Nabih Ebrahim ElKhouly, Hitham Abo ali Hamz, Hanaa Fayz Abdo Serety, M. Anter
Objective : To study the evaluation of the value of the posterior cervical angle (PCA) and cervical length, measured by transvaginal ultrasonography, compared with the Bishop score in the prediction of successful labor induction. Background : Induction of labor represents a common procedure in everyday obstetric practice. It is used in 30 e 40% of women in labor. Induction of labor refers to the initiation of uterine contractions before the spontaneous onset of labor, which may be either elective or indicated. Patients and methods : A prospective observational study was conducted in the Department of Obstetrics and Gyne-cology, Shebin El-Kom University Hospitals, from March to December 2020. Results : Our study included 90 candidates for labor induction, after assessment of PCA and cervical length (by transvaginal ultrasonography) and Bishop score. Conclusion : In this study, we found that success of labor induction can be highly predicted by transvaginal sonography of cervical length and PCA, as it is more objective and accurate than the Bishop score, This is owing to the signi fi cant correlation between successful labor induction and PCA.
{"title":"Diagnostic accuracy of posterior cervical angle, and cervical length in Prediction of Successful labor induction","authors":"Nabih Ebrahim ElKhouly, Hitham Abo ali Hamz, Hanaa Fayz Abdo Serety, M. Anter","doi":"10.59204/2314-6788.1001","DOIUrl":"https://doi.org/10.59204/2314-6788.1001","url":null,"abstract":"Objective : To study the evaluation of the value of the posterior cervical angle (PCA) and cervical length, measured by transvaginal ultrasonography, compared with the Bishop score in the prediction of successful labor induction. Background : Induction of labor represents a common procedure in everyday obstetric practice. It is used in 30 e 40% of women in labor. Induction of labor refers to the initiation of uterine contractions before the spontaneous onset of labor, which may be either elective or indicated. Patients and methods : A prospective observational study was conducted in the Department of Obstetrics and Gyne-cology, Shebin El-Kom University Hospitals, from March to December 2020. Results : Our study included 90 candidates for labor induction, after assessment of PCA and cervical length (by transvaginal ultrasonography) and Bishop score. Conclusion : In this study, we found that success of labor induction can be highly predicted by transvaginal sonography of cervical length and PCA, as it is more objective and accurate than the Bishop score, This is owing to the signi fi cant correlation between successful labor induction and PCA.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85216219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective : This study aimed to determine the incidence of neonatal mortality percentage in Neonatal ICUs in Giza Governorate hospitals for early prediction of the disease. Background : Neonatal mortality rates, de fi ned as death of a live born newborn within the fi rst 28 days, vary greatly between countries, even within high-income countries. Patients and methods : A retrospective study was conducted on 155 Egyptian neonates aged from 1 day up to 4 weeks to evaluate the risk factors of the mortality rates in the Neonatal ICU of Giza Governorate hospitals during the period from August 2021 to December 2021. Results : Approximately 6.5% of the studied neonates experienced complications such as sepsis, chronic heart disease or hypoxic ischemic encephalopathy, and another 20.6% of the studied neonates were on mechanical ventilation. Survival rates were reported to be 84.5% of the studied neonates; moreover, the incidence of neonatal mortality among the studied sample was 15.5%. The most common cause of death was sepsis followed by chronic heart disease and sepsis with prematurity (50, 20.8, and 8.3%, respectively). Conclusion : Prematurity, sepsis, respiratory distress syndrome, low birth weight, mechanical ventilation, and positive history of maternal illness and infection are considered as signi fi cant predictors of neonatal mortality.
