800x600 Background and Purpose: Few studies of psychopathology in patients with cognitive problems and refractory epilepsy (RE) have been performed . We aimed to assess depression, anxiety, and their determining factors in Bulgarian patients with RE and cognitive problems. Method s: We conduct ed a study based on questionnaires designed for people with intellectual disability (stigma scale, Glasgow Depression Scale, Glasgow Anxiety Scale) and a purposeful interview on clinical and social factors of 6 4 patients with RE and cognitive problems . Results : We found depression in 40.63% and anxiety in 71.43% of study participants. Depression correlated with female gender P < 0.01 ( c 2 = 6.48), seizure type P < 0.05 ( c 2 = 7.68), seizure severity P < 0.05 ( c 2 = 9.04), educational level P < 0.05 ( c 2 = 3.86), and stigma P < 0.01 ( c 2 = 12.57). Seizure severity, gender, stigma, and educational level proved to be predictors of depression on multivariate regression analysis P < 0.001 (F = 12.08). Anxiety correlated with seizure severity P < 0.05 ( c 2 = 8.65), focal neurological deficit P < 0.05 ( c 2 = 5.91), stigma P < 0.05 ( c 2 = 7.01), and depression P < 0.05 ( c 2 = 5.31). Seizure severity and focal neurological deficit were the only predictors of anxiety on multivariate regression analysis P < 0.001 (F = 6.35). Conclusions : W e have affirmed frequent anxiety and depression in patients with RE and cognitive problems and their clinical, social, and demographic determinants. The results from our study prove the necessity of a multidisciplinary approach to these patients. Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";}
{"title":"Determinants of depression and anxiety in patients with refractory epilepsy and cognitive problems","authors":"V. Ekaterina","doi":"10.14800/MCE.137","DOIUrl":"https://doi.org/10.14800/MCE.137","url":null,"abstract":"800x600 Background and Purpose: Few studies of psychopathology in patients with cognitive problems and refractory epilepsy (RE) have been performed . We aimed to assess depression, anxiety, and their determining factors in Bulgarian patients with RE and cognitive problems. Method s: We conduct ed a study based on questionnaires designed for people with intellectual disability (stigma scale, Glasgow Depression Scale, Glasgow Anxiety Scale) and a purposeful interview on clinical and social factors of 6 4 patients with RE and cognitive problems . Results : We found depression in 40.63% and anxiety in 71.43% of study participants. Depression correlated with female gender P < 0.01 ( c 2 = 6.48), seizure type P < 0.05 ( c 2 = 7.68), seizure severity P < 0.05 ( c 2 = 9.04), educational level P < 0.05 ( c 2 = 3.86), and stigma P < 0.01 ( c 2 = 12.57). Seizure severity, gender, stigma, and educational level proved to be predictors of depression on multivariate regression analysis P < 0.001 (F = 12.08). Anxiety correlated with seizure severity P < 0.05 ( c 2 = 8.65), focal neurological deficit P < 0.05 ( c 2 = 5.91), stigma P < 0.05 ( c 2 = 7.01), and depression P < 0.05 ( c 2 = 5.31). Seizure severity and focal neurological deficit were the only predictors of anxiety on multivariate regression analysis P < 0.001 (F = 6.35). Conclusions : W e have affirmed frequent anxiety and depression in patients with RE and cognitive problems and their clinical, social, and demographic determinants. The results from our study prove the necessity of a multidisciplinary approach to these patients. Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ \u0000 table.MsoNormalTable \u0000 {mso-style-name:\"Table Normal\"; \u0000 mso-tstyle-rowband-size:0; \u0000 mso-tstyle-colband-size:0; \u0000 mso-style-noshow:yes; \u0000 mso-style-priority:99; \u0000 mso-style-parent:\"\"; \u0000 mso-padding-alt:0cm 5.4pt 0cm 5.4pt; \u0000 mso-para-margin:0cm; \u0000 mso-para-margin-bottom:.0001pt; \u0000 mso-pagination:widow-orphan; \u0000 font-size:10.0pt; \u0000 font-family:\"Times New Roman\",\"serif\";}","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78558210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reflex epilepsies are a rare, unusual, complex & bizarre group of epilepsies seen most commonly in adolescent females ,most probably due to the hyper synchronization & propagation of epileptic cortex which are connected to each other through functional network occurring in innocuous ways such as an olfactory stimuli or as common as a sensory, visual, somato-sensory or a proprioceptive stimuli either isolated or in combination. However, there could be other set of unusual, however more complex & well known precipitants such as praxis, listening to music or reading a book. These can be diagnosed through a combination of good clinical history, Video EEG monitoring & Imaging of the brain especially functional MRI, ictal SPECT. Avoiding exposure to inciting stimulus and adequate anti-epileptic medication, forms the corner stone of treatment of this condition.
