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Isolated Fragments of Intact Microvessels: Tissue Vascularization, Modeling, and Therapeutics 完整微血管的分离片段:组织血管化、建模和治疗
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-04-15 DOI: 10.1111/micc.12852
Hannah A. Strobel, Sarah M. Moss, James B. Hoying

The microvasculature is integral to nearly every tissue in the body, providing not only perfusion to and from the tissue, but also homing sites for immune cells, cellular niches for tissue dynamics, and cooperative interactions with other tissue elements. As a microtissue itself, the microvasculature is a composite of multiple cell types exquisitely organized into structures (individual vessel segments and extensive vessel networks) capable of considerable dynamics and plasticity. Consequently, it has been challenging to include a functional microvasculature in assembled or fabricated tissues. Isolated fragments of intact microvessels, which retain the cellular composition and structures of native microvessels, are proving effective in a variety of vascularization applications including tissue in vitro disease modeling, vascular biology, mechanistic discovery, and tissue prevascularization in regenerative therapeutics and grafting. In this review, we will discuss the importance of recapitulating native tissue biology and the successful vascularization applications of isolated microvessels.

微血管几乎与人体的每个组织都密不可分,它不仅提供组织间的灌注,还提供免疫细胞的归宿地、组织动力学的细胞龛以及与其他组织元素的合作互动。微血管本身也是一种微组织,它由多种细胞类型组成,并巧妙地组织成具有相当动态性和可塑性的结构(单个血管段和广泛的血管网络)。因此,在组装或制造的组织中加入功能性微血管一直是一项挑战。完整微血管的分离片段保留了原生微血管的细胞组成和结构,在各种血管化应用中证明是有效的,包括组织体外疾病建模、血管生物学、机理发现以及再生治疗和移植中的组织前血管化。在本综述中,我们将讨论重现原生组织生物学的重要性以及分离微血管的成功血管化应用。
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引用次数: 0
Increased Angio-Derived Index of Microcirculatory Resistance Within a Timeframe of 30–60 days After COVID-19 Infection 在 COVID-19 感染后 30-60 天内,血管衍生的微循环阻力指数增加。
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-03-18 DOI: 10.1111/micc.12851
Lei Dong, Ritai Na, Lang Peng, Xinye Xu

Background and Objectives

Chest pain is a relatively long-term symptom that commonly occurs in patients who have contracted COVID-19. The reasons for these symptoms remain unclear, with coronary microvascular dysfunction (CMD) emerging as a potential factor. This study aimed to assess the presence of CMD in these patients by measuring the angio-derived index of microcirculatory resistance (AMR).

Methods

In this cross-sectional case–control study, patients who had chest pain and a history of COVID-19 infection within the preceding 30 to 60 days were included. The control subjects were patients without COVID-19. Demographic, clinical, and echocardiographic data were recorded. Angiographic images were collected for AMR analysis through an angioplus quantitative flow ratio measurement system. Propensity score matching (PSM) was performed to match the two groups. Multivariate logistic regression was used to examine the association between COVID-19 incidence and the increase in AMR (AMR > 285 mmHg*s/m) after correction for other confounders.

Results

After PSM, there were 58 patients in each group (the mean age was 66.3 ± 9.04 years, and 55.2% were men). The average time between the onset of COVID-19 infection and patient presentation at the hospital for coronary angiography was 41 ± 9.5 days. Moreover, there was no significant difference in the quantitative flow ratio between the two groups. Patients with COVID-19 had a greater mean AMR (295 vs. 266, p = 0.002). Multivariate logistic regression analysis revealed that COVID-19 (OR = 3.32, 95% CI = 1.50–7.60, p = 0.004) was significantly associated with an increase in AMR.

Conclusions

Long-term COVID-19 patients who experience chest pain without evidence of myocardial ischemia exhibit an increase in AMR, and CMD may be one of the reasons for this increase. COVID-19 is an independent risk factor for an increase in AMR.

