Objectives : To assess the prevalence and types of skin diseases among primary school children in Benha City, Kalubia Governorate, Egypt. Background : Skin diseases are common among school-aged children, and many of such diseases are distressing for children in this age group. Patients and methods : An analytical cross-sectional study was performed on 400 primary school children of both sexes in Benha City, Kalubia Governorate, Egypt, in the period from April 2019 to February 2022. A well-designed interviewer-based questionnaire was applied to collect their demographic data and medical history, whereas signs of any skin disease were checked by the researcher through using a checklist. Results : The mean age of the studied participants was 9.65 ± 1.33 years. More than half of them were females (55.0%). Overall prevalence of skin diseases among them was 76.0%. The most common diseases were pediculosis capitis (23.0%), followed by pityriasis alba (10.0%), scabies (6%), and papular urticaria (6%). Residency, mother ' s work, computer use, per capita income, family size, crowding index, and nutritional status were determinants for disease occurrences ( P < 0.05). Conclusion : Skin diseases were common among primary school children in Benha City. The most common diseases were pediculosis capitis followed by pityriasis alba and then papular urticaria and scabies. Focused health education sessions are very crucial for school children, their parents, as well as their teachers to prevent such diseases. School health programs have to be empowered for early detection of any skin diseases through regular investigation of school children.
{"title":"Prevalence of Skin Diseases among Primary School Children in Benha City, Kalubia Governorate, Egypt","authors":"S. Alkalash, Mohammed A. Gaber, Ahmed Anwar Kamal","doi":"10.59204/2314-6788.1020","DOIUrl":"https://doi.org/10.59204/2314-6788.1020","url":null,"abstract":"Objectives : To assess the prevalence and types of skin diseases among primary school children in Benha City, Kalubia Governorate, Egypt. Background : Skin diseases are common among school-aged children, and many of such diseases are distressing for children in this age group. Patients and methods : An analytical cross-sectional study was performed on 400 primary school children of both sexes in Benha City, Kalubia Governorate, Egypt, in the period from April 2019 to February 2022. A well-designed interviewer-based questionnaire was applied to collect their demographic data and medical history, whereas signs of any skin disease were checked by the researcher through using a checklist. Results : The mean age of the studied participants was 9.65 ± 1.33 years. More than half of them were females (55.0%). Overall prevalence of skin diseases among them was 76.0%. The most common diseases were pediculosis capitis (23.0%), followed by pityriasis alba (10.0%), scabies (6%), and papular urticaria (6%). Residency, mother ' s work, computer use, per capita income, family size, crowding index, and nutritional status were determinants for disease occurrences ( P < 0.05). Conclusion : Skin diseases were common among primary school children in Benha City. The most common diseases were pediculosis capitis followed by pityriasis alba and then papular urticaria and scabies. Focused health education sessions are very crucial for school children, their parents, as well as their teachers to prevent such diseases. School health programs have to be empowered for early detection of any skin diseases through regular investigation of school children.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84430860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azza G A Farag, E. Badr, Eman A. Tayel, E. Elshafey
Objectives : To measure the level of YKL-40 in coronavirus disease 2019 (COVID-19) patients with and without skin lesions in El-Bagour Hospital. Background : The outbreak of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 and rapidly spread to more than 196 countries worldwide. Patients and methods : A case e control study was conducted on a total of 180 patients including 60 COVID-19 patients with skin manifestations and 60 COVID-19 patients without skin manifestations besides 60 age-matched and sex-matched healthy individuals as a control group. The patients were those attending El-Bagour Hospital COVID-19 isolation from March 2020 to March 2021. Diagnosis of COVID-19 was done clinically and by laboratory investigations, con fi rmed by PCR. Results : The mean levels of YKL-40 were signi fi cantly higher in COVID-19 patients than in controls (66.47 ± 66.52 vs. 17.25 ± 3.16 ng/ml). The mean levels of YKL-40 were signi fi cantly higher in COVID-19 patients with cutaneous manifestations than those without cutaneous manifestations (94.85 ± 84.50 vs. 38.09 ± 12.12 ng/ml). Conclusion : The mean level of YKL-40 was signi fi cantly higher in COVID-19 patients, especially severe cases than the controls and in COVID-19 patients with cutaneous manifestations than those without cutaneous manifestations.
