Pub Date : 2024-05-20DOI: 10.2174/0122102981301480240514113753
Sadia Noor Mou, Afsana Akter Rupa, Md Arko Ayon Chowdhury, Md. Lifat Rahi, Abdul Baten, Amin Ahsan Ali, Haseena Khan, Md. Ashraful Amin, Mohammad Riazul Islam
Hilsa shad (Tenualosa ilisha) is a popular anadromous fish in Bangladesh known to cause allergies. Despite recognized allergenicity, there is a paucity of research at the molecular level on hilsa allergen. Muscle transcriptomes of hilsa from freshwater, brackish, and deep sea habitats were sequenced using Illumina NovaSeq 6000 and assembled. BLASTx analysis of the AllergenOnline database identified potential allergens. The molecular docking study investigated parvalbumin’s interaction with human IgE. An analysis of hilsa muscle transcriptomes revealed 28 known fish allergens, including parvalbumin, tropomyosin, including parvalbumin, tropomyosin, filamin C, creatine kinase-2, aldolase A, triosephosphate isomerase B, and Glyceraldehyde-3-phosphate Dehydrogenase (G3PD). Creatine kinase showed significantly higher abundance (p & 0.05) and habitat variation (freshwater vs. brackish water). In silico analysis suggested upregulation of Sal s 2 enolase and Equ c 6 lysozyme in freshwater and brackish water compared to the deep sea. Docking studies identified a potential B-cell epitope in parvalbumin that interacts with human IgE. This study has unveiled 28 potential allergens in hilsa, including habitat-specific variations. The parvalbumin-IgE interaction has been suggested as a mechanism for allergies. The findings have illuminated fish allergy in Bangladesh and paved the way for further investigation.
鲥鱼（Tenualosa ilisha）是孟加拉国一种常见的溯河鱼类，已知会引起过敏。使用 Illumina NovaSeq 6000 对淡水、咸水和深海栖息地的鲥鱼肌肉转录组进行测序并组装。通过对 AllergenOnline 数据库进行 BLASTx 分析，确定了潜在的过敏原。分子对接研究调查了副卵白蛋白与人类 IgE 的相互作用。对希尔萨肌肉转录组的分析发现了 28 种已知的鱼类过敏原，包括副卵白蛋白、肌球蛋白、丝蛋白 C、肌酸激酶-2、醛缩酶 A、磷酸三糖异构酶 B 和甘油醛-3-磷酸脱氢酶（G3PD）。肌酸激酶的丰度（p & 0.05）和生境差异（淡水与咸水）明显更高。硅学分析表明，与深海相比，淡水和咸水中的 Sal s 2 enolase 和 Equ c 6 溶菌酶上调。对接研究发现了副卵磷脂中与人类 IgE 相互作用的潜在 B 细胞表位。这项研究揭示了希尔沙鱼中 28 种潜在的过敏原，包括栖息地的特异性变化。这些发现揭示了孟加拉国的鱼类过敏症，为进一步研究铺平了道路。
{"title":"Muscle Transcriptome Provides Insights into the Allergen Profile of Habitat-Specific Mature Hilsa shad Tenualosa ilisha","authors":"Sadia Noor Mou, Afsana Akter Rupa, Md Arko Ayon Chowdhury, Md. Lifat Rahi, Abdul Baten, Amin Ahsan Ali, Haseena Khan, Md. Ashraful Amin, Mohammad Riazul Islam","doi":"10.2174/0122102981301480240514113753","DOIUrl":"https://doi.org/10.2174/0122102981301480240514113753","url":null,"abstract":"\u0000\u0000Hilsa shad (Tenualosa ilisha) is a popular anadromous fish in Bangladesh\u0000known to cause allergies. Despite recognized allergenicity, there is a paucity of research at the\u0000molecular level on hilsa allergen.\u0000\u0000\u0000\u0000Muscle transcriptomes of hilsa from freshwater, brackish, and deep sea habitats were\u0000sequenced using Illumina NovaSeq 6000 and assembled. BLASTx analysis of the AllergenOnline\u0000database identified potential allergens. The molecular docking study investigated parvalbumin’s\u0000interaction with human IgE.\u0000\u0000\u0000\u0000An analysis of hilsa muscle transcriptomes revealed 28 known fish allergens, including\u0000parvalbumin, tropomyosin, including parvalbumin, tropomyosin, filamin C, creatine kinase-2,\u0000aldolase A, triosephosphate isomerase B, and Glyceraldehyde-3-phosphate Dehydrogenase\u0000(G3PD). Creatine kinase showed significantly higher abundance (p & 0.05) and habitat variation\u0000(freshwater vs. brackish water). In silico analysis suggested upregulation of Sal s 2 enolase and\u0000Equ c 6 lysozyme in freshwater and brackish water compared to the deep sea. Docking studies\u0000identified a potential B-cell epitope in parvalbumin that interacts with human IgE.\u0000\u0000\u0000\u0000This study has unveiled 28 potential allergens in hilsa, including habitat-specific variations.\u0000The parvalbumin-IgE interaction has been suggested as a mechanism for allergies. The\u0000findings have illuminated fish allergy in Bangladesh and paved the way for further investigation.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"66 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141121611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.2174/0122102981299289240324072639
Ruobing Wang, Lingyu Meng, Jianjun Tan
