滋病(PLWH)中的肿瘤。
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引用次数: 0
Classic hodgkin lymphoma involving spleen, stomach, and pancreas without peripheral lymphadenopathy: Report of a very rare case 经典霍奇金淋巴瘤累及脾、胃和胰腺,无周围淋巴结病变:报告一例非常罕见的病例
Pub Date : 2022-01-01 DOI: 10.4103/ljms.ljms_46_21
S. Krishnan, B. Mohan, Ravindran Chirukandath, M. Feroze
Classic Hodgkin lymphoma (HL) is a lymphoid neoplasm most often affecting the lymph nodes of the cervical region (75%), followed by mediastinal, axillary, and para-aortic areas. Extranodal involvement is much less common in HL. We present an extremely rare case of classic HL (CHL) with involvement of the spleen, stomach, and pancreas and perigastric, mesenteric, and para-aortic lymph nodes without peripheral lymphadenopathy, in a 54-year-old male, which clinicoradiologically mimicked a carcinoma. An extensive English literature search did not reveal any case of CHL involving the spleen, stomach, and pancreas simultaneously.
经典霍奇金淋巴瘤(HL)是一种淋巴样肿瘤,最常累及颈部淋巴结(75%),其次是纵隔、腋窝和主动脉旁区域。结外受累在HL中较少见。我们报告一例极其罕见的典型HL (CHL)病例,累及脾、胃、胰腺、胃周、肠系膜和主动脉旁淋巴结,无周围淋巴结病变,54岁男性,临床放射学模拟癌。广泛的英文文献检索未发现任何同时累及脾、胃和胰腺的CHL病例。
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引用次数: 0
Hepatitis B virus-related nephropathy: Review and update 乙型肝炎病毒相关肾病:综述与最新进展
Pub Date : 2022-01-01 DOI: 10.4103/ljms.ljms_29_22
E. Habas, F. Khan, Khalifa L Farfar, Aml Habas, Aisha Al Aldab, M. Errayes, Eshrak Habas, I. Kamal, A. Rayani, Abdel-Naser Elzouki
Viral-associated nephropathy indicates the direct pathogenic relationship between viral status and the development of nephropathy. Hepatitis B virus (HBV) infection (especially chronic) causes different glomerular, tubular, and interstitium damages. Membranous and membranoproliferative are the common HBV-associated nephropathy. The pathogenesis of HBV-associated nephropathy is primarily immune complex mediated; however, direct tubular damage may occur. The virus load and activity are essential risk factors in HBV-associated nephropathy development. Decreasing virus load and early treatment reduce the risk of HBV-associated nephropathy and may prevent the disease progression. Prevention of HBV infection by a worldwide vaccination program governed by the World Health Organization is the prime target to prevent hepatic and extrahepatic HBV-related complications. The authors searched the EMBASE, Google Scholar, Scopus, and Google search engines for articles about HBV-associated nephropathy using phrases, texts, and keywords such as chronic HBV infection and kidney, HBV-associated glomerulonephritis, nephritis in HBV infection, viral nephropathy, and HBV vaccination. Following multiple meetings and discussions, each author was given a section on the topic to search and summarize. Then, this narrative review manuscript has been written and revised to update HBV-associated nephropathy pathogenesis and treatment.
病毒相关性肾病表明病毒状态与肾病的发生有直接的致病关系。乙型肝炎病毒(HBV)感染(特别是慢性)引起不同的肾小球、小管和间质损伤。膜性和膜增生性是常见的hbv相关肾病。hbv相关肾病的发病机制主要是免疫复合物介导的;然而,直接管状损伤可能会发生。病毒载量和活性是hbv相关肾病发展的重要危险因素。降低病毒载量和早期治疗可降低hbv相关肾病的风险,并可能预防疾病进展。通过世界卫生组织管理的全球疫苗接种计划预防HBV感染是预防肝脏和肝外HBV相关并发症的主要目标。作者在EMBASE、Google Scholar、Scopus和Google搜索引擎中搜索关于HBV相关肾病的文章,使用短语、文本和关键词,如慢性HBV感染和肾脏、HBV相关肾小球肾炎、HBV感染肾炎、病毒性肾病和HBV疫苗接种。在多次会议和讨论之后,每个作者都有一个关于主题的部分来搜索和总结。然后,撰写并修订了这篇叙述性综述手稿,以更新hbv相关肾病的发病机制和治疗。
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引用次数: 0
Pathology pick up rate in routine preoperative endoscopy and its impact on patients undergoing gastric bypass surgery 术前常规内镜检查病理检出率及其对胃分流术患者的影响
Pub Date : 2022-01-01 DOI: 10.4103/ljms.ljms_26_22
Abdulmajid Ali, P. Ishak, Chinaka Ugochukwu, A. Bakhshi, Rifat Mohamed, J. Rankin
Background and Aims: Patients with obesity are known for higher chances of having upper gastrointestinal (UGI) pathology and diseases. Esophagogastroduodenoscopy (OGD) is considered the investigation of choice to detect and confirm UGI pathology in patient with obesity. The routine OGD as a preoperative workup remained controversial before gastric bypass surgery. The need for preoperative OGD on patients undergoing bariatric surgery has been a subject of debate among bariatric surgeons. The study's aim is to evaluate the impact of routine preoperative endoscopy on patients underwent gastric bypass surgery laparoscopic Roux-en-Y gastric bypass (LRYGB). Patients and Materials: Retrospective review of prospectively kept patients' records who