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XVII Meeting of the Academy AIPMB and I National Congress SPPMB. December 2-3, 2022. Proceedings and Abstract. 学会第十七次会议暨学会第一次全国代表大会。2022年12月2-3日。论文集与摘要。
IF 2.2 3区 医学 Pub Date : 2023-04-11 DOI: 10.4317/medoral.1122335667799
42.8
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引用次数: 0
Systematic mapping review of interventions to prevent blood loss, infection and relapse in orthognathic surgery. 对正颌外科手术中预防失血、感染和复发的干预措施进行系统性绘图审查。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25530
J Bendersky, M Uribe, M Bravo, J-P Vargas, J Villanueva, G Urrutia, X Bonfill

Background: This systematic mapping review aims to identify, describe, and organize the currently available evidence in systematic reviews (SR) and primary studies regarding orthognathic surgery (OS) co-interventions and surgical modalities, focusing on the outcomes blood loss, infection and relapse.

Material and methods: A comprehensive search strategy was performed to identify all SRs, randomized controlled trials and observational studies that evaluate surgical modalities and perioperative co-interventions in OS that evaluate the outcomes blood loss, infection and relapse, regardless of language or publication date. Searches were conducted in MEDLINE, EMBASE, Epistemonikos, Lilacs, Web of Science, and CENTRAL. In addition, grey literature was screened.

Results: 27 SRs and 150 primary studies fulfilled the inclusion criteria, 91 from SRs, and 59 from our search strategy. Overall, the quality of the SRs was graded as "Critically low," and only two SRs were rated as "High" quality. 11 PICO questions were extracted from SRs and 31 from primary studies, which focused on osteosynthesis methods, surgical cutting devices, use of antibiotics, and induced hypotension. In addition, evidence bubble maps for each outcome were created to analyze in a visual manner the existing evidence.

Conclusions: Future primary and secondary high-quality research should be addressed focused on the eight knowledge gaps identified in this mapping review. We concluded that the evidence mapping approach is a practical methodology for organizing the current evidence and identifying knowledge gaps in OS, helping to reduce research waste and canalize future efforts in developing studies for unsolved questions.

背景:本系统图谱综述旨在识别、描述和整理系统综述(SR)和主要研究中有关正颌外科手术(OS)联合干预和手术方式的现有证据,重点关注失血、感染和复发结果:采用综合检索策略,以确定所有对正颌外科手术中的手术方式和围手术期共同干预进行评估的SR、随机对照试验和观察性研究,这些研究对失血、感染和复发等结果进行评估,而不论语言或出版日期。在 MEDLINE、EMBASE、Epistemonikos、Lilacs、Web of Science 和 CENTRAL 中进行了检索。结果:符合纳入标准的有 27 篇自选报告和 150 篇主要研究,其中 91 篇来自自选报告,59 篇来自我们的检索策略。总体而言,研究报告的质量被评为 "极低",只有两份研究报告的质量被评为 "高"。从研究报告中提取了 11 个 PICO 问题,从主要研究中提取了 31 个 PICO 问题,主要集中在骨合成方法、手术切割设备、抗生素的使用和诱导性低血压。此外,还为每项结果绘制了证据气泡图,以直观的方式分析现有证据:结论:未来的主要和次要高质量研究应集中在本图谱审查中确定的八个知识缺口上。我们的结论是,证据图谱法是一种实用的方法,可用于组织现有证据和确定操作系统中的知识差距,有助于减少研究浪费,并使未来的研究工作更有针对性,以解决尚未解决的问题。
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引用次数: 0
Paediatric head and neck malignant neoplasms: A brazilian retrospective study. 儿童头颈部恶性肿瘤:巴西回顾性研究。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25614
W-A Cunha, A-C Corazza, K-M Rezende, M Bönecker, M Gallottini

Background: To assess the prevalence of oral and maxillofacial malignant neoplasias in children and adolescents diagnosed through biopsies sent to the Oral Pathology Laboratory at the University of Sao Paulo School of Dentistry.

Material and methods: A retrospective analysis of anatomopathological reports on patients between 1 and 18 years old issued by the oral and maxillofacial pathology laboratory between 1997 and 2021 was performed for demographic data, lesion site, type of biopsy, diagnostic hypothesis and final diagnosis.

Results: The laboratory issued 76,194 anatomopathological reports during this period, of which 10.77% were of children and adolescents. Of this total, only 32 biopsies (32/8.204; 0.39%) were neoplasias in children and adolescents. Sarcomas were the most prevalent malignant neoplasms (19/32; 59%), followed by carcinomas (7/32; 22%), lymphomas (5/32; 16%) and ganglioneuroblastomas (1/32; 3%). Of these 32 patients, the most affected individuals were aged between 4 and 11 years old (47%), 18 (56%) were male, and the mandible was the main anatomical site involved (28%). In 41% of the cases (13/32), the diagnostic hypothesis of the biopsied lesion was mistakenly considered benign and there was no diagnostic hypothesis in 18% of the cases.