In recent years, long non-coding RNAs (lncRNAs) have played important roles in various biological processes. Mutations and regulation of lncRNAs are closely associated with many human cancers. Predicting potential lncRNA-cancer associations helps to understand cancer's pathogenesis and provides new ideas and approaches for cancer prevention, treatment and diagnosis. Predicting lncRNA-cancer associations based on computational methods helps systematic biological studies. In particular, machine learning methods have received much attention and are commonly used to solve these problems. Therefore, many machine learning computational models have been proposed to improve the prediction performance and achieve accurate diagnosis and effective treatment of cancer. This review provides an overview of existing models for predicting lncRNA-cancer associations by machine learning methods. The evaluation metrics of each model are briefly described, analyzed the advantages and limitations of these models are analyzed. We also provide a case study summary of the two cancers listed. Finally, the challenges and future trends of predicting lncRNA-cancer associations with machine learning methods are discussed.
{"title":"Recent Advances in Machine Learning Methods for LncRNA-Cancer Associations Prediction","authors":"Ruobing Wang, Lingyu Meng, Jianjun Tan","doi":"10.2174/0122102981299289240324072639","DOIUrl":"https://doi.org/10.2174/0122102981299289240324072639","url":null,"abstract":"\u0000\u0000In recent years, long non-coding RNAs (lncRNAs) have played important roles in various\u0000biological processes. Mutations and regulation of lncRNAs are closely associated with many\u0000human cancers. Predicting potential lncRNA-cancer associations helps to understand cancer's\u0000pathogenesis and provides new ideas and approaches for cancer prevention, treatment and diagnosis.\u0000Predicting lncRNA-cancer associations based on computational methods helps systematic biological\u0000studies. In particular, machine learning methods have received much attention and are\u0000commonly used to solve these problems. Therefore, many machine learning computational models\u0000have been proposed to improve the prediction performance and achieve accurate diagnosis and\u0000effective treatment of cancer. This review provides an overview of existing models for predicting\u0000lncRNA-cancer associations by machine learning methods. The evaluation metrics of each model\u0000are briefly described, analyzed the advantages and limitations of these models are analyzed. We\u0000also provide a case study summary of the two cancers listed. Finally, the challenges and future\u0000trends of predicting lncRNA-cancer associations with machine learning methods are discussed.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"247 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.2174/0122102981289400240228182937
Ran Wang, Shaohong Cheng, David S.-K. Ting
A delayed detached eddy simulation in OpenFOAM was performed to study flow separation of a circular cylinder with roundness imperfection up to 4% of its diameter at Reynolds numbers of 100, 3900, and 10! in normal flow. The flow was considered to be Newtonian and incompressible. The separation position was determined independently based on surface pressure distribution and skin friction. Results show that the patterns of these distributions depend on both Reynolds number and roundness imperfection level, and flow separation in an imperfectly round cylinder may be induced by either an adverse pressure gradient or a Gentle Bend (GB) introduced by the roughness. For the separation point determined by the pressure-based method, its accuracy can be affected by the characteristic of pressure distribution near the separation point at low Reynolds numbers, and, thus, its physical validity needs to be verified by flow visualization at high Reynolds numbers. The skin friction-based method can accurately predict separation point for both perfectly and imperfectly round cylinders without additional information. When the roundness imperfection ratio reaches 2% and the Reynolds number reaches 3900, both approaches indicate that the flow separation point converges to the location of GB on the cylinder surface and the two sets of predicted separation points agree well.
