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Approach to Hyperkalemia 高钾血症的治疗方法
Pub Date : 2022-06-29 DOI: 10.26443/mjm.v20i2.903
C. Najjar
Hyperkalemia is one of the most common electrolytic disorders encountered in clinical practice. Serum potassium concentration is tightly regulated by cellular transfer via insulin, catecholamines, and acid-base equilibrium and secondarily by the kidney via aldosterone and renal flow. Severe hyperkalemia can result in dangerous and potentially life-threatening manifestations, mainly cardiac in nature. It is therefore crucial for physicians to be able to identify the causes of hyperkalemia and provide appropriate treatment. This approach article provides an overview of potassium homeostasis, diagnostic strategies, and treatment guidelines for patients with mild, moderate, and severe hyperkalemia.  
高钾血症是临床上最常见的电解质紊乱之一。血清钾浓度通过胰岛素、儿茶酚胺和酸碱平衡的细胞转移受到严格调节,其次通过醛固酮和肾流量受到肾脏的调节。严重的高钾血症会导致危险且可能危及生命的表现,主要是心脏性质的表现。因此,医生能够确定高钾血症的原因并提供适当的治疗至关重要。这篇方法文章概述了轻度、中度和重度高钾血症患者的钾稳态、诊断策略和治疗指南。
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引用次数: 0
Avant-garde Approach to Life: Reviewing the Current Applications of 3D Bioprinting 前卫的生命之道:回顾当前3D生物打印的应用
Pub Date : 2022-06-23 DOI: 10.26443/mjm.v20i1.919
Iqra Nawaz, Yashfa Nawaz, Eisha Nawaz
Introduction: The promise of bioprinting tissue constructs that could potentially serve the same function in the human body as native tissues has taken the world of regenerative medicine by storm. The current review describes system-wide clinical applications of three-dimensional (3D) bioprinting and aims to address ethical and social considerations, while also discussing the scope of this technology in the near future.Discussion: 3D bioprinting is believed to present new approaches to conventional treatment, offering the advantage of customization and on-time availability. It facilitates simultaneous deposition of appropriate bioinks and biomaterials onto scaffolds which can then be employed to develop tissue fabricates that can potentially mimic native tissues in both structure and functionality. It has been extensively employed to regenerate viable tissue constructs of skin, bone, cartilage, vasculature, myocardial tissue and heart valves, nervous tissue, lung and tracheal tissue, liver, pancreatic, and corneal tissue.Conclusion: To obviate the current restrictions associated with this technology, it is imperative to understand where we currently stand in terms of current clinical applications of 3D bioprinting. This technology is anticipated to contribute significantly to the fields of tissue engineering and regenerative medicine (TERM), where it can be employed to fabricate functional tissues that can simulate their counterparts in the human body.Relevance: The increasing disparity between organ demand and supply as well as the shortcomings associated with antiquated approaches to treatment call for utilizing 3D bioprinting to develop viable tissue constructs.