Conclusions: Oral and maxillofacial malignant neoplasms in children and adolescents are uncommon and the accuracy of provisional diagnoses is low in these cases. Better knowledge on oral and maxillofacial malignant lesions in this population would help professionals to reduce the diagnostic time and consequently improve the patient's prognosis.

背景:评估儿童和青少年口腔颌面部恶性肿瘤的患病率,这些儿童和青少年的口腔和颌面部恶性肿瘤是通过送到圣保罗大学牙科学院口腔病理实验室的活检诊断出来的。材料与方法:回顾性分析1997 - 2021年口腔颌面病理实验室发表的1 ~ 18岁患者的解剖病理报告,包括人口学资料、病变部位、活检类型、诊断假设和最终诊断。结果:实验室在此期间共发表解剖病理报告76,194份,其中儿童和青少年占10.77%。其中,只有32例活组织检查(32/8.204;0.39%)为儿童和青少年的肿瘤。肉瘤是最常见的恶性肿瘤(19/32;59%),其次是癌症(7/32;22%),淋巴瘤(5/32;16%)和神经节神经母细胞瘤(1/32;3%)。32例患者中,年龄在4 ~ 11岁的患者最多(47%),男性18例(56%),下颌骨为主要受累解剖部位(28%)。在41%的病例(13/32)中,活检病变的诊断假设被错误地认为是良性的,18%的病例没有诊断假设。结论:口腔颌面部恶性肿瘤在儿童和青少年中并不常见,其临时诊断的准确性较低。更好的了解口腔颌面部恶性病变,有助于专业人员减少诊断时间,从而改善患者的预后。
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引用次数: 0
Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects: a systematic review. 去细胞异体移植物作为重建大下牙槽神经缺损的替代方法:系统综述。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25647
G Matus, J-P Aravena, D Mariño, S-E Niklander

Background: Inferior alveolar nerve (IAN) injuries are a clinical problem with devastating consequences, causing temporary or permanent paresthesia, significantly affecting the patient's quality of life. Despite morbidity, side effects and controversy regarding its results, autologous nerve grafting is still the main treatment for these type of lesions. However, due to advances in knowledge about nerve damage and with the aim of preventing the described problems of autografts, new treatment alternatives based on decellularized allografts have emerged. The aim of this systematic review was to evaluate the reported efficacy of decellularized allografts for the treatment of IAN damage.

Material and methods: We performed a systematic search in Pubmed, Scopus and Web of Science databases following the PRISMA guidelines. Cohort studies, randomized or non-randomized clinical studies, prospective or retrospective studies, without age limits and language restriction that included human subjects who received decellularized allograft as treatment for IAN damage were included.

Results: Six articles met the inclusion criteria and were included for data analysis. In all 6 articles, resolution of IAN damage was observed in more than 85% of patients after a 12-month follow-up period, and in 2 of them, complete resolution was observed in 100% of their patients at longer follow-ups.

Conclusions: Decellularized allograft appears to be a promising alternative to resolve IAN lesions, without requiring a nerve autograft procedure. However, more randomized clinical trials are needed to validate adequate treatment modalities with decellularized allografts.

背景:下肺泡神经(IAN)损伤是一个具有破坏性后果的临床问题,可引起暂时或永久性的感觉异常,严重影响患者的生活质量。尽管发病率、副作用和对其结果的争议,自体神经移植仍然是这类病变的主要治疗方法。然而,由于神经损伤知识的进步和防止自体移植物所描述的问题的目的,基于脱细胞异体移植物的新治疗方案已经出现。本系统综述的目的是评估报道的去细胞异体移植物治疗IAN损伤的疗效。材料和方法:我们按照PRISMA指南在Pubmed、Scopus和Web of Science数据库中进行了系统的检索。队列研究,随机或非随机临床研究,前瞻性或回顾性研究,没有年龄限制和语言限制,包括接受去细胞异体移植作为治疗IAN损伤的人类受试者。结果:6篇文章符合纳入标准,被纳入数据分析。在所有6篇文章中,超过85%的患者在12个月的随访期后观察到IAN损伤的消退,其中2篇文章在更长时间的随访中观察到100%的患者完全消退。结论:去细胞异体移植物似乎是解决IAN病变的一个有希望的选择,不需要神经自体移植手术。然而,需要更多的随机临床试验来验证脱细胞同种异体移植的适当治疗方式。
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引用次数: 1
Articaine versus lidocaine inferior alveolar nerve block in posterior mandible implant surgeries: a randomized controlled trial. 阿替卡因与利多卡因下牙槽神经阻滞在下颌骨植入手术中的应用:一项随机对照试验。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25475
Y Gülnahar, A-L Alpan, E Gülnahar

Background: The aim of this study is to compare the effects of %4 articaine and %2 lidocaine on inferior alveolar nerve block (IANB) for implant surgery in the posterior mandible.