{"title":"Comparison of Pressure-Based and Skin Friction-based Methods for the Determination of Flow Separation of a Circular Cylinder with Roundness\u0000Imperfection","authors":"Ran Wang, Shaohong Cheng, David S.-K. Ting","doi":"10.2174/0122102981289400240228182937","DOIUrl":"https://doi.org/10.2174/0122102981289400240228182937","url":null,"abstract":"\u0000\u0000A delayed detached eddy simulation in OpenFOAM was performed to\u0000study flow separation of a circular cylinder with roundness imperfection up to 4% of its diameter\u0000at Reynolds numbers of 100, 3900, and 10! in normal flow.\u0000\u0000\u0000\u0000The flow was considered to be Newtonian and incompressible. The separation position\u0000was determined independently based on surface pressure distribution and skin friction.\u0000\u0000\u0000\u0000Results show that the patterns of these distributions depend on both Reynolds number and\u0000roundness imperfection level, and flow separation in an imperfectly round cylinder may be induced\u0000by either an adverse pressure gradient or a Gentle Bend (GB) introduced by the roughness.\u0000For the separation point determined by the pressure-based method, its accuracy can be affected by\u0000the characteristic of pressure distribution near the separation point at low Reynolds numbers, and,\u0000thus, its physical validity needs to be verified by flow visualization at high Reynolds numbers.\u0000\u0000\u0000\u0000The skin friction-based method can accurately predict separation point for both perfectly\u0000and imperfectly round cylinders without additional information. When the roundness imperfection\u0000ratio reaches 2% and the Reynolds number reaches 3900, both approaches indicate that the\u0000flow separation point converges to the location of GB on the cylinder surface and the two sets of\u0000predicted separation points agree well.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"25 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140263726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.2174/0122102981274573231114060457
D. Patel
{"title":"Biological Significance and Therapeutic Potential of Militarine in Medicine: A Natural Glucosyloxybenzyl 2-isobutylmalate from Bletilla striata","authors":"D. Patel","doi":"10.2174/0122102981274573231114060457","DOIUrl":"https://doi.org/10.2174/0122102981274573231114060457","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"93 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.2174/0122102981258712231114073051
Xiao L, Luo H M, Ji X Y, Ren Y Y, Wu X Q, Jiang H Z
Rosmarinus officinalis L. belongs to the genus Rosemary in the family Labiatae, which is a perennial evergreen subshrub. It is currently cultivated in certain areas of Yunnan, Guangxi, and Guizhou. At present, in food, cosmetics, healthcare products, and other domains, R. officinalis has a wide range of applications; it has received widespread attention, and is also a hot topic of research today. Using modern spectroscopic techniques, it has been found that the main chemical components of rosemary can be divided into two major groups, including volatile components (essential oils) and non-volatile components (diterpenes, triterpenes, flavonoids, phenolic acids, sterols, etc.). Among them, carnosic acid, carnosol, rosemary phenol, and 1,8-cineole are the main components acting as antioxidants and they are highly regarded. The main methods for extracting the active ingredients of R. officinalis include water distillation, ultrasonic-assisted microwave method, supercritical CO2 extraction method, enzyme-assisted extraction method, and microwaveassisted extraction method. Modern research has shown that rosemary has anti-inflammatory, antioxidant, antibacterial, antiviral, antitumor, hepatoprotective, hypolipidemic, immunomodulatory, antiseptic, and antithrombotic effects, and is widely used in medical applications.