生物打印组织结构有望在人体中发挥与天然组织相同的功能,这一前景在再生医学领域掀起了一股风暴。当前的综述描述了三维(3D)生物打印的全系统临床应用,旨在解决伦理和社会问题,同时也讨论了这项技术在不久的将来的范围。讨论:3D生物打印被认为是传统治疗的新方法,具有定制化和准时可用的优势。它促进了适当的生物墨水和生物材料同时沉积到支架上,然后可以用来开发组织制造,可以在结构和功能上潜在地模仿天然组织。它已被广泛用于再生皮肤、骨骼、软骨、脉管系统、心肌组织和心脏瓣膜、神经组织、肺和气管组织、肝脏、胰腺和角膜组织的可再生组织结构。结论:为了消除目前与这项技术相关的限制,有必要了解我们目前在3D生物打印的临床应用方面所处的位置。这项技术预计将对组织工程和再生医学(TERM)领域做出重大贡献,在这些领域,它可以用来制造能够模拟人体对应组织的功能组织。相关性:器官需求和供应之间的差距越来越大,以及与过时治疗方法相关的缺点,要求利用3D生物打印来开发可行的组织结构。
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引用次数: 0
Prevention of Hamstring Injuries in Male Soccer Athletes 男足球运动员腿筋损伤的预防
Pub Date : 2022-06-21 DOI: 10.26443/mjm.v20i1.939
Arya Teymourlouei
Abstract Background: One of the most frequently injured muscle groups in soccer is the hamstring group. Soccer players have high rates of hamstring injury (HSI) due to frequent sprinting, changes in direction and similar high-risk activities. Such movements put immense stress on the hamstrings which can lead to injury. Over the last decade, at least four different HSI prevention programs and techniques have been explored in research. The purpose of this review is to assess the effectiveness of these methods. Methods: Studies in this review were collected using multiple database searches of PubMed. A total of six studies were selected, all either randomized controlled trials (RCTs) or cluster-RCTs. The selected trials were from various soccer leagues in Denmark, Japan, the Netherlands, and the United States.Results: The most prevalently studied method is the Nordic hamstring exercise (NHE). Studies that utilized the NHE, either as a stand-alone or within a program, reduced the risk of HSI by 15-71%. In addition, effective programs were characterized by progressively increasing the difficulty of exercises and high compliance rates. Conclusion: Studies that utilized the NHE showed effectiveness in the prevention of hamstring injuries in male soccer athletes. Based on the limited research available, it is unclear whether adding other exercises to prevention programs further reduces injury risk. More research is needed to explore new and existing prevention methods in a variety of populations and regions.
摘要背景:足球运动中最常见的肌肉群之一是腘绳肌群。足球运动员由于频繁的冲刺、改变方向和类似的高风险活动,腿筋受伤率很高。这样的动作会给腘绳肌带来巨大的压力,从而导致受伤。在过去的十年里,研究中至少探索了四种不同的HSI预防方案和技术。本次审查的目的是评估这些方法的有效性。方法:本综述中的研究使用PubMed的多个数据库搜索进行收集。共选择了六项研究,均为随机对照试验或集群随机对照试验。选定的试验来自丹麦、日本、荷兰和美国的各个足球联赛。结果:研究最普遍的方法是北欧腘绳肌锻炼(NHE)。利用NHE的研究,无论是作为一个独立的还是在一个项目中,都将HSI的风险降低了15-71%。此外,有效的计划的特点是逐渐增加锻炼的难度和高依从性。结论:利用NHE的研究表明,NHE在预防男性足球运动员腿筋损伤方面是有效的。根据现有的有限研究,尚不清楚在预防计划中增加其他锻炼是否会进一步降低受伤风险。需要更多的研究来探索各种人群和地区的新的和现有的预防方法。
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引用次数: 0
impact of COVID-19 pandemic and associated restrictions on skin cancer diagnosis and treatment in the western world 新冠肺炎大流行及其相关限制对西方国家癌症诊断和治疗的影响
Pub Date : 2022-06-21 DOI: 10.26443/mjm.v20i2.946
S. Bendayan, F. Lagacé, Elena Netchiporou, I. Litvinov
No abstract for letter to editor as per author guidlines. 
根据作者指南,给编辑的信没有摘要。
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引用次数: 0
Approach to Hemoptysis 咯血的方法
Pub Date : 2022-06-16 DOI: 10.26443/mjm.v20i1.311
M. Peeva
Hemoptysis is the expectoration of blood from the lower airway. A study in the United Kingdom showed that the annual incidence of hemoptysis in primary care is 0.1%. Between 5 and 15% of patients presenting with hemoptysis have a life-threatening hemoptysis  Approach to hemoptysis can be particularly perplexing for medical students considering the extensive list of differential diagnosis. It is important for physicians to be able to recognize and manage life-threatening hemoptysis as it is associated with high morbidity and mortality if untreated. Understanding when to further investigate patients at risk of lung cancer can help detect the disease at an earlier stage.This article begins with a brief introduction to life-threatening and nonlife-threatening hemoptysis and provides a detailed discussion of its management including diagnostic approaches followed by appropriate imaging modalities, laboratory findings, and clinical management. The target audience of this article are medical students at their preclinical or clinical phase.
