Introduction: There are no data so far regarding the frequency and outcome of the different types of atrial fibrillation (AF) in the clinical setting for Libyan patients. Furthermore, it is unknown whether the actual clinical management and therapy of AF in Libya conform to the international guidelines. The aim of this study was to determine the frequency, demographic, and clinical characteristics of AF patients. Patients and Methods: Three hundred patients attending the outpatient clinic and cardiology department at Benghazi Medical Center and National Cardiac Center between May 2020 and October 2020 were included. Patients' data were obtained through medical records using the chart review. Patients were categorized into a clinical type of AF, based on the physician's perception of the AF at the time of presentation. Results: Three hundred patients with an established diagnosis of AF were enrolled, including 210 (70%) females and 90 (30%) males. The mean age at the time of diagnosis was 49.5 ± 21.5 years, with an age range of 29–79 years. Of them 139 (46.3%) were diagnosed as permanent AF, 132 (44%) paroxysmal AF, while new-onset AF was diagnosed in 29 (9.7%). The three clinical categories of AF were enrolled under the care of both cardiologists and internal medicine physicians, but permanent AF patients were more often enrolled under the care of a cardiologist. Patients with permanent AF were older compared with those with paroxysmal subtype (61.8 ± 9 and 50.1 ± 12, respectively), with significant female predominance (P = 0.03), and more often had coronary artery disease (CAD), valvular heart disease, and a previous stroke/TIA (P = 0.01, P = 0.124, and P = 0.002, respectively). Diabetes was the most prevalent associated medical condition, followed by hypertension and hyperlipidemia. CAD was diagnosed among 122 patients. Of permanent AF patients, 28 patients (20.1%) previously suffered from a stroke, mostly TIA, in contrast to 14 patients (10.6%) of the other AF patients. Conclusion: Our AF patients were characterized by an unfavorable cardiovascular risk profile. We recognize a lower rate of oral anticoagulation prescription, which needs further evaluation.
{"title":"Clinical characteristics and management practice among patients diagnosed with atrial ibrillation in Benghazi Libya, A cross sectional study","authors":"Abdelhadi Elkadiki, M. Ali, Khaled D. Alsaeiti","doi":"10.4103/LJMS.LJMS_3_21","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_3_21","url":null,"abstract":"Introduction: There are no data so far regarding the frequency and outcome of the different types of atrial fibrillation (AF) in the clinical setting for Libyan patients. Furthermore, it is unknown whether the actual clinical management and therapy of AF in Libya conform to the international guidelines. The aim of this study was to determine the frequency, demographic, and clinical characteristics of AF patients. Patients and Methods: Three hundred patients attending the outpatient clinic and cardiology department at Benghazi Medical Center and National Cardiac Center between May 2020 and October 2020 were included. Patients' data were obtained through medical records using the chart review. Patients were categorized into a clinical type of AF, based on the physician's perception of the AF at the time of presentation. Results: Three hundred patients with an established diagnosis of AF were enrolled, including 210 (70%) females and 90 (30%) males. The mean age at the time of diagnosis was 49.5 ± 21.5 years, with an age range of 29–79 years. Of them 139 (46.3%) were diagnosed as permanent AF, 132 (44%) paroxysmal AF, while new-onset AF was diagnosed in 29 (9.7%). The three clinical categories of AF were enrolled under the care of both cardiologists and internal medicine physicians, but permanent AF patients were more often enrolled under the care of a cardiologist. Patients with permanent AF were older compared with those with paroxysmal subtype (61.8 ± 9 and 50.1 ± 12, respectively), with significant female predominance (P = 0.03), and more often had coronary artery disease (CAD), valvular heart disease, and a previous stroke/TIA (P = 0.01, P = 0.124, and P = 0.002, respectively). Diabetes was the most prevalent associated medical condition, followed by hypertension and hyperlipidemia. CAD was diagnosed among 122 patients. Of permanent AF patients, 28 patients (20.1%) previously suffered from a stroke, mostly TIA, in contrast to 14 patients (10.6%) of the other AF patients. Conclusion: Our AF patients were characterized by an unfavorable cardiovascular risk profile. We recognize a lower rate of oral anticoagulation prescription, which needs further evaluation.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"25 1","pages":"66 - 69"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74457226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mesenteric panniculitis is a rare benign fibrotic condition that manifests with acute or chronic inflammation. It commonly affects small bowels whereas the mesenteric adipose tissue of large bowels is less commonly (20%) involved. In literature, there cases, mostly children and adolescents, where surgery has been used to relieve compression symptoms. We present a rare case of an adult patient who presented with acute mechanical intestinal obstruction secondary to isolated mesenteric panniculitis. We present this case to highlight the fact that this rare condition can cause acute mechanical intestinal obstruction even in adult patients and should be factored into the differential diagnosis.
