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Antipsychotics and Risk of Neuroleptic Malignant Syndrome Among A Sample of Egyptian Psychiatric Patients: Role of Alpha-synuclein as A Biomarker for Brain Damage 抗精神病药物和埃及精神病患者样本中抗精神病药物恶性综合征的风险:α -突触核蛋白作为脑损伤的生物标志物的作用
Pub Date : 2021-09-17 DOI: 10.21608/mjfmct.2021.83612.1035
Muhammad Musa, A. Ghanem, O. Shabka, S. Motawei, A. El-Bakary
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引用次数: 0
Assessment of Acute Physiology and Chronic Health Evaluation, Modified Early Warning and Worthing Physiological Scores as Predictor for Mechanical Ventilation in Acute Organophosphorus Toxicity Patients 急性有机磷中毒患者机械通气的急性生理和慢性健康评估、修正预警和Worthing生理评分预测指标
Pub Date : 2021-08-16 DOI: 10.21608/mjfmct.2021.87219.1036
M. Helmy, A. Farahat, M. Ismael, S. Mahmoud, A. Ghanem
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引用次数: 0
Morphometric Study of Patella and Its Role in Sex Determination Among Egyptians Using Magnetic Resonance Imaging 用磁共振成像研究埃及人髌骨形态计量学及其在性别决定中的作用
Pub Date : 2021-06-23 DOI: 10.21608/mjfmct.2021.74572.1032
Dalia Ahmed, Nehal Tharwat, Nermin M Emam
In the morphometry of the patella, there are several naturally occurring variations. Few studies have focused on these anatomical differences among the Egyptian population. The present work aimed to evaluate age and gender variations in different morphometric patellar measurements using magnetic resonance imaging (MRI) in the Egyptian population. Nine patellar parameters were measured on 200 individuals “100 males and 100 females”, aged from 20 to 70 years old using knee joint MRI obtained retrospectively from the picture archiving and communication system (PACS) of Radiology Department, Mansoura University. The mean values revealed statistically significant differences across gender for 5 out of 9 patellar measurements and 4 out of 9 across age, denoting sex and age differentiation in patellar morphology among the Egyptian population. Patellar height (PH), width (PW), thickness (PT), lateral facet width (PLFW), and facet thickness (PFT) showed statistically significant sexual dimorphism (p≤ 0.05) in all age groups. On the other hand, patellar angle (PA) showed the highest statistically significant difference (p ≤ 0.001) for age estimation in all age groups. PH, PW, and PLFW showed a statistically significant negative correlation with age. Moreover, patellar measurements showed high accuracy rates for sex determination among the Egyptian population (84.3-93.6%) in different age groups. Morphometric patellar measurements obtained by non-invasive MRI examination were shown to be useful for sex determination and age prediction in the Egyptian population.
在髌骨的形态测量中,有几种自然发生的变化。很少有研究关注埃及人的这些解剖差异。目前的工作旨在评估年龄和性别变化在不同形态髌骨测量使用磁共振成像(MRI)在埃及人口。采用曼苏拉大学放射科图片存档与通讯系统(PACS)的膝关节MRI,对年龄在20 ~ 70岁的200名患者(男100名,女100名)的9个髌骨参数进行了回顾性测量。平均值显示,9次髌骨测量中有5次的性别差异有统计学意义,9次髌骨测量中有4次的年龄差异有统计学意义,这表明埃及人口中髌骨形态的性别和年龄差异。各年龄组髌骨高度(PH)、宽度(PW)、厚度(PT)、外侧关节突宽度(PLFW)、关节突厚度(PFT)的性别二态性均有统计学意义(p≤0.05)。髌骨角(PA)在各年龄组的年龄估计中差异最大(p≤0.001)。PH、PW、PLFW与年龄呈显著负相关。此外,髌骨测量显示,在不同年龄组的埃及人口中,性别测定的准确率很高(84.3-93.6%)。通过非侵入性MRI检查获得的形态测量髌骨被证明对埃及人口的性别确定和年龄预测有用。
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引用次数: 1
Cases of suicide and attempted suicide by self-poisoning in Alexandria, Egypt- An updated report - Retracted 埃及亚历山大港自杀和企图自残自杀案件-更新报告-撤回
Pub Date : 2021-01-01 DOI: 10.21608/mjfmct.2021.138142
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引用次数: 0
Khat (Catha edulis) Plant Abuse in Saudi Arabia 沙特阿拉伯的阿拉伯茶(Catha edulis)植物滥用
Pub Date : 2020-06-23 DOI: 10.21203/rs.3.rs-36880/v1
Tareq AlAhmadi
