Pub Date : 2022-05-21DOI: 10.1007/s00795-022-00323-y
Lian-qian Li, T. Irie, D. Yoshii, Y. Komohara, Yukio Fujiwara, Shigeyuki Esumi, M. Kadohisa, M. Honda, S. Suzu, T. Matsuura, Kenichi Kohashi, Y. Oda, T. Hibi
{"title":"M-CSFR expression in the embryonal component of hepatoblastoma and cell-to-cell interaction between macrophages and hepatoblastoma","authors":"Lian-qian Li, T. Irie, D. Yoshii, Y. Komohara, Yukio Fujiwara, Shigeyuki Esumi, M. Kadohisa, M. Honda, S. Suzu, T. Matsuura, Kenichi Kohashi, Y. Oda, T. Hibi","doi":"10.1007/s00795-022-00323-y","DOIUrl":"https://doi.org/10.1007/s00795-022-00323-y","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"16 1","pages":"236 - 247"},"PeriodicalIF":1.8,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78855226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-20DOI: 10.1007/s00795-022-00324-x
Yumi Nozawa, Kazuyuki Ishida, Niki Maiko, A. Takada-Owada, Masato Onozaki, Mina Takaoka, Kinichi Matsuyama, Y. Sakuraoka, Y. Nakazato, K. Kubota
{"title":"Mixed adenoneuroendocrine carcinoma of the non-ampullary duodenum with mismatch repair deficiency: a rare case report","authors":"Yumi Nozawa, Kazuyuki Ishida, Niki Maiko, A. Takada-Owada, Masato Onozaki, Mina Takaoka, Kinichi Matsuyama, Y. Sakuraoka, Y. Nakazato, K. Kubota","doi":"10.1007/s00795-022-00324-x","DOIUrl":"https://doi.org/10.1007/s00795-022-00324-x","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"45 1","pages":"258 - 266"},"PeriodicalIF":1.8,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87491355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-10DOI: 10.1007/s00795-022-00322-z
N. Takaoka, Michiko Yamane, K. Obara, K. Shirai, R. Aki, Y. Hamada, N. Arakawa, Robert M. Hoffman, Y. Amoh
{"title":"Hair-follicle-associated pluripotent (HAP) stem cells differentiate into mature beating cardiomyocyte sheets on flexible substrates in vitro","authors":"N. Takaoka, Michiko Yamane, K. Obara, K. Shirai, R. Aki, Y. Hamada, N. Arakawa, Robert M. Hoffman, Y. Amoh","doi":"10.1007/s00795-022-00322-z","DOIUrl":"https://doi.org/10.1007/s00795-022-00322-z","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"41 1","pages":"248 - 257"},"PeriodicalIF":1.8,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73424268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.1007/s00795-022-00320-1
S. Togo, H. Imanishi, M. Hayashi, M. Koyama, Y. Kira, K. Sugawara, D. Tsuruta
{"title":"Exploring the impact of ovariectomy on hair growth: can ovariectomized mouse serve as a model for investigating female pattern hair loss in humans?","authors":"S. Togo, H. Imanishi, M. Hayashi, M. Koyama, Y. Kira, K. Sugawara, D. Tsuruta","doi":"10.1007/s00795-022-00320-1","DOIUrl":"https://doi.org/10.1007/s00795-022-00320-1","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"11 1","pages":"210 - 226"},"PeriodicalIF":1.8,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88970632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-23DOI: 10.1007/s00795-022-00317-w
H. Aoki, E. Suzuki, Takashi Nakamura, Shoko Onodera, A. Saito, M. Ohtaka, M. Nakanishi, K. Nishimura, Atsushi Saito, Toshifumi Azuma
{"title":"Induced pluripotent stem cells from homozygous Runx2-deficient mice show poor response to vitamin D during osteoblastic differentiation","authors":"H. Aoki, E. Suzuki, Takashi Nakamura, Shoko Onodera, A. Saito, M. Ohtaka, M. Nakanishi, K. Nishimura, Atsushi Saito, Toshifumi Azuma","doi":"10.1007/s00795-022-00317-w","DOIUrl":"https://doi.org/10.1007/s00795-022-00317-w","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"77 1","pages":"174 - 186"},"PeriodicalIF":1.8,"publicationDate":"2022-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75738775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-21DOI: 10.1007/s00795-022-00319-8
Yasuhiko Taki, Atsushi Fuku, Yuka Nakamura, Terutsugu Koya, H. Kitajima, Ikuhiro Tanida, T. Takaki, Kaori Nozaki, H. Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Takeo Shimasaki, Togen Masauji, Naoki Yamamoto, Y. Ishigaki, S. Shimodaira, Yusuke Shimizu, T. Ichiseki, A. Kaneuji, S. Osawa, N. Kawahara
{"title":"A morphological study of adipose-derived stem cell sheets created with temperature-responsive culture dishes using scanning electron microscopy","authors":"Yasuhiko Taki, Atsushi Fuku, Yuka Nakamura, Terutsugu Koya, H. Kitajima, Ikuhiro Tanida, T. Takaki, Kaori Nozaki, H. Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Takeo Shimasaki, Togen Masauji, Naoki Yamamoto, Y. Ishigaki, S. Shimodaira, Yusuke Shimizu, T. Ichiseki, A. Kaneuji, S. Osawa, N. Kawahara","doi":"10.1007/s00795-022-00319-8","DOIUrl":"https://doi.org/10.1007/s00795-022-00319-8","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"34 1","pages":"187 - 198"},"PeriodicalIF":1.8,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74055766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-04DOI: 10.1007/s00795-022-00316-x