{"title":"YKL-40 Serum Level in COVID-19 Patients Having Skin Manifestations","authors":"Azza G A Farag, E. Badr, Eman A. Tayel, E. Elshafey","doi":"10.59204/2314-6788.1009","DOIUrl":"https://doi.org/10.59204/2314-6788.1009","url":null,"abstract":"Objectives : To measure the level of YKL-40 in coronavirus disease 2019 (COVID-19) patients with and without skin lesions in El-Bagour Hospital. Background : The outbreak of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 and rapidly spread to more than 196 countries worldwide. Patients and methods : A case e control study was conducted on a total of 180 patients including 60 COVID-19 patients with skin manifestations and 60 COVID-19 patients without skin manifestations besides 60 age-matched and sex-matched healthy individuals as a control group. The patients were those attending El-Bagour Hospital COVID-19 isolation from March 2020 to March 2021. Diagnosis of COVID-19 was done clinically and by laboratory investigations, con fi rmed by PCR. Results : The mean levels of YKL-40 were signi fi cantly higher in COVID-19 patients than in controls (66.47 ± 66.52 vs. 17.25 ± 3.16 ng/ml). The mean levels of YKL-40 were signi fi cantly higher in COVID-19 patients with cutaneous manifestations than those without cutaneous manifestations (94.85 ± 84.50 vs. 38.09 ± 12.12 ng/ml). Conclusion : The mean level of YKL-40 was signi fi cantly higher in COVID-19 patients, especially severe cases than the controls and in COVID-19 patients with cutaneous manifestations than those without cutaneous manifestations.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88764623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives : This study aimed to spotlight on the diagnostic value of MRI in the assessment of anterior cruciate ligament (ACL) reconstruction graft and detection of its complications. Background : ACL is the most frequently reported injured knee ligament that requires surgical reconstruction. MRI is the modality of choice for evaluation of ACL graft reconstruction surgery and assessment of its complication. Patients and methods : This prospective study was conducted on 100 patients with postoperative knee reconstruction of the ACL. All patients were subjected to clinical history followed by MRI examination. MRI examination of the knee was performed in axial, coronal, and sagittal planes. Patients were positioned in the supine position with the knee placed in 10 e 15 (cid:1) of external rotation, and surface coil was applied. Different MRI sequences were obtained. Results : According to our results, of the studied patients, 66 (66%) cases showed an intact ACL graft. The commonest post-ACL reconstruction complication was osteoarthritis, being noticed in 21 (21%) cases of the studied patients. The second most common complication was complete graft tear, where it was observed in 15 (15%) cases. The least common complications were the graft laxity and iliotibial band syndrome; each was seen in one case, representing only 1% for each. Conclusion : We conclude that MRI is the gold standard method for evaluation of postoperative ACL reconstruction, as it plays an important role not only in the assessment of graft integrity but also in detection of the postoperative ACL reconstruction complications.
