Shahrzad Mirashrafi, Mohammad Borzoo-Isfahani, Iman Namjoo, Mohammad Ali Hojjati Kermani, A. R. Moravejolahkami
BACKGROUND: There is overwhelming scientific evidence that dietary modifications is beneficial in neurodegenerative diseases like Multiple Sclerosis (MS). OBJECTIVE: The goal of this study was to explore the effects of modified Mediterranean Diet (mMeD) on systemic inflammation, anthropometric indices, and relapse rate in MS patients. METHODS: This single-center, randomized controlled trial compared mMeD and traditional Iranian diet (as control) during six months in 180 Relapsing-Remitting MS (RRMS) patients. Serum high sensitivity C Reactive Protein (hs-CRP), body weight, Body Mass Index (BMI), percent body fat, and relapse rate were evaluated at baseline, and 3 and 6 months later. Multivariate analysis of covariance test (MANCOVA; conducted by SPSS 24) was adjusted for age, gender, family history, duration of MS and education level. RESULTS: Of 261 screened patients (July 2018-February 2019), 180 patients were eligible; 68/90 as mMeD and 79/90 as control group completed the study. Self-reported adherence was excellent (95%). The mean change on the relapse rate was –0.54±0.9 compared to –0.03±0.4 for control group (P = 0.004). In addition, hs-CRP levels decreased in the mMeD group (–2.9±3.3 mg/L; P < 0.001) and mean changes were significant between two groups (P < 0.001). Anthropometric indices were modified in mMeD group, whereas between-group comparisons were not statistically different. CONCLUSIONS: Overall, mMeD improved inflammatory status and relapse rate in RRMS patients. Future trials with larger scale and longer duration should be conducted to confirm the role of diet as a disease-modifier in MS.
{"title":"A Mediterranean-type diet improved systemic inflammation in multiple sclerosis patients, as compared to the traditional Iranian diet: A single-center randomized controlled trial","authors":"Shahrzad Mirashrafi, Mohammad Borzoo-Isfahani, Iman Namjoo, Mohammad Ali Hojjati Kermani, A. R. Moravejolahkami","doi":"10.3233/mnm-210557","DOIUrl":"https://doi.org/10.3233/mnm-210557","url":null,"abstract":"BACKGROUND: There is overwhelming scientific evidence that dietary modifications is beneficial in neurodegenerative diseases like Multiple Sclerosis (MS). OBJECTIVE: The goal of this study was to explore the effects of modified Mediterranean Diet (mMeD) on systemic inflammation, anthropometric indices, and relapse rate in MS patients. METHODS: This single-center, randomized controlled trial compared mMeD and traditional Iranian diet (as control) during six months in 180 Relapsing-Remitting MS (RRMS) patients. Serum high sensitivity C Reactive Protein (hs-CRP), body weight, Body Mass Index (BMI), percent body fat, and relapse rate were evaluated at baseline, and 3 and 6 months later. Multivariate analysis of covariance test (MANCOVA; conducted by SPSS 24) was adjusted for age, gender, family history, duration of MS and education level. RESULTS: Of 261 screened patients (July 2018-February 2019), 180 patients were eligible; 68/90 as mMeD and 79/90 as control group completed the study. Self-reported adherence was excellent (95%). The mean change on the relapse rate was –0.54±0.9 compared to –0.03±0.4 for control group (P = 0.004). In addition, hs-CRP levels decreased in the mMeD group (–2.9±3.3 mg/L; P < 0.001) and mean changes were significant between two groups (P < 0.001). Anthropometric indices were modified in mMeD group, whereas between-group comparisons were not statistically different. CONCLUSIONS: Overall, mMeD improved inflammatory status and relapse rate in RRMS patients. Future trials with larger scale and longer duration should be conducted to confirm the role of diet as a disease-modifier in MS.","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/mnm-210557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Elío, Sandra Jarrín, María Eléxpuru, J. Crespo, I. Domínguez, Killian Tutusaus, Roberto Ruíz, Rubén Calderón, S. Sumalla
