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The 8th Libyan Cardiac Society Congress Recommendations 第八届利比亚心脏学会大会建议
Pub Date : 2022-07-01 DOI: 10.1055/s-0042-1758811
A. Smer, O. Bheleel, Khalid Ellafi, A. Neihoum, Hanifa Alrabte, Omar Msalam
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引用次数: 2
2022: A Challenging Year for LIMUJ 2022年:宝马挑战之年
Pub Date : 2022-07-01 DOI: 10.1055/s-0043-1761299
A. S. Elhwuegi
2022 was a transition year for the Libyan International Medical University Journal (LIMUJ). The transfer process from our old publisher (Medknow) to our new publisher (Thieme) was not smooth and took longer than expected. Besides, we were faced with many difficulties at the beginning that resulted in a loss of communication with many of our authors, readers, and referees; we apologize to them for any inconveniences they faced in reconnection with LIMUJ. However, our train now is back on track, and we hope for a smooth fast ride toward our goals.1 With Thieme, we have received 16 articles (excluding the editorials), 3 were rejected before review, two were rejected after review, and 11 articles were accepted after review with an acceptance rate of approximately 69%. The average review time from the first submission to the final decision was 33.6 days, and the average handling time after acceptance till article publication was 32.7 days. One of our short-term goals is to improve these indicators, the time for the reviewing process, and the time of production after acceptance. The articles accepted were from different countries including Libya (seven articles), Turkey (two articles), India (one article), and the United States (one article). The subjects of the accepted articles were of different diversities of the medical sciences, including coronavirus disease 2019 related complications like lung abscess,2 pulmonary mycosis,3 and vaccination status of healthcare workers in Turkey.4 In an ophthalmological study, different ocular parameters in Libyan subjects were reported.5 Another study was performed to examine the effect of intramuscular injection of vitamin D on serum 25-hydroxyvitamin D levels, glycemic control, and liver enzymes in Libyan patients suffering from type 2 diabetes mellitus with vitamin D deficiency.6 Animal studies included evaluation of the protective effects of doxycycline against vanadiuminduced hepatoxicity in rats,7 and central nervous system effects of the methanolic extract of the leaves of Capparis spinosa L.8 A clinicopathological characteristics of prostate lesions in surgical specimens of Libyan patients were prescribed in a retrospective study,9 and a review article provided information on the current state of antimicrobial resistance in Libya.10 Another original research article reported the magnitude of burnout among physicians in Benghazi-Libya,11 and a letter to the editor describing the 8th Libyan Cardiac Society Congress Recommendations.12 Publication in LIMUJ is still free, charging no processing or publication fees. It is open access under the terms of the Creative Commons permitting copying and reproduction so long as the work is properly cited. I always say that perfection is slow in onset but long in duration. We are aiming for near perfection, andwe hopewe can reach this aim with your help as an author, reader, and reviewer. Wishing you all a happy, healthy new year.
2022年是《利比亚国际医科大学学报》(LIMUJ)的过渡期。从我们的老发行商(Medknow)到新发行商(Thieme)的转移过程并不顺利,花费的时间比预期的要长。此外,我们一开始遇到了很多困难,导致我们与许多作者、读者和审稿人失去了沟通;对于他们在与LIMUJ重新联系时遇到的任何不便,我们深表歉意。然而,我们的火车现在已经回到了轨道上,我们希望能平稳快速地驶向我们的目标使用Thieme,我们共收到16篇文章(不包括社论),审稿前被拒3篇,审稿后被拒2篇,审稿后被接受11篇,接受率约为69%。从首次投稿到最终决定的平均审稿时间为33.6天,从录用到文章发表的平均处理时间为32.7天。我们的短期目标之一是改善这些指标,审查过程的时间,以及验收后的生产时间。被接纳的文章来自利比亚(7篇)、土耳其(2篇)、印度(1篇)、美国(1篇)等不同国家。被接受文章的受试者来自不同的医学学科,包括2019冠状病毒病相关并发症,如肺脓肿、肺真菌病、3和土耳其医护人员的疫苗接种状况。4在一项眼科研究中,报告了利比亚受试者的不同眼部参数另一项研究检查了肌肉注射维生素D对利比亚2型糖尿病患者血清25-羟基维生素D水平、血糖控制和肝酶的影响,这些患者患有维生素D缺乏动物研究包括多西环素对大鼠vanadiv诱导的肝毒性的保护作用的评估,7和Capparis spinosa l .叶甲醇提取物的中枢神经系统作用的评估。在一项回顾性研究中规定了利比亚患者手术标本前列腺病变的临床病理特征,9和一篇综述文章提供了利比亚抗微生物药物耐药性现状的信息。10另一篇原创研究文章报告了班加西-利比亚医生的职业倦怠程度,11以及给编辑的一封信,描述了第8届利比亚心脏病协会大会的建议。12在LIMUJ上发表仍然是免费的,不收取处理费或出版费。它是在知识共享协议的条款下开放获取的,只要作品被正确引用,就允许复制和复制。我总是说,完美是缓慢而持久的。我们的目标是接近完美,我们希望在您作为作者、读者和审稿人的帮助下能够达到这一目标。祝大家新年快乐,身体健康。
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引用次数: 0
Burnout among Physicians at Medical Departments in Benghazi-Libya 班加西-利比亚医疗部门医生的职业倦怠
Pub Date : 2022-07-01 DOI: 10.1055/s-0042-1758810
Khaled D. Alsaeiti, Abdelhdi Elkadiki, Mohamed Hamedh, R. M. Ezwaie, Sarah Muftah Younis, S. O. Elfigih
