Pub Date : 2023-08-01DOI: 10.2174/221029810304230807101718
Yuliang Li
{"title":"Meet the Honorary Senior Advisor","authors":"Yuliang Li","doi":"10.2174/221029810304230807101718","DOIUrl":"https://doi.org/10.2174/221029810304230807101718","url":null,"abstract":"","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136106964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.2174/2210298103666230726163734
Shuqun Cheng, Zhenhua Chen, Jinkai Feng, Zong-Han Liu, Kang Wang
Macrovascular tumor thrombosis (MVTT) is common among patients with advanced hepatocellular carcinoma (HCC), and it contains two main types, portal vein tumor thrombus (PVTT) and hepatic vein tumor thrombus (HVTT). MVTT is a significant prognostic factor, and the prognosis of HCC with MVTT remains unsatisfactory. The classification of MVTT varies in different studies, and the management of HCC and MVTT differs among Eastern and Western countries. Over the past years, a multidisciplinary approach, including surgical resection, radiotherapy, and transcatheter arterial chemoembolization, especially the advent of new targeted drugs and immune checkpoint inhibitors, has brought considerable survival benefits for HCC patients with MVTT. Recently, multiple novel treatment strategies, such as neoadjuvant therapy or tumor downstaging based on radiotherapy, immunotherapy, and molecular-targeted therapy, have broadened the treatment landscape of MVTT. In this review, we conclude the consensus and progress regarding diagnosis and treatment for patients with HCC and MVTT.
{"title":"Current Diagnosis and Treatment for Hepatocellular Carcinoma with Macrovascular Tumor Thrombosis","authors":"Shuqun Cheng, Zhenhua Chen, Jinkai Feng, Zong-Han Liu, Kang Wang","doi":"10.2174/2210298103666230726163734","DOIUrl":"https://doi.org/10.2174/2210298103666230726163734","url":null,"abstract":"\u0000\u0000Macrovascular tumor thrombosis (MVTT) is common among patients with advanced hepatocellular carcinoma (HCC), and it contains two main types, portal vein tumor thrombus (PVTT) and hepatic vein tumor thrombus (HVTT). MVTT is a significant prognostic factor, and the prognosis of HCC with MVTT remains unsatisfactory. The classification of MVTT varies in different studies, and the management of HCC and MVTT differs among Eastern and Western countries. Over the past years, a multidisciplinary approach, including surgical resection, radiotherapy, and transcatheter arterial chemoembolization, especially the advent of new targeted drugs and immune checkpoint inhibitors, has brought considerable survival benefits for HCC patients with MVTT. Recently, multiple novel treatment strategies, such as neoadjuvant therapy or tumor downstaging based on radiotherapy, immunotherapy, and molecular-targeted therapy, have broadened the treatment landscape of MVTT. In this review, we conclude the consensus and progress regarding diagnosis and treatment for patients with HCC and MVTT.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121059137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.2174/221029810303230322161923
Enguo Fan
{"title":"Meet the Honorary Senior Advisor","authors":"Enguo Fan","doi":"10.2174/221029810303230322161923","DOIUrl":"https://doi.org/10.2174/221029810303230322161923","url":null,"abstract":"","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135421913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-16DOI: 10.2174/2210298103666230516153457
Jingxia Wang, Guangchen Pei, Pingping Wu
Colloidal crystal (CC) fiber has unique light manipulation characteristics, fiber flexibility, and the potential to be used in the textile industry as an alternative to chemical dyes. Introducing polyamide 66 (PA66) into CC fiber can effectively improve the performance of fibers. In this study, polyamide 66 (PA66) CC fibers with various morphologies were fabricated by electrospinning using high-tensile PA66 and P(St-MMA-AA) latex particles as raw materials, such as close-packed, inlaid, noodle-like, spindle knots, bamboo-like, semi-enclosed, hat-like, etc. The formation mechanism of various fibers was analyzed based on the phase separation and assembly interaction. The prepared PA66 CC fiber film was reported to have unique structural color and enhanced mechanical properties, which can be used as a substrate for drawing various patterns. This work will provide a novel idea for the fabrication of functional CC fiber, which is helpful for the potential application in the textile industry.