{"title":"A rare case of acute mechanical intestinal obstruction due to isolated mesenteric panniculitis","authors":"R. Sarı, M. Buldanlı","doi":"10.4103/ljms.ljms_34_21","DOIUrl":"https://doi.org/10.4103/ljms.ljms_34_21","url":null,"abstract":"Mesenteric panniculitis is a rare benign fibrotic condition that manifests with acute or chronic inflammation. It commonly affects small bowels whereas the mesenteric adipose tissue of large bowels is less commonly (20%) involved. In literature, there cases, mostly children and adolescents, where surgery has been used to relieve compression symptoms. We present a rare case of an adult patient who presented with acute mechanical intestinal obstruction secondary to isolated mesenteric panniculitis. We present this case to highlight the fact that this rare condition can cause acute mechanical intestinal obstruction even in adult patients and should be factored into the differential diagnosis.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"228 1","pages":"87 - 89"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90493396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.4103/LJMS.LJMS_109_20
S. Pareek, Nitesh Kumar, C. Chouhan
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection has a wide range of consequences of human body. In the literature, only a few cases with uncertain hair fall related to COVID-19 infection. In the case report, we enumerated a case of 33-year-old female with alopecia followed by SARS-Cov-2 infection. On the visit, the patient was afebrile; vitals were within normal range and breathing normally. The patient was not suffering from any stress, and her psychological status was sound. Physical examination revealed asymptomatic alopecia on the temporal region of her scalp. The scalp area was smooth, and there was no inflammation was there. The pull test outcome was positive. The patient was managed with topical lotions and biotin supplements. After 1 month, the hair fall was limited and pull test found negative. No cutaneous infection was observed on the scalp. The present case showed alopecia as a rare complication of SARS-Cov-2 infection. Early initiation of the therapy can decline the consequences of alopecia among SARS-Cov-2 patients.
{"title":"Diffused alopecia followed by severe acute respiratory syndrome coronavirus-2 infection","authors":"S. Pareek, Nitesh Kumar, C. Chouhan","doi":"10.4103/LJMS.LJMS_109_20","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_109_20","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection has a wide range of consequences of human body. In the literature, only a few cases with uncertain hair fall related to COVID-19 infection. In the case report, we enumerated a case of 33-year-old female with alopecia followed by SARS-Cov-2 infection. On the visit, the patient was afebrile; vitals were within normal range and breathing normally. The patient was not suffering from any stress, and her psychological status was sound. Physical examination revealed asymptomatic alopecia on the temporal region of her scalp. The scalp area was smooth, and there was no inflammation was there. The pull test outcome was positive. The patient was managed with topical lotions and biotin supplements. After 1 month, the hair fall was limited and pull test found negative. No cutaneous infection was observed on the scalp. The present case showed alopecia as a rare complication of SARS-Cov-2 infection. Early initiation of the therapy can decline the consequences of alopecia among SARS-Cov-2 patients.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"s1-1 1","pages":"100 - 101"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85966293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Bacterial vaginosis is a worldwide issue due to the raised risk of acquisition of sexually transmitted infections. The aim of the study was to assess the incidence of bacterial vaginosis and their antimicrobial pattern in women attending different private clinics in Tripoli, Libya. Methods: A cross-sectional study was conducted among 204 women between January and October 2020. Gram-stained vaginal swabs were examined microscopically, characterized by colony morphology, and their antimicrobial susceptibility pattern was determined. Results: The overall prevalence of bacterial vaginosis was 41%. Out of 48 bacterial isolates, 76.1% were gram-positive and 23.8% were Gram-negative bacteria. The overall drug resistance level of gram-positive bacteria was high against penicillin, co-amoxiclav, and amoxicillin. Vancomycin and imipenem were the most active drugs against Gram-positive bacteria. High level of drug resistance of Gram-negative bacteria against co-amoxiclav. Ceftriaxone, cefotaxime, and amikacin were the most active drugs against Gram-negative bacteria. Conclusions: The prevalence of bacterial vaginosis was high. Routine culture of vaginal samples should be performed on patients with vaginitis and the drug susceptibility pattern of each isolate should be determined.