咳血是指血液从下呼吸道排出。英国的一项研究表明,初级保健中咳血的年发病率为0.1%。5%至15%的咳血患者有危及生命的咳血。考虑到大量的鉴别诊断,对医学生来说,咳血的方法尤其令人困惑。对于医生来说,能够识别和处理危及生命的咳血是很重要的,因为如果不治疗,咳血会导致高发病率和死亡率。了解何时进一步调查有患癌症风险的患者有助于早期发现疾病。本文首先简要介绍了危及生命和无生命威胁的咳血,并对其管理进行了详细讨论,包括诊断方法、适当的成像模式、实验室检查结果和临床管理。这篇文章的目标受众是处于临床前或临床阶段的医学生。
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引用次数: 0
7th Annual McGill Family Medicine Research Symposium, May 12-13, 2022 第七届麦吉尔家庭医学研究年度研讨会,2022年5月12日至13日
Pub Date : 2022-05-13 DOI: 10.26443/mjm.v20i2.992
n/a
没有
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引用次数: 0
Implementing Telehealth Services with the B.E.L.T. Tool 利用B.E.L.T.工具实现远程医疗服务
Pub Date : 2022-04-22 DOI: 10.26443/mjm.v20i1.804
Jennifer Savinsky, Nikida Brisson Maclean, Mérédith Lavoie, Catherine Jabert, Geneva Fournier
Nowadays, as technology takes on a more important role in our everyday lives, telehealth is emerging. Evidence proves that it can ease and improve access to quality care.(1) This commentary offers a synopsis of the narrative on the use of B.E.L.T. mnemonic to be used by a nurse champion to structure the implementation of telehealth services. This opinion and later research indicate that further testing is needed to adapt and validate the tool. The COVID-19 worldwide pandemic could not be a better opportunity to further test the tool through the implementation of telehealth in different settings across the world.
如今,随着技术在我们的日常生活中发挥着越来越重要的作用,远程医疗正在兴起。有证据表明,它可以方便和改善获得优质护理的机会。(1) 这篇评论简要介绍了护士冠军使用B.E.L.T.助记符来构建远程医疗服务的实施。这一观点和后来的研究表明,需要进一步的测试来适应和验证该工具。新冠肺炎全球大流行是通过在世界各地不同环境中实施远程医疗来进一步测试该工具的绝佳机会。
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引用次数: 0
Development of the Evidence-Informed “OI Splint Kit” for Children with Osteogenesis Imperfecta and Their Families 用于儿童成骨不全及其家庭的循证“OI夹板试剂盒”的研制
Pub Date : 2022-04-22 DOI: 10.26443/mjm.v20i1.895
Sofia Addab, Stephanie Thierry, Marie-Elaine Lafrance, Su-Yang Jeong, Jennifer M. Brown, C. Brown, Sylvie-Anne Plourde, Angela Gugliotti, K. Thorstad, R. Hamdy, F. Rauch, A. Tsimicalis
Background: Children with osteogenesis imperfecta (OI) live in fear of fracturing a bone. As fractures are unpredictable, there is a need for tools and knowledge to immobilize a fracture during emergencies. Inspired by a patient recognized in their local OI community for fracture management, the aim of this patient-initiated project was to establish best practices for the safe handling of fractures, including the creation of an evidence-informed OI Splint Kit.    Methods: A systematic review of the literature was conducted to identify kits and tools used to immobilize fractures during emergencies. An expert Task Force consisting of patients, clinicians, and decision makers was conjured to review the synthesized results. Priorities were delineated and a timeline was established to create the OI Splint Kit. The prototype underwent iterative cycles of modifications based on feedback from the Task Force.   Results: Four electronic data bases were searched (Medline, CINHAL, PsychInfo, and Scopus), revealing zero publications pertaining to kits for fracture immobilization. The Task Force used their clinical expertise and patient experiences to develop the OI Splint Kit. The following items were included: splinting tools, bilingual educational material, instructional cards, video tutorials, and a memory card game.   Conclusion: A gap remains in validated kits to assist in fracture immobilization during emergencies. A tangible and practical OI Splint Kit was developed to fulfill this need, based on inter-professional clinical expertise and patient experiential knowledge. The kit is subject to rigorous testing and ongoing quality evaluations, ensuring it will be suitable for use in various contexts. 