{"title":"Electrospinning Fabrication of PA66 Colloidal Crystal Fibers with Various Morphologies","authors":"Jingxia Wang, Guangchen Pei, Pingping Wu","doi":"10.2174/2210298103666230516153457","DOIUrl":"https://doi.org/10.2174/2210298103666230516153457","url":null,"abstract":"\u0000\u0000Colloidal crystal (CC) fiber has unique light manipulation characteristics, fiber flexibility, and the potential to be used in the textile industry as an alternative to chemical dyes. Introducing polyamide 66 (PA66) into CC fiber can effectively improve the performance of fibers. In this study, polyamide 66 (PA66) CC fibers with various morphologies were fabricated by electrospinning using high-tensile PA66 and P(St-MMA-AA) latex particles as raw materials, such as close-packed, inlaid, noodle-like, spindle knots, bamboo-like, semi-enclosed, hat-like, etc. The formation mechanism of various fibers was analyzed based on the phase separation and assembly interaction. The prepared PA66 CC fiber film was reported to have unique structural color and enhanced mechanical properties, which can be used as a substrate for drawing various patterns. This work will provide a novel idea for the fabrication of functional CC fiber, which is helpful for the potential application in the textile industry.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130550713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-11DOI: 10.2174/2210298103666230511162421
R. Bharti, Ajay Thakur, M. Verma, Renu Sharma
Because of its miscellaneous properties, developing less environmentally hazardous and trustworthy methodologies has become one of the most crucial steps toward synthesizing nanoparticles (NPs) among researchers and scientists. In this direction, silver nanoparticles (AgNPs or SNPs) have gained much attention because of their anti-inflammatory, antibacterial, antiviral, and antifungal properties, potential toxicity, and unusual physicochemical features. Concerning the toxicity of silver nanoparticles, silver nanoparticles may prove to be an essential tool against many drug-resistant microorganisms and substitutes for antibiotics. However, the synthesis of AgNPs using conventional methods had a toxic impact and caused much damage to the ecosystem. Researchers have used various production techniques to prevent the adverse effects of toxic chemicals, including algae, bacteria, fungi, and plants. This review study has covered recent advancements in green synthetic methodologies for synthesizing AgNPs. This insight provides a comprehensive overview of key findings in the green synthesis of Ag nanoparticles and attempts to focus on factors affecting their synthesis, characterization, applications, potential toxic impact on living organisms, merits/demerits, and prospects.
{"title":"Recent Advancement in the Green Synthesis of Silver Nanoparticles","authors":"R. Bharti, Ajay Thakur, M. Verma, Renu Sharma","doi":"10.2174/2210298103666230511162421","DOIUrl":"https://doi.org/10.2174/2210298103666230511162421","url":null,"abstract":"\u0000\u0000Because of its miscellaneous properties, developing less environmentally hazardous and trustworthy methodologies has become one of the most crucial steps toward synthesizing nanoparticles (NPs) among researchers and scientists. In this direction, silver nanoparticles (AgNPs or SNPs) have gained much attention because of their anti-inflammatory, antibacterial, antiviral, and antifungal properties, potential toxicity, and unusual physicochemical features. Concerning the toxicity of silver nanoparticles, silver nanoparticles may prove to be an essential tool against many drug-resistant microorganisms and substitutes for antibiotics. However, the synthesis of AgNPs using conventional methods had a toxic impact and caused much damage to the ecosystem. Researchers have used various production techniques to prevent the adverse effects of toxic chemicals, including algae, bacteria, fungi, and plants. This review study has covered recent advancements in green synthetic methodologies for synthesizing AgNPs. This insight provides a comprehensive overview of key findings in the green synthesis of Ag nanoparticles and attempts to focus on factors affecting their synthesis, characterization, applications, potential toxic impact on living organisms, merits/demerits, and prospects.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121372909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.2174/2210298103666230501154634