{"title":"Mortality Rate Risk Factors in Neonatal Intensive Care Units in El Giza Governorate","authors":"Ghada Elmashad, S. A. Ibrahim, H. Elsayed","doi":"10.59204/2314-6788.1013","DOIUrl":"https://doi.org/10.59204/2314-6788.1013","url":null,"abstract":"Objective : This study aimed to determine the incidence of neonatal mortality percentage in Neonatal ICUs in Giza Governorate hospitals for early prediction of the disease. Background : Neonatal mortality rates, de fi ned as death of a live born newborn within the fi rst 28 days, vary greatly between countries, even within high-income countries. Patients and methods : A retrospective study was conducted on 155 Egyptian neonates aged from 1 day up to 4 weeks to evaluate the risk factors of the mortality rates in the Neonatal ICU of Giza Governorate hospitals during the period from August 2021 to December 2021. Results : Approximately 6.5% of the studied neonates experienced complications such as sepsis, chronic heart disease or hypoxic ischemic encephalopathy, and another 20.6% of the studied neonates were on mechanical ventilation. Survival rates were reported to be 84.5% of the studied neonates; moreover, the incidence of neonatal mortality among the studied sample was 15.5%. The most common cause of death was sepsis followed by chronic heart disease and sepsis with prematurity (50, 20.8, and 8.3%, respectively). Conclusion : Prematurity, sepsis, respiratory distress syndrome, low birth weight, mechanical ventilation, and positive history of maternal illness and infection are considered as signi fi cant predictors of neonatal mortality.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88974225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Shaaban, N. Aboelkhair, O. Darwish, Moustafa B. Hamed
Objectives : To investigate the level of cystatin C in patients with type 2 diabetes mellitus (T2DM) with obesity. Background : The risk of T2DM increases many folds in association with obesity. Cystatin C is an early marker for nephropathy, and it can predict neuropathy, retinopathy, and arterial sclerosis apart from renal function. Patients and methods : This was a cross-sectional and observational study. A total of 561 participants were divided into group A, which included 130 obese patients with no T2DM; group B, which included 155 T2DM with obesity; group C, which included 146 patients with T2DM with no obesity who attended Internal Medicine Department in Menou fi a University Hospital, and group D, which included 130 healthy persons as a control group during the period from November 2020 to December 2021. All participants were subjected to full history taking, clinical examination, and estimation of serum cystatin C using enzyme-linked immunosorbent assay. Nonalcoholic fatty liver disease fi brosis score and BMI were assessed for the patients. Results : Serum cystatin C level, nonalcoholic fatty liver disease fi brosis score, and BMI were signi fi cantly increased among the diabetic obese group than other groups (P < 0.001). Moreover, the sensitivity of serum cystatin C to detect obesity among obese diabetics versus nonobese diabetics was 95.6% and speci fi city was 72% at a cutoff value of 760.7 ng/ ml and area under the curve 0.956 (P < 0.001). There was a signi fi cant positive correlation between serum cystatin C and BMI in addition to waist e hip circumference. Conclusion : Serum cystatin C was positively correlated with obesity. Therefore, it can be regarded as an early predictor of metabolic syndrome.
{"title":"Study of the Level of Cystatin C in Type 2 Diabetes Mellitus with Obesity","authors":"M. Shaaban, N. Aboelkhair, O. Darwish, Moustafa B. Hamed","doi":"10.59204/2314-6788.1014","DOIUrl":"https://doi.org/10.59204/2314-6788.1014","url":null,"abstract":"Objectives : To investigate the level of cystatin C in patients with type 2 diabetes mellitus (T2DM) with obesity. Background : The risk of T2DM increases many folds in association with obesity. Cystatin C is an early marker for nephropathy, and it can predict neuropathy, retinopathy, and arterial sclerosis apart from renal function. Patients and methods : This was a cross-sectional and observational study. A total of 561 participants were divided into group A, which included 130 obese patients with no T2DM; group B, which included 155 T2DM with obesity; group C, which included 146 patients with T2DM with no obesity who attended Internal Medicine Department in Menou fi a University Hospital, and group D, which included 130 healthy persons as a control group during the period from November 2020 to December 2021. All participants were subjected to full history taking, clinical examination, and estimation of serum cystatin C using enzyme-linked immunosorbent