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Increased incidence of mixed drug toxicity deaths involving tapentadol - A forensic study. 涉及他喷他多的混合药物中毒死亡病例增加--一项法医研究。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-04-01 Epub Date: 2023-06-23 DOI: 10.1177/00258024231183504
Lilli Stephenson, Corinna van den Heuvel, Melissa Humphries, Timothy Scott, Roger W Byard

Tapentadol is a relatively new synthetic opioid analgesic prescribed for the management of moderate to severe pain. While tapentadol has been shown to be more effective than traditional opioid analgesics, it still carries the risk of addiction, abuse, and misuse. In Australia, tapentadol has become one of the top five most commonly prescribed opioid drugs, with prescriptions increasing by approximately 150,000 each year since it first became available. The rapid increase in tapentadol prescriptions has occurred in parallel to an increasing number of post-mortem tapentadol detections in South Australia (SA). While the number of deaths in SA related to tapentadol use was low in the current study, findings suggest that an increasing trend of deaths involving tapentadol will continue in parallel to a rapidly increasing number of prescriptions, mirroring trends associated with traditional opioids in SA. As a comparatively new opioid analgesic, monitoring future trends will be important to determine if additional prescribing education, intervention, or restrictions are required.

他喷他多是一种相对较新的合成阿片类镇痛药,用于治疗中度至重度疼痛。虽然事实证明他喷他多比传统的阿片类镇痛药更有效,但它仍有成瘾、滥用和误用的风险。在澳大利亚,他喷他多已成为最常用的五大阿片类处方药之一,自上市以来,处方量每年增加约 15 万份。在阿片类药物处方迅速增加的同时,南澳大利亚(South Australia,SA)在尸检中发现的阿片类药物也越来越多。虽然在目前的研究中,南澳大利亚州与使用他喷他多有关的死亡人数较少,但研究结果表明,在处方数量迅速增加的同时,涉及他喷他多的死亡人数也将呈上升趋势,这与南澳大利亚州传统阿片类药物的相关趋势如出一辙。作为一种相对较新的阿片类镇痛药,监测未来的趋势对于确定是否需要进行额外的处方教育、干预或限制非常重要。
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引用次数: 0
Suspected serial killers and unsuspected statistical blunders. 疑似连环杀手和不为人知的统计失误。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-04-01 DOI: 10.1177/00258024241242549
John O'Quigley

A whole branch of theoretical statistics devotes itself to the analysis of clusters, the aim being to distinguish an apparent cluster arising randomly from one that is more likely to have been produced as a result of some systematic influence. There are many examples in medicine and some that involve both medicine and the legal field; criminal law in particular. Observed clusters or a series of cases in a given setting can set off alarm bells, the recent conviction of Lucy Letby in England being an example. It was an observed cluster, a series of deaths among neonates, that prompted the investigation of Letby. There have been other similar cases in the past and there will be similar cases in the future. Our purpose is not to reconsider any particular trial but, rather, to work with similar, indeed more extreme numbers of cases as a way to underline the statistical mistakes that can be made when attempting to make sense of the data. These notions are illustrated via a made-up case of 10 incidents where the anticipated count was only 2. The most common statistical analysis would associate a probability of less than 0.00005 with this outcome: A very rare event. However, a more careful analysis that avoids common pitfalls results in a probability close to 0.5, indicating that, given the circumstances, we were as likely to see 10 or more as we were to see less than 10.