{"title":"A Mini-review on the Chemical Composition, Extraction and Isolation\u0000Techniques, and Pharmacological Activity of Rosmarinus officinalis L","authors":"Xiao L, Luo H M, Ji X Y, Ren Y Y, Wu X Q, Jiang H Z","doi":"10.2174/0122102981258712231114073051","DOIUrl":"https://doi.org/10.2174/0122102981258712231114073051","url":null,"abstract":"\u0000\u0000Rosmarinus officinalis L. belongs to the genus Rosemary in the family Labiatae, which\u0000is a perennial evergreen subshrub. It is currently cultivated in certain areas of Yunnan, Guangxi,\u0000and Guizhou. At present, in food, cosmetics, healthcare products, and other domains, R. officinalis\u0000has a wide range of applications; it has received widespread attention, and is also a hot topic of\u0000research today. Using modern spectroscopic techniques, it has been found that the main chemical\u0000components of rosemary can be divided into two major groups, including volatile components\u0000(essential oils) and non-volatile components (diterpenes, triterpenes, flavonoids, phenolic acids,\u0000sterols, etc.). Among them, carnosic acid, carnosol, rosemary phenol, and 1,8-cineole are the main\u0000components acting as antioxidants and they are highly regarded. The main methods for extracting\u0000the active ingredients of R. officinalis include water distillation, ultrasonic-assisted microwave\u0000method, supercritical CO2 extraction method, enzyme-assisted extraction method, and microwaveassisted extraction method. Modern research has shown that rosemary has anti-inflammatory, antioxidant, antibacterial, antiviral, antitumor, hepatoprotective, hypolipidemic, immunomodulatory,\u0000antiseptic, and antithrombotic effects, and is widely used in medical applications.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.2174/0122102981267217231114191056
Liang Zhang, Wenying Yu
The study aimed to discuss the possible mechanisms of Houpu Wenzhong Decoction in the treatment of chronic gastritis and depression based on network pharmacology and molecular docking. The chemical components and corresponding targets of seven crude drugs in Houpu Wenzhong Decoction were retrieved from the database TCMSP. The targets for treating chronic gastritis and depression were obtained from the database GeneCards. STRING 11.5 was used to establish the protein-protein interaction network of common targets among “chemical components-chronic gastritis-depression”, and then Cytoscape was employed for visual analysis. The targets with the top ten degrees were selected as key targets, which were then imported to BioGPS to obtain the distribution in organs and tissues. The common targets were analyzed via Go and KEGG pathway enrichment analyses using Metascape. The top ten degrees of active components were verified by molecular docking of key targets. Under the conditions of OB ≥ 30% and DL ≥ 0.18, a total of 144 chemical components and related 251 targets of Houpu Wenzhong Decoction were retrieved. 1192 and 12902 targets were retrieved for chronic gastritis and depression from the GeneCards database, respectively. 104 common targets were obtained by intersection among the two diseases and drug targets. The key common targets have been found to be mainly distributed in organs and tissues, such as the adrenal cortex, amygdala, appendix, adrenal gland, colorectal, liver, and prostates, as observed through BioGPS analysis. 5141 biological processes, 354 cell components, and 615 molecular functions were obtained by GO functional enrichment analysis, and 302 signal pathways were obtained by KEGG enrichment analysis. Among these, IL-17, TNF, PI3K-Akt, and toll-like receptor signaling pathway have been found to be involved. Molecular docking results showed the key active components, naringenin and hesperidin, to have good binding activities with targets STAT3 and Jun. 104 common targets between chronic gastritis and depression have been obtained as the basis for Houpu Wenzhong Decoction to treat the two diseases. The ten key active ingredients have been found to act on 15 key signal pathways through 104 common key targets to treat the two diseases.