assay. Nonalcoholic fatty liver disease fi brosis score and BMI were assessed for the patients. Results : Serum cystatin C level, nonalcoholic fatty liver disease fi brosis score, and BMI were signi fi cantly increased among the diabetic obese group than other groups (P < 0.001). Moreover, the sensitivity of serum cystatin C to detect obesity among obese diabetics versus nonobese diabetics was 95.6% and speci fi city was 72% at a cutoff value of 760.7 ng/ ml and area under the curve 0.956 (P < 0.001). There was a signi fi cant positive correlation between serum cystatin C and BMI in addition to waist e hip circumference. Conclusion : Serum cystatin C was positively correlated with obesity. Therefore, it can be regarded as an early predictor of metabolic syndrome.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83362933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives : To evaluate the effect of milk temperature either at warm temperatures closer to freshly expressed breast milk versus at room temperature on feeding tolerance in premature infants. Background : Feeding intolerance is frequent among preterm infants in neonatal intensive care units. It has several symptoms and is attributed to many factors including milk temperature. Patients and methods : This prospective cohort study included 70 preterm neonates who were divided into two groups: group I included 35 preterm neonates fed with milk at 22 e 24 (cid:1) C, closer to room temperature and group II included 35 preterm neonates fed with milk at 32 e 34 (cid:1) C, closer to freshly expressed breast milk. All the included neonates underwent full history taking, examination, and laboratory investigations. Results : Apnea and antire fl ux treatment were statistically decreased in group II who were fed milk at body temperature ( P ¼ 0.01). However, the difference regarding feeding tolerance between the two groups was statistically insigni fi cant ( P > 0.05). Subgroup analysis revealed that the difference between the subgroups was also statistically insigni fi cant ( P > 0.05). Conclusion : Feeding preterm infants milk at body temperature versus room temperature milk had signi fi cantly reduced episodes of apnea and antire fl ux treatment.
{"title":"Relation Between Milk Temperature and Feeding Tolerance in Premature Infants","authors":"El'chaninov Gm, El Bastawesy N T M, E. H M","doi":"10.59204/2314-6788.1006","DOIUrl":"https://doi.org/10.59204/2314-6788.1006","url":null,"abstract":"Objectives : To evaluate the effect of milk temperature either at warm temperatures closer to freshly expressed breast milk versus at room temperature on feeding tolerance in premature infants. Background : Feeding intolerance is frequent among preterm infants in neonatal intensive care units. It has several symptoms and is attributed to many factors including milk temperature. Patients and methods : This prospective cohort study included 70 preterm neonates who were divided into two groups: group I included 35 preterm neonates fed with milk at 22 e 24 (cid:1) C, closer to room temperature and group II included 35 preterm neonates fed with milk at 32 e 34 (cid:1) C, closer to freshly expressed breast milk. All the included neonates underwent full history taking, examination, and laboratory investigations. Results : Apnea and antire fl ux treatment were statistically decreased in group II who were fed milk at body temperature ( P ¼ 0.01). However, the difference regarding feeding tolerance between the two groups was statistically insigni fi cant ( P > 0.05). Subgroup analysis revealed that the difference between the subgroups was also statistically insigni fi cant ( P > 0.05). Conclusion : Feeding preterm infants milk at body temperature versus room temperature milk had signi fi cantly reduced episodes of apnea and antire fl ux treatment.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89280513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Seleem, Ayman El Lehleh, M. Elkhayat, Osama El Abd, E. Badr, Enas F. ElMezein, A. Teima
Objective : To study the levels of serum adiponectin and chemerin in patients with nonalcoholic fatty liver disease (NAFLD) and their diagnostic role. Background : NAFLD is the most common cause of chronic liver disease, which is a major cause of morbidity and mortality. Liver biopsy remains the gold standard for its diagnosis, but it is an invasive procedure. Chemerin and adiponectin can be possible noninvasive diagnostic markers. Patients and method : sThis prospective study was conducted from March 2020 to October 2021 on 90 participants including 60 patients with NAFLD and 30 age-matched and sex-matched healthy individuals as a control group. All were subjected to history taking, complete medical examination, thorough