Pub Date : 2024-08-01Epub Date: 2024-09-20DOI: 10.1051/medsci/2024088
Marion V Guérin, Mathilde Ruggiu, Philippe Bousso
{"title":"[The unexpected role of interleukin 4 within the draining lymph node in response to anti-PD1 therapy].","authors":"Marion V Guérin, Mathilde Ruggiu, Philippe Bousso","doi":"10.1051/medsci/2024088","DOIUrl":"10.1051/medsci/2024088","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 8-9","pages":"613-615"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-09-20DOI: 10.1051/medsci/2024086
Jean-Léon Thomas, Ligia S B Boisserand, Marie-Rénée El Kamouh
{"title":"[Impact of meningeal lymphatic circulation on the response to ischemic stroke].","authors":"Jean-Léon Thomas, Ligia S B Boisserand, Marie-Rénée El Kamouh","doi":"10.1051/medsci/2024086","DOIUrl":"10.1051/medsci/2024086","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 8-9","pages":"604-608"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-09-20DOI: 10.1051/medsci/2024099
Luciano Paolozzi
{"title":"[Earth as seen by its extremophile organisms: an astonishing perspective of life].","authors":"Luciano Paolozzi","doi":"10.1051/medsci/2024099","DOIUrl":"10.1051/medsci/2024099","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 8-9","pages":"599-600"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-09-20DOI: 10.1051/medsci/2024100
Fatima El It, Laurence Faivre, Christel Thauvin-Robinet, Antonio Vitobello, Laurence Duplomb
Rare genetic diseases with neurodevelopmental disorders (NDDs) encompass several heterogeneous conditions (autism spectrum disorder (ASD), intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), specific learning disorder (SLD), among others). Currently, few treatments are available for these patients. The difficulty in accessing human brain samples and the discrepancies between human and animal models highlight the need for new research approaches. One promising approach is the use of the cerebral organoids. These 3D, self-organized structures, generated from induced pluripotent stem cells (iPSCs), enable the reproduction of the stages of human brain development, from the proliferation of neural stem cells to their differentiation into neurons, oligodentrocytes, and astrocytes. Cerebral organoids hold great promise in understanding brain development and in the search for treatments.
{"title":"[The contribution of cerebral organoids to the understanding and treatment of rare genetic diseases with neurodevelopmental disorders].","authors":"Fatima El It, Laurence Faivre, Christel Thauvin-Robinet, Antonio Vitobello, Laurence Duplomb","doi":"10.1051/medsci/2024100","DOIUrl":"https://doi.org/10.1051/medsci/2024100","url":null,"abstract":"<p><p>Rare genetic diseases with neurodevelopmental disorders (NDDs) encompass several heterogeneous conditions (autism spectrum disorder (ASD), intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), specific learning disorder (SLD), among others). Currently, few treatments are available for these patients. The difficulty in accessing human brain samples and the discrepancies between human and animal models highlight the need for new research approaches. One promising approach is the use of the cerebral organoids. These 3D, self-organized structures, generated from induced pluripotent stem cells (iPSCs), enable the reproduction of the stages of human brain development, from the proliferation of neural stem cells to their differentiation into neurons, oligodentrocytes, and astrocytes. Cerebral organoids hold great promise in understanding brain development and in the search for treatments.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 8-9","pages":"643-652"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-09-20DOI: 10.1051/medsci/2024102
Évelyne Collignon, Giacomo Furlan
{"title":"[RNA methylation at the heart of embryonic dormancy].","authors":"Évelyne Collignon, Giacomo Furlan","doi":"10.1051/medsci/2024102","DOIUrl":"https://doi.org/10.1051/medsci/2024102","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 8-9","pages":"620-622"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-09-20DOI: 10.1051/medsci/2024091
Alaedine Benani, Julien Vibert, Stanislas Demuth
Recent technological advances in data science hold great promise in medicine. Large-sized high-quality datasets are essential but often difficult to obtain due to privacy, cost, and practical challenges. Here, we discuss synthetic data's generation, evaluation, and regulation, highlighting its current applications and limits.
{"title":"[Synthetic data in medicine: Generation, evaluation and limits].","authors":"Alaedine Benani, Julien Vibert, Stanislas Demuth","doi":"10.1051/medsci/2024091","DOIUrl":"10.1051/medsci/2024091","url":null,"abstract":"<p><p>Recent technological advances in data science hold great promise in medicine. Large-sized high-quality datasets are essential but often difficult to obtain due to privacy, cost, and practical challenges. Here, we discuss synthetic data's generation, evaluation, and regulation, highlighting its current applications and limits.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 8-9","pages":"661-664"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01Epub Date: 2024-09-20DOI: 10.1051/medsci/2024090
Henri Gruffat, Evelyne Manet
{"title":"[Sir Anthony Epstein (1921-2024): the discoverer of the Epstein-Barr virus].","authors":"Henri Gruffat, Evelyne Manet","doi":"10.1051/medsci/2024090","DOIUrl":"https://doi.org/10.1051/medsci/2024090","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 8-9","pages":"665-668"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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