{"title":"Prevalence of bacterial vaginosis and their antibiotic susceptibility among women attending different private clinics in Tripoli, Libya","authors":"Ahmed Atia","doi":"10.4103/ljms.ljms_9_21","DOIUrl":"https://doi.org/10.4103/ljms.ljms_9_21","url":null,"abstract":"Background: Bacterial vaginosis is a worldwide issue due to the raised risk of acquisition of sexually transmitted infections. The aim of the study was to assess the incidence of bacterial vaginosis and their antimicrobial pattern in women attending different private clinics in Tripoli, Libya. Methods: A cross-sectional study was conducted among 204 women between January and October 2020. Gram-stained vaginal swabs were examined microscopically, characterized by colony morphology, and their antimicrobial susceptibility pattern was determined. Results: The overall prevalence of bacterial vaginosis was 41%. Out of 48 bacterial isolates, 76.1% were gram-positive and 23.8% were Gram-negative bacteria. The overall drug resistance level of gram-positive bacteria was high against penicillin, co-amoxiclav, and amoxicillin. Vancomycin and imipenem were the most active drugs against Gram-positive bacteria. High level of drug resistance of Gram-negative bacteria against co-amoxiclav. Ceftriaxone, cefotaxime, and amikacin were the most active drugs against Gram-negative bacteria. Conclusions: The prevalence of bacterial vaginosis was high. Routine culture of vaginal samples should be performed on patients with vaginitis and the drug susceptibility pattern of each isolate should be determined.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"622 1","pages":"79 - 82"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76805512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a case of a 32-year-old female with a 6-month history of excruciating pain in hypothenar region of the left hand. Pain was aggravated by pressure, touch, and cold temperature. Musculoskeletal ultrasonography revealed a well-defined, hypoechoic lesion in the deep dermis and subcutaneous fat in the left hypothenar eminence with mixed arterial and venous signals within on Doppler study, suggestive of subcutaneous vascular lesion, and a diagnosis of glomus tumor was suggested. The patient underwent excision of the lesion. Pathological examination of the specimen showed a glomus tumor and excluded malignant transformation to glomangiosarcoma. Extra digital glomus tumor can be diagnosed on ultrasound with high confidence in appropriate clinical setting.
{"title":"Ultrasonographic features of hypothenar region extra digital glomus tumor","authors":"M. Kachare, Alamgir Khan, Umesh Joshi, S. Patil","doi":"10.4103/LJMS.LJMS_93_20","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_93_20","url":null,"abstract":"We report a case of a 32-year-old female with a 6-month history of excruciating pain in hypothenar region of the left hand. Pain was aggravated by pressure, touch, and cold temperature. Musculoskeletal ultrasonography revealed a well-defined, hypoechoic lesion in the deep dermis and subcutaneous fat in the left hypothenar eminence with mixed arterial and venous signals within on Doppler study, suggestive of subcutaneous vascular lesion, and a diagnosis of glomus tumor was suggested. The patient underwent excision of the lesion. Pathological examination of the specimen showed a glomus tumor and excluded malignant transformation to glomangiosarcoma. Extra digital glomus tumor can be diagnosed on ultrasound with high confidence in appropriate clinical setting.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"31 1","pages":"34 - 35"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81095886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4103/LJMS.LJMS_103_20
Ans A. Alamami, Rabee Tawel, Farahmandinia Zahra, M. Abelaty
Guillain–Barre syndrome (GBS) is an autoimmune disorder of the peripheral nerves manifested as inflammatory polyneuropathy of acute onset. The posterior reversible encephalopathy syndrome (PRES) is composed of gradual-onset neurological characteristics with unique radiological distribution (at the posterior brain region). Several etiologies, including hypertension, renal insufficiency, autoimmune diseases, medication use, and immunodeficiency, immunotherapy with intravenous immunoglobulin (IVIG) for various immune-related conditions, were associated with renal impairment, thrombotic manifestation, and reported PRES occurrence. Herein, we report a 73-year-old male who developed a clinical manifestation of PRES on top of IVIG therapy for Miller Fisher variant of GBS; therefore, PRES to be considered in a patient with GBS who treated with IVIG and developed alteration in the state of consciousness.