laboratory, and radiological investigations. Serum chemerin and adiponectin were measured by enzyme-linked immunosorbent assay technique, and liver stiffness was measured by point shear wave elastography (pSWE). Results : There was a highly statistically signi fi cant elevation of serum chemerin levels and pSWE measurements in patients with NAFLD than the control group. There was a highly statistically signi fi cant decrease of serum adiponectin levels in patients with NAFLD than the control group. Serum chemerin levels can predict patients with simple steatosis (at a cutoff point of > 280 ng/ml), nonalcoholic steatohepatitis (NASH) (at a cutoff point of > 698 ng/ml), and cirrhosis (at a cutoff point of > 997.5 ng/ml), with area under the curve (AUC) of 0.988, 0.951, and 1, respectively, whereas adiponectin levels can predict simple steatosis (at a cutoff point of < 9 m g/ml), NASH (at a cutoff point of < 6.95 m g/ml), and cirrhosis (at a cutoff point of < 5.40 m g/ml), with AUC of 0.996, 0.999, and 0.984, respectively. Liver stiffness measurements by pSWE can predict patients with simple steatosis (at a cutoff point of > 6.10 kPa), NASH (at a cutoff point of > 6.85 kPa), and cirrhosis (at a cutoff point of > 9.85 kPa), with AUC of 0.928, 0.984, and 1.00, respectively. Conclusion : Serum chemerin, adiponectin, and pSWE can be used as noninvasive parameters for diagnosis of NAFLD.
{"title":"Study of Serum Adiponectin and Chemerin in Patients with Non-Alcoholic Fatty Liver Disease","authors":"H. Seleem, Ayman El Lehleh, M. Elkhayat, Osama El Abd, E. Badr, Enas F. ElMezein, A. Teima","doi":"10.59204/2314-6788.1005","DOIUrl":"https://doi.org/10.59204/2314-6788.1005","url":null,"abstract":"Objective : To study the levels of serum adiponectin and chemerin in patients with nonalcoholic fatty liver disease (NAFLD) and their diagnostic role. Background : NAFLD is the most common cause of chronic liver disease, which is a major cause of morbidity and mortality. Liver biopsy remains the gold standard for its diagnosis, but it is an invasive procedure. Chemerin and adiponectin can be possible noninvasive diagnostic markers. Patients and method : sThis prospective study was conducted from March 2020 to October 2021 on 90 participants including 60 patients with NAFLD and 30 age-matched and sex-matched healthy individuals as a control group. All were subjected to history taking, complete medical examination, thorough laboratory, and radiological investigations. Serum chemerin and adiponectin were measured by enzyme-linked immunosorbent assay technique, and liver stiffness was measured by point shear wave elastography (pSWE). Results : There was a highly statistically signi fi cant elevation of serum chemerin levels and pSWE measurements in patients with NAFLD than the control group. There was a highly statistically signi fi cant decrease of serum adiponectin levels in patients with NAFLD than the control group. Serum chemerin levels can predict patients with simple steatosis (at a cutoff point of > 280 ng/ml), nonalcoholic steatohepatitis (NASH) (at a cutoff point of > 698 ng/ml), and cirrhosis (at a cutoff point of > 997.5 ng/ml), with area under the curve (AUC) of 0.988, 0.951, and 1, respectively, whereas adiponectin levels can predict simple steatosis (at a cutoff point of < 9 m g/ml), NASH (at a cutoff point of < 6.95 m g/ml), and cirrhosis (at a cutoff point of < 5.40 m g/ml), with AUC of 0.996, 0.999, and 0.984, respectively. Liver stiffness measurements by pSWE can predict patients with simple steatosis (at a cutoff point of > 6.10 kPa), NASH (at a cutoff point of > 6.85 kPa), and cirrhosis (at a cutoff point of > 9.85 kPa), with AUC of 0.928, 0.984, and 1.00, respectively. Conclusion : Serum chemerin, adiponectin, and pSWE can be used as noninvasive parameters for diagnosis of NAFLD.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78803810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Elshaarawy, Eman Gawish, N. Bayoumi, Asmaa Zaky Turky, K. Diab
Objectives : To evaluate the association of serum level of tumor necrosis factor alpha (TNF a ) and its gene polymorphism with hepatocellular carcinoma (HCC). Background : HCC is one of the commonest fatal tumors worldwide. It is a major international public health concern and considered the third leading cause of cancer-related death in the world. HCC is the second and sixth most prevalent cancer in men and women, respectively, in Egypt. TNF a is a pleiotropic cytokine mainly produced by monocytes and macrophages. It has been linked to a number of physiological and pathological disorders. TNF a serum levels and its gene polymorphism have been shown to be signi fi cantly elevated in patients with various liver diseases. Patients