{"title":"Mechanism of Houpu Wenzhong Decoction in the Treatment of Chronic\u0000Gastritis and Depression Based on Network Pharmacology and Molecular\u0000Docking","authors":"Liang Zhang, Wenying Yu","doi":"10.2174/0122102981267217231114191056","DOIUrl":"https://doi.org/10.2174/0122102981267217231114191056","url":null,"abstract":"\u0000\u0000The study aimed to discuss the possible mechanisms of Houpu Wenzhong\u0000Decoction in the treatment of chronic gastritis and depression based on network pharmacology\u0000and molecular docking.\u0000\u0000\u0000\u0000The chemical components and corresponding targets of seven crude drugs in Houpu\u0000Wenzhong Decoction were retrieved from the database TCMSP. The targets for treating chronic\u0000gastritis and depression were obtained from the database GeneCards. STRING 11.5 was used to\u0000establish the protein-protein interaction network of common targets among “chemical components-chronic gastritis-depression”, and then Cytoscape was employed for visual analysis. The\u0000targets with the top ten degrees were selected as key targets, which were then imported to BioGPS\u0000to obtain the distribution in organs and tissues. The common targets were analyzed via Go and\u0000KEGG pathway enrichment analyses using Metascape. The top ten degrees of active components\u0000were verified by molecular docking of key targets.\u0000\u0000\u0000\u0000Under the conditions of OB ≥ 30% and DL ≥ 0.18, a total of 144 chemical components\u0000and related 251 targets of Houpu Wenzhong Decoction were retrieved. 1192 and 12902 targets\u0000were retrieved for chronic gastritis and depression from the GeneCards database, respectively. 104\u0000common targets were obtained by intersection among the two diseases and drug targets. The key\u0000common targets have been found to be mainly distributed in organs and tissues, such as the adrenal cortex, amygdala, appendix, adrenal gland, colorectal, liver, and prostates, as observed through\u0000BioGPS analysis. 5141 biological processes, 354 cell components, and 615 molecular functions\u0000were obtained by GO functional enrichment analysis, and 302 signal pathways were obtained by\u0000KEGG enrichment analysis. Among these, IL-17, TNF, PI3K-Akt, and toll-like receptor signaling\u0000pathway have been found to be involved. Molecular docking results showed the key active components, naringenin and hesperidin, to have good binding activities with targets STAT3 and Jun.\u0000\u0000\u0000\u0000104 common targets between chronic gastritis and depression have been obtained as\u0000the basis for Houpu Wenzhong Decoction to treat the two diseases. The ten key active ingredients\u0000have been found to act on 15 key signal pathways through 104 common key targets to treat the\u0000two diseases.\u0000","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-30DOI: 10.2174/0122102981260447231115115150
Yu. Nedotsuk, A. Laptev
For the first time, in the aspect of biophysics, the reasons for the increase in the power of the threshold of anaerobic metabolism developed by the test person during functional diagnostics. This occurs with an increase in the pedaling frequency with which the specified load on a bicycle ergometer in the range from 40 to 140 rpm (0.73-2.56 m/s) is overcome, have been substantiated. It was determined that the ratio of force and velocity in the studied range of pedaling frequencies (muscle contractile speed) corresponds to the hyperbolic type with displaced axes At the same time, with an increase in pedaling frequency, power increases in a cubic dependence, and the rate of oxygen consumption by the test subject decreases linearly in the process of overcoming the same fixed-power load set on a bicycle ergometer and vice versa.
