Jade L. Taylor, Miguel Martin-Aragon Baudel, Madeline Nieves-Cintron, Manuel F. Navedo
This review paper explores the critical role of vascular ion channels in the regulation of cerebral artery function and examines the impact of Alzheimer's disease (AD) on these processes. Vascular ion channels are fundamental in controlling vascular tone, blood flow, and endothelial function in cerebral arteries. Dysfunction of these channels can lead to impaired cerebral autoregulation, contributing to cerebrovascular pathologies. AD, characterized by the accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles, has been increasingly linked to vascular abnormalities, including altered vascular ion channel activity. Here, we briefly review the role of vascular ion channels in cerebral blood flow control and neurovascular coupling. We then examine the vascular defects in AD, the current understanding of how AD pathology affects vascular ion channel function, and how these changes may lead to compromised cerebral blood flow and neurodegenerative processes. Finally, we provide future perspectives and conclusions. Understanding this topic is important as ion channels may be potential therapeutic targets for improving cerebrovascular health and mitigating AD progression.
这篇综述论文探讨了血管离子通道在调节脑动脉功能中的关键作用,并研究了阿尔茨海默病(AD)对这些过程的影响。血管离子通道是控制脑动脉血管张力、血流量和内皮功能的基础。这些通道的功能失调会导致大脑自动调节功能受损,从而引发脑血管病变。以淀粉样β(Aβ)斑块和神经纤维缠结的积累为特征的注意力缺失症与血管异常(包括血管离子通道活性的改变)的关系日益密切。在此,我们简要回顾了血管离子通道在脑血流控制和神经血管耦合中的作用。然后,我们研究了 AD 的血管缺陷、目前对 AD 病理如何影响血管离子通道功能的理解,以及这些变化如何可能导致脑血流受损和神经退行性过程。最后,我们提出了未来的展望和结论。了解这一主题非常重要,因为离子通道可能是改善脑血管健康和缓解 AD 进展的潜在治疗靶点。
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