and methods : This study included 105 participants: 40 patients with HCC and 30 cirrhotic patients with no evidence of HCC who presented to the Hepatology Department, National Liver Institute, Menou fi a University, as well as 35 age-matched and sex-matched healthy controls. TNF serum levels were measured using ELISA, and its gene polymorphism (rs1799964) was determined by PCR. Results : Our study found a signi fi cant statistical difference between patients with HCC and control group, as well as be-tween cirrhotic patients and control group, but no signi fi cant difference between patients with HCC and cirrhotic patients regarding TNF polymorphism (rs1799964). Moreover, we found a signi fi cant statistical difference in TNF serum levels be-tweenpatientswithHCCandcontrolgroup,cirrhoticpatientsandcontrolgroup,andpatientswithHCCandcirrhoticpatients. Conclusion : Serum levels of TNF a and its gene polymorphism (rs1799964) may be associated with an increased risk of HCC development.
{"title":"Serum Level of TNFα and Its Gene Polymorphism Association with Hepatocellular Carcinoma","authors":"A. Elshaarawy, Eman Gawish, N. Bayoumi, Asmaa Zaky Turky, K. Diab","doi":"10.59204/2314-6788.1017","DOIUrl":"https://doi.org/10.59204/2314-6788.1017","url":null,"abstract":"Objectives : To evaluate the association of serum level of tumor necrosis factor alpha (TNF a ) and its gene polymorphism with hepatocellular carcinoma (HCC). Background : HCC is one of the commonest fatal tumors worldwide. It is a major international public health concern and considered the third leading cause of cancer-related death in the world. HCC is the second and sixth most prevalent cancer in men and women, respectively, in Egypt. TNF a is a pleiotropic cytokine mainly produced by monocytes and macrophages. It has been linked to a number of physiological and pathological disorders. TNF a serum levels and its gene polymorphism have been shown to be signi fi cantly elevated in patients with various liver diseases. Patients and methods : This study included 105 participants: 40 patients with HCC and 30 cirrhotic patients with no evidence of HCC who presented to the Hepatology Department, National Liver Institute, Menou fi a University, as well as 35 age-matched and sex-matched healthy controls. TNF serum levels were measured using ELISA, and its gene polymorphism (rs1799964) was determined by PCR. Results : Our study found a signi fi cant statistical difference between patients with HCC and control group, as well as be-tween cirrhotic patients and control group, but no signi fi cant difference between patients with HCC and cirrhotic patients regarding TNF polymorphism (rs1799964). Moreover, we found a signi fi cant statistical difference in TNF serum levels be-tweenpatientswithHCCandcontrolgroup,cirrhoticpatientsandcontrolgroup,andpatientswithHCCandcirrhoticpatients. Conclusion : Serum levels of TNF a and its gene polymorphism (rs1799964) may be associated with an increased risk of HCC development.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"os-34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87418126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. A. El-Kapany, I. A. Al-Ahmar, Mona Sabry Elkholy, Rasha Abdelhafiz Aly, Ahmed Ali Saad Ali Hassan
Background : Temporal lobe epilepsy (TLE) is the most common type of intractable and partial epilepsies. The only standard treatment for seizure-free status with manifest TLE is surgical, which includes amygdalohippocampectomy. The majority of temporal lobe seizures originates in the mesial temporal structures, primarily in the hippocampus, parahippocampal gyrus, and amygdala. Objectives : To compare the lateralizing ability of magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in patients with TLE. Patients and methods : The study recruited 50 participants who were assigned into two groups: the fi rst group included 25 epileptic cases and the second group included 25 normal controls. Age showed a mean ± SD of 24.22 ± 9.7 years. All participants were subjected to the following, clinical assessment, electroencephalography, and radiological assessment including MRI epilepsy protocol, MRS, and DTI. Data were collected, revised, then extracted, and coded in Excel fi les. Results : MRS has demonstrated consistent metabolic abnormalities in partial seizures. Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%), followed by MRS (accuracy ¼ 92%), and DTI difference more than or equal to 0.014 (accuracy ¼ 86%). Conclusion : Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%). MRS is a highly sensitive tool to predict the TLE (accuracy ¼ 92%). DTI difference more than or equal to 0.014 (accuracy ¼ 86%), so it has high value also in the diagnosis of TLE.