BACKGROUND: In Spain, there are several studies published on the relationship between eating habits and lifestyle among university students; but only a few of them are focused on online postgraduate students. OBJECTIVE: Herein we aimed to evaluate the degree of adherence to the Mediterranean diet pyramid (2010 edition), non-communicable diseases (NCDs), and lifestyle in online postgraduate students aged 20–65 years belonging to the food area of the Fundación Universitaria Iberoamericana (FUNIBER). METHODS: We performed a descriptive cross-sectional study including 100 online post-graduate students aged 20–65 years who were recruited by an accidental non-probabilistic sampling method consisting of a questionnaire on their sociodemographic characteristics, NCDs, lifestyle, and a 3-day food intake record (3-d). RESULTS: The profile of the students was 74% women, with a mean age of 36.6 (±10.5) years and body mass index (BMI) of 22.6 kg / m2 (±3.3). 71% of the volunteers presented normal weight, while 20% were overweight. Indeed, only a low percentage of the volunteers presented hypertension (1%), cardiovascular disease (0%), diabetes mellitus 1 (2%), diabetes mellitus 2 (3%), hypercholesterolemia (9%), and hyperuricemia (2%). Concerning lifestyle, (77%) of students were non-smokers, (78%) consumed beverages with caffeine, (51%) did not consume alcoholic beverages, and nearly all of them (84%) frequently (3 times /week) practiced physical activity. 68% of the recruited students exhibited adherence to “Medium diet quality diet (4–7)” followed by (26%) with a “Poor diet quality (<3)” and “Optimal diet quality” (6%). CONCLUSIONS: Spanish postgraduate students of the nutritional area, have good health and a healthy lifestyle but are moving away from the MD model, should be established campaigns for the improvement of eating habits of the postgraduate university population.
背景:在西班牙，有几项关于大学生饮食习惯和生活方式关系的研究发表;但只有少数院校关注在线研究生。目的:本研究旨在评估属于Fundación伊比利亚美洲大学(FUNIBER)食品领域的20-65岁在线研究生对地中海饮食金字塔(2010年版)、非传染性疾病(NCDs)和生活方式的依从程度。方法:我们进行了一项描述性横断面研究，包括100名年龄在20-65岁之间的在线研究生，他们通过意外非概率抽样方法招募，包括关于他们的社会人口学特征、非传染性疾病、生活方式和3天食物摄入记录(3-d)的问卷调查。结果:女性占74%，平均年龄36.6(±10.5)岁，体重指数(BMI) 22.6 kg / m2(±3.3)。71%的志愿者体重正常，20%的人超重。事实上，只有低比例的志愿者出现高血压(1%)、心血管疾病(0%)、1型糖尿病(2%)、2型糖尿病(3%)、高胆固醇血症(9%)和高尿酸血症(2%)。在生活方式方面，77%的学生不吸烟，78%的学生饮用含咖啡因的饮料，51%的学生不饮用含酒精的饮料，几乎所有的学生(84%)都经常(每周3次)进行体育锻炼。68%的被招募学生坚持“中等饮食质量(4-7)”，其次是“不良饮食质量(<3)”(26%)和“最佳饮食质量”(6%)。结论:营养领域的西班牙研究生健康状况良好，生活方式健康，但正在远离MD模式，应建立改善研究生大学人口饮食习惯的运动。
{"title":"Adherence to the pyramid of the Mediterranean diet (2010), non-communicable diseases and lifestyle in online postgraduate Spanish students in the food area","authors":"I. Elío, Sandra Jarrín, María Eléxpuru, J. Crespo, I. Domínguez, Killian Tutusaus, Roberto Ruíz, Rubén Calderón, S. Sumalla","doi":"10.3233/MNM-200521","DOIUrl":"https://doi.org/10.3233/MNM-200521","url":null,"abstract":"BACKGROUND: In Spain, there are several studies published on the relationship between eating habits and lifestyle among university students; but only a few of them are focused on online postgraduate students. OBJECTIVE: Herein we aimed to evaluate the degree of adherence to the Mediterranean diet pyramid (2010 edition), non-communicable diseases (NCDs), and lifestyle in online postgraduate students aged 20–65 years belonging to the food area of the Fundación Universitaria Iberoamericana (FUNIBER). METHODS: We performed a descriptive cross-sectional study including 100 online post-graduate students aged 20–65 years who were recruited by an accidental non-probabilistic sampling method consisting of a questionnaire on their sociodemographic characteristics, NCDs, lifestyle, and a 3-day food intake record (3-d). RESULTS: The profile of the students was 74% women, with a mean age of 36.6 (±10.5) years and body mass index (BMI) of 22.6 kg / m2 (±3.3). 