背景和目的:胸痛是一种相对长期的症状,常见于感染 COVID-19 的患者。出现这些症状的原因尚不清楚,冠状动脉微血管功能障碍(CMD)是一个潜在因素。本研究旨在通过测量血管衍生的微循环阻力指数(AMR)来评估这些患者是否存在CMD:在这项横断面病例对照研究中,纳入了在之前 30 到 60 天内有胸痛和 COVID-19 感染史的患者。对照组为未感染 COVID-19 的患者。研究人员记录了人口统计学、临床和超声心动图数据。收集血管造影图像,通过血管造影定量流量比测量系统进行 AMR 分析。进行倾向得分匹配(PSM)以匹配两组患者。在校正其他混杂因素后,采用多变量逻辑回归法检测 COVID-19 发病率与 AMR(AMR > 285 mmHg*s/m)增加之间的关联:PSM 后,每组有 58 名患者(平均年龄为 66.3 ± 9.04 岁,55.2% 为男性)。从感染 COVID-19 到患者到医院接受冠状动脉造影术的平均时间为 41 ± 9.5 天。此外,两组患者的定量血流比率没有明显差异。COVID-19 患者的平均 AMR 更大(295 对 266,P = 0.002)。多变量逻辑回归分析显示,COVID-19(OR = 3.32,95% CI = 1.50-7.60,p = 0.004)与 AMR 的增加显著相关:结论:长期患有 COVID-19 的胸痛但无心肌缺血证据的患者会出现 AMR 增高,而 CMD 可能是导致 AMR 增高的原因之一。COVID-19是导致AMR增加的一个独立风险因素。
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引用次数: 0
Abstract 摘要
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-03-07 DOI: 10.1111/micc.12846
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引用次数: 0
Modeling cerebrovascular responses to assess the impact of the collateral circulation following middle cerebral artery occlusion 建立脑血管反应模型,评估大脑中动脉闭塞后侧支循环的影响。
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-02-14 DOI: 10.1111/micc.12849
Erin Zhao, Jared Barber, Shomita S. Mathew-Steiner, Savita Khanna, Chandan K. Sen, Julia Arciero

Objective

An improved understanding of the role of the leptomeningeal collateral circulation in blood flow compensation following middle cerebral artery (MCA) occlusion can contribute to more effective treatment development for ischemic stroke. The present study introduces a model of the cerebral circulation to predict cerebral blood flow and tissue oxygenation following MCA occlusion.

Methods

The model incorporates flow regulation mechanisms based on changes in pressure, shear stress, and metabolic demand. Oxygen saturation in cerebral vessels and tissue is calculated using a Krogh cylinder model. The model is used to assess the effects of changes in oxygen demand and arterial pressure on cerebral blood flow and oxygenation after MCA occlusion.

Results

An increase from five to 11 leptomeningeal collateral vessels was shown to increase the oxygen saturation in the region distal to the occlusion by nearly 100%. Post-occlusion, the model also predicted a loss of autoregulation and a decrease in flow to the ischemic territory as oxygen demand was increased; these results were consistent with data from experiments that induced cerebral ischemia.

Conclusions

This study highlights the importance of leptomeningeal collaterals following MCA occlusion and reinforces the idea that lower oxygen demand and higher arterial pressure improve conditions of flow and oxygenation.

目的:进一步了解大脑中动脉(MCA)闭塞后脑侧支循环在血流补偿中的作用有助于缺血性脑卒中更有效的治疗发展。本研究引入了一个脑循环模型来预测大脑中动脉闭塞后的脑血流和组织氧合:该模型结合了基于压力、剪应力和代谢需求变化的血流调节机制。使用 Krogh 气瓶模型计算脑血管和组织中的氧饱和度。该模型用于评估 MCA 闭塞后氧需求和动脉压的变化对脑血流和氧饱和度的影响:结果表明,如果侧支血管从 5 条增加到 11 条,闭塞远端区域的血氧饱和度将提高近 100%。闭塞后,随着氧需求的增加,模型还预测缺血区域会失去自动调节功能,血流量也会减少;这些结果与诱导脑缺血的实验数据一致:这项研究强调了MCA闭塞后左脑膜袢的重要性,并强化了降低需氧量和提高动脉压能改善血流和氧合条件的观点。
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引用次数: 0
Sex-specific microvascular and hemodynamic responses to passive limb heating in young adults 青壮年微血管和血液动力学对被动肢体加热的反应具有性别特异性。
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-01-28 DOI: 10.1111/micc.12848
Miranda K. Traylor, Genevieve B. Batman, Kylie N. Sears, Kyndall V. Ransom, Shane M. Hammer, Joshua L. Keller

Objective

We examined sex-specific microvascular reactivity and hemodynamic responses under conditions of augmented resting blood flow induced by passive heating compared to normal blood flow.