BackgroundThe khat (Catha edulis) shrub is cultivated in both the Arabian Peninsula and North Africa. The citizens of this region have carried the tradition of chewing khat leaves since the 15th century. This plant is a natural stimulant which contains two main substances, cathine and cathinone, which cause excitement, euphoria, and loss of appetite. Moreover, the khat trade is considered a source of income within countries of these regions. However, khat holds both benefits and negative aspects for mankind, society, and the environment. This article focuses on the issue of khat smuggling to Saudi Arabia, which has increased over between 2010 and 2016 according to the recent statistics.MethodResearch on the problem of khat smuggling to Saudi Arabia was performed through the analysis of seven years of data (2010–2016) obtained by Saudi Customs and other governmental entities responsible for monitoring the smuggling of drugs, which includes data reflecting the amount of khat seized and smuggled to Saudi Arabia.ResultsKhat smuggling has increased in Saudi Arabia over seven (2010–2016) years. The analysis of data on both the promotion and smuggling of khat were considered, and placed khat in third place among other drugs since the year 1999.ConclusionStatistically, Jazan is the most vulnerable to the smuggling of khat. As such, the to design of intervention programs is recommended to address the problem of khat smuggling in the Jazan region. Additionally, awareness should be increased among the youth through cooperation between public education and higher education, which should include further research on this problem.
阿拉伯茶(Catha edulis)灌木在阿拉伯半岛和北非都有种植。这个地区的居民自15世纪以来就有嚼阿拉伯茶叶的传统。这种植物是一种天然兴奋剂,它含有两种主要物质,cathine和cathinone,它们会引起兴奋、欣快和食欲不振。此外,阿拉伯茶贸易被认为是这些地区国家的收入来源。然而,阿拉伯茶对人类、社会和环境既有好处也有坏处。本文关注的是沙特阿拉伯的阿拉伯茶走私问题,根据最近的统计数据,2010年至2016年间,沙特阿拉伯的阿拉伯茶走私数量有所增加。方法通过分析沙特海关和其他负责监测毒品走私的政府实体获得的7年数据(2010-2016年),研究阿拉伯茶走私到沙特阿拉伯的问题,其中包括反映查获和走私到沙特阿拉伯的阿拉伯茶数量的数据。结果沙特阿拉伯的烟草走私在2010-2016年期间有所增加。对阿拉伯茶的促销和走私数据进行了分析,自1999年以来,阿拉伯茶在其他毒品中排名第三。结论从统计上看,吉赞是最容易受到阿拉伯茶走私的地区。因此,建议设计干预方案以解决吉赞地区阿拉伯茶走私问题。此外,应该通过公共教育和高等教育的合作来提高年轻人的意识,这应该包括对这个问题的进一步研究。
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引用次数: 0
Differential Hepatic Gene Expression and Antioxidant Activity in Male and Female Rats Induced by Subchronic Aflatoxicosis B1 亚慢性黄曲霉毒素B1诱导的雌雄大鼠肝脏基因表达差异及抗氧化活性
Pub Date : 2019-07-01 DOI: 10.21608/mjfmct.2019.52468
G. Omran, N. el-Maali, M. Ismail, Nashwa A Ahmed, M. Mostafa, N. Nasser
Aflatoxin B1 (AFB1) is the most toxic mycotoxin that was proven to be deleterious to human and several animal species. Current work aimed at evaluating the sex-based differential hepatic genotoxic effect and the antioxidant activity as implications of subchronic aflatoxicosis B1. Albino rats were used that comprised two equal AFB1treated groups with AFB1 contaminated olive oil (50µg/kg) and a control group for each gender that received the vehicle only. Parts of animals’ livers were homogenized for gene expression assessment using quantitative RT-PCR and antioxidant activity analyses. Caspase-3 immunohistopathological examination was concomitantly undertaken. Results showed that AFB1 induced significant overexpression in cell cycle proliferation (ODC1), apoptosis (Aen), and antioxidant heme oxygenase (Hmox) genes in males alongside Bax (Bcl2- associated protein) under-expression. Meanwhile, female rats showed significant overexpression for (Hmox) and under-expression of Bax and Tnf (Tumor necrosis factor). Concomitant total hepatic antioxidant activity of liver homogenates showed a reduction in males, contrasting females. Degenerate vacuolated hepatocytes, polymorphic nuclei, cellular infiltration with concomitant Caspase-3 positive cells were profound findings in male rats. Hence, AFB1 is deferentially genotoxic at the given dose especially to male rats towards carcinogenicity, oxidative stress and apoptosis compared to a brief but compensated oxidative stress in females.