71% of the volunteers presented normal weight, while 20% were overweight. Indeed, only a low percentage of the volunteers presented hypertension (1%), cardiovascular disease (0%), diabetes mellitus 1 (2%), diabetes mellitus 2 (3%), hypercholesterolemia (9%), and hyperuricemia (2%). Concerning lifestyle, (77%) of students were non-smokers, (78%) consumed beverages with caffeine, (51%) did not consume alcoholic beverages, and nearly all of them (84%) frequently (3 times /week) practiced physical activity. 68% of the recruited students exhibited adherence to “Medium diet quality diet (4–7)” followed by (26%) with a “Poor diet quality (<3)” and “Optimal diet quality” (6%). CONCLUSIONS: Spanish postgraduate students of the nutritional area, have good health and a healthy lifestyle but are moving away from the MD model, should be established campaigns for the improvement of eating habits of the postgraduate university population.","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"14 1","pages":"191-205"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/MNM-200521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUND: Military staff are required to be in a proper condition of mental health and weight standards and have a specific level of physical performances (PP). Dairy products are rich sources of essential nutrients. It was demonstrated that Iranians consume much less milk and its products and there is no exception in the military staff. OBJECTIVES: To examine the association between consumption of low or whole-fat dairy and psychological disorders and PP in military personnel. METHODS: This cross-sectional study was conducted in four military zones of Iran. Dairy products intake were evaluated by using a semi-quantitative food-frequency questionnaire (FFQ). The Persian version of Depression, Anxiety, Stress Scale-21 (DASS-21) were used to assess participants’ depression, anxiety and stress and PP were assessed by a 2-mile run, sit-up, push-up and pull-up. RESULTS: There was a significant negative relationship between the tertiles of total and low-fat dairy consumption and depression (OR 0.28, 95% CI 0.10 to 0.79, P < 0.05), and low-fat dairy consumption and stress (OR 0.34, 95% CI 0.13 to 0.93, P < 0.05). Also, there was a positive association between the last tertiles of low-fat dairy consumption and suitable PP (OR 5.28, 95% CI 1.08 to 25.71, P < 0.05). CONCLUSIONS: We concluded that consumption of dairy products and particularly low-fat products are related to less psychological problems and a better PP level.
背景:军事工作人员需要有适当的心理健康状况和体重标准，并具有特定水平的体能表现(PP)。乳制品是必需营养素的丰富来源。事实证明，伊朗人消耗的牛奶及其制品要少得多，军事人员也不例外。目的:探讨军事人员低脂或全脂乳制品消费与心理障碍和PP之间的关系。方法:本横断面研究在伊朗四个军区进行。采用半定量食物频率问卷(FFQ)评估乳制品摄入量。波斯语版抑郁、焦虑、压力量表21 (DASS-21)用于评估参与者的抑郁、焦虑和压力，PP通过2英里跑步、仰卧起坐、俯卧撑和引体向上来评估。结果:低脂乳制品总消费量和低脂乳制品总消费量与抑郁(OR 0.28, 95% CI 0.10 ~ 0.79, P < 0.05)、低脂乳制品消费量与应激(OR 0.34, 95% CI 0.13 ~ 0.93, P < 0.05)呈显著负相关。低脂乳制品消费的最后1 / 5与适宜的PP呈正相关(OR 5.28, 95% CI 1.08 ~ 25.71, P < 0.05)。结论:食用乳制品，尤其是低脂乳制品与较少的心理问题和较好的PP水平相关。