Methods

Thirty-eight adults (19 females) completed a vascular occlusion test (VOT) on two occasions preceded by rest with or without passive heating in a randomized, counterbalanced order. Skeletal muscle tissue oxygenation (StO2, %) was assessed with near-infrared spectroscopy (NIRS), and the rate of desaturation and resaturation as well as maximal StO2 (StO2max) and prolonged hypersaturation (area under the curve, StO2AUC) were quantified. Before the VOT, brachial artery blood flow (BABF), vascular conductance, and relative BABF (BABF normalized to forearm lean mass) were determined. Sex × condition ANOVAs were used. A p-value ≤.05 was considered statistically significant.

Results

Twenty minutes of heating increased BABF compared to the control (102.9 ± 28.3 vs. 36.0 ± 20.9 mL min−1; p < .01). Males demonstrated greater BABF than females (91.9 ± 34.0 vs. 47.0 ± 19.1 mL min−1; p < .01). There was no sex difference in normalized BABF. There were no significant interactions for NIRS-VOT outcomes, but heat did increase the rate of desaturation (−0.140 ± 0.02 vs. −0.119 ± 0.03% s−1; p < .01), whereas regardless of condition, males exhibited greater rates of resaturation and StO2max than females.

Conclusions

These results suggest that blood flow is not the primary factor causing sex differences in NIRS-VOT outcomes.

目的我们研究了与正常血流相比,在被动加热引起静息血流增加的条件下,不同性别的微血管反应性和血流动力学反应:38名成年人(19名女性)完成了两次血管闭塞测试(VOT),测试前以随机、平衡的顺序进行了休息,同时进行或不进行被动加热。用近红外光谱(NIRS)评估骨骼肌组织氧饱和度(StO2,%),并对去饱和度和再饱和度以及最大 StO2(StO2max)和长时间高饱和度(曲线下面积,StO2AUC)进行量化。在 VOT 之前,测定了肱动脉血流(BABF)、血管传导和相对 BABF(BABF 与前臂瘦体重的归一化)。采用性别×条件方差分析。P值≤.05为具有统计学意义:结果:与对照组相比,加热 20 分钟可增加 BABF(102.9 ± 28.3 vs. 36.0 ± 20.9 mL min-1 ; p -1 ; p -1 ; p 2max than females):这些结果表明,血流量并不是造成 NIRS-VOT 结果性别差异的主要因素。
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引用次数: 0
Impact of stalling events on microcirculatory hemodynamics in the aged brain 停滞事件对老年大脑微循环血流动力学的影响。
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-01-24 DOI: 10.1111/micc.12845
Mohammad Jamshidi, Thomas Ventimiglia, Patrice Sudres, Cong Zhang, Frédéric Lesage, William Rooney, Daniel Schwartz, Andreas A. Linninger

Objective

The role of cerebral microvasculature in cognitive dysfunction can be investigated by identifying the impact of blood flow on cortical tissue oxygenation. In this paper, the impact of capillary stalls on microcirculatory characteristics such as flow and hematocrit (Ht) in the cortical angioarchitecture is studied.

Methods

Using a deterministic mathematical model to simulate blood flow in a realistic mouse cortex, hemodynamics parameters, including pressure, flow, vessel diameter-adjustable hematocrit, and transit time are calculated as a function of stalling events.

Results

Using a non-linear plasma skimming model, it is observed that Ht increases in the penetrating arteries from the pial vessels as a function of cortical depth. The incidence of stalling on Ht distribution along the blood network vessels shows reduction of RBCs around the tissue near occlusion sites and decreased Ht concentration downstream from the blockage points. Moreover, upstream of the occlusion, there is a noticeable increase of the Ht, leading to larger flow resistance due to higher blood viscosity. We predicted marked changes in transit time behavior due to stalls which match trends observed in mice in vivo.