{"title":"The Mechanism Of Energy Changes That Occur Depending On The Ratio Of Force And Speed In The Example Of Bicycle Ergometric Testing","authors":"Yu. Nedotsuk, A. Laptev","doi":"10.2174/0122102981260447231115115150","DOIUrl":"https://doi.org/10.2174/0122102981260447231115115150","url":null,"abstract":"For the first time, in the aspect of biophysics, the reasons for the increase in the power of the threshold of anaerobic metabolism developed by the test person during functional diagnostics. This occurs with an increase in the pedaling frequency with which the specified load on a bicycle ergometer in the range from 40 to 140 rpm (0.73-2.56 m/s) is overcome, have been substantiated. It was determined that the ratio of force and velocity in the studied range of pedaling frequencies (muscle contractile speed) corresponds to the hyperbolic type with displaced axes At the same time, with an increase in pedaling frequency, power increases in a cubic dependence, and the rate of oxygen consumption by the test subject decreases linearly in the process of overcoming the same fixed-power load set on a bicycle ergometer and vice versa.","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"367 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139203066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-29DOI: 10.2174/0122102981252254231113102428
Guo Li, KunPeng Yu
The installation of optical devices is a necessary operation before their use. Therefore, the configuration of the optical system affects the performance of the whole optical system. However, in the process of optical system installation, there are still some technical breakthroughs to be made in order to better carry out optical system installation in the future. Through the introduction and discussion of the devices, methods and patent features of optical alignment testing in recent years, some valuable conclusions are summarized, and future research and development are prospected. The patents of optical system assembly were studied, and the patents and research progress of optical alignment were summarized. With the development of optical technology, optical alignment has become more and more important, so optical alignment is needed to realize the design of optical systems. It is concluded that there is still a large space for the development of optical alignment, and the main development trend is towards high precision and large caliber
{"title":"Recent Patents for Optical Alignment","authors":"Guo Li, KunPeng Yu","doi":"10.2174/0122102981252254231113102428","DOIUrl":"https://doi.org/10.2174/0122102981252254231113102428","url":null,"abstract":"The installation of optical devices is a necessary operation before their use. Therefore, the configuration of the optical system affects the performance of the whole optical system. However, in the process of optical system installation, there are still some technical breakthroughs to be made in order to better carry out optical system installation in the future. Through the introduction and discussion of the devices, methods and patent features of optical alignment testing in recent years, some valuable conclusions are summarized, and future research and development are prospected. The patents of optical system assembly were studied, and the patents and research progress of optical alignment were summarized. With the development of optical technology, optical alignment has become more and more important, so optical alignment is needed to realize the design of optical systems. It is concluded that there is still a large space for the development of optical alignment, and the main development trend is towards high precision and large caliber","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-02DOI: 10.2174/0122102981266814231016051712
Zhuang Xue, Tingting Peng, Wei Wang
Abstract: The top taxonomic position among non-chordate invertebrates, which make up the evolutionary connection between invertebrates and vertebrates, is held by echinoderms. Their immune responses rely on coelomocyte activity functioning concurrently with a range of humoral components that directly interact with invasive pathogens. However, markedly lower numbers of systematic reviews of the classification and immune function of coelomocytes have been performed compared with those of vertebrates. Studying echinoderm coelomocytes continues to be an important evolutionary vantage point for determining the origins of bilaterian immunity as well as the principles behind the adaptive immune system of vertebrates. This article reviews the classifications and immune functions of coelomocytes (sea urchin, sea cucumber and sea star). It summarizes the research progress on immune-related genes/proteins, signal transduction pathways and effector molecules in echinoderms according to the recent literature. This summary provides a theoretical basis for studying coelomocytes and disease control in echinoderms. In the future, a variety of methods and techniques should be used and combined with the surface receptors of cells to study the classification and function of coelomocytes of echinoderms.