Abstract Background  Burnout syndrome is recognized as a global issue, and as medical practice is stressful, healthcare workers are found to be burnt out and exhausted very soon, which is reflected negatively on the medical staff well-being, patients' outcome, and the overall organizational performance. Aim  This study is planned to assess the magnitude of burnout among physicians in Benghazi-Libya. Methods  This cross-sectional study was carried out in 2020 on a total of 150 physicians working at different departments of internal medicine in Benghazi-Libya. The Maslach Burnout Inventory collection instrument was used to assess the three components of burnout syndrome: emotional exhaustion, depersonalization, and reduced personal accomplishment. High scores in emotional exhaustion and depersonalization and low scores in personal accomplishment are indicative of high burnout. The statistical analyses of the data were performed using the SPSS version 21. The level of statistical significance was considered as p -value less than 0.05. Results  60% of the respondents were females and 40% were males. About 14.7% had high emotional exhaustion, 92% had high depersonalization, and 87.3% had low personal accomplishment scores. Statistical analysis showed no significant relationship between gender and burnout. Alternatively, a significant association was found between degree certificate and emotional exhaustion, as moderate- and high-level burnout were more prevalent among MBCHB participants than those with masters and board degrees. No association was found between degree certificate and depersonalization or personal accomplishment. Conclusion  Burnout is prevalent among internal medicine doctors in Benghazi, with the newly graduated medical personnel scoring higher rates of burnout than doctors with higher degrees. No relationship was found between gender and burnout.
摘要背景职业倦怠综合征是公认的全球性问题,由于医疗实践压力大,医护人员很快就会感到倦怠和疲惫,这对医务人员的幸福感、患者的预后和整体组织绩效都有负面影响。目的本研究旨在评估班加西-利比亚医师的职业倦怠程度。方法本横断面研究于2020年对利比亚班加西不同内科的150名医生进行。采用Maslach倦怠量表量表评估倦怠综合征的三个组成部分:情绪耗竭、人格解体和个人成就感降低。情绪耗竭和去人格化得分高,个人成就感得分低是高倦怠的表现。数据的统计分析使用SPSS version 21进行。以p值< 0.05为差异有统计学意义。结果被调查者中女性占60%,男性占40%。情绪耗竭程度高的占14.7%,人格解体程度高的占92%,个人成就感低的占87.3%。统计分析显示性别与职业倦怠无显著相关。此外,学位证书与情绪耗竭之间存在显著关联,与硕士和董事学位相比,MBCHB参与者的中度和高度倦怠更为普遍。学位证书与人格解体或个人成就之间没有关联。结论班加西地区内科医生职业倦怠普遍存在,应届毕业医务人员的职业倦怠率高于高学历医生。性别与职业倦怠之间没有关系。
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引用次数: 1
Preliminary Investigation into the Anticonvulsant, Sedative and Muscle Relaxant Effects of the Methanolic Extract of Capparis spinosa L. Leaves in Mice 荆芥叶甲醇提取物对小鼠的抗惊厥、镇静和肌肉松弛作用的初步研究
Pub Date : 2022-07-01 DOI: 10.1055/s-0043-1760832
A. Dugani, Sarah Saleh Khasheba, A. Auzzi
Abstract Background   Capparis spinosa L is a Mediterranean plant. In Libya, the plant grows in rocky areas and at high altitudes. It is commonly used by the inhabitants of the Mediterranean region in their kitchen and treatment of many diseases. Aim  This study was undertaken to investigate the central nervous system depressant, anticonvulsant, and the muscle relaxant activities of orally administered methanolic extract from the leaves of C. spinosa L. (MECS) in mice. Methods  The oral administration of three doses of the MECS in mice (500, 1000, and 2000 mg/kg) were evaluated in the picrotoxin (PC)-induced convulsion model, ketamine-induced sleep, and rota rod test. Diazepam was used as a reference drug for comparison. Results were analyzed using SPSS program version 16. Data are presented as mean ± SEM, and compared using one-way ANOVA followed by Duncan's test. The significance level was set at p  < 0.05 Results  Oral administration of MECS (1000 and 2000 mg/kg) significantly prolonged the onset of seizures ( p  < 0.01) and produced dose-dependent protection against PC-induced seizures compared with the control group (12.5% and 50% protection, respectively). MECS significantly ( p  < 0.05) and dose dependently reduced ketamine sleep latency (from 3.16 ± 0.16 to a minimum of 1.5 ± 0.22 minutes) and prolonged ketamine-induced sleeping time (from 11.33 ± 1.99 to a maximum of 33.33 ± 0.95 minutes). In the accelerated rotarod test, MECS significantly ( p  < 0.01) decreased the riding time on the rotarod (from 128.83 ± 14.6 to a minimum of 1.83 ± 0.47 seconds) as compared with the normal saline control group. Conclusion  The results showed that the MECS possesses anticonvulsant, sedative, and muscle relaxant properties in mice.