Conclusions

These changes to blood cell quantity and quality may be implicated in the development of Alzheimer's disease and contribute to the course of the illness.

目的:通过确定血流量对大脑皮层组织氧合的影响,可以研究大脑微血管在认知功能障碍中的作用。本文研究了毛细血管滞留对大脑皮层血管结构中流量和血细胞比容(Ht)等微循环特征的影响:方法:使用确定性数学模型模拟现实小鼠皮层中的血流,计算血流动力学参数,包括压力、流量、血管直径可调血细胞比容和转运时间与滞留事件的函数关系:结果:利用非线性血浆撇取模型观察到,随着皮层深度的增加,从皮层血管穿入动脉的 Ht 也在增加。停滞对沿血网血管 Ht 分布的影响显示,闭塞点附近组织周围的红细胞减少,而堵塞点下游的 Ht 浓度降低。此外,在闭塞点上游,由于血液粘度较高,Ht 明显增加,导致流动阻力增大。我们预测,由于滞流,血流通过时间会发生明显变化,这与在小鼠体内观察到的趋势一致:血细胞数量和质量的这些变化可能与阿尔茨海默氏症的发展有关,并对疾病的进程起着促进作用。
{"title":"Impact of stalling events on microcirculatory hemodynamics in the aged brain","authors":"Mohammad Jamshidi,&nbsp;Thomas Ventimiglia,&nbsp;Patrice Sudres,&nbsp;Cong Zhang,&nbsp;Frédéric Lesage,&nbsp;William Rooney,&nbsp;Daniel Schwartz,&nbsp;Andreas A. Linninger","doi":"10.1111/micc.12845","DOIUrl":"10.1111/micc.12845","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The role of cerebral microvasculature in cognitive dysfunction can be investigated by identifying the impact of blood flow on cortical tissue oxygenation. In this paper, the impact of capillary stalls on microcirculatory characteristics such as flow and hematocrit (Ht) in the cortical angioarchitecture is studied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using a deterministic mathematical model to simulate blood flow in a realistic mouse cortex, hemodynamics parameters, including pressure, flow, vessel diameter-adjustable hematocrit, and transit time are calculated as a function of stalling events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Using a non-linear plasma skimming model, it is observed that Ht increases in the penetrating arteries from the pial vessels as a function of cortical depth. The incidence of stalling on Ht distribution along the blood network vessels shows reduction of RBCs around the tissue near occlusion sites and decreased Ht concentration downstream from the blockage points. Moreover, upstream of the occlusion, there is a noticeable increase of the Ht, leading to larger flow resistance due to higher blood viscosity. We predicted marked changes in transit time behavior due to stalls which match trends observed in mice in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These changes to blood cell quantity and quality may be implicated in the development of Alzheimer's disease and contribute to the course of the illness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18459,"journal":{"name":"Microcirculation","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/micc.12845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal vascular dynamics: A window for observing an irregular heartbeat. A case report 视网膜血管动力学:观察不规则心跳的窗口。病例报告
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-01-19 DOI: 10.1111/micc.12844
Rebekka Heitmar, Paulus Kirchhoff, Andrew Blann, Konstantin Kotliar

Objective

We aimed to characterize several aspects of retinal vascular dynamics in a patient with arrythmia in order to elicit additional diagnostic information on microvascular dysfunction.

Methods

A 68-year-old male patient with arrythmia and an age- and gender-matched control subject underwent ocular examination including dynamic retinal vessel assessment with flicker light provocation. Retinal vessel diameters were measured continuously following a standard protocol (IMEDOS Systems, Jena, Germany). The data were evaluated using methods of signal analysis.

Results

Retinal vessel response following flicker provocation as well as local structural and functional behavior of retinal vessels were comparable between both individuals. The arrhythmia case demonstrated irregular arterial and venous heart rate (HR) pulsation with an average frequency of 1 Hz. Moreover, the case showed a higher magnitude and larger periods of low-frequency retinal vessel oscillations as well as lower periodicity of both HR pulsations and low-frequency vasomotions.