{"title":"Role Of Magnetic Resonance Imaging In Evaluation Of Post-Operative Anterior Cruciate Ligament Reconstruction","authors":"T. Ella, Abeer Nabil Ali Mostafa","doi":"10.59204/2314-6788.1018","DOIUrl":"https://doi.org/10.59204/2314-6788.1018","url":null,"abstract":"Objectives : This study aimed to spotlight on the diagnostic value of MRI in the assessment of anterior cruciate ligament (ACL) reconstruction graft and detection of its complications. Background : ACL is the most frequently reported injured knee ligament that requires surgical reconstruction. MRI is the modality of choice for evaluation of ACL graft reconstruction surgery and assessment of its complication. Patients and methods : This prospective study was conducted on 100 patients with postoperative knee reconstruction of the ACL. All patients were subjected to clinical history followed by MRI examination. MRI examination of the knee was performed in axial, coronal, and sagittal planes. Patients were positioned in the supine position with the knee placed in 10 e 15 (cid:1) of external rotation, and surface coil was applied. Different MRI sequences were obtained. Results : According to our results, of the studied patients, 66 (66%) cases showed an intact ACL graft. The commonest post-ACL reconstruction complication was osteoarthritis, being noticed in 21 (21%) cases of the studied patients. The second most common complication was complete graft tear, where it was observed in 15 (15%) cases. The least common complications were the graft laxity and iliotibial band syndrome; each was seen in one case, representing only 1% for each. Conclusion : We conclude that MRI is the gold standard method for evaluation of postoperative ACL reconstruction, as it plays an important role not only in the assessment of graft integrity but also in detection of the postoperative ACL reconstruction complications.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85873940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives : We conducted this cross-sectional study to explore the relation between coronavirus disease 2019 (COVID-19) and frequency of musculoskeletal manifestations and the possible cause of rheumatoid arthritis as one of the autoimmune diseases. Background : COVID-19 has the capability to trigger the immune response and induce cytokine release, which is directly linked to musculoskeletal pain initiation, besides fever and cough. Patients and methods : A cross-sectional study was conducted among a number of 120 critically hospitalized Egyptian patients and home-isolated patients proved positive for COVID-19 tested with RT-PCR aged 20 e 70 years. These patients were drawn randomly in the period from March 2020 to July 2020. Clinical assessments were done by sociodemographic data, assessment of musculoskeletal system, and severity of COVID symptoms. Data were analyzed using SPSS. Results : The characteristic features of patients with COVID-19 were fever (48.3%), fatigue (80.8%), myalgia (72%), and arthralgia (60%). Some patients developed peripheral neuritis (54%), neck pain in 40.0% of patients, Guillain e Barr (cid:1) e in 31.7%, back pain in 29%, and rheumatoid arthritis in 24.2%. Conclusion : COVID-19 may be manifested by musculoskeletal manifestation and rheumatoid arthritis as one of the autoimmune diseases.
{"title":"Musculoskeletal Manifestations of COVID-19: A Cross Sectional Study in Egyptian Patients","authors":"Soha Shaaban, A. Elfert","doi":"10.59204/2314-6788.1002","DOIUrl":"https://doi.org/10.59204/2314-6788.1002","url":null,"abstract":"Objectives : We conducted this cross-sectional study to explore the relation between coronavirus disease 2019 (COVID-19) and frequency of musculoskeletal manifestations and the possible cause of rheumatoid arthritis as one of the autoimmune diseases. Background : COVID-19 has the capability to trigger the immune response and induce cytokine release, which is directly linked to musculoskeletal pain initiation, besides fever and cough. Patients and methods : A cross-sectional study was conducted among a number of 120 critically hospitalized Egyptian patients and home-isolated patients proved positive for COVID-19 tested with RT-PCR aged 20 e 70 years. These patients were drawn randomly in the period from March 2020 to July 2020. Clinical assessments were done by sociodemographic data, assessment of musculoskeletal system, and severity of COVID symptoms. Data were analyzed using SPSS. Results : The characteristic features of patients with COVID-19 were fever (48.3%), fatigue (80.8%), myalgia (72%), and arthralgia (60%). Some patients developed peripheral neuritis (54%), neck pain in 40.0% of patients, Guillain e Barr (cid:1) e in 31.7%, back pain in 29%, and rheumatoid arthritis in 24.2%. Conclusion : COVID-19 may be manifested by musculoskeletal manifestation and rheumatoid arthritis as one of the autoimmune diseases.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80285515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. G. Allah, Abdallah Abdel Aziz Bahnacy, T. Salman, Ahlam Rabea Mahmoud Kanner, A. Wahed