{"title":"Classification and Immune Function of Coelomocytes in Echinoderms","authors":"Zhuang Xue, Tingting Peng, Wei Wang","doi":"10.2174/0122102981266814231016051712","DOIUrl":"https://doi.org/10.2174/0122102981266814231016051712","url":null,"abstract":"Abstract: The top taxonomic position among non-chordate invertebrates, which make up the evolutionary connection between invertebrates and vertebrates, is held by echinoderms. Their immune responses rely on coelomocyte activity functioning concurrently with a range of humoral components that directly interact with invasive pathogens. However, markedly lower numbers of systematic reviews of the classification and immune function of coelomocytes have been performed compared with those of vertebrates. Studying echinoderm coelomocytes continues to be an important evolutionary vantage point for determining the origins of bilaterian immunity as well as the principles behind the adaptive immune system of vertebrates. This article reviews the classifications and immune functions of coelomocytes (sea urchin, sea cucumber and sea star). It summarizes the research progress on immune-related genes/proteins, signal transduction pathways and effector molecules in echinoderms according to the recent literature. This summary provides a theoretical basis for studying coelomocytes and disease control in echinoderms. In the future, a variety of methods and techniques should be used and combined with the surface receptors of cells to study the classification and function of coelomocytes of echinoderms.","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"6 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135974642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-18DOI: 10.2174/0122102981264993230925164537
Lu Pang, Yanfeng Hou, Xin Wang, Jialin Du, Haiming Huang, Mingyu Yang, Sisi Wang, Chongwen An, Tao Meng, Haixia Li
Background: Clear cell renal carcinoma (ccRCC) is one of the most common urological tumors worldwide and metabolic reprogramming is its distinguishing feature. A systematic study on the role of the metabolism-related genes in ccRCC cancer stem cells (CSCs) is still lacking. Moreover, an effective metabolism-related prediction signature is urgently needed to assess the prognosis of ccRCC patients. background: Clear cell renal carcinoma (ccRCC) is one of the most common urological tumors worldwide and metabolic reprogramming is its distinguishing feature. A systematic study on the role of the metabolism-related genes in ccRCC cancer stem cells (CSCs) is still lacking. Moreover, an effective metabolism-related prediction signature is urgently needed to assess the prognosis of ccRCC patients. Methods: Gene expression profiles of GSE48550 and GSE84546 were analyzed for the role of metabolism-related gene in ccRCC-CSCs. The GSE22541 dataset were used to construct and validate an effective metabolism-related prediction signature to assess the prognosis of ccRCC patients. Results: For glycolytic metabolism, we found that HKDC1, PFKM and LDHB were significantly upregulated in ccRCC-CSCs in GSE84546. For TCA cycle, ACO1, SDHA and MDH1 were significantly downregulated in ccRCC-CSCs in both GSE48550 and GSE84546. For fatty acid metabolism, CPT1A and ACACB were significantly upregulated in ccRCC-CSCs in GSE84546. It is worth noting that SCD was significantly downregulated in both GSE48550 and GSE84546. For glutamine metabolism, SLC1A5, GLS and GOT1 were significantly upregulated in GSE84546. An eight-gene CSCs metabolism-related risk signature including HKDC1, PFKM, LDHB, IDH1, OGDH, SDHA, GLS and GLUL were constructed to predict the overall survival (OS) of ccRCC patients. Patients could be separated into two groups, and the patients with lower risk scores had longer survival time. Conclusion: Our study indicated that metabolic reprogramming, including glycolytic metabolism, TCA cycle, fatty acid metabolism and glutamine metabolism, is more obvious in CD105+ renal cells (GSE84546) than CD133+ renal cells (GSE48550). An eight-gene metabolismrelated risk signature including HKDC1, PFKM, LDHB, IDH1, OGDH, SDHA, GLS and GLUL can effectively predict OS in ccRCC. other: N/A