黄曲霉毒素B1 (AFB1)是毒性最强的真菌毒素,已被证明对人类和几种动物有害。目前的研究旨在评估亚慢性黄曲霉毒素B1的性别差异肝基因毒性效应和抗氧化活性。白化病大鼠分为两个等量的AFB1处理组,分别给予AFB1污染的橄榄油(50µg/kg)和每个性别的对照组,只接受载具。部分动物肝脏均质化,使用定量RT-PCR和抗氧化活性分析进行基因表达评估。同时进行Caspase-3免疫组织病理学检查。结果显示,AFB1诱导雄性细胞周期增殖(ODC1)、细胞凋亡(Aen)和抗氧化血红素加氧酶(Hmox)基因过表达,同时Bcl2相关蛋白Bax基因过表达。雌性大鼠(Hmox)高表达,Bax、Tnf(肿瘤坏死因子)低表达。同时,肝脏匀浆的总抗氧化活性在男性中降低,而在女性中则相反。雄性大鼠的肝细胞变性、细胞核多形性、细胞浸润伴Caspase-3阳性细胞。因此,在给定剂量下,AFB1对雄性大鼠具有致癌、氧化应激和细胞凋亡的遗传毒性,而对雌性大鼠具有短暂但可补偿的氧化应激。
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引用次数: 3
Forensic Medical Study of Road Traffic Accident Cases Admitted to Minia University Hospital 南京大学医院道路交通事故案件的法医研究
Pub Date : 2019-07-01 DOI: 10.21608/mjfmct.2019.52465
R. Younis, Rana Adel
Road traffic accident, Egypt, Injuries, Deaths. Road traffic accidents (RTAs) constitute a significant public health problem, they are rising in an alarming rate and causing increased morbidity and mortality among people. The objective of this study is to retrospectively analyze the data of road traffic accidents cases in Minia University Hospital from January to December 2016. The data was obtained from sheets of road traffic accident cases enrolled to the hospital within the year 2016 and statistically analyzed as regard the age groups and sex distribution, the causal vehicle, the pattern of injuries occurred, seasonal variation, and the number of deaths due to RTA, the leading causes of death and the survival period following the accident. The total number of studied cases was 370; most of the injuries were observed in adults (74.3%), with marked increase in males (79.5 %). Four wheels were the most causal vehicles (58.9%) for RTAs with higher incidence in spring. Bone fractures were the most common injury pattern (60.5 %) followed by head injuries (37.6 %), then abdominal injuries (9.7%), and finally chest injuries (8.4%). Skin injuries were observed only in (27.8%) of cases. The total number of deaths was 126 (34.1%) cases. Range of survival period was 0-11 days; the most frequent injury presented in dead cases was head injuries (69.8%). The present study concluded that bone fractures were the most common injury pattern in RTAs while head injuries were the main contributing factor for death. The skin injury is not indicative of severity of internal injury.