Material and methods: The patients who have inserted implants in the posterior mandible were divided into 2 groups for IANB: lidocaine and articaine. VAS = visual analog scale, pain during surgery and injection, lip numbness time, mandibular canal-implant apex distance, age, gender, bone density, implant number, release incision, adjacent teeth, and duration of surgery were analyzed using t-test, Mann-Whitney U test, Spearman's coefficient, and, Pearson's chi-squared test. This trial followed the recommendations of the Consort Statement for reporting randomized controlled trials.

Results: 577 patients were included and 1185 dental implants were analyzed. There was no significant difference between the two groups in terms of injection and surgery VAS values (p>0.05). The lip numbness time of lidocaine was 3.06±3.22min while articaine was found to be 2.96±3.09min (p>0.05). Mandibular canal-implant apex distance was found to be 2.28±0.75mm in the articaine and 2.45±0.86mm in the lidocaine group (p<0.05). Release incision was made more in the articaine group (51/252) than in the lidocaine group (40/325) (p<0.05).

Conclusions: There was no difference between the %4 articaine and %2 lidocaine in terms of pain perception in posterior mandible implant applications. Both anesthetics provided adequate anesthesia for implant application.

背景:本研究的目的是比较%4阿替卡因和%2利多卡因对下颌骨种植手术中下牙槽神经阻滞(IANB)的影响。材料和方法:将后颌骨种植体患者分为利多卡因组和阿替卡因组进行IANB治疗。采用t检验、Mann-Whitney U检验、Spearman系数、Pearson卡方检验对VAS =视觉模拟量表、术中及注射疼痛、唇麻时间、下颌管-种植体尖端距离、年龄、性别、骨密度、种植体数量、释放切口、邻牙、手术时间进行分析。该试验遵循Consort声明中关于报告随机对照试验的建议。结果:共纳入577例患者,共分析种植体1185颗。两组注射、手术VAS评分差异无统计学意义(p>0.05)。利多卡因组唇部麻木时间为3.06±3.22min,阿替卡因组唇部麻木时间为2.96±3.09min (p>0.05)。结论:%4阿替卡因组与%2利多卡因组在下颌后种植体应用时的疼痛感觉无显著差异。结论:%4阿替卡因组与%2利多卡因组在下颌后种植体应用时的疼痛感觉无显著差异。两种麻醉药均为植入物的应用提供了充分的麻醉。
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引用次数: 0
Association between sleep-disordered breathing and periodontitis: a meta-analysis. 睡眠呼吸障碍与牙周炎之间的关系:一项荟萃分析。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25627
X Liu, Z Zhu, P Zhang

Background: Systemic inflammation is a feature of sleep-disordered breathing (SDB) as well as periodontitis. The association between SDB and periodontitis, however, has been inconsistent in previous studies. In order to fully evaluate the above association, we conducted a meta-analysis.

Material and methods: Observational studies related to the aim of the meta-analysis were identified by search of PubMed, Embase, Web of Science, Wanfang, and CNKI databases. Only studies with SDB diagnosed with the objective polysomnography examination were included. The results were analyzed using a random-effects model that incorporated potential heterogeneity between studies.

Results: Ten cross-sectional or case-control studies with 43,296 participants contributed to the meta-analysis. Pooled results showed that SDB was significantly associated with periodontitis (odds ratio [OR]: 1.83, 95% confidence interval [CI]: 1.52 to 2.20, I2 = 40%, p < 0.001). Sensitivity analysis showed consistent association for severe periodontitis (OR: 1.39, 95% CI: 1.20 to 1.61, I2 = 0%, p < 0.001). Subgroup analyses showed consistent results in patients with mild (OR: 1.66, p < 0.001), moderate (OR: 2.23, p = 0.009), and severe SDB (OR: 2.66, p < 0.001). Moreover, the association between SDB and periodontitis was consistent in Asian and non-Asian studies, in cross-sectional and case-control studies, in studies with univariate and multivariate regression models, and in studies with different quality scores (p for subgroup effects all < 0.05).

Conclusions: Polysomnography confirmed diagnosis of SDB is associated with periodontitis in adult population.