理论统计学有一个完整的分支专门研究聚类分析,目的是将随机产生的明显聚类与更有可能是受某种系统影响而产生的聚类区分开来。在医学领域有很多这样的例子,有些例子同时涉及医学和法律领域,尤其是刑法。在特定环境下观察到的案件群或一系列案件可能会敲响警钟,最近英国对露西-莱特比的定罪就是一个例子。对莱特比进行调查的原因是观察到的集群现象,即一系列新生儿死亡事件。过去有其他类似案件,将来还会有类似案件。我们的目的不是要重新考虑任何特定的试验,而是要通过类似的、甚至更极端的病例来强调在试图理解数据时可能会犯的统计错误。最常见的统计分析会将小于 0.00005 的概率与这一结果联系起来:这是一个非常罕见的事件。然而,通过避免常见误区的更仔细的分析,得出的概率接近 0.5,表明在这种情况下,我们看到 10 起或更多事件的可能性与看到少于 10 起事件的可能性相同。
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引用次数: 0
Narabali: A rare case of human sacrifice. 纳拉巴利:罕见的人祭案例。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-04-01 Epub Date: 2023-05-07 DOI: 10.1177/00258024231173347
Harshwardhan Khushalrao Khartade, Shikha Shrivastava, Priyanka Kumarsen Meshram, Vikas Meshram, Ponnambily Ponnappan

With modern civilization and the rise in literacy, cases of human sacrifice are rarely encountered by forensic practitioners. Human sacrifice, also called 'Narabali' in India, involves an act of deliberately killing an individual due to ritualistic beliefs for the appeasement of the Gods, spirits, or ancestors. Human sacrifice and ritual murder are often considered synonymous, but ritual murder further involves offering the body part to the deity after killing. Diverse methods were historically adopted for human sacrifice across the globe, strongly influenced by their superstitious, religious, and cultural beliefs. Cases of human sacrifice mostly involve children. We report the rare case of human sacrifice involving an adult victim assaulted by a sharp weapon over the posterior aspect of the neck. The deceased succumbed due to the transection of the cervical spine and corresponding spinal cord. Corroboration of circumstances of death and profiles of the deceased and the perpetrator with autopsy findings were essential in the investigation. This case report discusses extreme superstitions and beliefs, resulting in homicide.

随着现代文明和识字率的提高,法医很少遇到人祭案件。人祭在印度也被称为 "Narabali",指的是为了安抚神灵或祖先,出于仪式信仰而故意杀害个人的行为。人祭和仪式谋杀通常被认为是同义词,但仪式谋杀还包括在杀人后将身体的一部分献给神灵。受迷信、宗教和文化信仰的影响,历史上全球各地采用了不同的方法进行人祭。人祭案件大多涉及儿童。我们报告了一例罕见的人祭案例,受害者是一名成年人,颈部后侧遭到利器攻击。死者因颈椎和相应脊髓横断而死亡。在调查中,死者的死亡情况以及死者和行凶者的特征与尸检结果的相互印证至关重要。本案例报告讨论了导致凶杀的极端迷信和信仰。
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引用次数: 0
Artificial Intelligence (AI) in the asylum system. 庇护系统中的人工智能(AI)。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-04-01 Epub Date: 2024-01-30 DOI: 10.1177/00258024241227721
Amina Memon, Zoe Given-Wilson, Derya Ozkul, Karen McGregor Richmond, Julia Muraszkiewicz, Ella Weldon, Cornelius Katona
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引用次数: 0
Cable ties in forensic practice. 法医实践中的电缆扎带。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-02-22 DOI: 10.1177/00258024241233464
Roger W Byard

Cable or zip ties are mass produced inexpensive nylon fasteners, which have a locking mechanism to prevent them from being loosened. Their use in medicolegal cases is infrequent, being involved in situations of neck compression or restraint. The Forensic Science SA Pathology Database (in Adelaide, Australia) and search engines PubMed, Google Scholar and Google were examined for cases where cable ties were documented as either causing death or being potentially lethal, being a contributor to death, or having been used for restraint purposes. Neck compression resulting in ligature strangulation was found in cases of homicide and suicide in adults. Accidental neck compression was rarely reported in children. Cases of restraint again occurred in both homicides and suicides, with nonlethal wrist restraint being used by law enforcement officers in lieu of traditional handcuffs. Cable ties may also be used to fasten ligatures to suspension points in case of hanging. Despite their ready availability, cable ties are only relatively rarely involved in medicolegal cases. More traditional forms of manual or ligature neck compression are still favoured possibly because they require less dexterity.