Objectives : To assess the prevalence and factors that predict hepatitis C virus (HCV) relapse after direct-acting antiviral drugs. Background : Egypt is known to be one of the countries with a heavy burden of HCV infections. The introduction of direct-acting antivirals has represented a paradigm shift in HCV management. Patients and methods : The current study was a retrospective study done on 422 consecutive patients with HCV, who were selected from those attending the viral hepatitis C unit at Shebin El-Kom Teaching Hospital, Egypt from March 2019 to March 2020. All cases were subjected to thorough history taking, full clinical examination, and laboratory tests such as liver function pro fi les, renal function tests, complete blood count, serum alpha-fetoprotein, viral markers, and imaging data (abdominal ultrasonography and triphasic computed tomography). Results : Alanine aminotransferase, aspartate transferase, creatinine, fi brosis 4 (FIB-4), direct bilirubin, albumin, PCR, and international normalized ratio showed signi fi cant increases in nonresponders when compared with responders. Platelets showed signi fi cant increase in responders when compared with nonresponders. Treatment experience, high viral load, and appearance of liver cirrhosis (ultrasound) and FIB-4 were independent RF for relapse between the studied cases with odds ratio of 26.36 (6.4 e 108.6), 2.42 (1.16 e 9.03), 12.14 (3.0 e 49.16), and 2.01 (1.3 e 9.91), respectively. FIB-4 showed area under curve of 0.744 and at a cutoff point of 0.996had a sensitivity of 75%, speci fi city of 61%, positive predictive value of 10.2%, and negative predictive value of 98.2%. Regarding viral load, area under curve was 0.729, and at a cutoff point of 860 063.0, sensitivity was 70%, speci fi city 65.5%, positive predictive value 9.0%, and negative predictive value 97.7%. Conclusion : Simple basic investigations (complete blood count, liver function tests, renal function tests, and ultrasound) and case characteristics (age, sex, diabetes mellitus, hypertension, and smoking) are predictors of unrespon-siveness and selection of more potent regimens aiming at possible eradication.
{"title":"Prevalence and PredictorsofHCV Relapse inEgyptian Patients After Direct Acting Antiviral Drugs","authors":"A. G. Allah, Abdallah Abdel Aziz Bahnacy, T. Salman, Ahlam Rabea Mahmoud Kanner, A. Wahed","doi":"10.59204/2314-6788.1004","DOIUrl":"https://doi.org/10.59204/2314-6788.1004","url":null,"abstract":"Objectives : To assess the prevalence and factors that predict hepatitis C virus (HCV) relapse after direct-acting antiviral drugs. Background : Egypt is known to be one of the countries with a heavy burden of HCV infections. The introduction of direct-acting antivirals has represented a paradigm shift in HCV management. Patients and methods : The current study was a retrospective study done on 422 consecutive patients with HCV, who were selected from those attending the viral hepatitis C unit at Shebin El-Kom Teaching Hospital, Egypt from March 2019 to March 2020. All cases were subjected to thorough history taking, full clinical examination, and laboratory tests such as liver function pro fi les, renal function tests, complete blood count, serum alpha-fetoprotein, viral markers, and imaging data (abdominal ultrasonography and triphasic computed tomography). Results : Alanine aminotransferase, aspartate transferase, creatinine, fi brosis 4 (FIB-4), direct bilirubin, albumin, PCR, and international normalized ratio showed signi fi cant increases in nonresponders when compared with responders. Platelets showed signi fi cant increase in responders when compared with nonresponders. Treatment experience, high viral load, and appearance of liver cirrhosis (ultrasound) and FIB-4 were independent RF for relapse between the studied cases with odds ratio of 26.36 (6.4 e 108.6), 2.42 (1.16 e 9.03), 12.14 (3.0 e 49.16), and 2.01 (1.3 e 9.91), respectively. FIB-4 showed area under curve of 0.744 and at a cutoff point of 0.996had a sensitivity of 75%, speci fi city of 61%, positive predictive value of 10.2%, and negative predictive value of 98.2%. Regarding viral load, area under curve was 0.729, and at a cutoff point of 860 063.0, sensitivity was 70%, speci fi city 65.5%, positive predictive value 9.0%, and negative predictive value 97.7%. Conclusion : Simple basic investigations (complete blood count, liver function tests, renal function tests, and ultrasound) and case characteristics (age, sex, diabetes mellitus, hypertension, and smoking) are predictors of unrespon-siveness and selection of more potent regimens aiming at possible eradication.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80996163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Essam A. Amin, T. Sayyed, Mohamed Shawk Abdullah, Aya Ali Mousa Elshaer, Hamed El Sayed El Lakwa
