Pub Date : 2021-09-17DOI: 10.21608/mjfmct.2021.83612.1035
Muhammad Musa, A. Ghanem, O. Shabka, S. Motawei, A. El-Bakary
{"title":"Antipsychotics and Risk of Neuroleptic Malignant Syndrome Among A Sample of Egyptian Psychiatric Patients: Role of Alpha-synuclein as A Biomarker for Brain Damage","authors":"Muhammad Musa, A. Ghanem, O. Shabka, S. Motawei, A. El-Bakary","doi":"10.21608/mjfmct.2021.83612.1035","DOIUrl":"https://doi.org/10.21608/mjfmct.2021.83612.1035","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76780478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-16DOI: 10.21608/mjfmct.2021.87219.1036
M. Helmy, A. Farahat, M. Ismael, S. Mahmoud, A. Ghanem
{"title":"Assessment of Acute Physiology and Chronic Health Evaluation, Modified Early Warning and Worthing Physiological Scores as Predictor for Mechanical Ventilation in Acute Organophosphorus Toxicity Patients","authors":"M. Helmy, A. Farahat, M. Ismael, S. Mahmoud, A. Ghanem","doi":"10.21608/mjfmct.2021.87219.1036","DOIUrl":"https://doi.org/10.21608/mjfmct.2021.87219.1036","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88707497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-23DOI: 10.21608/mjfmct.2021.74572.1032
Dalia Ahmed, Nehal Tharwat, Nermin M Emam
In the morphometry of the patella, there are several naturally occurring variations. Few studies have focused on these anatomical differences among the Egyptian population. The present work aimed to evaluate age and gender variations in different morphometric patellar measurements using magnetic resonance imaging (MRI) in the Egyptian population. Nine patellar parameters were measured on 200 individuals “100 males and 100 females”, aged from 20 to 70 years old using knee joint MRI obtained retrospectively from the picture archiving and communication system (PACS) of Radiology Department, Mansoura University. The mean values revealed statistically significant differences across gender for 5 out of 9 patellar measurements and 4 out of 9 across age, denoting sex and age differentiation in patellar morphology among the Egyptian population. Patellar height (PH), width (PW), thickness (PT), lateral facet width (PLFW), and facet thickness (PFT) showed statistically significant sexual dimorphism (p≤ 0.05) in all age groups. On the other hand, patellar angle (PA) showed the highest statistically significant difference (p ≤ 0.001) for age estimation in all age groups. PH, PW, and PLFW showed a statistically significant negative correlation with age. Moreover, patellar measurements showed high accuracy rates for sex determination among the Egyptian population (84.3-93.6%) in different age groups. Morphometric patellar measurements obtained by non-invasive MRI examination were shown to be useful for sex determination and age prediction in the Egyptian population.
{"title":"Morphometric Study of Patella and Its Role in Sex Determination Among Egyptians Using Magnetic Resonance Imaging","authors":"Dalia Ahmed, Nehal Tharwat, Nermin M Emam","doi":"10.21608/mjfmct.2021.74572.1032","DOIUrl":"https://doi.org/10.21608/mjfmct.2021.74572.1032","url":null,"abstract":"In the morphometry of the patella, there are several naturally occurring variations. Few studies have focused on these anatomical differences among the Egyptian population. The present work aimed to evaluate age and gender variations in different morphometric patellar measurements using magnetic resonance imaging (MRI) in the Egyptian population. Nine patellar parameters were measured on 200 individuals “100 males and 100 females”, aged from 20 to 70 years old using knee joint MRI obtained retrospectively from the picture archiving and communication system (PACS) of Radiology Department, Mansoura University. The mean values revealed statistically significant differences across gender for 5 out of 9 patellar measurements and 4 out of 9 across age, denoting sex and age differentiation in patellar morphology among the Egyptian population. Patellar height (PH), width (PW), thickness (PT), lateral facet width (PLFW), and facet thickness (PFT) showed statistically significant sexual dimorphism (p≤ 0.05) in all age groups. On the other hand, patellar angle (PA) showed the highest statistically significant difference (p ≤ 0.001) for age estimation in all age groups. PH, PW, and PLFW showed a statistically significant negative correlation with age. Moreover, patellar measurements showed high accuracy rates for sex determination among the Egyptian population (84.3-93.6%) in different age groups. Morphometric patellar measurements obtained by non-invasive MRI examination were shown to be useful for sex determination and age prediction in the Egyptian population.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90692056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21608/mjfmct.2021.138142
{"title":"Cases of suicide and attempted suicide by self-poisoning in Alexandria, Egypt- An updated report - Retracted","authors":"","doi":"10.21608/mjfmct.2021.138142","DOIUrl":"https://doi.org/10.21608/mjfmct.2021.138142","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80486994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-23DOI: 10.21203/rs.3.rs-36880/v1
Tareq AlAhmadi
BackgroundThe khat (Catha edulis) shrub is cultivated in both the Arabian Peninsula and North Africa. The citizens of this region have carried the tradition of chewing khat leaves since the 15th century. This plant is a natural stimulant which contains two main substances, cathine and cathinone, which cause excitement, euphoria, and loss of appetite. Moreover, the khat trade is considered a source of income within countries of these regions. However, khat holds both benefits and negative aspects for mankind, society, and the environment. This article focuses on the issue of khat smuggling to Saudi Arabia, which has increased over between 2010 and 2016 according to the recent statistics.MethodResearch on the problem of khat smuggling to Saudi Arabia was performed through the analysis of seven years of data (2010–2016) obtained by Saudi Customs and other governmental entities responsible for monitoring the smuggling of drugs, which includes data reflecting the amount of khat seized and smuggled to Saudi Arabia.ResultsKhat smuggling has increased in Saudi Arabia over seven (2010–2016) years. The analysis of data on both the promotion and smuggling of khat were considered, and placed khat in third place among other drugs since the year 1999.ConclusionStatistically, Jazan is the most vulnerable to the smuggling of khat. As such, the to design of intervention programs is recommended to address the problem of khat smuggling in the Jazan region. Additionally, awareness should be increased among the youth through cooperation between public education and higher education, which should include further research on this problem.