Conclusions

Besides numerical examination of irregular HR pulsations in case of arrhythmia, from the direct noninvasive assessment of retinal vessel dynamics one can derive more detailed information on microvascular function including the whole spectrum of retinal arterial and venous pulsations and vasomotions. This may have implications for health screening not limited to atrial fibrillation.

我们的目的是描述一名心律失常患者视网膜血管动态的几个方面,以获得有关微血管功能障碍的更多诊断信息。
{"title":"Retinal vascular dynamics: A window for observing an irregular heartbeat. A case report","authors":"Rebekka Heitmar,&nbsp;Paulus Kirchhoff,&nbsp;Andrew Blann,&nbsp;Konstantin Kotliar","doi":"10.1111/micc.12844","DOIUrl":"10.1111/micc.12844","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We aimed to characterize several aspects of retinal vascular dynamics in a patient with arrythmia in order to elicit additional diagnostic information on microvascular dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A 68-year-old male patient with arrythmia and an age- and gender-matched control subject underwent ocular examination including dynamic retinal vessel assessment with flicker light provocation. Retinal vessel diameters were measured continuously following a standard protocol (IMEDOS Systems, Jena, Germany). The data were evaluated using methods of signal analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Retinal vessel response following flicker provocation as well as local structural and functional behavior of retinal vessels were comparable between both individuals. The arrhythmia case demonstrated irregular arterial and venous heart rate (HR) pulsation with an average frequency of 1 Hz. Moreover, the case showed a higher magnitude and larger periods of low-frequency retinal vessel oscillations as well as lower periodicity of both HR pulsations and low-frequency vasomotions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Besides numerical examination of irregular HR pulsations in case of arrhythmia, from the direct noninvasive assessment of retinal vessel dynamics one can derive more detailed information on microvascular function including the whole spectrum of retinal arterial and venous pulsations and vasomotions. This may have implications for health screening not limited to atrial fibrillation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18459,"journal":{"name":"Microcirculation","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/micc.12844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139495613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Men with nonobstructive coronary disease have higher burden of ischemic heart disease detected by cardiopulmonary exercise test 通过心肺运动测试发现,患有非阻塞性冠状动脉疾病的男性患缺血性心脏病的比例更高
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-01-17 DOI: 10.1111/micc.12841
Siyuan Li, Yifang Yuan, Lanting Zhao, Tingting Lv, Fei She, Fang Liu, Yajun Xue, Boda Zhou, Ying Xie, Yu Geng, Ping Zhang

Background

Nonobstructive coronary artery disease (NOCAD), characterized by the presence of myocardial ischemic symptoms and signs without obstructive coronaries, is a common clinical condition, but it is less well understood. Few studies have analyzed the gender differences in inducible myocardial ischemia assessed by cardiopulmonary exercise test (CPET) in NOCAD.

Methods

We conducted a study of 289 NOCAD patients (mean age 60, 56% women) with ischemic symptoms and confirmed ⫹50% coronaries stenoses by coronary angiography who underwent symptom-limited CPET. We assessed ischemic response using predicted % peak VO2, O2 pulse trajectory, and exercise ECG test.

Results

Men with NOCAD had significantly lower predicted % peak VO2 (62% vs. 73%), higher proportions of flattening pattern (16% vs. 2%), and downward patterns of O2 pulse trajectory (2% vs. 0%) (p < .0001) compared with women. In contrast, women with NOCAD had a higher prevalence of shallow patterns of O2 pulse trajectory (21% vs. 6%, p < .0001). Men with NOCAD had a higher risk ischemic profile (medium risk: 63% vs. 54%, high risk: 18% vs. 4%, p < .0001). After adjustment, men with NOCAD had significantly lower predicted % peak VO2 (β −27.4, 95% CI −30.74 to −24.07), higher risk for abnormal O2 pulse trajectories (OR 4.21, 95% CI 1.93 to 9.19), and myocardial ischemia risk per CPET parameters (OR 3.14, 95% CI 1.78 to 5.54) (p < .0001).