Objective : To evaluate the predictive role of fi rst-trimester fetal heart rate (FHR) in early prediction of gestational diabetes mellitus (GDM). Background : Diabetes represents a clinical challenge, especially in pregnant women, where it is critical to monitor and assess both the maternal and the fetal well-being. Apart from women with pregestational diabetes (type-1 or type-2 diabetes mellitus), there is a growing rate of women who develop GDM. Patients and methods : This cohort study was conducted at Menou fi a University Hospitals and Menou fi a General Hospital from March 2020 to January 2022. The study participants were pregnant women at fi rst trimester who had attended the outpatient clinic (prenatal care). Each patient had undergone through history taking and physical examination and then had fi rst-trimester ultrasound scan where nuchal translucency, FHR, and crown rump length were recorded. Results : The best cutoff value of fi rst-trimester FHR in predicting GDM was more than or equal to 162 bpm, area under the curve ¼ 0.853, with sensitivity of 76% and speci fi city of 78.9%, positive predictive value 23.43, negative predictive value 76.57, and accuracy of 78%, while the results of multiple logistic regression analysis indicate that fi rst-trimester FHR was highly signi fi cant as a predictor for GDM ( P < 0.001) Conclusion : First-trimester FHR at cutoff value of more than or equal to 162 had moderate screening parameters for GDM.
{"title":"First trimester fetal heart rate tracing, a novel tool for prediction of gestational diabetes mellitus","authors":"Essam A. Amin, T. Sayyed, Mohamed Shawk Abdullah, Aya Ali Mousa Elshaer, Hamed El Sayed El Lakwa","doi":"10.59204/2314-6788.1003","DOIUrl":"https://doi.org/10.59204/2314-6788.1003","url":null,"abstract":"Objective : To evaluate the predictive role of fi rst-trimester fetal heart rate (FHR) in early prediction of gestational diabetes mellitus (GDM). Background : Diabetes represents a clinical challenge, especially in pregnant women, where it is critical to monitor and assess both the maternal and the fetal well-being. Apart from women with pregestational diabetes (type-1 or type-2 diabetes mellitus), there is a growing rate of women who develop GDM. Patients and methods : This cohort study was conducted at Menou fi a University Hospitals and Menou fi a General Hospital from March 2020 to January 2022. The study participants were pregnant women at fi rst trimester who had attended the outpatient clinic (prenatal care). Each patient had undergone through history taking and physical examination and then had fi rst-trimester ultrasound scan where nuchal translucency, FHR, and crown rump length were recorded. Results : The best cutoff value of fi rst-trimester FHR in predicting GDM was more than or equal to 162 bpm, area under the curve ¼ 0.853, with sensitivity of 76% and speci fi city of 78.9%, positive predictive value 23.43, negative predictive value 76.57, and accuracy of 78%, while the results of multiple logistic regression analysis indicate that fi rst-trimester FHR was highly signi fi cant as a predictor for GDM ( P < 0.001) Conclusion : First-trimester FHR at cutoff value of more than or equal to 162 had moderate screening parameters for GDM.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77162750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samar Mohamed El-Maadaw, Sherihan W. Y. Gareer, H. Mikhael, Hebatalla Elkassas
Objectives : To correlate between the breast ultrasound imaging features and molecular subtypes of breast cancer and to assess the predictive value of their correlation. Background : Molecular subtyping of breast cancer has become the standard of care in breast cancer management. Survival, pattern of recurrence, and treatment response vary between different molecular subtypes. Patients and methods : This prospective cross-sectional study included all consecutive female patients referred to the Radiology Department from January 2020 to April 2022 who underwent breast ultrasound and surgical excision followed by histopathology and immunohistochemistry of the surgical specimen. Results : A total of 105 patients with pathologically proven breast cancer were included. Multifocal tumors with cal-ci fi cations were strongly associated with human epidermal growth receptor 2-positive tumors, with a P value of less than 0.001. Lesions with noncircumscribed margins and posterior acoustic shadowing were more likely to be luminal A (LA) or luminal B (LB) subtype, with a P value of less than 0.001, and a tendency of luminal B tumors to elicit high-grade vascularity on color and power Doppler. Lesions with circumscribed margins and posterior acoustic enhancement were signi fi cantly more likely to be triple-negative breast cancer, with a P value of less than 0.001, and a higher tendency for older age and larger mean tumor diameter compared with non-triple-negative breast cancer groups. Conclusion : Certain ultrasound imaging characteristics like tumor margins, posterior acoustic features, vascularity on color Doppler, and calci fi cations are highly predictive of certain molecular subtypes of breast cancer, further expanding the role of ultrasound and potentially enhancing patient outcome by accelerating diagnosis and treatment.