道路交通事故,埃及,伤害,死亡。道路交通事故是一个重大的公共卫生问题,它们正以惊人的速度上升,造成人们发病率和死亡率的增加。本研究的目的是回顾性分析2016年1 - 12月南京医科大学附属医院道路交通事故病例资料。数据来自2016年医院登记的道路交通事故病例表,并对年龄组和性别分布、因果车辆、受伤模式、季节变化、RTA死亡人数、主要死亡原因和事故发生后的生存期进行统计分析。研究病例总数为370例;以成人(74.3%)为主,以男性(79.5%)居多。四轮是导致rta的主要交通工具(58.9%),春季发病率较高。骨折是最常见的损伤类型(60.5%),其次是头部损伤(37.6%),其次是腹部损伤(9.7%),最后是胸部损伤(8.4%)。皮肤损伤仅占27.8%。死亡126例(34.1%)。生存期0 ~ 11 d;死亡病例中最常见的损伤是头部损伤(69.8%)。本研究得出结论,骨折是rta中最常见的损伤模式,而头部损伤是导致死亡的主要因素。皮肤损伤不能说明内伤的严重程度。
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引用次数: 2
Gas Chromatography-Mass Spectrometric Analysis of a Counterfeit Sildenafil product and its Potential Hepatotoxicity in Mice 假药西地那非的气相色谱-质谱分析及其对小鼠的潜在肝毒性
Pub Date : 2019-07-01 DOI: 10.21608/mjfmct.2019.52475
Asmaa M. Ahmed, Nora Z. Abdellah, Eman S. Shaltout
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引用次数: 2
Effect of Obidoxime Therapy on Cholinesterase Enzymes' Reactivation in Clinically Diagnosed Patients With Acute Organophosphate Toxicity 奥比肟治疗对临床诊断急性有机磷中毒患者胆碱酯酶再激活的影响
Pub Date : 2019-07-01 DOI: 10.21608/mjfmct.2019.52471
A. Othman, H. A. El-Atta, Seham A Gadelhak, A. Ghanem
Organophosphorus poisoning has significant clinical importance, especially in the developing countries, due to its major health consequences. The study evaluated role of obidoxime in reactivation of cholinesterase (ACHE, BuCHE) enzymes in acute organophosphorus (OP) intoxicated patients. It was conducted on group I: 50 patients received obidoxime therapy after acute OP intoxication, and group II: 50 patients did not receive obidoxime. Patients were subjected to neurological evaluation, determination of ACHE and BuCHE levels. Results revealed that there were statistically significant differences between both groups regarding clinical outcomes, with variability of significance regarding initial and final levels of cholinesterase enzymes. It was concluded that BuCHE enzymes' levels can be considered sensitive biomarker for OP exposure and severity, while, ACHE activity reflected the recovery.
有机磷中毒具有重要的临床意义,特别是在发展中国家,因为它具有重大的健康后果。本研究评价了奥比肟在急性有机磷中毒患者胆碱酯酶(ACHE, BuCHE)再激活中的作用。ⅰ组50例急性OP中毒后接受奥比肟治疗的患者,ⅱ组50例未接受奥比肟治疗的患者。对患者进行神经学评估,测定ACHE和BuCHE水平。结果显示两组在临床结果上有统计学上的显著差异,在初始和最终的胆碱酯酶水平上有显著性差异。综上所述,BuCHE酶水平可作为OP暴露和严重程度的敏感生物标志物,而ACHE活性可反映恢复情况。
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引用次数: 0
Prediction of Sex from Teeth Linear Dimensions and Indices 从牙齿线性尺寸和指数预测性别
Pub Date : 2019-07-01 DOI: 10.21608/mjfmct.2019.52478
Hassnaa Ahmed Ahmed Ali, R. Radwan, Maha A. Hilal
Determination of sex is one of the most important and vital steps in forensic medicine. Sexual dimorphism using odontometric analysis is found to vary in different populations making it necessary to attain values of a specific population which makes identification of person as easy as possible. The present study aims to establish sexual differentiation using dental parameters including dental linear dimensions and indices. Maxillary jaw casts from total of 100 subjects (50 males and 50 females) between ages 17 and 24 years were taken. Mesiodistal (MD) and Buccolingual (BL) dimensions of each tooth of from maxillary jaw cast excluding third molar were measured using precision calipers, dental indices were calculated. Data was collected and statistical analysis was done using SPSS software version 20. Bucccolingual dimension was proved to be a better parameter than MD for assessment of gender in case of left central incisor, canines and left first molar. Crown index of right central incisor, second premolars, and left first molars was the best index for sex prediction of most of the teeth.
性别鉴定是法医学中最重要、最关键的步骤之一。使用牙齿测量分析发现性别二态性在不同的人群中有所不同,因此有必要获得特定人群的值,从而尽可能容易地识别人。本研究的目的是利用牙齿的线性尺寸和指数等参数来建立性别分化。选取年龄在17至24岁之间的100名受试者(男性50名,女性50名)的上颌模型。采用精密卡尺测量除第三磨牙外上颌铸型各牙的中远端(MD)和颊舌(BL)尺寸,计算牙指数。采用SPSS软件20进行数据收集和统计分析。在左中切牙、犬齿和左第一磨牙的情况下,颊舌尺寸是比MD更好的评价性别的参数。右侧中切牙、第二前磨牙和左侧第一磨牙的冠指数是大多数牙齿性别预测的最佳指标。
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引用次数: 2
期刊
Mansoura Journal of Forensic Medicine and Clinical Toxicology
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