Yao Wang, Huiyun Hu, Lanpeng Guo, Hongping Liang, Ruofei Lu, Sitao Lv, Chenxu Wang, Liming Liu, Haihong Yang, Yi-Kuen Lee, Paddy J. French, Hao Li, G. Zhou
Formaldehyde (HCHO) is one of the sources of indoor air pollution and a recognized carcinogenic gas, which sets a huge threat to human health. Therefore, it is urgent to develop a formaldehyde gas sensor with high efficiency, low consumption, and low limit of detection. With solvothermal and supramolecular assembly methods, we fabricate a nanocomposite of ZnO/5-aminonaphthalene-1-sulfonic acid (ANS)-reduced graphene oxide (rGO) through in situ assembling flower-like ZnO nanoclusters on ANS-modified graphene nanosheets for room temperature formaldehyde detection. The flower-like ZnO/ANS-rGO based gas sensor exhibits high response (32%, 5 ppm), ultra-fast response/recovery times (18/23 s), high selectivity, long-term stability and a low practical limit of detection (pLOD) of 1 ppm toward HCHO at room temperature, offering significant advantages and competitiveness in chemiresistive room temperature HCHO sensors. The unique flower-like nanostructure of ZnO and the functionalization with ANS molecules jointly improved the HCHO sensing performance of the composite at room temperature. This work provides a new approach to designing and preparing high-performance room temperature gas sensing materials.
{"title":"Construction of Flower-like ZnO Nanoclusters on Functionalized Graphene Nanosheets for Room Temperature Formaldehyde Sensing","authors":"Yao Wang, Huiyun Hu, Lanpeng Guo, Hongping Liang, Ruofei Lu, Sitao Lv, Chenxu Wang, Liming Liu, Haihong Yang, Yi-Kuen Lee, Paddy J. French, Hao Li, G. Zhou","doi":"10.2174/2210298103666230501154634","DOIUrl":"https://doi.org/10.2174/2210298103666230501154634","url":null,"abstract":"\u0000\u0000Formaldehyde (HCHO) is one of the sources of indoor air pollution and a recognized carcinogenic gas, which sets a huge threat to human health. Therefore, it is urgent to develop a formaldehyde gas sensor with high efficiency, low consumption, and low limit of detection.\u0000\u0000\u0000\u0000With solvothermal and supramolecular assembly methods, we fabricate a nanocomposite of ZnO/5-aminonaphthalene-1-sulfonic acid (ANS)-reduced graphene oxide (rGO) through in situ assembling flower-like ZnO nanoclusters on ANS-modified graphene nanosheets for room temperature formaldehyde detection.\u0000\u0000\u0000\u0000The flower-like ZnO/ANS-rGO based gas sensor exhibits high response (32%, 5 ppm), ultra-fast response/recovery times (18/23 s), high selectivity, long-term stability and a low practical limit of detection (pLOD) of 1 ppm toward HCHO at room temperature, offering significant advantages and competitiveness in chemiresistive room temperature HCHO sensors.\u0000\u0000\u0000\u0000The unique flower-like nanostructure of ZnO and the functionalization with ANS molecules jointly improved the HCHO sensing performance of the composite at room temperature. This work provides a new approach to designing and preparing high-performance room temperature gas sensing materials.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134138238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polymeric hollow particles with a single-hole structure have attracted broad interest due to their combined advantages of a hollow cavity and an opening hole in the shell. In the past decades, much progress has been made in the fabrication of such particles with various strategies. However, there is a lack of research on the easy fabrication of biodegradable polylactide (PLA) single hole particles (PLA SHHPs). Method: In this work, we reported a simple double emulsion method for the fabrication of PLA SHHPs. The W/O/W double emulsion was formed by homogenizing PLA chloroform and brilliant blue G (BBG) solution. Scanning electron microscopy and confocal laser scanning microscopy were used for the characterization. It was found that the concentrations of PLA chloroform and BBG solution both had a significant influ-ence on the emulsion structure. PLA SHHPs with a percentage >85% were obtained from the emulsion composed of PLA chloroform (10.0w%) and BBG solution (4 mM). The particle formation mechanism was also pro-posed based on the result of the low interfacial tension between PLA chloroform/BBG solution. The results may inspire new development of PLA particles with unique structures, which are promising to be used in drug delivery, catalysis, microreaction and micromotors.