{"title":"Value of Breast Ultrasound in the Prediction of Molecular Subtypes in Patients with Breast Cancer","authors":"Samar Mohamed El-Maadaw, Sherihan W. Y. Gareer, H. Mikhael, Hebatalla Elkassas","doi":"10.59204/2314-6788.1010","DOIUrl":"https://doi.org/10.59204/2314-6788.1010","url":null,"abstract":"Objectives : To correlate between the breast ultrasound imaging features and molecular subtypes of breast cancer and to assess the predictive value of their correlation. Background : Molecular subtyping of breast cancer has become the standard of care in breast cancer management. Survival, pattern of recurrence, and treatment response vary between different molecular subtypes. Patients and methods : This prospective cross-sectional study included all consecutive female patients referred to the Radiology Department from January 2020 to April 2022 who underwent breast ultrasound and surgical excision followed by histopathology and immunohistochemistry of the surgical specimen. Results : A total of 105 patients with pathologically proven breast cancer were included. Multifocal tumors with cal-ci fi cations were strongly associated with human epidermal growth receptor 2-positive tumors, with a P value of less than 0.001. Lesions with noncircumscribed margins and posterior acoustic shadowing were more likely to be luminal A (LA) or luminal B (LB) subtype, with a P value of less than 0.001, and a tendency of luminal B tumors to elicit high-grade vascularity on color and power Doppler. Lesions with circumscribed margins and posterior acoustic enhancement were signi fi cantly more likely to be triple-negative breast cancer, with a P value of less than 0.001, and a higher tendency for older age and larger mean tumor diameter compared with non-triple-negative breast cancer groups. Conclusion : Certain ultrasound imaging characteristics like tumor margins, posterior acoustic features, vascularity on color Doppler, and calci fi cations are highly predictive of certain molecular subtypes of breast cancer, further expanding the role of ultrasound and potentially enhancing patient outcome by accelerating diagnosis and treatment.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76810861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives : To investigate the contribution of vascular endothelial growth factor (VEGF) variants 2578 C/A (rs699947) to vaso-occlusive crisis (VOC) pathogenesis in sickle cell disease (SCD) patients. Background : Vascular in fl ammation has been proven to play a signi fi cant role in the pathogenesis of vaso-occlusive events in SCD. VEGF has been shown to contribute to the increased expression of cell adhesion molecules on the endothelium during in fl ammation. Patients and methods : In this case e control study, human VEGF 2578 C/A (rs699947) genotypes were detected using real-time PCR to study the genotypic distribution among 101 SCD patients (subdivided into 61 with VOC and 40 with the steady state) and 40 healthy controls. Results : The frequency of the AA genotype was signi fi cantly higher in SCD patients with VOC (62.3%) than in those with a steady state (37.5%). However, the CA genotype was signi fi cantly higher in SCD with a steady state than in those with VOC. No signi fi cant difference between both groups as regards the CC genotype ( P ˃ 0.05). For the minor allele effect, the frequency of the A allele was signi fi cantly higher in SCD patients with VOC (72.1%) than in SCD with a steady state (57.5%). Conclusion : Our fi ndings suggest that the VEGF 2578 AA genotype could be a potential risk factor for the development of VOC in SCD.