{"title":"Khat (Catha edulis) Plant Abuse in Saudi Arabia","authors":"Tareq AlAhmadi","doi":"10.21203/rs.3.rs-36880/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-36880/v1","url":null,"abstract":"\u0000 BackgroundThe khat (Catha edulis) shrub is cultivated in both the Arabian Peninsula and North Africa. The citizens of this region have carried the tradition of chewing khat leaves since the 15th century. This plant is a natural stimulant which contains two main substances, cathine and cathinone, which cause excitement, euphoria, and loss of appetite. Moreover, the khat trade is considered a source of income within countries of these regions. However, khat holds both benefits and negative aspects for mankind, society, and the environment. This article focuses on the issue of khat smuggling to Saudi Arabia, which has increased over between 2010 and 2016 according to the recent statistics.MethodResearch on the problem of khat smuggling to Saudi Arabia was performed through the analysis of seven years of data (2010–2016) obtained by Saudi Customs and other governmental entities responsible for monitoring the smuggling of drugs, which includes data reflecting the amount of khat seized and smuggled to Saudi Arabia.ResultsKhat smuggling has increased in Saudi Arabia over seven (2010–2016) years. The analysis of data on both the promotion and smuggling of khat were considered, and placed khat in third place among other drugs since the year 1999.ConclusionStatistically, Jazan is the most vulnerable to the smuggling of khat. As such, the to design of intervention programs is recommended to address the problem of khat smuggling in the Jazan region. Additionally, awareness should be increased among the youth through cooperation between public education and higher education, which should include further research on this problem.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91178707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.21608/mjfmct.2019.52468
G. Omran, N. el-Maali, M. Ismail, Nashwa A Ahmed, M. Mostafa, N. Nasser
Aflatoxin B1 (AFB1) is the most toxic mycotoxin that was proven to be deleterious to human and several animal species. Current work aimed at evaluating the sex-based differential hepatic genotoxic effect and the antioxidant activity as implications of subchronic aflatoxicosis B1. Albino rats were used that comprised two equal AFB1treated groups with AFB1 contaminated olive oil (50µg/kg) and a control group for each gender that received the vehicle only. Parts of animals’ livers were homogenized for gene expression assessment using quantitative RT-PCR and antioxidant activity analyses. Caspase-3 immunohistopathological examination was concomitantly undertaken. Results showed that AFB1 induced significant overexpression in cell cycle proliferation (ODC1), apoptosis (Aen), and antioxidant heme oxygenase (Hmox) genes in males alongside Bax (Bcl2- associated protein) under-expression. Meanwhile, female rats showed significant overexpression for (Hmox) and under-expression of Bax and Tnf (Tumor necrosis factor). Concomitant total hepatic antioxidant activity of liver homogenates showed a reduction in males, contrasting females. Degenerate vacuolated hepatocytes, polymorphic nuclei, cellular infiltration with concomitant Caspase-3 positive cells were profound findings in male rats. Hence, AFB1 is deferentially genotoxic at the given dose especially to male rats towards carcinogenicity, oxidative stress and apoptosis compared to a brief but compensated oxidative stress in females.