背景:透明细胞肾癌(ccRCC)是世界范围内最常见的泌尿系统肿瘤之一，代谢重编程是其显著特征。代谢相关基因在ccRCC肿瘤干细胞(CSCs)中的作用尚缺乏系统的研究。此外，迫切需要一种有效的代谢相关预测信号来评估ccRCC患者的预后。背景:透明细胞肾癌(ccRCC)是世界范围内最常见的泌尿系统肿瘤之一，代谢重编程是其显著特征。代谢相关基因在ccRCC肿瘤干细胞(CSCs)中的作用尚缺乏系统的研究。此外，迫切需要一种有效的代谢相关预测信号来评估ccRCC患者的预后。方法:分析GSE48550和GSE84546基因表达谱，探讨代谢相关基因在ccRCC-CSCs中的作用。使用GSE22541数据集构建并验证有效的代谢相关预测签名，以评估ccRCC患者的预后。结果:对于糖酵解代谢，我们发现GSE84546的cccc - cscs中HKDC1、PFKM和LDHB显著上调。对于TCA循环，GSE48550和GSE84546的cccc - cscs中ACO1、SDHA和MDH1均显著下调。对于脂肪酸代谢，GSE84546中ccRCC-CSCs的CPT1A和ACACB显著上调。值得注意的是，SCD在GSE48550和GSE84546中均显著下调。对于谷氨酰胺代谢，SLC1A5、GLS和GOT1在GSE84546中显著上调。构建包括HKDC1、PFKM、LDHB、IDH1、OGDH、SDHA、GLS和GLUL在内的8个基因CSCs代谢相关风险特征，预测ccRCC患者的总生存期(OS)。患者可分为两组，风险评分越低的患者生存时间越长。结论:我们的研究表明，CD105+肾细胞(GSE84546)比CD133+肾细胞(GSE48550)的糖酵解代谢、TCA循环、脂肪酸代谢和谷氨酰胺代谢等代谢重编程更为明显。包括HKDC1、PFKM、LDHB、IDH1、OGDH、SDHA、GLS和GLUL在内的8个基因代谢相关风险标志可以有效预测ccRCC的OS。其他:N / A
{"title":"Metabolic Reprogramming of Cancer Stem Cells and a Novel Eight-Gene Metabolism-Related Risk Signature in Clear Cell Renal Carcinoma","authors":"Lu Pang, Yanfeng Hou, Xin Wang, Jialin Du, Haiming Huang, Mingyu Yang, Sisi Wang, Chongwen An, Tao Meng, Haixia Li","doi":"10.2174/0122102981264993230925164537","DOIUrl":"https://doi.org/10.2174/0122102981264993230925164537","url":null,"abstract":"Background: Clear cell renal carcinoma (ccRCC) is one of the most common urological tumors worldwide and metabolic reprogramming is its distinguishing feature. A systematic study on the role of the metabolism-related genes in ccRCC cancer stem cells (CSCs) is still lacking. Moreover, an effective metabolism-related prediction signature is urgently needed to assess the prognosis of ccRCC patients. background: Clear cell renal carcinoma (ccRCC) is one of the most common urological tumors worldwide and metabolic reprogramming is its distinguishing feature. A systematic study on the role of the metabolism-related genes in ccRCC cancer stem cells (CSCs) is still lacking. Moreover, an effective metabolism-related prediction signature is urgently needed to assess the prognosis of ccRCC patients. Methods: Gene expression profiles of GSE48550 and GSE84546 were analyzed for the role of metabolism-related gene in ccRCC-CSCs. The GSE22541 dataset were used to construct and validate an effective metabolism-related prediction signature to assess the prognosis of ccRCC patients. Results: For glycolytic metabolism, we found that HKDC1, PFKM and LDHB were significantly upregulated in ccRCC-CSCs in GSE84546. For TCA cycle, ACO1, SDHA and MDH1 were significantly downregulated in ccRCC-CSCs in both GSE48550 and GSE84546. For fatty acid metabolism, CPT1A and ACACB were significantly upregulated in ccRCC-CSCs in GSE84546. It is worth noting that SCD was significantly downregulated in both GSE48550 and GSE84546. For glutamine metabolism, SLC1A5, GLS and GOT1 were significantly upregulated in GSE84546. An eight-gene CSCs metabolism-related risk signature including HKDC1, PFKM, LDHB, IDH1, OGDH, SDHA, GLS and GLUL were constructed to predict the overall survival (OS) of ccRCC patients. Patients could be separated into two groups, and the patients with lower risk scores had longer survival time. Conclusion: Our study indicated that metabolic reprogramming, including glycolytic metabolism, TCA cycle, fatty acid metabolism and glutamine metabolism, is more obvious in CD105+ renal cells (GSE84546) than CD133+ renal cells (GSE48550). An eight-gene metabolismrelated risk signature including HKDC1, PFKM, LDHB, IDH1, OGDH, SDHA, GLS and GLUL can effectively predict OS in ccRCC. other: N/A","PeriodicalId":184819,"journal":{"name":"Current Chinese Science","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135888311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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