{"title":"Associations between whole and low-fat dairy products consumption, physical performance and mental health","authors":"R. Ghodsi, H. Rostami, K. Parastouei, M. Taghdir","doi":"10.3233/MNM-200474","DOIUrl":"https://doi.org/10.3233/MNM-200474","url":null,"abstract":"BACKGROUND: Military staff are required to be in a proper condition of mental health and weight standards and have a specific level of physical performances (PP). Dairy products are rich sources of essential nutrients. It was demonstrated that Iranians consume much less milk and its products and there is no exception in the military staff. OBJECTIVES: To examine the association between consumption of low or whole-fat dairy and psychological disorders and PP in military personnel. METHODS: This cross-sectional study was conducted in four military zones of Iran. Dairy products intake were evaluated by using a semi-quantitative food-frequency questionnaire (FFQ). The Persian version of Depression, Anxiety, Stress Scale-21 (DASS-21) were used to assess participants’ depression, anxiety and stress and PP were assessed by a 2-mile run, sit-up, push-up and pull-up. RESULTS: There was a significant negative relationship between the tertiles of total and low-fat dairy consumption and depression (OR 0.28, 95% CI 0.10 to 0.79, P < 0.05), and low-fat dairy consumption and stress (OR 0.34, 95% CI 0.13 to 0.93, P < 0.05). Also, there was a positive association between the last tertiles of low-fat dairy consumption and suitable PP (OR 5.28, 95% CI 1.08 to 25.71, P < 0.05). CONCLUSIONS: We concluded that consumption of dairy products and particularly low-fat products are related to less psychological problems and a better PP level.","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"14 1","pages":"127-136"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/MNM-200474","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70142644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gaddi, M. Savo, F. Capello, Gaetano Castiglione
BACKGROUND: Pasta plays an important role in human nutrition, nevertheless its organoleptic, structural and bromatologic properties have not been completely studied. OBJECTIVE: The study aims to compare the ultrastructure pasta cross-sections produced with reduced mechanic stress and low heat exposure technique (Pietro Massi Technology ™) to common samples obtained with traditional technology in order to assess if a different process can alter the ultrastructure of starch and then, its digestibility. METHODS: A comparative study was performed on the ultrastructure of pasta using scanning electron microscopy (S.E.M). 55 were pasta cross-sections made with Pietro Massi technology, 33 were samples from different pasta factory produced using traditional process, for a total of 88 samples analysed. RESULTS: According to an Index based on what it was observed at one slide at S.E.M we classified samples and compared the number of grains, caves and canals visible, their dimensions in μm and average size of grains. The number of grains in group 1 (9.06±5.01) in group 2 (5.71±5.77), in group 3 (5.93±7.65) resulted significative more elevated compared to group 4 (0.73±2.58); in group 1 and group 2 the number of caves observed was higher than group 4. The size in μm of canals resulted significantly more elevated in group 1 than group 3 (p = 0.008), group 2(p = 0.013), and group 4 (p = 0.02). CONCLUSION: The analysis of average size of caves and canals in μm, the number of caves and grains demonstrated in samples obtained with Massi technology elevated values compared to samples obtained with traditional technique. The number of caves, grains and canals visible in the starch surface demonstrate the high quality of this pasta because they likely ensure penetration of water during cooking, facilitating at the same time the penetration of pancreatic amylases during digestion, suggesting a better digestibility in pasta produced according to this methodology.