{"title":"Association of Vascular Endothelial Growth Factor gene Polymorphism 2578C/A with Vaso-occlusive Crisis in sickle disease","authors":"M. S. Farhan, M. ElSheemy, H. Attalla, W. Radwan","doi":"10.59204/2314-6788.1015","DOIUrl":"https://doi.org/10.59204/2314-6788.1015","url":null,"abstract":"Objectives : To investigate the contribution of vascular endothelial growth factor (VEGF) variants 2578 C/A (rs699947) to vaso-occlusive crisis (VOC) pathogenesis in sickle cell disease (SCD) patients. Background : Vascular in fl ammation has been proven to play a signi fi cant role in the pathogenesis of vaso-occlusive events in SCD. VEGF has been shown to contribute to the increased expression of cell adhesion molecules on the endothelium during in fl ammation. Patients and methods : In this case e control study, human VEGF 2578 C/A (rs699947) genotypes were detected using real-time PCR to study the genotypic distribution among 101 SCD patients (subdivided into 61 with VOC and 40 with the steady state) and 40 healthy controls. Results : The frequency of the AA genotype was signi fi cantly higher in SCD patients with VOC (62.3%) than in those with a steady state (37.5%). However, the CA genotype was signi fi cantly higher in SCD with a steady state than in those with VOC. No signi fi cant difference between both groups as regards the CC genotype ( P ˃ 0.05). For the minor allele effect, the frequency of the A allele was signi fi cantly higher in SCD patients with VOC (72.1%) than in SCD with a steady state (57.5%). Conclusion : Our fi ndings suggest that the VEGF 2578 AA genotype could be a potential risk factor for the development of VOC in SCD.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90982140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
El-Sayed El Shayeb, E. E. El Gayed, Janet George Hanna Sedhom, Abdel-Naser Abdel-Atty Gadallah
Objective : To assess the role of plasma pentraxin 3 (PTX-3) in nonalcoholic fatty liver disease (NAFLD) among Egyptian patients. Background : NAFLD is a serious health concern and amounts to signi fi cant burden on health care systems. Patients and methods : A randomized controlled trial was conducted on 90 participants at the outpatient clinic and inpatient Internal Medicine Departments, Menou fi a University Hospitals. All included participants were divided into 70 patients with NAFLD and 20 control healthy persons. Blood pressure, weight, height, BMI, waist circumference, fasting blood glucose, prothrombin time, activated partial prothrombin time, international normalized ratio, liver enzymes, lipid pro fi le, and PTX-3 level were investigated. Results : There were signi fi cantly higher PTX-3 levels in both steatohepatitis and steatosis groups than the control group ( P < 0.001). Moreover, patients with steatosis had signi fi cantly higher PTX-3 levels than the control group ( P < 0.001). Receiver operating characteristic curve analysis showed that PTX-3 is an excellent diagnostic marker in predicting steatosis cases from a healthy free cohort at a cut-off point more than 2.7745, with sensitivity 97%, speci fi city 75%, and area under the curve of 98%. Conclusion : Patients with steatohepatitis and steatosis showed signi fi cant increased PTX-3 levels with a signi fi cant positive correlation with respect to PTX-3 levels, BMI, and cholesterol levels when compared with the control group.