电缆扎带或拉链扎带是大量生产的廉价尼龙紧固件,具有防止松脱的锁定装置。它们在法医案件中的使用并不多,主要用于压迫或束缚颈部。我们通过法医学南澳大利亚病理学数据库(位于澳大利亚阿德莱德)以及 PubMed、Google Scholar 和 Google 等搜索引擎,检查了记录在案的电缆扎带导致死亡或可能致死、导致死亡或用于束缚目的的案例。在成年人的凶杀和自杀案件中发现了导致结扎勒死的颈部压迫。儿童中很少有意外压迫颈部的报告。在凶杀和自杀案件中,执法人员还使用了非致命性的腕部束缚手段来代替传统的手铐。电缆扎带还可用于将结扎固定在悬挂点上,以防上吊。尽管扎线带随处可得,但在法医案件中却很少使用。更传统的手动或结扎颈部加压方式仍然受到青睐,这可能是因为它们对灵巧性的要求较低。
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引用次数: 0
Navigating the legal complexities of telesurgery in China: An assessment of tort liability and the path forward. 驾驭中国远程手术的复杂法律问题:侵权责任评估与未来之路。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-02-07 DOI: 10.1177/00258024241229831
Jiao Xue, Sunzhe Weng

This study investigates the legal challenges posed by telesurgery, an emergent healthcare modality facilitated by advancements in 5G and Artificial Intelligence. It highlights the urgent need for a comprehensive legal framework reconciling the complexities of healthcare delivery and technology integration. The paper examines the Chinese adjudication of negligence and the evidentiary hurdles in telesurgery, interrogating the application of the 'reasonable doctor' standard, the intricate causation-negligence nexus and the distribution of evidentiary burdens. The analysis contends that current statutes require revision to apportion telesurgery-induced damages fairly. Further, it proposes the formation of multidisciplinary committees to oversee medical technology, calls for systemic reforms, more reasonable liability differentiation and fortifying medical insurance frameworks.

本研究调查了远程手术带来的法律挑战,远程手术是在 5G 和人工智能进步推动下出现的一种新兴医疗模式。它强调了迫切需要一个全面的法律框架来协调医疗服务和技术整合的复杂性。本文研究了中国对过失的裁定以及远程手术中的证据障碍,探讨了 "合理的医生 "标准的应用、错综复杂的因果关系与过失之间的联系以及证据责任的分配。分析认为,需要对现行法规进行修订,以公平分摊远程手术造成的损害。此外,它还建议成立多学科委员会来监督医疗技术,呼吁进行系统性改革、更合理地区分责任和加强医疗保险框架。
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引用次数: 0
An examination of service user satisfaction in forensic mental health settings. 法医精神卫生机构服务使用者满意度调查。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-01-31 DOI: 10.1177/00258024241227719
Al Adiya Khan, Victoria Stirrup, Douglas MacInnes

High levels of service user satisfaction are viewed as a reliable indicator of a service providing good care and treatment. There has been limited research looking into levels of satisfaction in forensic mental health settings with most work focused on staff satisfaction in these settings. This study examined service users' levels of satisfaction with a forensic mental health service in the United Kingdom. The service covered two sites; one a purpose-built secure unit and the other based in an old cottage hospital. Thirty-nine in-patients completed a 60-item validated forensic satisfaction scale. The scale measured seven domains of satisfaction as well as reporting an overall satisfaction score. The results indicated the service users were reasonably satisfied with the care and treatment they received. The domains of rehabilitation, safety, staff interaction and overall care showed the highest level of satisfaction. The high rehabilitation satisfaction score demonstrated the importance of meaningful activities for users accessing forensic services and may have been influenced by the security measures on the wards. The high safety domain score indicated respondents felt safe and secure within the wards and were likely to be influenced by positive interpersonal interactions. Good staff interaction was also an important factor in helping service users feel safe on the wards. These interactions are likely to be associated with longer periods of admission in secure services allowing therapeutic relationships to develop. Financial advice/support was the one domain that recorded negative satisfaction levels. Financial literacy training may help develop money management skills.

