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[Microplastics and nanoplastics and cardiovascular events: guilty or slander?] [微塑料和纳米塑料与心血管事件：有罪还是诽谤？］
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024114
Sara Thietart, Alain Tedgui, Hafid Ait-Oufella
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引用次数: 0
[Microglial cells: Guardians of tissue integrity during fetal brain development]. [小胶质细胞：胎儿大脑发育过程中组织完整性的守护者]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024122
Akindé René Lawrence, Alice Canzi, Cécile Bridlance, Clarissa Catale, Morgane Sonia Thion, Ludmilla Lokmane, Sonia Garel
{"title":"[Microglial cells: Guardians of tissue integrity during fetal brain development].","authors":"Akindé René Lawrence, Alice Canzi, Cécile Bridlance, Clarissa Catale, Morgane Sonia Thion, Ludmilla Lokmane, Sonia Garel","doi":"10.1051/medsci/2024122","DOIUrl":"https://doi.org/10.1051/medsci/2024122","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"719-722"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Functional diversity of NLRP3 gain-of-function mutations and impact on the diagnosis of CAPS hereditary auto-inflammation disease]. [NLRP3功能增益突变的功能多样性及其对CAPS遗传性自身炎症疾病诊断的影响]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024110
Camille Cosson, Romane Riou, Bénédicte F Py
{"title":"[Functional diversity of NLRP3 gain-of-function mutations and impact on the diagnosis of CAPS hereditary auto-inflammation disease].","authors":"Camille Cosson, Romane Riou, Bénédicte F Py","doi":"10.1051/medsci/2024110","DOIUrl":"https://doi.org/10.1051/medsci/2024110","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"707-710"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Some scientific highlights: a selection by MD/Pharmacy-PhD students]. [一些科学亮点：医学博士/药学博士生的精选]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024125
{"title":"[Some scientific highlights: a selection by MD/Pharmacy-PhD students].","authors":"","doi":"10.1051/medsci/2024125","DOIUrl":"10.1051/medsci/2024125","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"793-796"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Multiple sclerosis: The hopes of research]. [多发性硬化症：研究的希望]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024105
Armelle Rancillac, Céline Louapre, Brahim Nait Oumesmar, Emmanuelle Plassart-Schiess, Anne-Cécile Boulay
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引用次数: 0
[Correcting pathogenic mutations using prime editing: an overview]. [利用素材编辑纠正致病突变：概述]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024109
Camille Bouchard, Kelly Godbout, Jacques P Tremblay

Gene editing is an ever-evolving field and Prime editing technology is among the latest ones. It makes it possible to modify a gene using a Cas9 nickase that cuts a single strand of DNA. This Cas9 nickase is fused with a reverse transcriptase that copies a single guide RNA synthetized by the researcher. This technique is used on one hand to create pathogenic mutations to obtain cell or animal models with a specific mutation. On the other hand, Prime editing is also used in research to treat hereditary diseases by correcting mutations associated with a pathogenic effect. The mode of delivery of the treatment to the affected cells in living organisms constitutes a main challenge. Different methods are studied to reach the organs specific to each disease. This review article presents the latest results in the field as well as the challenges to solve to optimize the possible uses of Prime editing.

基因编辑是一个不断发展的领域，Prime 编辑技术是其中最新的一种。它能利用切割 DNA 单链的 Cas9 切断酶修改基因。这种 Cas9 切断酶与反转录酶融合在一起，反转录酶复制研究人员合成的单个指导 RNA。这种技术一方面用于制造致病突变，以获得具有特定突变的细胞或动物模型。另一方面，Prime 编辑也可用于研究，通过纠正与致病作用相关的突变来治疗遗传性疾病。向生物体内受影响细胞提供治疗的方式是一大挑战。人们研究了不同的方法，以达到每种疾病特有的器官。这篇综述文章介绍了该领域的最新成果，以及为优化 Prime 编辑的可能用途而需要解决的挑战。
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引用次数: 0
[FGL1 : a new target for the treatment of anemia ?] [FGL1：治疗贫血的新靶点？］
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024123
Thanina Medjbeur, Jean Personnaz, Léon Kautz
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引用次数: 0
[Prediction of complex biomolecular structures by AlphaFold 3]. [利用 AlphaFold 3 预测复杂的生物分子结构]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024124
Antoine Taly, Alexis Verger
{"title":"[Prediction of complex biomolecular structures by AlphaFold 3].","authors":"Antoine Taly, Alexis Verger","doi":"10.1051/medsci/2024124","DOIUrl":"https://doi.org/10.1051/medsci/2024124","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"725-727"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The dengue vaccine: a major scientific challenge and a public health issue]. [登革热疫苗：重大科学挑战和公共卫生问题]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024116
Philippe Desprès, Dominique Salmon, Laurent Bellec, André Cabié, Marie-Lise Gougeon

Almost half of the world's population is exposed to the risk of transmission of the four dengue virus serotypes (DENV 1-4), by mosquitoes of the genus Aedes. A dengue vaccine is effective if it induces prolonged protective immunity against all circulating viral strains, irrespective of the age and infection history of the vaccinated subject. An effective vaccine strategy against dengue is based on the injection of live attenuated viruses in a tetravalent formulation. In this review, we present the most promising candidate vaccines against dengue, their successes and also the questions raised by the correlates of protection that have been adopted to assess their level of effectiveness against the disease.

全球近一半的人口面临着四种登革热病毒血清型（DENV 1-4）通过伊蚊传播的风险。登革热疫苗如果能针对所有流行的病毒株诱导长期的保护性免疫，则是有效的，与接种对象的年龄和感染史无关。预防登革热的有效疫苗策略是注射四价减毒活疫苗。在这篇综述中，我们将介绍最有希望的登革热候选疫苗、它们的成功经验，以及为评估其对登革热的有效程度而采用的保护相关性所提出的问题。
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引用次数: 0
[Orthologous gene]. [同源基因]。
IF 0.6 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
M S-medecine Sciences
Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.1051/medsci/2024112
Anna Salvetti
{"title":"[Orthologous gene].","authors":"Anna Salvetti","doi":"10.1051/medsci/2024112","DOIUrl":"https://doi.org/10.1051/medsci/2024112","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 10","pages":"788"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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