{"title":"Postintravenous immunoglobulins posterior reversible encephalopathy syndrome in a patient with miller fisher variant of guillain–barre syndrome: A case report and literature review","authors":"Ans A. Alamami, Rabee Tawel, Farahmandinia Zahra, M. Abelaty","doi":"10.4103/LJMS.LJMS_103_20","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_103_20","url":null,"abstract":"Guillain–Barre syndrome (GBS) is an autoimmune disorder of the peripheral nerves manifested as inflammatory polyneuropathy of acute onset. The posterior reversible encephalopathy syndrome (PRES) is composed of gradual-onset neurological characteristics with unique radiological distribution (at the posterior brain region). Several etiologies, including hypertension, renal insufficiency, autoimmune diseases, medication use, and immunodeficiency, immunotherapy with intravenous immunoglobulin (IVIG) for various immune-related conditions, were associated with renal impairment, thrombotic manifestation, and reported PRES occurrence. Herein, we report a 73-year-old male who developed a clinical manifestation of PRES on top of IVIG therapy for Miller Fisher variant of GBS; therefore, PRES to be considered in a patient with GBS who treated with IVIG and developed alteration in the state of consciousness.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"16 1","pages":"31 - 33"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87354175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shahzad, Phool Iqbal, M. Jamshaid, Rubab F. Malik, M. Tayyeb, Abdulaziz Zafar
steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is an autoimmune entity with a strong association with elevated antithyroid antibodies. It is a rare cause of encephalopathy and is usually a diagnosis of exclusion. Responsive to corticosteroids is required to make the diagnosis. Herein, we report a male patient presented with recurrent convulsive episodes not controlled well by anticonvulsant drugs and had drops in Glasgow coma scale (GCS). After unremarkable of extensive investigations, Hashimoto's encephalitis was suspected and antithyroid peroxidase antibodies test turned out to be positive, while thyroid function tests were normal and the diagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) was made. He received a course of intravenous methylprednisolone for 5 days and responded very well to therapy, with an improvement of his GCS to 15/15.
{"title":"Steroid-responsive encephalopathy associated with thyroiditis: A diagnostic challenge","authors":"A. Shahzad, Phool Iqbal, M. Jamshaid, Rubab F. Malik, M. Tayyeb, Abdulaziz Zafar","doi":"10.4103/LJMS.LJMS_86_20","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_86_20","url":null,"abstract":"steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is an autoimmune entity with a strong association with elevated antithyroid antibodies. It is a rare cause of encephalopathy and is usually a diagnosis of exclusion. Responsive to corticosteroids is required to make the diagnosis. Herein, we report a male patient presented with recurrent convulsive episodes not controlled well by anticonvulsant drugs and had drops in Glasgow coma scale (GCS). After unremarkable of extensive investigations, Hashimoto's encephalitis was suspected and antithyroid peroxidase antibodies test turned out to be positive, while thyroid function tests were normal and the diagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) was made. He received a course of intravenous methylprednisolone for 5 days and responded very well to therapy, with an improvement of his GCS to 15/15.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"68 1","pages":"36 - 38"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90534863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. A. A. Rabee, Y. E. E Mansour, Huda Mariz, S. Eljamay
Aim: The aim of this experimental study was to evaluate the possible cytoprotective effects of renin-angiotensin-aldosterone system (RAAS) blockade, captopril (10 mg/kg), telmisartan (10 mg/kg), and a proton-pump inhibitor (lansoprazole) on intestinal injury induced by indomethacin in rats. Materials and Methods: This effect was evaluated through the assessment of intestinal inflammatory biomarkers and oxidative stress parameters. Forty adult male albino rats weighing 170–200 g were used and divided equally into five groups. After the treatment, the following were assessed: Myeloperoxidase (MPO) enzyme activity, pro-inflammatory (interleukin-1beta [IL-1 β]) content and anti-inflammatory (IL-10) content, malondialdehyde (MDA) content, reduced glutathione (GSH) content, and superoxide dismutase (SOD) enzyme activity, and histopathological examination of the intestinal tissues was conducted. Results: Indomethacin group induced a significant increase in MDA content, also in inflammatory biomarker (MPO enzyme activity, IL-1 β content, and IL-10 content) compared to normal control, while indomethacin group induced a significant decrease in GSH content, SOD enzyme activity compared to normal control group. Captopril, telmisartan, lansoprazole administration before indomethacin-induced significant increase in GSH content, SOD enzyme activity, while induced significant decrease in MDA content as well as in inflammatory biomarker compared to indomethacin group, which indicate the antioxidant, anti-inflammatory effects, and the gastroprotective properties of RAAS blockers, which also shown in the histopathological examination of intestinal tissues. Conclusion: This study showed the possible antioxidant and anti-inflammatory effects as well as the gastroprotective properties of RAAS blockers. Telmisartan has more antioxidant and anti-inflammatory effect as well as cytoprotective action than captopril.