underwent LRYGB in our unit from February 2009 to March 2020. Patients were divided into two groups according to the absence or presence of symptoms before their preoperative OGD: Group A (asymptomatic patients) and Group B (symptomatic patients). Further data on OGD reports, campylobacter-like organism test and histology results and changes in the management plan were collected and analyzed. Calculation of post hoc power and Fisher's exact test was to investigate the correlation between OGD indication and its findings. All analyses were conducted at a 5% critical level. Results: A total of 114 patients included in the analysis, 85 (74.56%) were in Group A and 29 in Group B. OGD detected pathology in 34 patients in Group A and 21 in Group B (P = 0.004). Those included hiatus hernia (HH) (17.65% Group A, 44.83% Group B, P = 0.006); stomach ulcer (7.06% Group A, 3.45% Group B, P = 0.676), Helicobacter pylori (H. pylori) infection (12.86% Group A, 29.41% Group B). This led to change of management in 22 patients in Group A and 12 in Group B (P = 0.157). Those changes included H. pylori eradication (10.59% Group A, 17.24% Group B, P = 0.153), HH repair (3.53% Group A, 24.14% Group B, P = 0.002). Conclusions: Preoperative OGD has some significant impact on symptomatic patients. However, this is debatable among asymptomatic patients; hence, cheaper noninvasive alternatives could replace preoperative OGD.
背景和目的:肥胖患者患上胃肠道(UGI)病理和疾病的几率较高。食管胃十二指肠镜检查(OGD)被认为是检测和确认肥胖患者UGI病理的首选方法。胃分流术术前常规OGD检查仍有争议。是否需要对接受减肥手术的患者进行术前OGD一直是减肥外科医生争论的话题。本研究的目的是评估常规术前内镜检查对行胃旁路手术腹腔镜Roux-en-Y胃旁路术(LRYGB)患者的影响。患者和材料:回顾性审查2009年2月至2020年3月在我单位接受LRYGB的前瞻性患者记录。根据术前OGD前有无症状分为A组(无症状患者)和B组(有症状患者)。进一步收集和分析OGD报告、弯曲杆菌样生物检测和组织学结果以及管理方案的变化。事后功效的计算和Fisher精确检验是为了研究OGD指征与其结果之间的相关性。所有分析均在5%的临界水平下进行。结果:共纳入114例患者,其中A组85例(74.56%),B组29例(P = 0.004), A组34例,B组21例(P = 0.004)。其中:裂孔疝(HH) (A组17.65%,B组44.83%,P = 0.006);胃溃疡(A组7.06%,B组3.45%,P = 0.676)、幽门螺杆菌感染(A组12.86%,B组29.41%),导致A组22例、B组12例患者改变治疗方法(P = 0.157)。其中幽门螺杆菌根除(A组10.59%,B组17.24%,P = 0.153)、HH修复(A组3.53%,B组24.14%,P = 0.002)。结论:术前OGD对有症状患者有一定的影响。然而,这在无症状患者中是有争议的;因此,更便宜的无创替代方案可以取代术前OGD。
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引用次数: 0
A comparative study of biological sample preparation methods conventional cryopreservation of human tissue 生物样品制备方法与人体组织冷冻保存方法的比较研究
Pub Date : 2022-01-01 DOI: 10.4103/ljms.ljms_28_22
Anisa Elhamili, S. Saad, Fathi Eladressi
Background/Aims: Data that compare the effectiveness of methodologies for cryopreservation of human tissue are very limited. Thus, two different biological sample preparation methods, the conventional cryopreservation of human ovarian tissue using either spontaneous or initiated (so-called “seeded”) ice formation, was carefully investigated and compared. Materials and Methods: Biopsies of ovarian tissue were obtained from women with indications for chemotherapy or radiotherapy, and small pieces of experimental tissue (0.5 mm × 1 mm × 1–3 mm) were randomly distributed into three different groups: group 1 immediately after biopsy, experimental pieces after cryopreservation (thawing) with spontaneous ice formation (Group 2) and cryopreservation with initiated ice formation (Group 3). The pieces of tissue were cultured in vitro for 16 days, after which follicle viability and hormonal activity were evaluated. The level of statistical significance was set at P < 0.05. Results: The obtained results indicated that culture supernatants for Groups 1, 2, and 3 showed estradiol 17-ß concentrations of 476, 465, and 459 pg/mL, respectively. Whereas pProgesterone concentrations were 9.68, 5.77, and 5.61 ng/mL, respectively. In addition, the mean primordial follicle density per mm3 for Group 1 was 12.1 ± 3.9, 3.1 ± 1.4 for Group 2 and 6.0 ± 2.3 for Group 3. Moreover, it was recognized that 91%, 16%, and 87% follicles for Groups 1, 2, and 3, respectively, were normal (P2-1, 3 < 0.05; P1-3 > 0.1). Conclusions: The obtained results revealed that for the best results using cryopreservation of human ovarian tissue, the protocol of conventional cryopreservation must include a step of initiated ice formation. Moreover, an advanced analytical detection technique of high sensitivity, mass spectrometry, can further be used in the future for an accurate determination of hormonal levels and other related compounds and for screening of possible biomarkers using the best-obtained sample preparation method.