背景:全身性炎症是睡眠呼吸障碍(SDB)和牙周炎的一个特征。然而,SDB与牙周炎之间的关系在以往的研究中并不一致。为了充分评价上述关联,我们进行了meta分析。材料和方法:通过检索PubMed、Embase、Web of Science、万方和CNKI数据库确定与meta分析目的相关的观察性研究。仅纳入经客观多导睡眠图检查诊断为SDB的研究。使用随机效应模型对结果进行分析,该模型纳入了研究之间的潜在异质性。结果:10项横断面研究或病例对照研究共纳入43,296名参与者。合并结果显示,SDB与牙周炎有显著相关性(优势比[OR]: 1.83, 95%可信区间[CI]: 1.52 ~ 2.20, I2 = 40%, p < 0.001)。敏感性分析显示与严重牙周炎的相关性一致(OR: 1.39, 95% CI: 1.20 ~ 1.61, I2 = 0%, p < 0.001)。亚组分析显示,轻度(OR: 1.66, p < 0.001)、中度(OR: 2.23, p = 0.009)和重度SDB (OR: 2.66, p < 0.001)患者的结果一致。此外,在亚洲和非亚洲研究中,在横断面和病例对照研究中,在单变量和多变量回归模型研究中,以及在不同质量评分的研究中,SDB与牙周炎的相关性是一致的(亚组效应p均< 0.05)。结论:多导睡眠图确诊的SDB与成人牙周炎相关。
{"title":"Association between sleep-disordered breathing and periodontitis: a meta-analysis.","authors":"X Liu,&nbsp;Z Zhu,&nbsp;P Zhang","doi":"10.4317/medoral.25627","DOIUrl":"https://doi.org/10.4317/medoral.25627","url":null,"abstract":"<p><strong>Background: </strong>Systemic inflammation is a feature of sleep-disordered breathing (SDB) as well as periodontitis. The association between SDB and periodontitis, however, has been inconsistent in previous studies. In order to fully evaluate the above association, we conducted a meta-analysis.</p><p><strong>Material and methods: </strong>Observational studies related to the aim of the meta-analysis were identified by search of PubMed, Embase, Web of Science, Wanfang, and CNKI databases. Only studies with SDB diagnosed with the objective polysomnography examination were included. The results were analyzed using a random-effects model that incorporated potential heterogeneity between studies.</p><p><strong>Results: </strong>Ten cross-sectional or case-control studies with 43,296 participants contributed to the meta-analysis. Pooled results showed that SDB was significantly associated with periodontitis (odds ratio [OR]: 1.83, 95% confidence interval [CI]: 1.52 to 2.20, I2 = 40%, p < 0.001). Sensitivity analysis showed consistent association for severe periodontitis (OR: 1.39, 95% CI: 1.20 to 1.61, I2 = 0%, p < 0.001). Subgroup analyses showed consistent results in patients with mild (OR: 1.66, p < 0.001), moderate (OR: 2.23, p = 0.009), and severe SDB (OR: 2.66, p < 0.001). Moreover, the association between SDB and periodontitis was consistent in Asian and non-Asian studies, in cross-sectional and case-control studies, in studies with univariate and multivariate regression models, and in studies with different quality scores (p for subgroup effects all < 0.05).</p><p><strong>Conclusions: </strong>Polysomnography confirmed diagnosis of SDB is associated with periodontitis in adult population.</p>","PeriodicalId":18351,"journal":{"name":"Medicina oral, patologia oral y cirugia bucal","volume":"28 2","pages":"e156-e166"},"PeriodicalIF":2.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microvascular density and tumor budding in oral squamous cell carcinoma. 口腔鳞状细胞癌微血管密度与肿瘤出芽。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25640
E-M Assis, M Rodrigues, J-C Vieira, M-I Pascoaloti, H-M Júnior, G-R Souto, P-E Souza, M-C Horta

Background: Oral squamous cell carcinoma (OSCC) is the most prevalent malignant head and neck tumor, excluding the nonmelanoma skin cancer. Despite recent advances in the diagnosis and treatment, the disease's mortality rate is nonetheless high. The presence of isolated neoplastic cells or small clusters of up to four cells at the tumor's invasive front, named tumor budding, is associated with a worse prognosis in OSCC. Angiogenesis has also been recognized as a determining factor in the progression of malignancies and in the development of metastases. Several studies have investigated the assessment of microvascular density (MVD) as a potential prognostic factor in OSCC. This study aimed to evaluate, in OSCC, differences in MVD between tumors with high-intensity tumor budding and tumors with low-intensity or no tumor budding. In samples with high-intensity tumor budding, differences in MVD between the budding area and the area outside the budding were also evaluated. Moreover, the study assessed differences in MVD concerning clinicopathological characteristics such as sex, age, tobacco smoking, tumor location and tumor size.

Material and methods: One hundred and fifty [150] samples of OSCC were subjected to immunohistochemistry to assess the intensity of tumor budding (by immunostaining for multi-cytokeratin) and MVD (by immunostaining for CD34 and CD105, independently). The data were treated using descriptive and analytical statistics.

Results: There were no differences in MVD, assessed by immunostaining for CD34 or CD105, concerning clinicopathological characteristics such as sex, age, tobacco smoking, tumor location and tumor size (p > 0.05). Tumors with high-intensity tumor budding did not show differences in MVD, assessed by immunostaining for CD34 or CD105, when compared to tumors with low-intensity or no tumor budding (p > 0.05). However, in samples with high-intensity tumor budding, the MVD assessed by immunostaining for CD34 was higher in the budding area than in the area outside the budding (p < 0.05). This difference was not observed when MVD was assessed by immunostaining for CD105 (p > 0.05).