背景:患有成骨不全症(OI)的儿童生活在骨折的恐惧中。由于骨折是不可预测的,因此需要在紧急情况下固定骨折的工具和知识。受当地OI社区公认的骨折管理患者的启发,该患者发起的项目旨在建立安全处理骨折的最佳实践,包括创建一个基于证据的OI Splint试剂盒。方法:对文献进行系统回顾,以确定在紧急情况下用于固定骨折的试剂盒和工具。一个由患者、临床医生和决策者组成的专家工作组被召唤来审查综合结果。确定了优先级,并制定了创建OI拆分试剂盒的时间表。原型根据工作队的反馈进行了反复修改。结果:检索了四个电子数据库(Medline、CINHAL、PsychInfo和Scopus),没有发现与骨折固定试剂盒有关的出版物。工作组利用他们的临床专业知识和患者经验开发了OI Splint试剂盒。包括以下物品:夹板工具、双语教育材料、教学卡、视频教程和记忆卡游戏。结论:在紧急情况下辅助骨折固定的有效试剂盒中仍存在空白。基于跨专业临床专业知识和患者经验知识,开发了一种切实可行的OI Splint试剂盒来满足这一需求。该试剂盒经过严格的测试和持续的质量评估,确保适合在各种情况下使用。
{"title":"Development of the Evidence-Informed “OI Splint Kit” for Children with Osteogenesis Imperfecta and Their Families","authors":"Sofia Addab, Stephanie Thierry, Marie-Elaine Lafrance, Su-Yang Jeong, Jennifer M. Brown, C. Brown, Sylvie-Anne Plourde, Angela Gugliotti, K. Thorstad, R. Hamdy, F. Rauch, A. Tsimicalis","doi":"10.26443/mjm.v20i1.895","DOIUrl":"https://doi.org/10.26443/mjm.v20i1.895","url":null,"abstract":"Background: Children with osteogenesis imperfecta (OI) live in fear of fracturing a bone. As fractures are unpredictable, there is a need for tools and knowledge to immobilize a fracture during emergencies. Inspired by a patient recognized in their local OI community for fracture management, the aim of this patient-initiated project was to establish best practices for the safe handling of fractures, including the creation of an evidence-informed OI Splint Kit.   \u0000 Methods: A systematic review of the literature was conducted to identify kits and tools used to immobilize fractures during emergencies. An expert Task Force consisting of patients, clinicians, and decision makers was conjured to review the synthesized results. Priorities were delineated and a timeline was established to create the OI Splint Kit. The prototype underwent iterative cycles of modifications based on feedback from the Task Force.   \u0000Results: Four electronic data bases were searched (Medline, CINHAL, PsychInfo, and Scopus), revealing zero publications pertaining to kits for fracture immobilization. The Task Force used their clinical expertise and patient experiences to develop the OI Splint Kit. The following items were included: splinting tools, bilingual educational material, instructional cards, video tutorials, and a memory card game.   \u0000Conclusion: A gap remains in validated kits to assist in fracture immobilization during emergencies. A tangible and practical OI Splint Kit was developed to fulfill this need, based on inter-professional clinical expertise and patient experiential knowledge. The kit is subject to rigorous testing and ongoing quality evaluations, ensuring it will be suitable for use in various contexts. ","PeriodicalId":18292,"journal":{"name":"McGill Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46459429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Cardiovascular Effects of Vaping Compared to Cigarette Smoking in Young Adults 与吸烟相比,吸烟对年轻人急性心血管系统的影响
Pub Date : 2022-04-22 DOI: 10.26443/mjm.v20i1.861
Keana Shahin, S. West, Ingrid K. M. Brenner
Background: First introduced as the safer alternative to smoking, vaping has become a popular activity among young adults. However, little is known about the potential health effects of vaping.  This pilot project examined the acute cardiovascular effects of nicotine vapes/e-cigarettes (EC) in comparison to tobacco cigarettes (TC) in young adults in order to determine if vaping is more detrimental to cardiovascular health than traditional cigarettes.  Methods: 16 healthy participants (7 M, 9 F; 20.2 ± 1.9 years) were recruited to participate in the study.  Anthropometric measures were determined upon entry into the study. Circulatory measures (heart rate [HR], blood pressure [BP] and heart rate variability [HRV]) were measured prior to and 10-min following vaping or cigarette smoking and in response to an orthostatic challenge. Results: Resting circulatory and HRV measures were not different between chronic EC-users and TC-smokers.  Vaping and cigarette smoking induced a significant increase in cardiovascular measures (HR and BP) but not HRV measures.  Both groups responded similarly to the orthostatic challenge prior to and following vaping/smoking. Conclusion: These results indicate that, from a cardiovascular perspective, vaping induces similar acute effects as cigarette smoking and that young adults should be counselled about these adverse effects accordingly.