{"title":"A Double-Emulsion Method for the Fabrication of PLA Single-Hole Hollow Particles","authors":"Linfeng Chen, Yanan Li, Liyun Zhang, Rui Tian, Dicky Pranantyo, Fan Xia","doi":"10.2174/2210298103666230428092735","DOIUrl":"https://doi.org/10.2174/2210298103666230428092735","url":null,"abstract":"\u0000\u0000Polymeric hollow particles with a single-hole structure have attracted broad interest due to their combined advantages of a hollow cavity and an opening hole in the shell.\u0000\u0000\u0000\u0000In the past decades, much progress has been made in the fabrication of such particles with various strategies. However, there is a lack of research on the easy fabrication of biodegradable polylactide (PLA) single hole particles (PLA SHHPs). Method: In this work, we reported a simple double emulsion method for the fabrication of PLA SHHPs. The W/O/W double emulsion was formed by homogenizing PLA chloroform and brilliant blue G (BBG) solution. Scanning electron microscopy and confocal laser scanning microscopy were used for the characterization. It was found that the concentrations of PLA chloroform and BBG solution both had a significant influ-ence on the emulsion structure.\u0000\u0000\u0000\u0000PLA SHHPs with a percentage >85% were obtained from the emulsion composed of PLA chloroform (10.0w%) and BBG solution (4 mM). The particle formation mechanism was also pro-posed based on the result of the low interfacial tension between PLA chloroform/BBG solution.\u0000\u0000\u0000\u0000The results may inspire new development of PLA particles with unique structures, which are promising to be used in drug delivery, catalysis, microreaction and micromotors.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132187076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
2-Aminopyridines are the typical pyridine α-site derivatives, which have received growing interest in using as a kind of synthons in organic synthesis and drug synthesis because of their special binucleophilic framework All these obtained compounds were characterized by NMR. Among them, 3a was characterized by single-crystal X-ray analysis. All the theoretical calculation works were performed by Gaussian software. A series of the desired compounds can be synthesized at room temperature via a mild procedure under the promotion of simple inorganic base K2CO3. This mild strategy fits the concept of green chemistry, providing a novel idea for the construction of nitrogen-containing polyheterocyclic compounds.
{"title":"Cyclization of 2-Aminopyridines as Binucleophile and Mucobromic Acid as C3 Synthon: A New Access to Imidazo[1,2-a]pyridines","authors":"Kai Yang, Zhao‐Yang Wang, Qi Chen, Huan-Qing Li, Zhao-Hua Chen, Zu-Jia Chen, You-Cai Zhang","doi":"10.2174/2210298103666230419084204","DOIUrl":"https://doi.org/10.2174/2210298103666230419084204","url":null,"abstract":"\u0000\u00002-Aminopyridines are the typical pyridine α-site derivatives, which have received\u0000growing interest in using as a kind of synthons in organic synthesis and drug synthesis because\u0000of their special binucleophilic framework\u0000\u0000\u0000\u0000All these obtained compounds were characterized by NMR. Among them, 3a was\u0000characterized by single-crystal X-ray analysis. All the theoretical calculation works were performed by Gaussian software.\u0000\u0000\u0000\u0000A series of the desired compounds can be synthesized at room temperature via a mild\u0000procedure under the promotion of simple inorganic base K2CO3.\u0000\u0000\u0000\u0000This mild strategy fits the concept of green chemistry, providing a novel idea for\u0000the construction of nitrogen-containing polyheterocyclic compounds.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128835063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-12DOI: 10.2174/2210298103666230412082214
C. Fang, Xiaojun Zeng, H. Tao, W. Lau
In the past 20 years, with the emergence and update of digital intelligent technology, the diagnosis and treatment of hepatocellular carcinoma (HCC) have undergone profound changes. Three-dimensional visualization technology has revolutionized the traditional two-dimensional diagnosis and treatment model of HCC and realized preoperative visualization of tumors and complex liver anatomy. The emergence of ICG fluorescence imaging has realized intraoperative tumor boundary visualization from the molecular and cellular levels. Augmented reality (AR) and mixed reality (MR) technology can realize the three-dimensional visualization of anatomical structures in surgical navigation. Traditional experiential surgery has been transformed into modern intelligent navigation surgery, and surgery has stepped into a new era of digital intelligent technology. In addition, artificial intelligence, molecular imaging and nanoprobes are also expected to achieve early diagnosis and treatment of HCC and improve the prognosis of patients. This article reviews the latest application of digital intelligent diagnosis and treatment technology related to diagnosing and treating HCC, hoping to help achieve accurate diagnosis and treatment of HCC.