Capparis spinosa L是一种地中海植物。在利比亚,这种植物生长在岩石地区和高海拔地区。它通常被地中海地区的居民用于他们的厨房和治疗许多疾病。目的研究经口服的棘叶甲醇提取物(MECS)对小鼠中枢神经系统的抑制作用、抗惊厥作用和肌肉松弛作用。方法采用微毒素(PC)致惊厥模型、氯胺酮致睡眠和rota棒试验,对MECS 3种剂量(500、1000、2000 mg/kg)小鼠口服进行评价。以安定为对照药进行比较。使用SPSS 16版程序对结果进行分析。数据以均数±SEM表示,采用单因素方差分析和邓肯检验进行比较。结果与对照组相比,口服MECS(1000和2000 mg/kg)可显著延长癫痫发作时间(p < 0.01),并对pc诱发的癫痫发作产生剂量依赖性保护(分别为12.5%和50%)。MECS显著(p < 0.05)且剂量依赖性地减少氯胺酮睡眠潜伏期(从3.16±0.16分钟减少到至少1.5±0.22分钟),延长氯胺酮诱导的睡眠时间(从11.33±1.99分钟减少到最多33.33±0.95分钟)。在加速轮轮试验中,与生理盐水对照组相比,MECS显著(p < 0.01)缩短了轮轮上的骑行时间(从128.83±14.6秒减少到至少1.83±0.47秒)。结论MECS对小鼠具有抗惊厥、镇静和肌肉松弛作用。
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引用次数: 1
Knowledge Levels, Attitudes, and Behaviors of Health Care Professionals regarding COVID-19 Vaccines 卫生保健专业人员对COVID-19疫苗的知识水平、态度和行为
Pub Date : 2022-06-22 DOI: 10.1055/s-0042-1747909
Fatih Uzer, Omer Yesil, Yasin Gokmen, Mehmet Reşit Sayan, Mucahit Cengiz
Background Shortly after the coronavirus disease 2019 (COVID-19) pandemic, vaccines were developed. Vaccination of the society in a short time may be the most important step in the fight against the pandemic. Health workers can be considered role models for society. Aim We aimed to investigate the COVID-19 vaccination status of health care workers. Methods The universe of our cross-sectional and descriptive study consisted of doctors, nurses, secretaries, interns, and other health care professionals. In the light of the literature, a questionnaire was prepared that questioned the attitudes and behaviors of the participants about vaccines. Face-to-face interviews were conducted during the visits. SPSS was used for statistical analysis. Results A total of 806 volunteers, 51.4% (414) male and 48.6% (392) female, with a mean age of 32.7 ± 9.3 years, were included in the study. In total, 4.6% (37) of the participants in the study had not received any COVID-19 vaccine. Male participants were vaccinated statistically significantly more than female participants (p = 0.044). Of those vaccinated against COVID-19, 98.3% (774) had received at least two doses. Also, 26.9% (217) of health care workers had COVID-19 disease. The rate of those whose first-degree relatives had COVID-19 was 42.2% (340). A total of 87.3% (704) of health care workers reported that COVID-19 vaccines were safe. Also, 25.3% (204), 29.5% (238), and 35.0% (282) of the participants reported that state officials' vaccination in front of the media, social media news, and national media news, respectively, affected the decision to vaccinate. Conclusion Although male health care workers have received more COVID-19 vaccines than female health care workers, vaccination rates of health care workers are at an acceptable level. Health workers comply with the calendar recommended by the ministry.