{"title":"Plasma pentraxin 3 as novel diagnostic marker in nonalcoholic fatty liver disease","authors":"El-Sayed El Shayeb, E. E. El Gayed, Janet George Hanna Sedhom, Abdel-Naser Abdel-Atty Gadallah","doi":"10.59204/2314-6788.1012","DOIUrl":"https://doi.org/10.59204/2314-6788.1012","url":null,"abstract":"Objective : To assess the role of plasma pentraxin 3 (PTX-3) in nonalcoholic fatty liver disease (NAFLD) among Egyptian patients. Background : NAFLD is a serious health concern and amounts to signi fi cant burden on health care systems. Patients and methods : A randomized controlled trial was conducted on 90 participants at the outpatient clinic and inpatient Internal Medicine Departments, Menou fi a University Hospitals. All included participants were divided into 70 patients with NAFLD and 20 control healthy persons. Blood pressure, weight, height, BMI, waist circumference, fasting blood glucose, prothrombin time, activated partial prothrombin time, international normalized ratio, liver enzymes, lipid pro fi le, and PTX-3 level were investigated. Results : There were signi fi cantly higher PTX-3 levels in both steatohepatitis and steatosis groups than the control group ( P < 0.001). Moreover, patients with steatosis had signi fi cantly higher PTX-3 levels than the control group ( P < 0.001). Receiver operating characteristic curve analysis showed that PTX-3 is an excellent diagnostic marker in predicting steatosis cases from a healthy free cohort at a cut-off point more than 2.7745, with sensitivity 97%, speci fi city 75%, and area under the curve of 98%. Conclusion : Patients with steatohepatitis and steatosis showed signi fi cant increased PTX-3 levels with a signi fi cant positive correlation with respect to PTX-3 levels, BMI, and cholesterol levels when compared with the control group.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89858097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rasha A. Elkapany, M. Melake, Fatma A. A. Elsayed, E. Arafat
Objective : To assess, for the fi rst time, the role of Factor V Leiden (FVL) and prothrombin gene/G20210A mutations as risk factors (RF) for cerebral venous thrombosis (CVT) in Egypt and secondarily to study the effect of simultaneous presence of acquired RF for thrombosis together with these mutations on the risk of developing CVT. Background : Inherited thrombophilias are responsible for 22.4% of CVT cases. Data from Arab countries are emerging. Patients and methods : A case e control study (50 patients with CVT and 150 controls) was performed in our university hospital. Genetic screening included single nucleotide polymorphisms detection for FVL/G1691A mutation and pro-thrombin gene/G20210A mutation. Acquired RF for thrombosis were also investigated. Results : Prothrombin gene mutation was found to be more prevalent and had more risk for CVT occurrence (20%, P ¼ 0.00019505, OR: 9.125, CI: 2.718 e 30.635) more than FVL mutation (12%, P ¼ 0.0489, OR: 3.273, CI: 1.005 e 10.660). This risk was increased if either mutation was simultaneously associated with acquired RF for thrombosis (OR ¼ 28.778, CI: 6.258 e 132.332). Conclusions : Prothrombin gene mutation and FVL mutation are important RF for CVT in Egypt. This risk is increased up to fourfold if either mutation was simultaneously associated with acquired RF for thrombosis.
{"title":"Factor V Leiden Mutation And Prothrombin G20210A Mutation As Genetic Risk Factors For Cerebral Venous Thrombosis In An Egyptian Sample: Consecutive Controlled Case Series","authors":"Rasha A. Elkapany, M. Melake, Fatma A. A. Elsayed, E. Arafat","doi":"10.59204/2314-6788.1008","DOIUrl":"https://doi.org/10.59204/2314-6788.1008","url":null,"abstract":"Objective : To assess, for the fi rst time, the role of Factor V Leiden (FVL) and prothrombin gene/G20210A mutations as risk factors (RF) for cerebral venous thrombosis (CVT) in Egypt and secondarily to study the effect of simultaneous presence of acquired RF for thrombosis together with these mutations on the risk of developing CVT. Background : Inherited thrombophilias are responsible for 22.4% of CVT cases. Data from Arab countries are emerging. Patients and methods : A case e control study (50 patients with CVT and 150 controls) was performed in our university hospital. Genetic screening included single nucleotide polymorphisms detection for FVL/G1691A mutation and pro-thrombin gene/G20210A mutation. Acquired RF for thrombosis were also investigated. Results : Prothrombin gene mutation was found to be more prevalent and had more risk for CVT occurrence (20%, P ¼ 0.00019505, OR: 9.125, CI: 2.718 e 30.635) more than FVL mutation (12%, P ¼ 0.0489, OR: 3.273, CI: 1.005 e 10.660). This risk was increased if either mutation was simultaneously associated with acquired RF for thrombosis (OR ¼ 28.778, CI: 6.258 e 132.332). Conclusions : Prothrombin gene mutation and FVL mutation are important RF for CVT in Egypt. This risk is increased up to fourfold if either mutation was simultaneously associated with acquired RF for thrombosis.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80607618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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