{"title":"Construction and Clinical Application of Digital Intelligent Diagnosis and Treatment System for Hepatocellular Carcinoma","authors":"C. Fang, Xiaojun Zeng, H. Tao, W. Lau","doi":"10.2174/2210298103666230412082214","DOIUrl":"https://doi.org/10.2174/2210298103666230412082214","url":null,"abstract":"\u0000\u0000In the past 20 years, with the emergence and update of digital intelligent technology, the diagnosis and treatment of hepatocellular carcinoma (HCC) have undergone profound changes. Three-dimensional visualization technology has revolutionized the traditional two-dimensional diagnosis and treatment model of HCC and realized preoperative visualization of tumors and complex liver anatomy. The emergence of ICG fluorescence imaging has realized intraoperative tumor boundary visualization from the molecular and cellular levels. Augmented reality (AR) and mixed reality (MR) technology can realize the three-dimensional visualization of anatomical structures in surgical navigation. Traditional experiential surgery has been transformed into modern intelligent navigation surgery, and surgery has stepped into a new era of digital intelligent technology. In addition, artificial intelligence, molecular imaging and nanoprobes are also expected to achieve early diagnosis and treatment of HCC and improve the prognosis of patients. This article reviews the latest application of digital intelligent diagnosis and treatment technology related to diagnosing and treating HCC, hoping to help achieve accurate diagnosis and treatment of HCC.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134519539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-10DOI: 10.2174/2210298103666230410104223
Yuyao Xiao, M. Zeng, Peng Huang, Chang Zhou, Fei Wu, Chun Yang
Significant advances in liver imaging technology have facilitated the early detection of subcentimeter hepatocellular carcinoma (HCC). Contrast-enhanced ultrasound, computed tomography, and magnetic resonance imaging (MRI) can be used to diagnose subcentimeter HCC based on the typical imaging features of HCC. Ancillary imaging features such as T2 weighted-imaging mild-moderate hyperintensity, restricted diffusion, and hepatobiliary phase hypointensity may improve the diagnostic accuracy of gadoxetic acid-enhanced MRI for subcentimeter HCC. More information is needed to choose between immediate treatment or watchful waiting in subcentimeter HCC. Surgical resection, ablation, and transarterial chemoembolization are effective and safe methods for the management of subcentimeter HCC.
{"title":"Current Status of Imaging Diagnosis and Treatment of Subcentimeter Hepatocellular Carcinoma","authors":"Yuyao Xiao, M. Zeng, Peng Huang, Chang Zhou, Fei Wu, Chun Yang","doi":"10.2174/2210298103666230410104223","DOIUrl":"https://doi.org/10.2174/2210298103666230410104223","url":null,"abstract":"\u0000\u0000Significant advances in liver imaging technology have facilitated the early detection of subcentimeter hepatocellular carcinoma (HCC). Contrast-enhanced ultrasound, computed tomography, and magnetic resonance imaging (MRI) can be used to diagnose subcentimeter HCC based on the typical imaging features of HCC. Ancillary imaging features such as T2 weighted-imaging mild-moderate hyperintensity, restricted diffusion, and hepatobiliary phase hypointensity may improve the diagnostic accuracy of gadoxetic acid-enhanced MRI for subcentimeter HCC. More information is needed to choose between immediate treatment or watchful waiting in subcentimeter HCC. Surgical resection, ablation, and transarterial chemoembolization are effective and safe methods for the management of subcentimeter HCC.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122218028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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