{"title":"Lateralizing Ability of Magnetic Resonance Spectroscopy and Diffusion Tensor imaging in Temporal Lobe Epilepsy","authors":"R. A. El-Kapany, I. A. Al-Ahmar, Mona Sabry Elkholy, Rasha Abdelhafiz Aly, Ahmed Ali Saad Ali Hassan","doi":"10.59204/2314-6788.1011","DOIUrl":"https://doi.org/10.59204/2314-6788.1011","url":null,"abstract":"Background : Temporal lobe epilepsy (TLE) is the most common type of intractable and partial epilepsies. The only standard treatment for seizure-free status with manifest TLE is surgical, which includes amygdalohippocampectomy. The majority of temporal lobe seizures originates in the mesial temporal structures, primarily in the hippocampus, parahippocampal gyrus, and amygdala. Objectives : To compare the lateralizing ability of magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in patients with TLE. Patients and methods : The study recruited 50 participants who were assigned into two groups: the fi rst group included 25 epileptic cases and the second group included 25 normal controls. Age showed a mean ± SD of 24.22 ± 9.7 years. All participants were subjected to the following, clinical assessment, electroencephalography, and radiological assessment including MRI epilepsy protocol, MRS, and DTI. Data were collected, revised, then extracted, and coded in Excel fi les. Results : MRS has demonstrated consistent metabolic abnormalities in partial seizures. Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%), followed by MRS (accuracy ¼ 92%), and DTI difference more than or equal to 0.014 (accuracy ¼ 86%). Conclusion : Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%). MRS is a highly sensitive tool to predict the TLE (accuracy ¼ 92%). DTI difference more than or equal to 0.014 (accuracy ¼ 86%), so it has high value also in the diagnosis of TLE.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91538989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives : To evaluate the potential antidepressant effect of rutin in diabetic rats and the assumed underlying mechanisms involved. Background : Depression is a common behavioral disorder among diabetic patients. Oxidative stress and in fl ammation are strongly involved in pathophysiology of diabetes-induced depression. Rutin is major fl avonoid that is proved to have neuroprotective effects through antioxidant and anti-in fl ammatory properties. Methods : A total of 24 male Wistar rats were distributed (eight/group) into control, diabetic, and diabetic þ rutin groups. The depressive-like behavior of the animals was assessed by forced swim test. Fasting serum glucose, serum glycosylated hemoglobin A1c, malondialdehyde, total antioxidant capacity, tumor necrosis factor-a , and interleukin 1 b were measured; in addition, hippocampal serotonin and hippocampal brain-derived neurotrophic factor (BDNF) were also assessed. Results : The diabetic group showed signi fi cant increase in fasting serum levels of glucose, serum glycosylated hemoglobin A1c, malondialdehyde, tumor necrosis factor-a , and interleukin 1 b and signi fi cant decrease in serum total antioxidant capacity, hippocampal serotonin, and hippocampal BDNF levels when compared with the control group, as well as increased immobility time and decrease latency to immobility of forced swim test compared with the control group. Rutin attenuated diabetes-induced depression through improving glycemic state, oxidative stress biomarkers, in fl ammatory mediators, and increased hippocampal serotonin and hippocampal BDNF levels. Conclusion : Rutin exerted antidepressant effects in diabetic rats via antioxidant and anti-in fl ammatory properties and increased serotonin and BDNF levels.