Conclusions: The higher MVD in the budding area may be an additional indication that this is a peculiar region of the tumor, associated with biological phenomena related to tumor progression.

背景:口腔鳞状细胞癌(Oral squamous cell carcinoma, OSCC)是除非黑色素瘤皮肤癌外最常见的头颈部恶性肿瘤。尽管最近在诊断和治疗方面取得了进展,但这种疾病的死亡率仍然很高。孤立的肿瘤细胞或在肿瘤侵袭前部出现多达4个细胞的小簇,称为肿瘤出芽,与OSCC较差的预后相关。血管生成也被认为是恶性肿瘤进展和转移发展的决定性因素。几项研究调查了微血管密度(MVD)作为OSCC潜在预后因素的评估。本研究旨在评估在OSCC中,高强度肿瘤出芽与低强度或无肿瘤出芽的肿瘤之间MVD的差异。在高强度肿瘤出芽的样品中,还评估了出芽区域和出芽外区域之间MVD的差异。此外,该研究还评估了MVD在性别、年龄、吸烟、肿瘤位置和肿瘤大小等临床病理特征方面的差异。材料和方法:150[150]份OSCC样本进行免疫组化,评估肿瘤出芽强度(通过多细胞角蛋白免疫染色)和MVD(通过CD34和CD105免疫染色,独立)。使用描述性和分析性统计对数据进行处理。结果:免疫染色CD34、CD105评价MVD在性别、年龄、吸烟情况、肿瘤部位、肿瘤大小等临床病理特征上无显著差异(p > 0.05)。通过免疫染色CD34或CD105评估,高强度肿瘤出芽的肿瘤与低强度或无肿瘤出芽的肿瘤相比,MVD无差异(p > 0.05)。然而,在高强度肿瘤出芽的样本中,CD34免疫染色评估的MVD在出芽区域高于出芽区域外的区域(p < 0.05)。用CD105免疫染色法检测MVD时,没有观察到这种差异(p > 0.05)。结论:出芽区较高的MVD可能是一个额外的迹象,表明这是肿瘤的一个特殊区域,与肿瘤进展相关的生物学现象有关。
{"title":"Microvascular density and tumor budding in oral squamous cell carcinoma.","authors":"E-M Assis,&nbsp;M Rodrigues,&nbsp;J-C Vieira,&nbsp;M-I Pascoaloti,&nbsp;H-M Júnior,&nbsp;G-R Souto,&nbsp;P-E Souza,&nbsp;M-C Horta","doi":"10.4317/medoral.25640","DOIUrl":"https://doi.org/10.4317/medoral.25640","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the most prevalent malignant head and neck tumor, excluding the nonmelanoma skin cancer. Despite recent advances in the diagnosis and treatment, the disease's mortality rate is nonetheless high. The presence of isolated neoplastic cells or small clusters of up to four cells at the tumor's invasive front, named tumor budding, is associated with a worse prognosis in OSCC. Angiogenesis has also been recognized as a determining factor in the progression of malignancies and in the development of metastases. Several studies have investigated the assessment of microvascular density (MVD) as a potential prognostic factor in OSCC. This study aimed to evaluate, in OSCC, differences in MVD between tumors with high-intensity tumor budding and tumors with low-intensity or no tumor budding. In samples with high-intensity tumor budding, differences in MVD between the budding area and the area outside the budding were also evaluated. Moreover, the study assessed differences in MVD concerning clinicopathological characteristics such as sex, age, tobacco smoking, tumor location and tumor size.</p><p><strong>Material and methods: </strong>One hundred and fifty [150] samples of OSCC were subjected to immunohistochemistry to assess the intensity of tumor budding (by immunostaining for multi-cytokeratin) and MVD (by immunostaining for CD34 and CD105, independently). The data were treated using descriptive and analytical statistics.</p><p><strong>Results: </strong>There were no differences in MVD, assessed by immunostaining for CD34 or CD105, concerning clinicopathological characteristics such as sex, age, tobacco smoking, tumor location and tumor size (p > 0.05). Tumors with high-intensity tumor budding did not show differences in MVD, assessed by immunostaining for CD34 or CD105, when compared to tumors with low-intensity or no tumor budding (p > 0.05). However, in samples with high-intensity tumor budding, the MVD assessed by immunostaining for CD34 was higher in the budding area than in the area outside the budding (p < 0.05). This difference was not observed when MVD was assessed by immunostaining for CD105 (p > 0.05).</p><p><strong>Conclusions: </strong>The higher MVD in the budding area may be an additional indication that this is a peculiar region of the tumor, associated with biological phenomena related to tumor progression.</p>","PeriodicalId":18351,"journal":{"name":"Medicina oral, patologia oral y cirugia bucal","volume":"28 2","pages":"e174-e182"},"PeriodicalIF":2.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Oral paracoccidioidomycosis: a retrospective study of 95 cases from a single center and literature review. 口腔副球孢子菌病:95例单中心回顾性研究及文献复习。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25613
L-L-C de Oliveira, J-A-A de Arruda, M-F-P Marinho, I-L Cavalcante, L-G Abreu, A-C Abrahão, M-J Romañach, B-A-B de Andrade, M Agostini