服务使用者的高满意度被视为服务提供良好护理和治疗的可靠指标。对法医精神卫生机构满意度的研究还很有限,大部分工作都集中在这些机构的员工满意度上。本研究调查了服务使用者对英国一家法医心理健康服务机构的满意度。该服务有两个地点:一个是专门建造的安全单位,另一个则位于一家老旧的平房医院内。39 名住院病人填写了一份包含 60 个项目的法医满意度量表。该量表测量了七个方面的满意度,并报告了总体满意度得分。结果表明,服务使用者对所接受的护理和治疗相当满意。康复、安全、员工互动和整体护理领域的满意度最高。康复满意度得分较高,这表明有意义的活动对使用法医服务的用户非常重要,这可能受到病房安全措施的影响。安全领域得分较高,表明受访者在病房内感到安全和有保障,这可能受到积极的人际互动的影响。工作人员之间的良好互动也是帮助服务使用者在病房中获得安全感的一个重要因素。这些互动很可能与安全服务机构较长的收治时间有关,从而使治疗关系得以发展。财务建议/支持是满意度较低的一个领域。金融知识培训可能有助于发展理财技能。
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引用次数: 0
Medically assisted suicide in Italy: Recent legal developments on a controversial topic. 意大利的医疗协助自杀:一个有争议话题的最新法律进展。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-01-01 Epub Date: 2023-06-12 DOI: 10.1177/00258024231182373
Rossana Cecchi, Matilde Sassani, Francesco Saverio Romolo, Alfredo Rovito, Massimo Montisci, Vittoria Masotti, Alessandra Sannella

On 16th June 2022, the first case of lawful 'medically assisted suicide' took place on Italian soil. This event is a result of decade-long debates on informed consent and end-of-life care stimulated by medical jurisprudence. The authors first retrace the crucial moments that allowed this to happen and underline the problems still to be solved. The cases of DJ Fabo, Davide Trentin, Mario and Fabio Ridolfi are discussed, signalling how they influenced the path implemented by Italian jurisprudence.

2022 年 6 月 16 日,意大利本土发生了第一例合法的 "医学协助自杀"。这一事件是长达十年之久的关于知情同意和临终关怀的辩论在医学判例的推动下产生的结果。作者首先回顾了导致这一事件发生的关键时刻,并强调了仍有待解决的问题。作者讨论了 DJ Fabo、Davide Trentin、Mario 和 Fabio Ridolfi 的案例,指出这些案例如何影响了意大利法理学的发展。
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引用次数: 0
Recidivism risk in male adult sex offenders with psychopathic traits assessed by PCL-R: A systematic review. PCL-R评估具有精神变态特征的男性成年性犯罪者的累犯风险:一项系统综述。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-01-01 Epub Date: 2023-07-24 DOI: 10.1177/00258024231187186
Giulia Moretti, Emma Flutti, Miriana Colanino, Danila Ferlito, Livio Amoresano, Guido Travaini

Psychopathy has been empirically associated with various forms of antisocial behavior including sexual assault. In fact, the lack of empathy characterizing psychopathic offenders may facilitate the perpetration of more extreme violence. This systematic review aims to explore the relationship between psychopathy traits in male adult sex offenders and the increase in recidivism risk for any type of reoffence, with a special focus on sexual recidivism. From an initial sample of 757 articles related to the topic, only 14 were selected from the current literature at the end of the inclusion process. Each of these assessed the relation between psychopathy traits (measured by PCL-R) and recidivism risk in male sex offenders (age > 18), providing an effect size (quantitative findings). The results of their analysis agree with the currently available literature: the presence of psychopathic traits in sex offenders would seem to correlate with an increased risk of recidivism of general but non-sexual. Furthermore, almost half of the included works highlighted a positive relationship between psychopathy and violent reoffences. However, the limited availability of studies and the unevenness in their results indicate the need to expand future research in this direction.