{"title":"Rutin exerts antidepressant effect in a rat model of diabetes","authors":"S. Khodir, E. Ali, Heba El-domiaty","doi":"10.59204/2314-6788.1016","DOIUrl":"https://doi.org/10.59204/2314-6788.1016","url":null,"abstract":"Objectives : To evaluate the potential antidepressant effect of rutin in diabetic rats and the assumed underlying mechanisms involved. Background : Depression is a common behavioral disorder among diabetic patients. Oxidative stress and in fl ammation are strongly involved in pathophysiology of diabetes-induced depression. Rutin is major fl avonoid that is proved to have neuroprotective effects through antioxidant and anti-in fl ammatory properties. Methods : A total of 24 male Wistar rats were distributed (eight/group) into control, diabetic, and diabetic þ rutin groups. The depressive-like behavior of the animals was assessed by forced swim test. Fasting serum glucose, serum glycosylated hemoglobin A1c, malondialdehyde, total antioxidant capacity, tumor necrosis factor-a , and interleukin 1 b were measured; in addition, hippocampal serotonin and hippocampal brain-derived neurotrophic factor (BDNF) were also assessed. Results : The diabetic group showed signi fi cant increase in fasting serum levels of glucose, serum glycosylated hemoglobin A1c, malondialdehyde, tumor necrosis factor-a , and interleukin 1 b and signi fi cant decrease in serum total antioxidant capacity, hippocampal serotonin, and hippocampal BDNF levels when compared with the control group, as well as increased immobility time and decrease latency to immobility of forced swim test compared with the control group. Rutin attenuated diabetes-induced depression through improving glycemic state, oxidative stress biomarkers, in fl ammatory mediators, and increased hippocampal serotonin and hippocampal BDNF levels. Conclusion : Rutin exerted antidepressant effects in diabetic rats via antioxidant and anti-in fl ammatory properties and increased serotonin and BDNF levels.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82810039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rasha A. El-Kapan, M. Melake, Asmaa M. Sharshar, Ahmed Mounir
Objectives : To de fi ne any neurological manifestations and problems of de fi nite coronavirus disease 2019 (COVID-19) infection patients, and its relation with onset and evolution of the infection. Background : Spread of COVID-19 infections has been rapid in both low-income and high-income countries. Outbreak of respiratory disease took place in China in December 2019, and it later spread to other countries. Acute neurological insults are more likely in studied cases who are badly infected. Patients and methods : This study is cross-sectional research. Data were obtained from the archived fi les of the selected COVID-19 patients, in addition to patients who were admitted at isolated ICU and inpatient rooms of Menou fi a University Hospitals, Shebin El-Kom Teaching Hospital, El-Bajur General Hospital, Menou fi a General Hospital, and Sirs-Ellian General Hospital. The duration of the recruiting period was from February to August 2021. Results : In the multivariate logistic regression, the signi fi cant predictors of the neurological manifestations are female sex, obesity, diabetes mellitus, and any comorbidity. Conclusion : A wide range of neurological manifestations, such as central nervous system and peripheral nervous system manifestations, can happen in COVID-19 studied cases, regardless of disease severity, with higher incidence in severe category of studied cases. In evaluation of studied cases with COVID-19 and neurological symptoms, detailed history and neurological examination, as well as proper assessment by expert neurologists, are required.