{"title":"Effect of renin-angiotensin-aldosterone system blockade on intestinal injury induced by indomethacin in rats","authors":"A. A. A. Rabee, Y. E. E Mansour, Huda Mariz, S. Eljamay","doi":"10.4103/LJMS.LJMS_95_20","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_95_20","url":null,"abstract":"Aim: The aim of this experimental study was to evaluate the possible cytoprotective effects of renin-angiotensin-aldosterone system (RAAS) blockade, captopril (10 mg/kg), telmisartan (10 mg/kg), and a proton-pump inhibitor (lansoprazole) on intestinal injury induced by indomethacin in rats. Materials and Methods: This effect was evaluated through the assessment of intestinal inflammatory biomarkers and oxidative stress parameters. Forty adult male albino rats weighing 170–200 g were used and divided equally into five groups. After the treatment, the following were assessed: Myeloperoxidase (MPO) enzyme activity, pro-inflammatory (interleukin-1beta [IL-1 β]) content and anti-inflammatory (IL-10) content, malondialdehyde (MDA) content, reduced glutathione (GSH) content, and superoxide dismutase (SOD) enzyme activity, and histopathological examination of the intestinal tissues was conducted. Results: Indomethacin group induced a significant increase in MDA content, also in inflammatory biomarker (MPO enzyme activity, IL-1 β content, and IL-10 content) compared to normal control, while indomethacin group induced a significant decrease in GSH content, SOD enzyme activity compared to normal control group. Captopril, telmisartan, lansoprazole administration before indomethacin-induced significant increase in GSH content, SOD enzyme activity, while induced significant decrease in MDA content as well as in inflammatory biomarker compared to indomethacin group, which indicate the antioxidant, anti-inflammatory effects, and the gastroprotective properties of RAAS blockers, which also shown in the histopathological examination of intestinal tissues. Conclusion: This study showed the possible antioxidant and anti-inflammatory effects as well as the gastroprotective properties of RAAS blockers. Telmisartan has more antioxidant and anti-inflammatory effect as well as cytoprotective action than captopril.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"12 1","pages":"6 - 10"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84318683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Halima El-Megei, Nadia O. El-houni, Somaia Ezeddin
Background/Aim: Progressive macular hypomelanosis (PMH) is a common skin disorder, predominantly affected young adults, especially women. The aim of the study was to evaluate the therapeutic response of this skin disease to narrowband ultraviolet B (UVB) phototherapy. Methods: A case series study of a total of 100 patients with PMH who were treated in the Phototherapy Unit at Tripoli Central Hospital in the period between January 2008 and December 2018. Results: Out of 100 patients, 82% were female and 18% were male with the mean age of 24.45 ± 4 years. NB-UVB therapy was given three times a week starting with 0.2 J/cm2, with 20% dose increment every session. The maximum cumulative dose was 65.13 J/cm2 with a mean cumulative dose of 20.48 ± 15 J/cm2. The maximum number of sessions was 36 sessions. A satisfactory response was achieved without any complications in most of the patients (89%) after a mean of 17.21 ± 7.2 treatments. Conclusion: PMH occurs mainly in adolescence and young adults with female predominance mainly with skin types IV and V. NB-UVB phototherapy seems to be effective, well-tolerated, safe, and easily administered treatment for progressive PMH.
