Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.47202
A. Zaki, Fouad Aldabah, Mostafa Mohammad, T. Emran, A. Amer
Chronic exposure to heavy metals represents a medical challenge especially in developing countries. The aim of the present study was to measure the levels of (lead and cadmium) in infertile male and correlate these levels with male fertility. After free informed consent, the present study included 70 infertile couples (without female infertility factor) attending the infertility clinics (Dermatology and Venereology Department; Al-Azhar Faculty of Medicine; New Damietta); who were well-known to be exposed to lead and/or cadmium confirmed by measuring blood lead and cadmium levels, and another 30 healthy fertile males without evidence of environmental exposure were included as controls. All patients underwent history taking, clinical and andrological examination and laboratory investigations (complete blood count, blood glucose level, renal and liver function tests and hormonal profile (serum FSH, LH, estrogen and testosterone) with measurement of lead and cadmium levels using graphite furnace atomic absorption spectrophotometry. Finally, a sample of semen was obtained for semen analysis. It was concluded that there was high concentrations of lead and cadmium linked to male infertility as revealed by changes in hormonal profile and seminal parameters.
{"title":"Effects of Environmental Exposure to Lead and Cadmium on Male Fertility","authors":"A. Zaki, Fouad Aldabah, Mostafa Mohammad, T. Emran, A. Amer","doi":"10.21608/mjfmct.2018.47202","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47202","url":null,"abstract":"Chronic exposure to heavy metals represents a medical challenge especially in developing countries. The aim of the present study was to measure the levels of (lead and cadmium) in infertile male and correlate these levels with male fertility. After free informed consent, the present study included 70 infertile couples (without female infertility factor) attending the infertility clinics (Dermatology and Venereology Department; Al-Azhar Faculty of Medicine; New Damietta); who were well-known to be exposed to lead and/or cadmium confirmed by measuring blood lead and cadmium levels, and another 30 healthy fertile males without evidence of environmental exposure were included as controls. All patients underwent history taking, clinical and andrological examination and laboratory investigations (complete blood count, blood glucose level, renal and liver function tests and hormonal profile (serum FSH, LH, estrogen and testosterone) with measurement of lead and cadmium levels using graphite furnace atomic absorption spectrophotometry. Finally, a sample of semen was obtained for semen analysis. It was concluded that there was high concentrations of lead and cadmium linked to male infertility as revealed by changes in hormonal profile and seminal parameters.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86378880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.47197
Hayam Z. Thabet, Nagwa M. Ghandour, M. Bakr
{"title":"Determination of Blood Age by Morphological Changes of Different White Blood Cells","authors":"Hayam Z. Thabet, Nagwa M. Ghandour, M. Bakr","doi":"10.21608/mjfmct.2018.47197","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47197","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74734124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.46999
Mona M. Ghonem, H. Lashin, Aliaa Hodeib, N. Soliman
{"title":"L-Carnitine as an Adjuvant Treatment in Acute Organophosphorus Pesticides Poisoning: A Randomized Clinical Trial","authors":"Mona M. Ghonem, H. Lashin, Aliaa Hodeib, N. Soliman","doi":"10.21608/mjfmct.2018.46999","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.46999","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89020842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.47198
D. Ali, O. Hassan, M. Ramzy, N. Zenhom
{"title":"Estimation of Postmortem Interval from mRNA Degradation and Autolytic Changes in the Brain and Adrenal Gland","authors":"D. Ali, O. Hassan, M. Ramzy, N. Zenhom","doi":"10.21608/mjfmct.2018.47198","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47198","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81728930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.47196
Hany M. Tawfik
Aluminum phosphide (ALP) poisoning has aroused interest in the past three decades. The percentage of poisoning is low, but the mortality is high and no effective antidote available. The objective of this study was to find out predictors of mortality for patients with acute aluminium phosphide poisoning. All patients with acute aluminium phosphide poisoning admitted to Poisoning Control Center, Ain Shams University Hospital between the years 2015 to 2017 were prospectively studied and compared between survival and non survivor patients. Data collected include demographic data, clinical manifestations, laboratory parameters, ECG and treatment offered to the patients. A total 31 patients were enrolled comprising 20 males and 11 females, 84% were suicide and mortality rate was 35%. Shock and cardiac arrhythmia were observed in 52% and39% respectively, while 26% presented with coma. Abnormal blood sugar and metabolic acidosis were found in 19% and 45% respectively. Fifty two percent of the patients needed inotropic therapy and 32% received N-acetylcysteine (NAC). Risk factors increasing mortality were found as shock, tachycardia, coma, metabolic acidosis, hyperglycemia, cardiac arrhythmia and the need for inotropic drug therapy. The study concluded that aluminum phosphide is a low-cost highly-toxic rodenticide. The circulatory collapse, metabolic acidosis and cardiac arrhythmia are the major causes of death. The role of NAC must be reassessed in larger scale. So, intensive observation in ICU and aggressive symptomatic management should be urgently taken into consideration.