2019冠状病毒病(COVID-19)大流行后不久,疫苗就被开发出来了。在短时间内对社会进行疫苗接种可能是抗击大流行病的最重要步骤。卫生工作者可被视为社会的榜样。目的了解医护人员新冠肺炎疫苗接种情况。方法横断面和描述性研究对象包括医生、护士、秘书、实习生和其他卫生保健专业人员。根据文献资料,编制了一份问卷,询问参与者对疫苗的态度和行为。访问期间进行了面对面访谈。采用SPSS软件进行统计分析。结果共纳入志愿者806人,其中男性414人占51.4%,女性392人占48.6%,平均年龄32.7±9.3岁。总共有4.6%(37)的研究参与者没有接种任何COVID-19疫苗。男性受试者接种疫苗的比例显著高于女性受试者(p = 0.044)。在接种COVID-19疫苗的人中,98.3%(774人)至少接种了两剂疫苗。此外,26.9%(217人)的医护人员患有COVID-19疾病。一级亲属感染的占42.2%(340人)。共有87.3%(704人)的医护人员报告COVID-19疫苗是安全的。此外,25.3%(204人)、29.5%(238人)和35.0%(282人)的参与者分别报告说,国家官员在媒体、社交媒体新闻和国家媒体新闻面前接种疫苗影响了他们接种疫苗的决定。结论尽管男性医务人员接种的COVID-19疫苗数量高于女性医务人员,但医务人员的疫苗接种率处于可接受水平。卫生工作者遵守卫生部推荐的日程表。
{"title":"Knowledge Levels, Attitudes, and Behaviors of Health Care Professionals regarding COVID-19 Vaccines","authors":"Fatih Uzer, Omer Yesil, Yasin Gokmen, Mehmet Reşit Sayan, Mucahit Cengiz","doi":"10.1055/s-0042-1747909","DOIUrl":"https://doi.org/10.1055/s-0042-1747909","url":null,"abstract":"\u0000 Background Shortly after the coronavirus disease 2019 (COVID-19) pandemic, vaccines were developed. Vaccination of the society in a short time may be the most important step in the fight against the pandemic. Health workers can be considered role models for society.\u0000 Aim We aimed to investigate the COVID-19 vaccination status of health care workers.\u0000 Methods The universe of our cross-sectional and descriptive study consisted of doctors, nurses, secretaries, interns, and other health care professionals. In the light of the literature, a questionnaire was prepared that questioned the attitudes and behaviors of the participants about vaccines. Face-to-face interviews were conducted during the visits. SPSS was used for statistical analysis.\u0000 Results A total of 806 volunteers, 51.4% (414) male and 48.6% (392) female, with a mean age of 32.7 ± 9.3 years, were included in the study. In total, 4.6% (37) of the participants in the study had not received any COVID-19 vaccine. Male participants were vaccinated statistically significantly more than female participants (p = 0.044). Of those vaccinated against COVID-19, 98.3% (774) had received at least two doses. Also, 26.9% (217) of health care workers had COVID-19 disease. The rate of those whose first-degree relatives had COVID-19 was 42.2% (340). A total of 87.3% (704) of health care workers reported that COVID-19 vaccines were safe. Also, 25.3% (204), 29.5% (238), and 35.0% (282) of the participants reported that state officials' vaccination in front of the media, social media news, and national media news, respectively, affected the decision to vaccinate.\u0000 Conclusion Although male health care workers have received more COVID-19 vaccines than female health care workers, vaccination rates of health care workers are at an acceptable level. Health workers comply with the calendar recommended by the ministry.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86668827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Axial Length, Anterior Chamber Depth, and Lens Thickness in Normal Libyan Eyes; Measured by the Aladdin Ocular Biometer 正常利比亚眼的眼轴长、前房深度和晶状体厚度由阿拉丁眼部生物计测量
Pub Date : 2022-06-06 DOI: 10.1055/s-0042-1749116
S. Bukhatwa, Masuod Suliman
Background: Ocular parameters as axial length (AL), anterior chamber depth (ACD), and lens thickness (LT) are important for refractive and cataract surgeries, and its normal data are important to be identified. Aim: This study was carried out to obtain data about AL, ACD, and LT parameters in normal Libyans. Methods: A cross-sectional study (first of July to end of August, 2021) was done in Benghazi teaching eye hospital on 106 nondiabetic volunteers aged between 17 and 75 years with no ophthalmic disease. Ocular parameters were measured using the Aladdin optical biometer that is a noninvasive machine and without the use of drugs. Descriptive statistics and data analysis were done by using SPSS version 23.0, IBM Corporation. Results: The mean age was 35.36 ±  13.35 years, the mean AL was 23.79 ± 0.91 mm, the mean ACD was 2.96 ± 0.62 mm, and the mean LT was 3.67 ± 0.62 mm. There was no statistically significant difference between these parameters regarding gender or age. Conclusion: This is the first study done on Libyan population to report the AL, ACD, and LT. It showed a comparable result with studies from other populations and that age and gender have no effect on these ocular parameters.