Conclusion

Men with NOCAD had a higher risk profile for ischemic heart disease per CPET. Therefore, they should receive rigorous management and follow-up to prevent cardiovascular events.

非阻塞性冠状动脉疾病(NOCAD)的特征是存在心肌缺血症状和体征,但没有阻塞性冠状动脉,这是一种常见的临床病症,但人们对它的了解较少。很少有研究分析了通过心肺运动测试(CPET)评估非阻塞性冠心病诱发性心肌缺血的性别差异。
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引用次数: 0
Coronary microvascular dysfunction as assessed by multimodal diagnostic imaging in patients with hypertrophic cardiomyopathy is related to the severity of cardiac dysfunction 通过多模式诊断成像评估肥厚型心肌病患者的冠状动脉微血管功能障碍与心功能不全的严重程度有关。
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2024-01-04 DOI: 10.1111/micc.12843
Tien Vuong Tran, Loic Djaileb, Laurent Riou, Lea Ruez Lantuejoul, Joris Giai, Gilles Barone-Rochette

Introduction

Coronary microvascular dysfunction (CMD) plays a major role in hypertrophic cardiomyopathy (HCM) physiopathology but its assessment in clinical practice remains a challenge. Nowadays, innovations in invasive and noninvasive coronary evaluation using multimodal imaging provide options for the diagnosis of CMD. The objective of the present study was to investigate if new multimodal imaging diagnosis of CMD could detect HCM patients with more impaired cardiac function by left atrioventricular coupling index (LACI).

Methods and Results

A total of 32 consecutive patients with a confirmed diagnosis of HCM (62 ± 13 years, 62% men) were prospectively screened for CMD using a multimodal imaging method. LACI was assessed by cardiovascular magnetic resonance imaging. Fifteen (47%) patients had CMD by multimodal imaging method. Patients with CMD presented a significantly higher LACI (48.5 ± 25.4 vs. 32.5 ± 10.6, p = .03). A multivariate logistic regression analysis demonstrated that CMD was independently associated with LACI (OR = 1.069, 95% CI 1.00–1.135, p = .03).

Conclusion

Multimodal imaging diagnosis of CMD is applicable to HCM patients and is associated with more impaired cardiac function.

导言:冠状动脉微血管功能障碍(CMD)在肥厚型心肌病(HCM)的生理病理中起着重要作用,但在临床实践中对其进行评估仍是一项挑战。如今,利用多模态成像技术进行有创和无创冠状动脉评估的创新为 CMD 的诊断提供了选择。本研究旨在探讨新的 CMD 多模态成像诊断是否能通过左房室耦合指数(LACI)发现心功能受损更严重的 HCM 患者:采用多模态成像方法对连续确诊为 HCM 的 32 名患者(62 ± 13 岁,62% 为男性)进行了 CMD 前瞻性筛查。心血管磁共振成像对 LACI 进行了评估。通过多模态成像方法,15 名(47%)患者患有 CMD。CMD患者的LACI明显更高(48.5 ± 25.4 vs. 32.5 ± 10.6,p = .03)。多变量逻辑回归分析表明,CMD与LACI独立相关(OR = 1.069,95% CI 1.00-1.135,p = .03):结论:CMD 的多模态成像诊断适用于 HCM 患者,且与心功能受损程度更严重相关。
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引用次数: 0
Nitric oxide-mediated vasodilation in human bone 一氧化氮介导的人体骨骼血管扩张。
IF 2.4 4区 医学 Q2 Medicine Pub Date : 2023-12-22 DOI: 10.1111/micc.12842
Adina E. Draghici, Matthew R. Ely, Jason W. Hamner, J. Andrew Taylor

Objective

Regulation of blood flow to bone is critical but poorly understood, particularly in humans. This study aims to determine whether nitric oxide (NO), a major regulator of vascular tone to other tissues, contributes also to the regulation of blood flow to bone.

Methods

In young healthy adults (n = 16, 8F, 8M), we characterized NO-mediated vasodilation in the tibia in response to sublingual nitroglycerin and contrasted it to lower leg. Blood flow responses were assessed in supine individuals by continuously measuring tibial total hemoglobin (tHb) via near-infrared spectroscopy and lower leg blood flow (LBF) as popliteal flow velocity via Doppler ultrasound in the same leg.