{"title":"Study of the Causes of Mortality in Acute Aluminium Phosphide Poisoning","authors":"Hany M. Tawfik","doi":"10.21608/mjfmct.2018.47196","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47196","url":null,"abstract":"Aluminum phosphide (ALP) poisoning has aroused interest in the past three decades. The percentage of poisoning is low, but the mortality is high and no effective antidote available. The objective of this study was to find out predictors of mortality for patients with acute aluminium phosphide poisoning. All patients with acute aluminium phosphide poisoning admitted to Poisoning Control Center, Ain Shams University Hospital between the years 2015 to 2017 were prospectively studied and compared between survival and non survivor patients. Data collected include demographic data, clinical manifestations, laboratory parameters, ECG and treatment offered to the patients. A total 31 patients were enrolled comprising 20 males and 11 females, 84% were suicide and mortality rate was 35%. Shock and cardiac arrhythmia were observed in 52% and39% respectively, while 26% presented with coma. Abnormal blood sugar and metabolic acidosis were found in 19% and 45% respectively. Fifty two percent of the patients needed inotropic therapy and 32% received N-acetylcysteine (NAC). Risk factors increasing mortality were found as shock, tachycardia, coma, metabolic acidosis, hyperglycemia, cardiac arrhythmia and the need for inotropic drug therapy. The study concluded that aluminum phosphide is a low-cost highly-toxic rodenticide. The circulatory collapse, metabolic acidosis and cardiac arrhythmia are the major causes of death. The role of NAC must be reassessed in larger scale. So, intensive observation in ICU and aggressive symptomatic management should be urgently taken into consideration.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90707048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.46828
A. Nagy, Ashraf Nasr A.Y, Abdelmoty Kabbash
{"title":"Medicolegal Importance of the Foramen Ovale, in Determination of Sex, in Dried Adult Egyptians Human Skulls (Morphometric & Morphological Study)","authors":"A. Nagy, Ashraf Nasr A.Y, Abdelmoty Kabbash","doi":"10.21608/mjfmct.2018.46828","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.46828","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91111755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.47200
Hamada Adree, Fouad Aldabah, Waleed E Abo Baraka, S. Alshazly
An increased rate of seizures due to tramadol poisoning has been observed. However, the actual incidence and related factors are not well-studied. The purpose of this work was to investigate the relationship between the incidence of seizures and plasma tramadol level in patients with tramadol-inducing seizures. In addition, we reported the pattern of tramadol overdoses in selected patients. The study was conducted from 1st January 2017 to 28th February 2018. It involved 102 cases who recruited from toxicological units of AlAzhar University Hospital (New Damietta). After free informed consent to contribute in this study and within one hour after arrival to a toxicological unit, 10 mL of blood were separated and the serum was used for extraction of tramadol residues by using a highperformance liquid chromatography (HPLC) and other blood samples were stored at _ 8oC for the following assays to all patients; fasting blood sugar, hemoglobin levels, serum urea, serum creatinine and liver enzymes. Then clinical examination to all patients included vital signs with a special attention to central nervous system (CNS) manifestations, gastrointestinal (GIT) manifestation. The frequency of seizures (27.4%) with acute tramadol poisoning in humans is not dose dependent and seizures occurred with therapeutic doses and there were no relation between blood tramadol level and seizures. We concluded that risk of seizures increase in cases took other drugs with tramadol as alcohol and heroin. The frequency of seizures is not dose dependent; seizures occurred with therapeutic doses.
{"title":"Incidence and Factors Influencing Acute Tramadol Toxicity-Inducing Seizures in Damietta Governorate","authors":"Hamada Adree, Fouad Aldabah, Waleed E Abo Baraka, S. Alshazly","doi":"10.21608/mjfmct.2018.47200","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47200","url":null,"abstract":"An increased rate of seizures due to tramadol poisoning has been observed. However, the actual incidence and related factors are not well-studied. The purpose of this work was to investigate the relationship between the incidence of seizures and plasma tramadol level in patients with tramadol-inducing seizures. In addition, we reported the pattern of tramadol overdoses in selected patients. The study was conducted from 1st January 2017 to 28th February 2018. It involved 102 cases who recruited from toxicological units of AlAzhar University Hospital (New Damietta). After free informed consent to contribute in this study and within one hour after arrival to a toxicological unit, 10 mL of blood were separated and the serum was used for extraction of tramadol residues by using a highperformance liquid chromatography (HPLC) and other blood samples were stored at _ 8oC for the following assays to all patients; fasting blood sugar, hemoglobin levels, serum urea, serum creatinine and liver enzymes. Then clinical examination to all patients included vital signs with a special attention to central nervous system (CNS) manifestations, gastrointestinal (GIT) manifestation. The frequency of seizures (27.4%) with acute tramadol poisoning in humans is not dose dependent and seizures occurred with therapeutic doses and there were no relation between blood tramadol level and seizures. We concluded that risk of seizures increase in cases took other drugs with tramadol as alcohol and heroin. The frequency of seizures is not dose dependent; seizures occurred with therapeutic doses.","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87323013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.46817
Mostafa Mohamed, K. Taha
{"title":"Possible Correlation Between Some Chronic Pesticides Exposure and Disturbance in Thyroid Hormones Levels and Some Biochemical Markers.","authors":"Mostafa Mohamed, K. Taha","doi":"10.21608/mjfmct.2018.46817","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.46817","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75298762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.47201
Hanem Roshdy, R. Abdel-Rahman, H. Azzam, A. El-Bakary
{"title":"Repeated Tramadol Administration Induced Bleeding in Albino Rats","authors":"Hanem Roshdy, R. Abdel-Rahman, H. Azzam, A. El-Bakary","doi":"10.21608/mjfmct.2018.47201","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.47201","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89324237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.21608/mjfmct.2018.46820
A. Othman, H. A. El-Atta, S. El-Hak, A. Ghanem
{"title":"Cholinesterase Enzymes as Predictors for Severity Among Acutely Organophosphorus Intoxicated Patients","authors":"A. Othman, H. A. El-Atta, S. El-Hak, A. Ghanem","doi":"10.21608/mjfmct.2018.46820","DOIUrl":"https://doi.org/10.21608/mjfmct.2018.46820","url":null,"abstract":"","PeriodicalId":18180,"journal":{"name":"Mansoura Journal of Forensic Medicine and Clinical Toxicology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84556264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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