背景:眼参数如轴长(AL)、前房深度(ACD)和晶状体厚度(LT)在屈光和白内障手术中很重要,其正常数据也很重要。目的:本研究旨在获得正常利比亚人AL、ACD和LT参数的数据。方法:于2021年7月1日至8月底在班加西眼科教学医院对106名年龄在17 ~ 75岁、无眼病的非糖尿病志愿者进行横断面研究。眼部参数测量使用阿拉丁光学生物计,这是一种无创机器,不使用药物。描述性统计和数据分析采用IBM公司SPSS 23.0版本进行。结果:患者平均年龄35.36±13.35岁,平均AL为23.79±0.91 mm,平均ACD为2.96±0.62 mm,平均LT为3.67±0.62 mm。关于性别和年龄,这些参数之间没有统计学上的显著差异。结论:这是首次在利比亚人群中报告AL, ACD和lt的研究。它显示了与其他人群研究的可比结果,年龄和性别对这些眼部参数没有影响。
{"title":"Axial Length, Anterior Chamber Depth, and Lens Thickness in Normal Libyan Eyes; Measured by the Aladdin Ocular Biometer","authors":"S. Bukhatwa, Masuod Suliman","doi":"10.1055/s-0042-1749116","DOIUrl":"https://doi.org/10.1055/s-0042-1749116","url":null,"abstract":"\u0000 Background: Ocular parameters as axial length (AL), anterior chamber depth (ACD), and lens thickness (LT) are important for refractive and cataract surgeries, and its normal data are important to be identified.\u0000 Aim: This study was carried out to obtain data about AL, ACD, and LT parameters in normal Libyans.\u0000 Methods: A cross-sectional study (first of July to end of August, 2021) was done in Benghazi teaching eye hospital on 106 nondiabetic volunteers aged between 17 and 75 years with no ophthalmic disease. Ocular parameters were measured using the Aladdin optical biometer that is a noninvasive machine and without the use of drugs. Descriptive statistics and data analysis were done by using SPSS version 23.0, IBM Corporation.\u0000 Results: The mean age was 35.36 ±  13.35 years, the mean AL was 23.79 ± 0.91 mm, the mean ACD was 2.96 ± 0.62 mm, and the mean LT was 3.67 ± 0.62 mm. There was no statistically significant difference between these parameters regarding gender or age.\u0000 Conclusion: This is the first study done on Libyan population to report the AL, ACD, and LT. It showed a comparable result with studies from other populations and that age and gender have no effect on these ocular parameters.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77570508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pulmonary Abscess as a Complication of SARS-CoV-2 Pneumonia SARS-CoV-2肺炎并发肺脓肿
Pub Date : 2022-05-16 DOI: 10.1055/s-0042-1744043
Fatih Uzer, Sukriye Oner, A. Çilli
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease originated in the Wuhan region of China and spread all over the world. This disease typically starts as an acute viral disease, and it is characterized by lung infiltrates and elevation of inflammatory markers. The definitive diagnosis of the disease is confirmed by polymerase chain reaction (PCR) results. Although majority of patients with positive PCR results had mild disease, 5 to 14% of them are severely affected. It has been reported in the literature that a significant proportion of adult patients develops virus-related complications. Lung abscess is one of these complications that is a suppurative infection with an air-fluid level greater than 2 cm in diameter on chest X-ray. Although there is usually a single cavity, it can also be multifocal. It was reported as a possible late-term complication of SARS-CoV-2. We are presenting two cases with lung abscess after SARS-CoV-2 treatment.
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)疾病起源于中国武汉地区,并传播到世界各地。这种疾病通常以急性病毒性疾病开始,其特征是肺部浸润和炎症标志物升高。该疾病的明确诊断由聚合酶链反应(PCR)结果证实。虽然大多数PCR阳性的患者病情较轻,但有5 - 14%的患者病情严重。据文献报道,相当大比例的成年患者出现病毒相关并发症。肺脓肿是一种化脓性感染,胸片显示气液面直径大于2cm。虽然通常只有一个空洞,但也可能是多灶性的。据报道,这可能是SARS-CoV-2的晚期并发症。我们报告两例经SARS-CoV-2治疗后出现肺脓肿的病例。
{"title":"Pulmonary Abscess as a Complication of SARS-CoV-2 Pneumonia","authors":"Fatih Uzer, Sukriye Oner, A. Çilli","doi":"10.1055/s-0042-1744043","DOIUrl":"https://doi.org/10.1055/s-0042-1744043","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease originated in the Wuhan region of China and spread all over the world. This disease typically starts as an acute viral disease, and it is characterized by lung infiltrates and elevation of inflammatory markers. The definitive diagnosis of the disease is confirmed by polymerase chain reaction (PCR) results. Although majority of patients with positive PCR results had mild disease, 5 to 14% of them are severely affected. It has been reported in the literature that a significant proportion of adult patients develops virus-related complications. Lung abscess is one of these complications that is a suppurative infection with an air-fluid level greater than 2 cm in diameter on chest X-ray. Although there is usually a single cavity, it can also be multifocal. It was reported as a possible late-term complication of SARS-CoV-2. We are presenting two cases with lung abscess after SARS-CoV-2 treatment.