背景/目的:比较人体组织低温保存方法有效性的数据非常有限。因此,仔细研究和比较了两种不同的生物样品制备方法,即使用自发或启动(所谓的“种子”)冰形成的人类卵巢组织的传统冷冻保存方法。材料与方法:对有化疗或放疗指征的女性进行卵巢组织活检,取小块实验组织(0.5 mm × 1 mm × 1 - 3 mm)随机分为3组:第1组活检后立即进行,第2组冷冻(解冻)后自发成冰(第3组),第3组冷冻(第3组)。组织块体外培养16天,评估卵泡活力和激素活性。P < 0.05为差异有统计学意义的水平。结果:1、2、3组培养上清液雌二醇17-ß浓度分别为476、465、459 pg/mL。孕酮浓度分别为9.68、5.77和5.61 ng/mL。实验组1的平均毛囊密度为12.1±3.9,实验组2为3.1±1.4,实验组3为6.0±2.3。此外,1组、2组和3组的卵泡正常率分别为91%、16%和87% (P2-1, 3 < 0.05;P1-3 > 0.1)。结论:为了获得最佳冷冻保存效果,常规冷冻保存方案必须包括初始冰形成步骤。此外,一种先进的高灵敏度分析检测技术,质谱法,可以在未来进一步用于准确测定激素水平和其他相关化合物,并使用最佳的样品制备方法筛选可能的生物标志物。
{"title":"A comparative study of biological sample preparation methods conventional cryopreservation of human tissue","authors":"Anisa Elhamili, S. Saad, Fathi Eladressi","doi":"10.4103/ljms.ljms_28_22","DOIUrl":"https://doi.org/10.4103/ljms.ljms_28_22","url":null,"abstract":"Background/Aims: Data that compare the effectiveness of methodologies for cryopreservation of human tissue are very limited. Thus, two different biological sample preparation methods, the conventional cryopreservation of human ovarian tissue using either spontaneous or initiated (so-called “seeded”) ice formation, was carefully investigated and compared. Materials and Methods: Biopsies of ovarian tissue were obtained from women with indications for chemotherapy or radiotherapy, and small pieces of experimental tissue (0.5 mm × 1 mm × 1–3 mm) were randomly distributed into three different groups: group 1 immediately after biopsy, experimental pieces after cryopreservation (thawing) with spontaneous ice formation (Group 2) and cryopreservation with initiated ice formation (Group 3). The pieces of tissue were cultured in vitro for 16 days, after which follicle viability and hormonal activity were evaluated. The level of statistical significance was set at P < 0.05. Results: The obtained results indicated that culture supernatants for Groups 1, 2, and 3 showed estradiol 17-ß concentrations of 476, 465, and 459 pg/mL, respectively. Whereas pProgesterone concentrations were 9.68, 5.77, and 5.61 ng/mL, respectively. In addition, the mean primordial follicle density per mm3 for Group 1 was 12.1 ± 3.9, 3.1 ± 1.4 for Group 2 and 6.0 ± 2.3 for Group 3. Moreover, it was recognized that 91%, 16%, and 87% follicles for Groups 1, 2, and 3, respectively, were normal (P2-1, 3 < 0.05; P1-3 > 0.1). Conclusions: The obtained results revealed that for the best results using cryopreservation of human ovarian tissue, the protocol of conventional cryopreservation must include a step of initiated ice formation. Moreover, an advanced analytical detection technique of high sensitivity, mass spectrometry, can further be used in the future for an accurate determination of hormonal levels and other related compounds and for screening of possible biomarkers using the best-obtained sample preparation method.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"14 1","pages":"14 - 18"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80900898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Libyan Journal of Medical Sciences
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