{"title":"Differential Hepatic Gene Expression and Antioxidant Activity in Male and Female Rats Induced by Subchronic Aflatoxicosis B1","authors":"G. Omran, N. el-Maali, M. Ismail, Nashwa A Ahmed, M. Mostafa, N. Nasser","doi":"10.21608/mjfmct.2019.52468","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.52468","url":null,"abstract":"Aflatoxin B1 (AFB1) is the most toxic mycotoxin that was proven to be deleterious to human and several animal species. Current work aimed at evaluating the sex-based differential hepatic genotoxic effect and the antioxidant activity as implications of subchronic aflatoxicosis B1. Albino rats were used that comprised two equal AFB1treated groups with AFB1 contaminated olive oil (50µg/kg) and a control group for each gender that received the vehicle only. Parts of animals’ livers were homogenized for gene expression assessment using quantitative RT-PCR and antioxidant activity analyses. Caspase-3 immunohistopathological examination was concomitantly undertaken. Results showed that AFB1 induced significant overexpression in cell cycle proliferation (ODC1), apoptosis (Aen), and antioxidant heme oxygenase (Hmox) genes in males alongside Bax (Bcl2- associated protein) under-expression. Meanwhile, female rats showed significant overexpression for (Hmox) and under-expression of Bax and Tnf (Tumor necrosis factor). Concomitant total hepatic antioxidant activity of liver homogenates showed a reduction in males, contrasting females. Degenerate vacuolated hepatocytes, polymorphic nuclei, cellular infiltration with concomitant Caspase-3 positive cells were profound findings in male rats. Hence, AFB1 is deferentially genotoxic at the given dose especially to male rats towards carcinogenicity, oxidative stress and apoptosis compared to a brief but compensated oxidative stress in females.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78325027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.21608/mjfmct.2019.52465
R. Younis, Rana Adel
Road traffic accident, Egypt, Injuries, Deaths. Road traffic accidents (RTAs) constitute a significant public health problem, they are rising in an alarming rate and causing increased morbidity and mortality among people. The objective of this study is to retrospectively analyze the data of road traffic accidents cases in Minia University Hospital from January to December 2016. The data was obtained from sheets of road traffic accident cases enrolled to the hospital within the year 2016 and statistically analyzed as regard the age groups and sex distribution, the causal vehicle, the pattern of injuries occurred, seasonal variation, and the number of deaths due to RTA, the leading causes of death and the survival period following the accident. The total number of studied cases was 370; most of the injuries were observed in adults (74.3%), with marked increase in males (79.5 %). Four wheels were the most causal vehicles (58.9%) for RTAs with higher incidence in spring. Bone fractures were the most common injury pattern (60.5 %) followed by head injuries (37.6 %), then abdominal injuries (9.7%), and finally chest injuries (8.4%). Skin injuries were observed only in (27.8%) of cases. The total number of deaths was 126 (34.1%) cases. Range of survival period was 0-11 days; the most frequent injury presented in dead cases was head injuries (69.8%). The present study concluded that bone fractures were the most common injury pattern in RTAs while head injuries were the main contributing factor for death. The skin injury is not indicative of severity of internal injury.
{"title":"Forensic Medical Study of Road Traffic Accident Cases Admitted to Minia University Hospital","authors":"R. Younis, Rana Adel","doi":"10.21608/mjfmct.2019.52465","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.52465","url":null,"abstract":"Road traffic accident, Egypt, Injuries, Deaths. Road traffic accidents (RTAs) constitute a significant public health problem, they are rising in an alarming rate and causing increased morbidity and mortality among people. The objective of this study is to retrospectively analyze the data of road traffic accidents cases in Minia University Hospital from January to December 2016. The data was obtained from sheets of road traffic accident cases enrolled to the hospital within the year 2016 and statistically analyzed as regard the age groups and sex distribution, the causal vehicle, the pattern of injuries occurred, seasonal variation, and the number of deaths due to RTA, the leading causes of death and the survival period following the accident. The total number of studied cases was 370; most of the injuries were observed in adults (74.3%), with marked increase in males (79.5 %). Four wheels were the most causal vehicles (58.9%) for RTAs with higher incidence in spring. Bone fractures were the most common injury pattern (60.5 %) followed by head injuries (37.6 %), then abdominal injuries (9.7%), and finally chest injuries (8.4%). Skin injuries were observed only in (27.8%) of cases. The total number of deaths was 126 (34.1%) cases. Range of survival period was 0-11 days; the most frequent injury presented in dead cases was head injuries (69.8%). The present study concluded that bone fractures were the most common injury pattern in RTAs while head injuries were the main contributing factor for death. The skin injury is not indicative of severity of internal injury.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80378292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.21608/mjfmct.2019.52475
Asmaa M. Ahmed, Nora Z. Abdellah, Eman S. Shaltout
{"title":"Gas Chromatography-Mass Spectrometric Analysis of a Counterfeit Sildenafil product and its Potential Hepatotoxicity in Mice","authors":"Asmaa M. Ahmed, Nora Z. Abdellah, Eman S. Shaltout","doi":"10.21608/mjfmct.2019.52475","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.52475","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82521409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.21608/mjfmct.2019.52471
A. Othman, H. A. El-Atta, Seham A Gadelhak, A. Ghanem
Organophosphorus poisoning has significant clinical importance, especially in the developing countries, due to its major health consequences. The study evaluated role of obidoxime in reactivation of cholinesterase (ACHE, BuCHE) enzymes in acute organophosphorus (OP) intoxicated patients. It was conducted on group I: 50 patients received obidoxime therapy after acute OP intoxication, and group II: 50 patients did not receive obidoxime. Patients were subjected to neurological evaluation, determination of ACHE and BuCHE levels. Results revealed that there were statistically significant differences between both groups regarding clinical outcomes, with variability of significance regarding initial and final levels of cholinesterase enzymes. It was concluded that BuCHE enzymes' levels can be considered sensitive biomarker for OP exposure and severity, while, ACHE activity reflected the recovery.