Background: The ecoepidemiological panorama of paracoccidioidomycosis (PCM) is dynamic and still ongoing in Brazil. In particular, data about the oral lesions of PCM are barely explored. The aim of this study was to report the clinicopathological features of individuals diagnosed with oral PCM lesions at an oral and maxillofacial pathology service in Rio de Janeiro, Brazil, in the light of a literature review.

Material and methods: A retrospective study was conducted on oral biopsies obtained from 1958 to 2021. Additionally, electronic searches were conducted in PubMed, Embase, Scopus, Web of Science, Latin American and Caribbean Center on Health Sciences Information, and Brazilian Library of Dentistry to gather information from large case series of oral PCM.

Results: Ninety-five cases of oral PCM were surveyed. The manifestations were more frequent among males (n=86/90.5%), middle-aged/older adults (n=54/58.7%), and white individuals (n=40/51.9%). The most commonly affected sites were the gingiva/alveolar ridge (n=40/23.4%) and lip/labial commissure (n=33/19.3%); however, one (n=40/42.1%) or multiple sites (n=55/57.9%) could also be affected. In 90 (94.7%) patients, "mulberry-like" ulcerations/moriform appearance were observed. Data from 21 studies (1,333 cases), mostly Brazilian (90.5%), revealed that men (92.4%; male/female: 11.8:1) and individuals in the fifth and sixth decades of life were the most affected (range: 7-89 years), with the gingiva/alveolar ridge, palate, and lips/labial commissure being the sites most frequently affected.

Conclusions: The features of oral PCM lesions are similar to those reported in previous studies from Latin America. Clinicians should be aware of the oral manifestations of PCM, with emphasis on the clinicodemographic aspects and differential diagnoses, especially considering the phenomenon of the emergence of reported cases in rural and/or urban areas of Brazil.

背景:副球孢子菌病(PCM)的生态流行病学全景是动态的,在巴西仍在进行中。特别是,关于PCM口腔病变的数据很少被探索。本研究的目的是根据文献综述,报告在巴西里约热内卢口腔颌面病理学服务中被诊断为口腔PCM病变的个体的临床病理特征。材料和方法:对1958年至2021年口腔活检进行回顾性研究。此外,在PubMed、Embase、Scopus、Web of Science、拉丁美洲和加勒比健康科学信息中心和巴西牙科图书馆进行电子检索,以收集大型口腔PCM病例系列的信息。结果:对95例口腔PCM进行了调查。男性(n=86/90.5%)、中老年人(n=54/58.7%)和白人(n=40/51.9%)多见。最常见的受累部位为牙龈/牙槽嵴(n=40/23.4%)和唇/唇连合(n=33/19.3%);然而,一个(n=40/42.1%)或多个站点(n=55/57.9%)也可能受到影响。在90例(94.7%)患者中,观察到“桑葚样”溃疡/死样外观。来自21项研究(1333例)的数据显示,男性(92.4%;男性/女性:11.8:1),年龄在50岁和60岁的个体受影响最大(范围:7-89岁),其中牙龈/牙槽嵴、上颚和嘴唇/唇连接是最常受影响的部位。结论:口腔PCM病变的特征与拉丁美洲先前的研究报告相似。临床医生应该了解PCM的口腔表现,重点是临床人口学方面和鉴别诊断,特别是考虑到巴西农村和/或城市地区报告病例的出现。
{"title":"Oral paracoccidioidomycosis: a retrospective study of 95 cases from a single center and literature review.","authors":"L-L-C de Oliveira,&nbsp;J-A-A de Arruda,&nbsp;M-F-P Marinho,&nbsp;I-L Cavalcante,&nbsp;L-G Abreu,&nbsp;A-C Abrahão,&nbsp;M-J Romañach,&nbsp;B-A-B de Andrade,&nbsp;M Agostini","doi":"10.4317/medoral.25613","DOIUrl":"https://doi.org/10.4317/medoral.25613","url":null,"abstract":"<p><strong>Background: </strong>The ecoepidemiological panorama of paracoccidioidomycosis (PCM) is dynamic and still ongoing in Brazil. In particular, data about the oral lesions of PCM are barely explored. The aim of this study was to report the clinicopathological features of individuals diagnosed with oral PCM lesions at an oral and maxillofacial pathology service in Rio de Janeiro, Brazil, in the light of a literature review.</p><p><strong>Material and methods: </strong>A retrospective study was conducted on oral biopsies obtained from 1958 to 2021. Additionally, electronic searches were conducted in PubMed, Embase, Scopus, Web of Science, Latin American and Caribbean Center on Health Sciences Information, and Brazilian Library of Dentistry to gather information from large case series of oral PCM.</p><p><strong>Results: </strong>Ninety-five cases of oral PCM were surveyed. The manifestations were more frequent among males (n=86/90.5%), middle-aged/older adults (n=54/58.7%), and white individuals (n=40/51.9%). The most commonly affected sites were the gingiva/alveolar ridge (n=40/23.4%) and lip/labial commissure (n=33/19.3%); however, one (n=40/42.1%) or multiple sites (n=55/57.9%) could also be affected. In 90 (94.7%) patients, \"mulberry-like\" ulcerations/moriform appearance were observed. Data from 21 studies (1,333 cases), mostly Brazilian (90.5%), revealed that men (92.4%; male/female: 11.8:1) and individuals in the fifth and sixth decades of life were the most affected (range: 7-89 years), with the gingiva/alveolar ridge, palate, and lips/labial commissure being the sites most frequently affected.</p><p><strong>Conclusions: </strong>The features of oral PCM lesions are similar to those reported in previous studies from Latin America. Clinicians should be aware of the oral manifestations of PCM, with emphasis on the clinicodemographic aspects and differential diagnoses, especially considering the phenomenon of the emergence of reported cases in rural and/or urban areas of Brazil.</p>","PeriodicalId":18351,"journal":{"name":"Medicina oral, patologia oral y cirugia bucal","volume":"28 2","pages":"e131-e139"},"PeriodicalIF":2.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9499476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Thermal necrosis-aided dental implant removal: A rabbit model pilot study. 热坏死辅助牙种植体去除:兔模型初步研究。
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25616
G-N Hasanoğlu-Erbaşar, M Güngörmüş, E Alimoğullari, S Çayli, E Peker, A Narin, M Orhan