Results

LBF increased by Δ9.73 ± 0.66 cm/s and peaked 4.4 min after NO administration and declined slowly but remained elevated (Δ3.63 ± 0.60 cm/s) at 10 min. In contrast, time to peak response was longer and smaller in magnitude in the tibia as tHb increased Δ2.08 ± 0.22 μM and peaked 5.3 min after NO administration and declined quickly but remained elevated (Δ0.87±0.22 μM) at 10 min (p = .01).

Conclusions

In young adults, the tibial vasculature demonstrates robust NO-mediated vasodilation, but tHb is delayed and diminishes faster compared to LBF, predominately reflective of skeletal muscle responses. Thus, NO-mediated vasodilation in bone may be characteristically different from other vascular beds.

目的:骨血流的调节至关重要,但人们对其了解甚少,尤其是对人类而言。本研究旨在确定一氧化氮(NO)作为其他组织血管张力的主要调节剂,是否也有助于调节骨骼的血流量:在年轻健康成人(n = 16,8F,8M)中,我们描述了一氧化氮介导的胫骨血管扩张对舌下含服硝酸甘油的反应,并将其与小腿进行对比。通过近红外光谱连续测量胫骨总血红蛋白(tHb)和小腿血流(LBF)(即同一腿部的腘绳肌血流速度),对仰卧者的血流反应进行了评估:施用 NO 后 4.4 分钟,小腿血流速度增加了 Δ9.73 ± 0.66 厘米/秒,达到峰值,随后缓慢下降,但在 10 分钟后仍保持升高(Δ3.63 ± 0.60 厘米/秒)。相比之下,胫骨的峰值反应时间更长,幅度更小,因为 tHb 增加了 Δ2.08 ± 0.22 μM,在施用 NO 后 5.3 分钟达到峰值,并迅速下降,但在 10 分钟时仍保持升高(Δ0.87±0.22 μM)(p = .01):结论:在青壮年中,胫骨血管表现出强有力的 NO 介导的血管舒张,但与 LBF 相比,tHb 的延迟和减少速度更快,这主要反映了骨骼肌的反应。因此,NO介导的骨骼血管舒张可能与其他血管床有本质区别。
{"title":"Nitric oxide-mediated vasodilation in human bone","authors":"Adina E. Draghici,&nbsp;Matthew R. Ely,&nbsp;Jason W. Hamner,&nbsp;J. Andrew Taylor","doi":"10.1111/micc.12842","DOIUrl":"10.1111/micc.12842","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Regulation of blood flow to bone is critical but poorly understood, particularly in humans. This study aims to determine whether nitric oxide (NO), a major regulator of vascular tone to other tissues, contributes also to the regulation of blood flow to bone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In young healthy adults (<i>n</i> = 16, 8F, 8M), we characterized NO-mediated vasodilation in the tibia in response to sublingual nitroglycerin and contrasted it to lower leg. Blood flow responses were assessed in supine individuals by continuously measuring tibial total hemoglobin (tHb) via near-infrared spectroscopy and lower leg blood flow (LBF) as popliteal flow velocity via Doppler ultrasound in the same leg.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LBF increased by Δ9.73 ± 0.66 cm/s and peaked 4.4 min after NO administration and declined slowly but remained elevated (Δ3.63 ± 0.60 cm/s) at 10 min. In contrast, time to peak response was longer and smaller in magnitude in the tibia as tHb increased Δ2.08 ± 0.22 μM and peaked 5.3 min after NO administration and declined quickly but remained elevated (Δ0.87±0.22 μM) at 10 min (<i>p</i> = .01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In young adults, the tibial vasculature demonstrates robust NO-mediated vasodilation, but tHb is delayed and diminishes faster compared to LBF, predominately reflective of skeletal muscle responses. Thus, NO-mediated vasodilation in bone may be characteristically different from other vascular beds.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18459,"journal":{"name":"Microcirculation","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Microcirculation
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