{"title":"Effect of Obidoxime Therapy on Cholinesterase Enzymes' Reactivation in Clinically Diagnosed Patients With Acute Organophosphate Toxicity","authors":"A. Othman, H. A. El-Atta, Seham A Gadelhak, A. Ghanem","doi":"10.21608/mjfmct.2019.52471","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.52471","url":null,"abstract":"Organophosphorus poisoning has significant clinical importance, especially in the developing countries, due to its major health consequences. The study evaluated role of obidoxime in reactivation of cholinesterase (ACHE, BuCHE) enzymes in acute organophosphorus (OP) intoxicated patients. It was conducted on group I: 50 patients received obidoxime therapy after acute OP intoxication, and group II: 50 patients did not receive obidoxime. Patients were subjected to neurological evaluation, determination of ACHE and BuCHE levels. Results revealed that there were statistically significant differences between both groups regarding clinical outcomes, with variability of significance regarding initial and final levels of cholinesterase enzymes. It was concluded that BuCHE enzymes' levels can be considered sensitive biomarker for OP exposure and severity, while, ACHE activity reflected the recovery.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90846868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-01DOI: 10.21608/mjfmct.2019.52476
Aliaa Hodeib, Mona M. Ghonem
Theophylline is a bronchodilator drug that is used in the treatment of asthma and chronic obstructive pulmonary diseases. Cardiovascular complications contribute to morbidity and mortality that associate acute theophylline intoxication. The current study aimed to investigate troponin I and creatine kinase-MB as predictors of the severity and outcomes in cases of acute theophylline intoxication. This prospective cohort study included thirty one patients with acute theophylline toxicity admitted to Tanta Poison Control Center during the period from the first of March 2018 to the end of February 2019. Patients were subjected to personal and toxicological history taking, vital signs collection, grading of acute theophylline toxicity and measurement of serum theophylline level. Both troponin I and creatine kinase-MB were measured at admission and 12 hours post admission. Results revealed that, troponin I at time of admission and 12 hours post admission in addition to creatine kinase-MB 12 hours post admission were significantly higher in cases with severe acute theophylline intoxication and patients who required intensive care unit admission. It was concluded that, troponin I could predict the severity and the requirement of intensive care unit admission in acute theophylline toxicity either with early or delayed presentation. On the other hand, creatine kinase-MB could be considered for patients with delayed presentation.
{"title":"Troponine I versus Creatinine Kinase-MB as Predictor Markers of the Severity and Outcomes in Acute Theophylline Toxicity","authors":"Aliaa Hodeib, Mona M. Ghonem","doi":"10.21608/mjfmct.2019.52476","DOIUrl":"https://doi.org/10.21608/mjfmct.2019.52476","url":null,"abstract":"Theophylline is a bronchodilator drug that is used in the treatment of asthma and chronic obstructive pulmonary diseases. Cardiovascular complications contribute to morbidity and mortality that associate acute theophylline intoxication. The current study aimed to investigate troponin I and creatine kinase-MB as predictors of the severity and outcomes in cases of acute theophylline intoxication. This prospective cohort study included thirty one patients with acute theophylline toxicity admitted to Tanta Poison Control Center during the period from the first of March 2018 to the end of February 2019. Patients were subjected to personal and toxicological history taking, vital signs collection, grading of acute theophylline toxicity and measurement of serum theophylline level. Both troponin I and creatine kinase-MB were measured at admission and 12 hours post admission. Results revealed that, troponin I at time of admission and 12 hours post admission in addition to creatine kinase-MB 12 hours post admission were significantly higher in cases with severe acute theophylline intoxication and patients who required intensive care unit admission. It was concluded that, troponin I could predict the severity and the requirement of intensive care unit admission in acute theophylline toxicity either with early or delayed presentation. On the other hand, creatine kinase-MB could be considered for patients with delayed presentation.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84061708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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