N. Kaku, T. Shimada, Tsuguaki Hosoyama, H. Tsumura
{"title":"Microvascular system of hip joint constituents with special reference to ultrastructural findings and early arteriosclerosis","authors":"N. Kaku, T. Shimada, Tsuguaki Hosoyama, H. Tsumura","doi":"10.1007/s00795-022-00316-x","DOIUrl":"https://doi.org/10.1007/s00795-022-00316-x","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"21 1","pages":"158 - 165"},"PeriodicalIF":1.8,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78252861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-03DOI: 10.1007/s00795-022-00314-z
Yudai Nakajima, Yuto Yamazaki, Xin Gao, Masatoshi Hashimoto, M. Nio, M. Wada, F. Fujishima, H. Sasano
{"title":"Association between mitochondrial and nuclear DNA damages and cellular senescence in the patients with biliary atresia undergoing Kasai portoenterostomy and liver transplantation","authors":"Yudai Nakajima, Yuto Yamazaki, Xin Gao, Masatoshi Hashimoto, M. Nio, M. Wada, F. Fujishima, H. Sasano","doi":"10.1007/s00795-022-00314-z","DOIUrl":"https://doi.org/10.1007/s00795-022-00314-z","url":null,"abstract":"","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"44 1","pages":"131 - 145"},"PeriodicalIF":1.8,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72814830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, attributable to inflammation and mitochondrial dysfunction. Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. However, whether MA-5 is effective against peritoneal fibrosis remains unclear. Therefore, we investigated the effect of MA-5 using a peritoneal fibrosis mouse model. Peritoneal fibrosis was induced in C57BL/6 mice via intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 3 weeks. MA-5 was administered daily by oral gavage. The mice were divided into control, MA-5, CG, and CG + MA-5 groups. Following treatment, immunohistochemical analyses were performed. Fibrotic thickening of the parietal peritoneum induced by CG was substantially attenuated by MA-5. The number of α-smooth muscle actin-positive myofibroblasts, transforming growth factor β-positive cells, F4/80-positive macrophages, monocyte chemotactic protein 1-positive cells, and 4-hydroxy-2-nonenal-positive cells was considerably decreased. In addition, reduced ATP5a1-positive and uncoupling protein 2-positive cells in the CG group were notably increased by MA-5. MA-5 may ameliorate peritoneal fibrosis by suppressing macrophage infiltration and oxidative stress, thus restoring mitochondrial function. Overall, MA-5 has therapeutic potential against peritoneal fibrosis.
{"title":"Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice.","authors":"Hiro Inoue, Kenta Torigoe, Miki Torigoe, Kumiko Muta, Yoko Obata, Takehiro Suzuki, Chitose Suzuki, Takaaki Abe, Takehiko Koji, Hiroshi Mukae, Tomoya Nishino","doi":"10.1007/s00795-021-00305-6","DOIUrl":"https://doi.org/10.1007/s00795-021-00305-6","url":null,"abstract":"<p><p>Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, attributable to inflammation and mitochondrial dysfunction. Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. However, whether MA-5 is effective against peritoneal fibrosis remains unclear. Therefore, we investigated the effect of MA-5 using a peritoneal fibrosis mouse model. Peritoneal fibrosis was induced in C57BL/6 mice via intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 3 weeks. MA-5 was administered daily by oral gavage. The mice were divided into control, MA-5, CG, and CG + MA-5 groups. Following treatment, immunohistochemical analyses were performed. Fibrotic thickening of the parietal peritoneum induced by CG was substantially attenuated by MA-5. The number of α-smooth muscle actin-positive myofibroblasts, transforming growth factor β-positive cells, F4/80-positive macrophages, monocyte chemotactic protein 1-positive cells, and 4-hydroxy-2-nonenal-positive cells was considerably decreased. In addition, reduced ATP5a1-positive and uncoupling protein 2-positive cells in the CG group were notably increased by MA-5. MA-5 may ameliorate peritoneal fibrosis by suppressing macrophage infiltration and oxidative stress, thus restoring mitochondrial function. Overall, MA-5 has therapeutic potential against peritoneal fibrosis.</p>","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":"55 1","pages":"27-40"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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