Background: The significant advances in the materials and biological aspects of dental implants haven't completely eradicated the implant failures. The removal of osseointegrated but otherwise failed implants present several challenges including adjacent tissues damage and necessity of bone augmentation for reimplantation. Controlled thermal necrosis has emerged as an alternative technique to aid removal of osseointegrated dental implants with minimal to no defect to healthy bone or surrounding tissues. This study aimed to evaluate the thermal necrosis-aided implant removal method in a rabbit osseointegration model.

Material and methods: A total of 8 male New Zealand rabbits were used in the study. Two dental implants were placed on each femur of the rabbits. Heating of the implants was performed after 7 weeks following the implantation. Heating was done by contacting the tip of an electrosurgey tool in monopolar mode at different power settings and contact durations (5W - 2 seconds, 5W - 10 seconds, and 10 W - 10 seconds). No heating was done on the control group. Implant stability right after implantation, before heat application and after heat application was determined using an Osstell™ Mentor Device. Following the removal of implants histological analyses were performed to determine the effects of heat application at cellular level.

Results: ISQ values of the 10W-10s group was significantly lower compared to the other groups (p<0.001). No indication of progressive necrosis or irreversible damage was observed in any of the groups. However, the percent of empty-apoptotic lacunae were statistically higher in the 5W-10s and the 10W-10s groups compared the control and the 5W-2s groups.

Conclusions: Within the conditions of this study, we conclude that heat application with an electrosurgery tool using monopolar mode at 10W power for 10 seconds is optimal for reversing osseointegration with no extensive or progressive damage to the bone.