{"title":"Prevalence of Neurological Manifestations and Complications of COVID-19 in Menoufia Governorate","authors":"Rasha A. El-Kapan, M. Melake, Asmaa M. Sharshar, Ahmed Mounir","doi":"10.59204/2314-6788.1007","DOIUrl":"https://doi.org/10.59204/2314-6788.1007","url":null,"abstract":"Objectives : To de fi ne any neurological manifestations and problems of de fi nite coronavirus disease 2019 (COVID-19) infection patients, and its relation with onset and evolution of the infection. Background : Spread of COVID-19 infections has been rapid in both low-income and high-income countries. Outbreak of respiratory disease took place in China in December 2019, and it later spread to other countries. Acute neurological insults are more likely in studied cases who are badly infected. Patients and methods : This study is cross-sectional research. Data were obtained from the archived fi les of the selected COVID-19 patients, in addition to patients who were admitted at isolated ICU and inpatient rooms of Menou fi a University Hospitals, Shebin El-Kom Teaching Hospital, El-Bajur General Hospital, Menou fi a General Hospital, and Sirs-Ellian General Hospital. The duration of the recruiting period was from February to August 2021. Results : In the multivariate logistic regression, the signi fi cant predictors of the neurological manifestations are female sex, obesity, diabetes mellitus, and any comorbidity. Conclusion : A wide range of neurological manifestations, such as central nervous system and peripheral nervous system manifestations, can happen in COVID-19 studied cases, regardless of disease severity, with higher incidence in severe category of studied cases. In evaluation of studied cases with COVID-19 and neurological symptoms, detailed history and neurological examination, as well as proper assessment by expert neurologists, are required.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80922112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. E. El Mashad, AyatMagdy Mohamed Abo El-Mag, Hanan Mostafa Elsayed
Background : Neonatal jaundice is a relatively prevalent disease. Probiotic supplementation therapy could assist in improving the recovery of neonatal jaundice. Objectives : The aim was to study the effect of probiotics on physiological jaundice. Patients and methods : This study was a double-blinded randomized clinical trial, which was prospectively conducted on 88 neonates admitted to the neonatal ICUs of Menou fi a University Hospital and Damanhour Teaching Hospital from January 2022 to April 2022. Infants were allocated into two groups: the probiotic group included 44 full-term neonates with physiological jaundice who were given the probiotics and the placebo group which included 44 neonates, who were given the placebo. Both groups received standard conventional phototherapy, but the probiotic group received a sachet of probiotic diluted in baby milk once daily until hospital discharge. The outcome variables were serum bilirubin level and the duration of phototherapy. Placebo was administered to the placebo group with 10 ml instilled water added to baby feeding. Results : There was statistically signi fi cant decrease in the duration of admission in the group that received prebiotics than the group that received placebo. There was no statistically signi fi cant difference found between the two groups regarding hemoglobin, platelets and white blood cells count, neutrophils, lymphocytes, C-reactive protein, total serum bilirubin, and direct serum bilirubin at discharge, blood group, and Coombs test. Conclusion : Probiotic supplementation therapy is an effective and safe therapy option for the treatment of physiological neonatal jaundice, without discernible side effects.
{"title":"Therapeutic effect of probiotics in neonatal physiological jaundice","authors":"G. E. El Mashad, AyatMagdy Mohamed Abo El-Mag, Hanan Mostafa Elsayed","doi":"10.59204/2314-6788.1000","DOIUrl":"https://doi.org/10.59204/2314-6788.1000","url":null,"abstract":"Background : Neonatal jaundice is a relatively prevalent disease. Probiotic supplementation therapy could assist in improving the recovery of neonatal jaundice. Objectives : The aim was to study the effect of probiotics on physiological jaundice. Patients and methods : This study was a double-blinded randomized clinical trial, which was prospectively conducted on 88 neonates admitted to the neonatal ICUs of Menou fi a University Hospital and Damanhour Teaching Hospital from January 2022 to April 2022. Infants were allocated into two groups: the probiotic group included 44 full-term neonates with physiological jaundice who were given the probiotics and the placebo group which included 44 neonates, who were given the placebo. Both groups received standard conventional phototherapy, but the probiotic group received a sachet of probiotic diluted in baby milk once daily until hospital discharge. The outcome variables were serum bilirubin level and the duration of phototherapy. Placebo was administered to the placebo group with 10 ml instilled water added to baby feeding. Results : There was statistically signi fi cant decrease in the duration of admission in the group that received prebiotics than the group that received placebo. There was no statistically signi fi cant difference found between the two groups regarding hemoglobin, platelets and white blood cells count, neutrophils, lymphocytes, C-reactive protein, total serum bilirubin, and direct serum bilirubin at discharge, blood group, and Coombs test. Conclusion : Probiotic supplementation therapy is an effective and safe therapy option for the treatment of physiological neonatal jaundice, without discernible side effects.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75500087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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