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"296 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77912168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effect of Intramuscular Injection of Vitamin D on 25-Hydroxyvitamin D Levels, Glycaemic Control, and Liver Enzymes in Libyan Patients with Type 2 Diabetes Mellitus 肌肉注射维生素D对利比亚2型糖尿病患者25-羟基维生素D水平、血糖控制和肝酶的影响
Pub Date : 2022-01-01 DOI: 10.1055/s-0042-1749117
Hafsa M. Alemam, M. Eljilani, A. Bashein
Background Vitamin D is a fat-soluble hormone that plays an important role in glycaemic control. In addition, it has a positive effect on improving liver enzyme function. Aim This study was performed to examine the effect of intramuscular injection of vitamin D on serum 25-hydroxyvitamin D [25(OH)D] levels, glycemic control, and liver enzymes in Libyan patients suffering from type 2 diabetes mellitus (T2DM) with vitamin D deficiency. Methods and Materials This cross-sectional study enrolled 100 T2DM (50 males and 50 females). Their serum 25(OH)D, fasting blood glucose (FBG), and liver enzymes were measured at the baseline and 12 weeks after treatment with vitamin D (200,000 IU) injection monthly for 3 months. Data analysis involved the estimation of mean ± standard error (SE) and comparison of means between pre and post-treatment values using paired t-test. Independent t-test was used to compare the means between males and females. The level of significance was set at p < 0.05. Results Females had a lower 25(OH)D blood levels than males at baseline (7.03 ± 0.25 ng/mL versus 7.86 ± 0.26 ng/mL, respectively p < 0.02). 25(OH)D levels in both sexes was increased significantly from 7.45 ± 0.18 ng/mL to 26.69 ± 0.24 ng/mL after 12 weeks of vitamin D injections (p < 0.001), with no significant differences between male and females. FBG levels in both sexes was significantly decreased from 144.68 ± 1.84 mg/dL to 85.96 ± 0.34 mg/dL post treatment (p < 0.001). Alanine aminotransferase (ALT) was increased from 10.24 ± 0.17 U/L at baseline to 20.34 ± 1.15 U/L post treatment (p < 0.001). Similarly, aspartate aminotransferase (AST) was increased from 11.23 ± 0.21 to 20.57 ± 0.22 U/L (p < 0.001), and alkaline phosphatase (ALP) was decreased from 124.95 ± 1.15 U/L to 111.17 ± 1.27 U/L (p < 0.001). There were no significant differences between male and female liver enzymes either pre- or post-vitamin D injections Conclusion Treatment with vitamin D injection showed a significant increase in 25(OH)D accompanied by decreased FBG and ALP levels and increased ALT and AST levels. Vitamin D levels should be monitored and adjusted in diabetic patients.
维生素D是一种脂溶性激素,在血糖控制中起着重要作用。此外,对改善肝酶功能也有积极作用。目的研究利比亚2型糖尿病(T2DM)患者肌肉注射维生素D对血清25-羟基维生素D [25(OH)D]水平、血糖控制和肝酶的影响。方法与材料本横断面研究纳入100例T2DM患者(男50例,女50例)。在基线和治疗后12周,每月注射20万IU维生素D,连续3个月测定血清25(OH)D、空腹血糖(FBG)和肝酶。数据分析采用配对t检验估计均数±标准误差(SE),比较处理前后值的均数。采用独立t检验比较男女均数。p < 0.05为显著性水平。结果女性25(OH)D水平低于男性(7.03±0.25 ng/mL和7.86±0.26 ng/mL, p < 0.02)。注射维生素D 12周后,男女血清25(OH)D水平由7.45±0.18 ng/mL显著升高至26.69±0.24 ng/mL (p < 0.001),男女差异无统计学意义。治疗后男女空腹血糖水平由144.68±1.84 mg/dL显著降低至85.96±0.34 mg/dL (p < 0.001)。谷丙转氨酶(ALT)由基线时的10.24±0.17 U/L升高至治疗后的20.34±1.15 U/L (p < 0.001)。天冬氨酸转氨酶(AST)由11.23±0.21上升至20.57±0.22 U/L (p < 0.001),碱性磷酸酶(ALP)由124.95±1.15 U/L下降至111.17±1.27 U/L (p < 0.001)。结论注射维生素D后,25(OH)D水平明显升高,FBG和ALP水平降低,ALT和AST水平升高。糖尿病患者应监测和调整维生素D水平。