{"title":"Therapeutic response of patients with progressive macular hypomelanosis to narrowband ultraviolet B phototherapy at dermatology department, Tripoli Central Hospital, Tripoli, Libya (2008–2018)","authors":"Halima El-Megei, Nadia O. El-houni, Somaia Ezeddin","doi":"10.4103/LJMS.LJMS_91_20","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_91_20","url":null,"abstract":"Background/Aim: Progressive macular hypomelanosis (PMH) is a common skin disorder, predominantly affected young adults, especially women. The aim of the study was to evaluate the therapeutic response of this skin disease to narrowband ultraviolet B (UVB) phototherapy. Methods: A case series study of a total of 100 patients with PMH who were treated in the Phototherapy Unit at Tripoli Central Hospital in the period between January 2008 and December 2018. Results: Out of 100 patients, 82% were female and 18% were male with the mean age of 24.45 ± 4 years. NB-UVB therapy was given three times a week starting with 0.2 J/cm2, with 20% dose increment every session. The maximum cumulative dose was 65.13 J/cm2 with a mean cumulative dose of 20.48 ± 15 J/cm2. The maximum number of sessions was 36 sessions. A satisfactory response was achieved without any complications in most of the patients (89%) after a mean of 17.21 ± 7.2 treatments. Conclusion: PMH occurs mainly in adolescence and young adults with female predominance mainly with skin types IV and V. NB-UVB phototherapy seems to be effective, well-tolerated, safe, and easily administered treatment for progressive PMH.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"4 1","pages":"28 - 30"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81965625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Central venous pressure (CVP) is a hemodynamic variable commonly used in the intensive care setting to estimate right arterial pressure for evaluation and monitoring a patient's volume status. Risks such as infection, arterial puncture, hematoma, and pneumothorax associated with central venous cannulation can outweigh its benefits. This study was undertaken to determine if peripheral venous pressure (PVP) predicts CVP in medical intensive care unit (ICU) patients. Materials and Methods: This study was conducted on patients admitted to the medical ICU at AlJamhoriya Teaching Hospital in the period from January to September 2009. Sixty-six patients (aged 40–70 years) who were required a central venous line (CVL) were included prospectively in the study. CVP measured through internal jugular vein or subclavian vein by three ways CVL set insertion; and CVL placement was confirmed by chest X-ray. We used the manometers for the measurement of PVP; and 66 paired recordings of CVP and PVP were made. The correlation and Bland-Altman analysis of agreement were performed. Results: The mean (standard deviation [SD]; range) CVP was 11.3778 cmH2O (±5.6; −1.0–27.0); the mean PVP was 15.80 cmH2O (±5.9; 0.0–33.0); offset (bias) of PVP > CVP was 4.42 cmH2O with SD ± 3.62. The correlation of PVP on CVP was r = 0.8059, ( r2 = 0.65), P < 0.0001. The 95% confidence intervals for the bias were 3.5352–5.3133 cmH2O. In the Bland-Altman analysis, lower and upper limits of agreement (95% LOA) were 2.7 (4.43–−7.20) and 11.63 (4.4–7.2) cmH2O. Four out of 66 points were outside the LOA. The dashed zero lies between the LOA. Conclusion: Measurement of PVP from both antecubital area and dorsum of the hand correlated with CVP measurement with acceptable agreement. PVP measurement may be a noninvasive alternative way for estimating CVP.
{"title":"Correlation between central venous pressure and peripheral venous pressure in medical intensive care unit patients","authors":"Mohamed I. Hamedh, Abdelaziz Al Shaari","doi":"10.4103/LJMS.LJMS_72_19","DOIUrl":"https://doi.org/10.4103/LJMS.LJMS_72_19","url":null,"abstract":"Introduction: Central venous pressure (CVP) is a hemodynamic variable commonly used in the intensive care setting to estimate right arterial pressure for evaluation and monitoring a patient's volume status. Risks such as infection, arterial puncture, hematoma, and pneumothorax associated with central venous cannulation can outweigh its benefits. This study was undertaken to determine if peripheral venous pressure (PVP) predicts CVP in medical intensive care unit (ICU) patients. Materials and Methods: This study was conducted on patients admitted to the medical ICU at AlJamhoriya Teaching Hospital in the period from January to September 2009. Sixty-six patients (aged 40–70 years) who were required a central venous line (CVL) were included prospectively in the study. CVP measured through internal jugular vein or subclavian vein by three ways CVL set insertion; and CVL placement was confirmed by chest X-ray. We used the manometers for the measurement of PVP; and 66 paired recordings of CVP and PVP were made. The correlation and Bland-Altman analysis of agreement were performed. Results: The mean (standard deviation [SD]; range) CVP was 11.3778 cmH2O (±5.6; −1.0–27.0); the mean PVP was 15.80 cmH2O (±5.9; 0.0–33.0); offset (bias) of PVP > CVP was 4.42 cmH2O with SD ± 3.62. The correlation of PVP on CVP was r = 0.8059, ( r2 = 0.65), P < 0.0001. The 95% confidence intervals for the bias were 3.5352–5.3133 cmH2O. In the Bland-Altman analysis, lower and upper limits of agreement (95% LOA) were 2.7 (4.43–−7.20) and 11.63 (4.4–7.2) cmH2O. Four out of 66 points were outside the LOA. The dashed zero lies between the LOA. Conclusion: Measurement of PVP from both antecubital area and dorsum of the hand correlated with CVP measurement with acceptable agreement. PVP measurement may be a noninvasive alternative way for estimating CVP.","PeriodicalId":18055,"journal":{"name":"Libyan Journal of Medical Sciences","volume":"10 1","pages":"21 - 24"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78853010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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