背景:种植体材料和生物学方面的巨大进步并没有完全根除种植体失败。骨整合但其他方面失败的植入物的移除提出了几个挑战,包括邻近组织损伤和骨增强的必要性。可控热坏死已成为一种替代技术,以帮助去除对健康骨骼或周围组织的最小或无缺陷的骨整合牙种植体。本研究旨在评估热坏死辅助种植体去除方法在兔骨整合模型中的应用。材料与方法:选用雄性新西兰兔8只。在兔的每根股骨上放置两颗牙种植体。植入7周后对植入物进行加热。在单极模式下,在不同的功率设置和接触时间(5W - 2秒,5W - 10秒和10w - 10秒)下,通过接触电手术工具的尖端来加热。对照组不进行加热。使用Osstell™Mentor Device测定植入后、热敷前和热敷后的植入物稳定性。移除植入物后,进行组织学分析以确定热应用在细胞水平上的影响。结果:与其他组相比,10W-10s组的ISQ值显著降低(p结论:在本研究条件下,我们得出结论,使用单极模式在10W功率下加热10秒的电手术工具是逆转骨整合的最佳选择,不会对骨骼造成广泛或进行性损伤。
{"title":"Thermal necrosis-aided dental implant removal: A rabbit model pilot study.","authors":"G-N Hasanoğlu-Erbaşar,&nbsp;M Güngörmüş,&nbsp;E Alimoğullari,&nbsp;S Çayli,&nbsp;E Peker,&nbsp;A Narin,&nbsp;M Orhan","doi":"10.4317/medoral.25616","DOIUrl":"https://doi.org/10.4317/medoral.25616","url":null,"abstract":"<p><strong>Background: </strong>The significant advances in the materials and biological aspects of dental implants haven't completely eradicated the implant failures. The removal of osseointegrated but otherwise failed implants present several challenges including adjacent tissues damage and necessity of bone augmentation for reimplantation. Controlled thermal necrosis has emerged as an alternative technique to aid removal of osseointegrated dental implants with minimal to no defect to healthy bone or surrounding tissues. This study aimed to evaluate the thermal necrosis-aided implant removal method in a rabbit osseointegration model.</p><p><strong>Material and methods: </strong>A total of 8 male New Zealand rabbits were used in the study. Two dental implants were placed on each femur of the rabbits. Heating of the implants was performed after 7 weeks following the implantation. Heating was done by contacting the tip of an electrosurgey tool in monopolar mode at different power settings and contact durations (5W - 2 seconds, 5W - 10 seconds, and 10 W - 10 seconds). No heating was done on the control group. Implant stability right after implantation, before heat application and after heat application was determined using an Osstell™ Mentor Device. Following the removal of implants histological analyses were performed to determine the effects of heat application at cellular level.</p><p><strong>Results: </strong>ISQ values of the 10W-10s group was significantly lower compared to the other groups (p<0.001). No indication of progressive necrosis or irreversible damage was observed in any of the groups. However, the percent of empty-apoptotic lacunae were statistically higher in the 5W-10s and the 10W-10s groups compared the control and the 5W-2s groups.</p><p><strong>Conclusions: </strong>Within the conditions of this study, we conclude that heat application with an electrosurgery tool using monopolar mode at 10W power for 10 seconds is optimal for reversing osseointegration with no extensive or progressive damage to the bone.</p>","PeriodicalId":18351,"journal":{"name":"Medicina oral, patologia oral y cirugia bucal","volume":"28 2","pages":"e148-e155"},"PeriodicalIF":2.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucormycosis infection associated with global COVID-19 pandemic - an institutional histopathological study. 与全球COVID-19大流行相关的毛霉病感染——一项机构组织病理学研究
IF 2.2 3区 医学 Pub Date : 2023-03-01 DOI: 10.4317/medoral.25130
R Keerthika, A Narwal, M Kamboj, A Devi, R Anand, S N, V Singh, V Agarwal, A Gupta

Background: Coronavirus disease 2019 (COVID-19) in the recent times have instilled signs of immunosuppression globally which has further precipitated increasing range of opportunistic infections. Mucormycosis is a distressing opportunistic fungal infection with a high incidence and is the third commonest acute invasive infection following candidiasis and aspergillosis. The aim of the present observational study is to delineate the enigmatic histopathological profile between mucormycosis cases seen prior to pandemic (PPM) and pandemic associated mucormycosis (PAM).

Material and methods: Tissue archives of 105 histopathologically diagnosed cases of mucormycosis were included and analysed for demographical details and histopathological parameters like fungal load and localization, granuloma formation, necrosis, inflammatory infiltrate and tissue invasion.

Results: 0ut of 105 included cases, 11/105 (10.48%) were reported PPM and 94/105 (89.52%) PAM. Among 94 cases of PAM, 51/94 (54%) cases also showed COVID-19 positivity, while 43/94 (46%) did not. Of all the histological variables, increased fungal load and necrosis were observed in PAM relative to PPM cases.

Conclusions: The histopathological variables like fungal load, necrosis, granuloma formation and tissue invasion, could help the clinician in assessing the clinical status at the time of tissue diagnosis and improve the treatment accordingly.

背景:近年来,新型冠状病毒病(COVID-19)在全球范围内出现免疫抑制迹象,进一步加剧了机会性感染范围的扩大。毛霉病是一种令人痛苦的机会性真菌感染,发病率高,是继念珠菌病和曲霉病之后第三常见的急性侵袭性感染。本观察性研究的目的是描述在大流行(PPM)和大流行相关毛霉病(PAM)之前发现的毛霉病病例之间的神秘组织病理学特征。材料与方法:收集105例毛霉病组织病理诊断病例的组织档案,分析其人口学特征及真菌负荷、定位、肉芽肿形成、坏死、炎症浸润、组织浸润等组织病理参数。结果:105例病例中,11/105例(10.48%)报告PPM, 94/105例(89.52%)报告PAM。94例PAM中51/94例(54%)同时呈COVID-19阳性,43/94例(46%)未呈COVID-19阳性。在所有组织学变量中,与PPM病例相比,PAM患者真菌负荷和坏死增加。结论:真菌负荷、坏死、肉芽肿形成、组织侵袭等组织病理指标可帮助临床医生在组织诊断时评估临床状况,并据此改进治疗。
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Medicina oral, patologia oral y cirugia bucal
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