{"title":"Effect of Intramuscular Injection of Vitamin D on 25-Hydroxyvitamin D Levels, Glycaemic Control, and Liver Enzymes in Libyan Patients with Type 2 Diabetes Mellitus","authors":"Hafsa M. Alemam, M. Eljilani, A. Bashein","doi":"10.1055/s-0042-1749117","DOIUrl":"https://doi.org/10.1055/s-0042-1749117","url":null,"abstract":"\u0000 Background Vitamin D is a fat-soluble hormone that plays an important role in glycaemic control. In addition, it has a positive effect on improving liver enzyme function.\u0000 Aim This study was performed to examine the effect of intramuscular injection of vitamin D on serum 25-hydroxyvitamin D [25(OH)D] levels, glycemic control, and liver enzymes in Libyan patients suffering from type 2 diabetes mellitus (T2DM) with vitamin D deficiency.\u0000 Methods and Materials This cross-sectional study enrolled 100 T2DM (50 males and 50 females). Their serum 25(OH)D, fasting blood glucose (FBG), and liver enzymes were measured at the baseline and 12 weeks after treatment with vitamin D (200,000 IU) injection monthly for 3 months. Data analysis involved the estimation of mean ± standard error (SE) and comparison of means between pre and post-treatment values using paired t-test. Independent t-test was used to compare the means between males and females. The level of significance was set at p < 0.05.\u0000 Results Females had a lower 25(OH)D blood levels than males at baseline (7.03 ± 0.25 ng/mL versus 7.86 ± 0.26 ng/mL, respectively p < 0.02). 25(OH)D levels in both sexes was increased significantly from 7.45 ± 0.18 ng/mL to 26.69 ± 0.24 ng/mL after 12 weeks of vitamin D injections (p < 0.001), with no significant differences between male and females. FBG levels in both sexes was significantly decreased from 144.68 ± 1.84 mg/dL to 85.96 ± 0.34 mg/dL post treatment (p < 0.001). Alanine aminotransferase (ALT) was increased from 10.24 ± 0.17 U/L at baseline to 20.34 ± 1.15 U/L post treatment (p < 0.001). Similarly, aspartate aminotransferase (AST) was increased from 11.23 ± 0.21 to 20.57 ± 0.22 U/L (p < 0.001), and alkaline phosphatase (ALP) was decreased from 124.95 ± 1.15 U/L to 111.17 ± 1.27 U/L (p < 0.001). There were no significant differences between male and female liver enzymes either pre- or post-vitamin D injections\u0000 Conclusion Treatment with vitamin D injection showed a significant increase in 25(OH)D accompanied by decreased FBG and ALP levels and increased ALT and AST levels. Vitamin D levels should be monitored and adjusted in diabetic patients.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89164340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Post-COVID-19-Invasive Pulmonary Mycosis covid -19后侵袭性肺真菌病
Pub Date : 2022-01-01 DOI: 10.1055/s-0042-1750711
S. Swain, K. Sharma, A. Ray, S. Vyas, Gagandeep Singh, M. Joshi, D. Jain, I. Xess, Sanjeev Sinha, N. Wig
COVID-19 has been associated with myriad manifestations as well as adverse outcomes. One of the less commonly reported consequences of COVID-19 is the occurrence of secondary infections in patients suffering acutely from COVID-19 or in those recuperating. Secondary invasive fungal infections (IFIs) have also been observed earlier in other viral infections such as influenza, parainfluenza, and respiratory syncytial virus infections. Severe lung damage and immunologic derangement resulting from SARS-CoV-2 infection predispose to superinfections. Risk factors for secondary IFI includes immunologic derangement and immunoparalysis resulting from SARS-CoV-2 infection, neutropenia, or lymphopenia, poorly controlled diabetes, structural lung disease fungal colonization, and drugs such as corticosteroids or immunomodulators given as therapies for COVID-19. Invasive aspergillosis following COVID-19 is most commonly described fungal infection but other non-Aspergillus fungal infections (including mucormycosis) has also been reported. Herein we describe two interesting cases of secondary infections developing in patients beyond the acute phase of COVID-19 who had similar presentations but with different diagnoses and requiring different management strategies. Patient in case 1 developed COVID-19-associated subacute invasive pulmonary aspergillosis (SAIA) and patient in case 2 had COVID-19 associated pulmonary mucormycosis (CAPM). We have also described the various postulated immune-pathogenesis of the super-added fungal infections in COVID-19 patients.
COVID-19与各种表现和不良后果有关。COVID-19不太常见的后果之一是急性COVID-19患者或恢复期患者发生继发感染。继发性侵袭性真菌感染(IFIs)在其他病毒感染如流感、副流感和呼吸道合胞病毒感染中也有早期观察到。SARS-CoV-2感染导致的严重肺损伤和免疫紊乱易发生重复感染。继发性IFI的危险因素包括由SARS-CoV-2感染、中性粒细胞减少或淋巴细胞减少、控制不良的糖尿病、结构性肺病真菌定植以及作为COVID-19治疗药物的皮质类固醇或免疫调节剂等药物引起的免疫紊乱和免疫瘫痪。COVID-19后的侵袭性曲霉病是最常见的真菌感染,但也有其他非曲霉真菌感染(包括毛霉病)的报道。本文描述了两个有趣的继发性感染病例,这些病例发生在COVID-19急性期以外的患者中,他们具有相似的症状,但诊断不同,需要不同的管理策略。病例1为新型冠状病毒相关亚急性侵袭性肺曲霉病(SAIA),病例2为新型冠状病毒相关肺毛霉菌病(CAPM)。我们还描述了COVID-19患者中超添加真菌感染的各种假定的免疫发病机制。