背景:电子烟最初是作为一种更安全的吸烟替代品引入的,现在已经成为年轻人的一项流行活动。然而,人们对电子烟对健康的潜在影响知之甚少。该试点项目检查了尼古丁电子烟(EC)与烟草香烟(TC)对年轻人的急性心血管影响,以确定电子烟是否比传统香烟对心血管健康更有害。方法:16名健康参与者(7M,9F;20.2±1.9岁)被招募参与该研究。在进入研究时确定了人体测量方法。循环测量(心率[HR]、血压[BP]和心率变异性[HRV])在吸电子烟或吸烟前和吸烟后10分钟以及对直立挑战的反应中进行测量。结果:慢性EC使用者和TC吸烟者的静息循环和HRV指标没有差异。Vaping和吸烟导致心血管指标(HR和BP)显著增加,但HRV指标没有增加。两组在吸电子烟之前和之后对直立挑战的反应相似。结论:这些结果表明,从心血管的角度来看,电子烟会引起与吸烟相似的急性影响,因此应向年轻人提供相应的不良影响建议。
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引用次数: 0
The Direct and Indirect Financial Costs Sustained by Parents of Children with Osteogenesis Imperfecta 成骨不全症患儿的父母承担的直接和间接经济成本
Pub Date : 2022-04-22 DOI: 10.26443/mjm.v20i1.831
Aimee R. Castro, M. Morand, F. Rauch, A. Tsimicalis
Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a rare genetic condition characterized by increased bone fragility. The financial costs of caring for a child with a rare condition can be a significantsource of stress for families. As such, the financial costs of care are a concern to the clinicians who care for these families. However, the financial impact of caring for a child with OI is under-reported. A secondary analysis was conducted on data collected from a qualitative study in nursing. The aim was to offer preliminary insights into the financial impacts of caring for a child living with OI. Participants reported many direct out-of-pocket costs, which presented with reimbursement barriers. Other indirect costs resulted from missed work, career changes, or workforce departures. Policy and clinical implications include optimizing accessibility of supportive childcare policies, simplifying healthcare reimbursements, and regularly assessing families’ knowledge of available financial supports. 
成骨不全(OI),也称为脆性骨病,是一种罕见的遗传病,其特征是骨脆性增加。照顾一个患有罕见疾病的孩子的经济成本可能是家庭压力的重要来源。因此,护理的经济成本是护理这些家庭的临床医生所关心的问题。然而,照顾患有OI的儿童的经济影响报告不足。对从护理学的一项定性研究中收集的数据进行了二次分析。其目的是对照顾患有OI的儿童的财务影响提供初步见解。与会者报告了许多直接自付费用,这些费用存在报销障碍。因误工、转行或员工离职而产生的其他间接成本。政策和临床影响包括优化支持性儿童保育政策的可及性,简化医疗报销,以及定期评估家庭对可用财政支持的了解。
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引用次数: 0
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McGill Journal of Medicine
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