背景:面食在人类营养中扮演着重要的角色，然而其感官、结构和色谱特性尚未被完全研究。目的:本研究旨在比较用降低机械应力和低热暴露技术(Pietro Massi Technology™)生产的意大利面横截面的超微结构与用传统技术获得的普通样品，以评估不同的工艺是否可以改变淀粉的超微结构，进而改变其消化率。方法:采用扫描电镜对面食的超微结构进行对比研究。55个是用Pietro Massi技术制作的意大利面横截面，33个是来自不同意大利面工厂使用传统工艺生产的样品，总共分析了88个样品。结果:根据sem上一张载玻片所观察到的指数对样品进行了分类，并比较了可见的颗粒、洞洞和沟渠的数量、μm尺寸和颗粒的平均尺寸。1组(9.06±5.01)、2组(5.71±5.77)、3组(5.93±7.65)粒数显著高于4组(0.73±2.58)粒数;1、2组观察到的溶洞数量均高于4组。1组的根管直径(μm)明显高于3组(p = 0.008)、2组(p = 0.013)和4组(p = 0.02)。结论:与传统方法相比，Massi技术获得的样品中洞洞和孔道的平均尺寸(μm)、洞洞和颗粒的数量均有所增加。淀粉表面可见的洞穴、谷物和沟渠的数量证明了这种面食的高质量，因为它们可能确保了水在烹饪过程中的渗透，同时促进了胰淀粉酶在消化过程中的渗透，这表明根据这种方法生产的面食具有更好的消化率。
{"title":"Can a different pasta making process preserve the starch’s ultrastructure, increasing its digestibility?","authors":"A. Gaddi, M. Savo, F. Capello, Gaetano Castiglione","doi":"10.3233/MNM-200518","DOIUrl":"https://doi.org/10.3233/MNM-200518","url":null,"abstract":"BACKGROUND: Pasta plays an important role in human nutrition, nevertheless its organoleptic, structural and bromatologic properties have not been completely studied. OBJECTIVE: The study aims to compare the ultrastructure pasta cross-sections produced with reduced mechanic stress and low heat exposure technique (Pietro Massi Technology ™) to common samples obtained with traditional technology in order to assess if a different process can alter the ultrastructure of starch and then, its digestibility. METHODS: A comparative study was performed on the ultrastructure of pasta using scanning electron microscopy (S.E.M). 55 were pasta cross-sections made with Pietro Massi technology, 33 were samples from different pasta factory produced using traditional process, for a total of 88 samples analysed. RESULTS: According to an Index based on what it was observed at one slide at S.E.M we classified samples and compared the number of grains, caves and canals visible, their dimensions in μm and average size of grains. The number of grains in group 1 (9.06±5.01) in group 2 (5.71±5.77), in group 3 (5.93±7.65) resulted significative more elevated compared to group 4 (0.73±2.58); in group 1 and group 2 the number of caves observed was higher than group 4. The size in μm of canals resulted significantly more elevated in group 1 than group 3 (p = 0.008), group 2(p = 0.013), and group 4 (p = 0.02). CONCLUSION: The analysis of average size of caves and canals in μm, the number of caves and grains demonstrated in samples obtained with Massi technology elevated values compared to samples obtained with traditional technique. The number of caves, grains and canals visible in the starch surface demonstrate the high quality of this pasta because they likely ensure penetration of water during cooking, facilitating at the same time the penetration of pancreatic amylases during digestion, suggesting a better digestibility in pasta produced according to this methodology.","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"14 1","pages":"37-47"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/MNM-200518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70142689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUND: Uric acid (UA) and homocysteine (HCys) are involved in cardiovascular diseases. Patients with obesity (PwO) are characterized by elevated cardiovascular risk. OBJECTIVE: To evaluate the relationship between HCys and UA concentrations in 1141 overweight patients and PwO with and without metabolic syndrome (MS). METHODS: MS was defined according to IDF criteria (2005). Anthropometric data were recorded and blood biochemical parameters were assessed with routine methods on fasting blood samples. Statistics: Spearman correlation and multiple regression analysis. RESULTS: Gender, obesity and MS influenced both UA and HCys levels, which were increased in males, MS patients, PwO with MS and positively correlated (p < 0.001). Patients without MS had normal or slightly high levels. Hypertension, hyperuricemia and hyperhomocysteinemia were found in PwO with MS. UA concentration correlated with systolic blood pressure, triglycerides and HDL (all p < 0.05). Multivariate analysis showed that HCys concentration was an independent determinant factor affecting UA levels (T value 3.5, p < 0.001). CONCLUSIONS: HCys and UA levels positively and significantly correlated in PwO, especially in those with MS. The significant correlation between UA and hypertension, triglycerides, HDL suggests the clinical usefulness of monitoring UA together with HCys concentrations as cardiovascular risk marker in these patients.