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引用次数: 3
Doxycycline: An Antibiotic Attenuates Oxidant Stress, Perturbation of Lipid Metabolites, and Antioxidants against Vanadium Toxicity in Rat Hepatocytes 强力霉素:一种减轻氧化应激、扰乱脂质代谢物和抗钒毒性大鼠肝细胞抗氧化剂的抗生素
Pub Date : 2022-01-01 DOI: 10.1055/s-0042-1751258
E. Gassar, N. Mohamed, Fatema Abdullah Emtawel, Rehab Elfakhri, S. Haider
Background The liver is target following exposure to pentavalent vanadium (V5+). Doxycycline is an antioxidant that prevents the progression of disease through inhibition of lipid peroxidation. Aim The present study was designed to evaluate the protective effects of doxycycline against vanadium-induced hepatoxicity. Methods Sixty two male Sprague-Dawley rats (250–300 g) were equally divided into the following four groups: control group (received 0.2 mL of physiological saline), doxycycline control group (received 4 mg/kg body weight on day 1 and 2 mg/kg body weight daily thereafter), vanadium group (received elemental vanadium 1.5 mg/kg-body weight in distilled water), and concomitantly treated group (doxycycline + vanadium) received (doxycycline 4 mg/kg body weight on day 1 and 2 mg/kg body weight thereafter + vanadium 1.5 mg/kg body weight), all given orally for 10 consecutive days. The rats were sacrificed by decapitation 24 hours after the last dose. The liver was removed rapidly and processed for the evaluation of metabolic variables: phospholipids, cholesterol, cerebrosides, gangliosides, reduced glutathione (GSH), vitamin C, calcium, acetylcholinesterase enzyme, and lipid peroxidation. Results Vanadium administration significantly reduced (−60 g) the body weight and significantly increased (+28%) the relative liver weight compared with controls. The rats exhibited neurological function deficits. Vanadium administration decreased the concentrations of metabolic variables compared with controls, cerebrosides (−50%), cholesterol (−39%), phospholipids (−18%), GSH (−45%), and inhibited acetylcholinesterase enzyme (–48%). Gangliosides (+ 38%), vitamin C (+ 20%), and calcium (+ 80%) were increased together with an enhancement (+64%) in lipid peroxidation. The combined treatment (vanadium and doxycycline) significantly increased (+25 g) the body weight and relative liver weight of rat was significantly reduced (+5%) compared with vanadium administered group. The levels of metabolic variables were significantly reversed in this group in the following order: cholesterol (+17%), phospholipids (+7%), vitamin C (−14%), acetylcholinesterase enzyme activity (−27%) together with inhibition (−16%) of lipid peroxidation. All levels were (p < 0.05). Doxycycline presented no effect on the levels of GSH, cerebrosides, and gangliosides. Conclusion Results of this study suggested vanadium-induced oxidation of lipids and sphingolipids in hepatocytes and much of GSH was consumed against high production of reactive oxygen species. Doxycycline protected against vanadium-induced oxidative damage that could be attributed to its free radical scavenging effects on membrane-bound lipids and acetylcholinesterase enzyme.
肝脏是暴露于五价钒(V5+)后的靶标。强力霉素是一种抗氧化剂,通过抑制脂质过氧化作用来防止疾病的进展。目的探讨强力霉素对钒致肝毒性的保护作用。方法雄性Sprague-Dawley大鼠62只(250 ~ 300 g),随机分为4组:对照组(生理盐水0.2 mL)、强力霉素对照组(第1天给予4 mg/kg体重,此后每天给予2 mg/kg体重)、钒组(在蒸馏水中给予1.5 mg/kg体重的单质钒)和联合治疗组(强力霉素+钒)(强力霉素第1天给予4 mg/kg体重,之后给予2 mg/kg体重+钒1.5 mg/kg体重),均为连续10天口服。末次给药后24小时处死大鼠。快速切除肝脏并处理代谢变量:磷脂、胆固醇、脑苷、神经节苷、还原性谷胱甘肽(GSH)、维生素C、钙、乙酰胆碱酯酶和脂质过氧化。结果与对照组相比,钒治疗组体重显著降低(- 60 g),肝脏相对重量显著增加(+28%)。大鼠表现出神经功能缺陷。与对照组相比,钒处理降低了代谢变量的浓度:脑苷(- 50%)、胆固醇(- 39%)、磷脂(- 18%)、谷胱甘肽(- 45%),并抑制了乙酰胆碱酯酶(-48%)。神经节苷(+ 38%)、维生素C(+ 20%)和钙(+ 80%)增加,脂质过氧化增强(+64%)。与给药组相比,钒+多西环素联合给药组大鼠体重显著增加(+25 g),肝脏相对重量显著降低(+5%)。代谢变量水平在这一组中显著逆转,其顺序如下:胆固醇(+17%)、磷脂(+7%)、维生素C(- 14%)、乙酰胆碱酯酶活性(- 27%)以及脂质过氧化抑制(- 16%)。各水平均为(p < 0.05)。强力霉素对GSH、脑苷和神经节苷的水平没有影响。结论钒诱导肝细胞脂质和鞘脂氧化,消耗大量谷胱甘肽,产生大量活性氧。强力霉素可以防止钒诱导的氧化损伤,这可能是由于它对膜结合脂质和乙酰胆碱酯酶的自由基清除作用。
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引用次数: 1
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Libyan International Medical University Journal
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