根据经验,精神病与包括性侵犯在内的各种形式的反社会行为有关。事实上,精神病罪犯缺乏同理心可能会助长更极端的暴力行为。本系统综述旨在探讨男性成年性犯罪者的心理变态特征与任何类型再犯的再犯风险增加之间的关系,特别关注性再犯。从757篇与该主题相关的文章的初始样本中,在纳入过程结束时,仅从当前文献中选择了14篇。每一项研究都评估了男性性犯罪者的精神变态特征(通过PCL-R测量)与累犯风险之间的关系(年龄 > 18) ,提供了一个效应大小(定量结果)。他们的分析结果与目前可用的文献一致:性犯罪者的心理变态特征似乎与一般但非性犯罪的再犯风险增加有关。此外,几乎一半的收录作品强调了精神病和暴力再犯之间的积极关系。然而,研究的可用性有限,结果参差不齐,这表明未来有必要扩大这一方向的研究。
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引用次数: 0
Age estimation in the combined long bones and ribs by histomorphometry: Past, present, and future. 用组织形态测量法估计长骨和肋骨的年龄:过去、现在和未来。
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-01-01 Epub Date: 2023-10-25 DOI: 10.1177/00258024231208280
Treerat Gumpangseth, Pasuk Mahakkanukrauh

Numerous age estimation methods in unidentified bone have been a long time developing for application in forensic anthropology. The histomorphometric technique is one of the alternative methods that relied upon the evaluation of the cortical bone microstructure over the lifespan as a result of the remodeling process in bone. Remodeling is a sophisticated event occurring from the coupled function of bone formation and resorption cells for maintaining mineral homeostasis and repairment of microdamage in bone tissue. Products derived from remodeling are primary changes in the osteon or haversian system in various regions in the cortical bone, including periosteum, endosteum, and trabecular bone. Throughout life, bone remodeling rate with osteon alteration can be predictable. In the forensic field, histological methods are getting more attention due to the unavailability of macroscopic methods. Histomorphometry approach can be accomplished in fragmentary or incomplete bone remains indicating the limited use of gross morphological methods. In addition, the microscopic methods can aid to increase the more accuracy of analyses and diminish the biased subjective assessment for determining age. Most histomorphometry method utilizes a cross-section of the midshaft of the long bones including the mandible, rib, and clavicle. This review provides the basic knowledge of bone biology and anatomy, several age-estimating methods of histology, and crucial factors for age methods. Studies regarding overall age determination methods from the past until now contribute to obtaining more benefits for developing methods of histomorphometry using human bone in forensic identification.

许多未鉴定骨骼的年龄估计方法在法医人类学中的应用已经发展了很长时间。组织形态计量技术是一种替代方法,它依赖于评估骨重塑过程中整个寿命期的皮质骨微观结构。重塑是一个复杂的事件,发生在骨形成和吸收细胞的耦合功能中,以维持矿物质稳态和修复骨组织中的微损伤。重塑产生的产物是皮质骨中不同区域骨单位或哈氏系统的主要变化,包括骨膜、骨内膜和骨小梁。在整个生命周期中,骨单位改变的骨重塑率是可以预测的。在法医学领域,由于缺乏宏观方法,组织学方法越来越受到关注。组织形态测量方法可以在零碎或不完整的骨遗骸中完成,这表明大体形态方法的使用有限。此外,微观方法有助于提高分析的准确性,减少确定年龄的主观评估。大多数组织形态计量学方法利用长骨(包括下颌骨、肋骨和锁骨)中段的横截面。这篇综述提供了骨生物学和解剖学的基本知识,几种组织学年龄估计方法,以及年龄方法的关键因素。从过去到现在,对整体年龄测定方法的研究有助于在法医鉴定中开发使用人骨的组织形态测量方法,从而获得更多的益处。
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