{"title":"Metabolic Syndrome, Homocysteine and uric acid in patients with obesity; experience from obesity and work centre","authors":"Gori Francesca, TirelliAmedea Silvia, Piontini Alessandra, Depinto Vito, Bamonti Fabrizia, C. Vassalle, Vigna Luisella","doi":"10.3233/mnm-210554","DOIUrl":"https://doi.org/10.3233/mnm-210554","url":null,"abstract":"BACKGROUND: Uric acid (UA) and homocysteine (HCys) are involved in cardiovascular diseases. Patients with obesity (PwO) are characterized by elevated cardiovascular risk. OBJECTIVE: To evaluate the relationship between HCys and UA concentrations in 1141 overweight patients and PwO with and without metabolic syndrome (MS). METHODS: MS was defined according to IDF criteria (2005). Anthropometric data were recorded and blood biochemical parameters were assessed with routine methods on fasting blood samples. Statistics: Spearman correlation and multiple regression analysis. RESULTS: Gender, obesity and MS influenced both UA and HCys levels, which were increased in males, MS patients, PwO with MS and positively correlated (p < 0.001). Patients without MS had normal or slightly high levels. Hypertension, hyperuricemia and hyperhomocysteinemia were found in PwO with MS. UA concentration correlated with systolic blood pressure, triglycerides and HDL (all p < 0.05). Multivariate analysis showed that HCys concentration was an independent determinant factor affecting UA levels (T value 3.5, p < 0.001). CONCLUSIONS: HCys and UA levels positively and significantly correlated in PwO, especially in those with MS. The significant correlation between UA and hypertension, triglycerides, HDL suggests the clinical usefulness of monitoring UA together with HCys concentrations as cardiovascular risk marker in these patients.","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"26 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/mnm-210554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asad Mirzaei, Asma Asal, Ali Seidkhani-Nahal, A. Noori-Zadeh
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) comorbidity with adipose tissue dysfunction is not new and studies have focused on how adipose tissue influences NAFLD pathophysiology. OBJECTIVE: Quantification of nature and magnitude of the association between serum resistin and also insulin resistance, by calculating pooled Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) score, with NAFLD pathophysiology was the objective of the current study. METHODS: Using systematic review and meta-analysis and standardized mean difference (SMD) as the effect size, the levels of resistin and HOMA-IR scores have been investigated in NAFLD subjects in comparison with controls in the case-control studies using random-effects models. RESULTS: This meta-analysis retrieved a total number of 665 and 522 cases and 671 and 555 control subjects until May 2020 for serum levels of resistin and HOMA-IR score until May 2020. The final analyses demonstrated that pooled SMD of resistin and HOMA-IR score was 0.687 (95% confidence interval, 0.070–1.304) and 1.368 (95% confidence interval, 1.080–1.655); respectively. Moreover, the p-value for the test of significance for each pooled SMD was examined by the z-test and calculated as 0.029 and 0.000 for resistin and HOMA-IR score (clearly considered as statistically significant). CONCLUSION: Based on the findings, the HOMA-IR score and the serum levels of resistin in NAFLD subjects are associated with disease pathogenesis.
{"title":"A systematic review and meta-analysis of serum resistin level and its relation to HOMA-IR score using meta-regression in nonalcoholic fatty liver disease patients","authors":"Asad Mirzaei, Asma Asal, Ali Seidkhani-Nahal, A. Noori-Zadeh","doi":"10.3233/MNM-210538","DOIUrl":"https://doi.org/10.3233/MNM-210538","url":null,"abstract":"BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) comorbidity with adipose tissue dysfunction is not new and studies have focused on how adipose tissue influences NAFLD pathophysiology. OBJECTIVE: Quantification of nature and magnitude of the association between serum resistin and also insulin resistance, by calculating pooled Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) score, with NAFLD pathophysiology was the objective of the current study. METHODS: Using systematic review and meta-analysis and standardized mean difference (SMD) as the effect size, the levels of resistin and HOMA-IR scores have been investigated in NAFLD subjects in comparison with controls in the case-control studies using random-effects models. RESULTS: This meta-analysis retrieved a total number of 665 and 522 cases and 671 and 555 control subjects until May 2020 for serum levels of resistin and HOMA-IR score until May 2020. The final analyses demonstrated that pooled SMD of resistin and HOMA-IR score was 0.687 (95% confidence interval, 0.070–1.304) and 1.368 (95% confidence interval, 1.080–1.655); respectively. Moreover, the p-value for the test of significance for each pooled SMD was examined by the z-test and calculated as 0.029 and 0.000 for resistin and HOMA-IR score (clearly considered as statistically significant). CONCLUSION: Based on the findings, the HOMA-IR score and the serum levels of resistin in NAFLD subjects are associated with disease pathogenesis.","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/MNM-210538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of malnutrition and stunting among under-five children: A cross-sectional study family of quality of life in agricultural areas of Indonesia","authors":"Tantut Susanto, Hanny Rasni, Latifa Aini Susumaningrum","doi":"10.3233/MNM-200492","DOIUrl":"https://doi.org/10.3233/MNM-200492","url":null,"abstract":"","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"14 1","pages":"147-161"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/MNM-200492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70142911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Bellotto, Alex Castro, I. L. Bonfante, D. Brunelli, M. P. Chacon-Mikahil, C. Cavaglieri
BACKGROUND: High visceral fat storage unbalance secretion inflammatory peptides, however diet plays an important role-protecting metabolism against chronic diseases inherent to this condition. OBJECTIVE: To assess obese diet quality and find association with inflammatory biomarkers. METHODS: aMED, a Food Quality Index, classified the inflammatory power of 26 obese men’s diet (aged: 48.1±5.1; BMI: 31.1±2.45). Pearson correlation coefficient associated diet quality in tertiles (1st as low, 2nd as average and 3 rd as high quality diet) with inflammatory variables (cytokines and waist circumference). RESULTS: The intake of anti-inflammatory food groups was significantly higher among tertiles (3rd > 2nd > 1st; P < 0.001). Adiponectin was lower in the 2nd tertile than in the 1st (P < 0.05). Whole cereal presented a positive correlation with TNF-alpha (p = 0.049), and a negative correlation with IL–15 (p = 0.002). Fish presented a positive correlation with IL–10 (p = 0.024), Resistin (p = 0.039) and PGE–2 (p = 0.001). These findings pointed to pro and anti-inflammatory responses. CONCLUSIONS: The method may need adjustments when used to assess obese food intake, since they don’t usually meet the daily-recommended intake. Other lifestyles variables should be considered, which may affect the inflammatory status.
{"title":"Association of food quality index with subclinical inflammation in middle-aged obese men","authors":"M. Bellotto, Alex Castro, I. L. Bonfante, D. Brunelli, M. P. Chacon-Mikahil, C. Cavaglieri","doi":"10.3233/MNM-200502","DOIUrl":"https://doi.org/10.3233/MNM-200502","url":null,"abstract":"BACKGROUND: High visceral fat storage unbalance secretion inflammatory peptides, however diet plays an important role-protecting metabolism against chronic diseases inherent to this condition. OBJECTIVE: To assess obese diet quality and find association with inflammatory biomarkers. METHODS: aMED, a Food Quality Index, classified the inflammatory power of 26 obese men’s diet (aged: 48.1±5.1; BMI: 31.1±2.45). Pearson correlation coefficient associated diet quality in tertiles (1st as low, 2nd as average and 3 rd as high quality diet) with inflammatory variables (cytokines and waist circumference). RESULTS: The intake of anti-inflammatory food groups was significantly higher among tertiles (3rd > 2nd > 1st; P < 0.001). Adiponectin was lower in the 2nd tertile than in the 1st (P < 0.05). Whole cereal presented a positive correlation with TNF-alpha (p = 0.049), and a negative correlation with IL–15 (p = 0.002). Fish presented a positive correlation with IL–10 (p = 0.024), Resistin (p = 0.039) and PGE–2 (p = 0.001). These findings pointed to pro and anti-inflammatory responses. CONCLUSIONS: The method may need adjustments when used to assess obese food intake, since they don’t usually meet the daily-recommended intake. Other lifestyles variables should be considered, which may affect the inflammatory status.","PeriodicalId":18424,"journal":{"name":"Mediterranean Journal of Nutrition and Metabolism","volume":"1 1","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/MNM-200502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70142653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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