{"title":"BRIEF REPORT ON REFLEX EPILEPSY","authors":"A. Deshpande, Vikram Khardenavis","doi":"10.14800/MCE.150","DOIUrl":"https://doi.org/10.14800/MCE.150","url":null,"abstract":"Reflex epilepsies are a rare, unusual, complex & bizarre group of epilepsies seen most commonly in adolescent females ,most probably due to the hyper synchronization & propagation of epileptic cortex which are connected to each other through functional network occurring in innocuous ways such as an olfactory stimuli or as common as a sensory, visual, somato-sensory or a proprioceptive stimuli either isolated or in combination. However, there could be other set of unusual, however more complex & well known precipitants such as praxis, listening to music or reading a book. These can be diagnosed through a combination of good clinical history, Video EEG monitoring & Imaging of the brain especially functional MRI, ictal SPECT. Avoiding exposure to inciting stimulus and adequate anti-epileptic medication, forms the corner stone of treatment of this condition.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75441204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Dewan, P. Kelly, S. Zuckerman, P. Morone, J. Mocco
Seizures complicate the hospital course of up to a quarter of patients suffering from aneurysmal subarachnoid hemorrhage. Despite limited evidence supporting the role of antiepileptic medications, many practitioners prescribe AEDs with the notion that any clinical benefit likely outweighs the minimal and rare deleterious effects. Herein we underscore recently published results of a survey of expert clinicians on this topic. While there was disagreement regarding the necessity to offer pharmacologic prophylaxis, those practitioners that did endorse prophylaxis utilized levetiracetam with far greater frequency than any other AED. The authors indicate the importance and timeliness of a randomized trial investigating on the topic.
{"title":"The role of levetiracetam following aneurysmal subarachnoid hemorrhage: current practice and future directions","authors":"M. Dewan, P. Kelly, S. Zuckerman, P. Morone, J. Mocco","doi":"10.14800/MCE.139","DOIUrl":"https://doi.org/10.14800/MCE.139","url":null,"abstract":"Seizures complicate the hospital course of up to a quarter of patients suffering from aneurysmal subarachnoid hemorrhage. Despite limited evidence supporting the role of antiepileptic medications, many practitioners prescribe AEDs with the notion that any clinical benefit likely outweighs the minimal and rare deleterious effects. Herein we underscore recently published results of a survey of expert clinicians on this topic. While there was disagreement regarding the necessity to offer pharmacologic prophylaxis, those practitioners that did endorse prophylaxis utilized levetiracetam with far greater frequency than any other AED. The authors indicate the importance and timeliness of a randomized trial investigating on the topic.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78981353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Periventricular nodular heterotopias (PNH) is a neuronal migration disorder characterized by nodules of gray matter located along the lateral ventricles, which can range from isolated single nodules to bilateral confluent nodules. This malformation of cortical development can be related genetic or extrinsic factors. Reading dysfluency, epilepsy and normal intelligence are main hallmark. PNH and overlying cortex integrate a (dis)functional network. In this review, we discuss the recent progress about pathogenes and epileptogenesis on PNH, and their participation in the processing of higher cortical functions.
{"title":"Periventricular Nodular Heterotopia: Pathogenesis, Epileptogenesis and Implications in Higher Cerebral Functions.","authors":"Valmir Passarelli, Camila Hobi Moreira","doi":"10.14800/MCE.20","DOIUrl":"https://doi.org/10.14800/MCE.20","url":null,"abstract":"Periventricular nodular heterotopias (PNH) is a neuronal migration disorder characterized by nodules of gray matter located along the lateral ventricles, which can range from isolated single nodules to bilateral confluent nodules. This malformation of cortical development can be related genetic or extrinsic factors. Reading dysfluency, epilepsy and normal intelligence are main hallmark. PNH and overlying cortex integrate a (dis)functional network. In this review, we discuss the recent progress about pathogenes and epileptogenesis on PNH, and their participation in the processing of higher cortical functions.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80052022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There are between 20 and 30 drugs available for the treatment of seizures but despite this ~30% of the epilepsy population remains unresponsive to treatment. The underlying mechanisms behind drug resistance in temporal lobe epilepsy (TLE) have not been completely identified. The purpose of this study was to determine if distinct types of neuronal firing patterns occurring in human epileptic cortex are altered by carbamazepine (CBZ). We used whole-cell patch-clamp techniques combined with intracellular labeling to electrophysiologically and morphologically characterize neuronal populations in resected cortical tissue from patients with drug resistant epilepsy. We then determined if cells were uniformly resistant to carbamazepine or whether only a subset did not respond. Cortical spiking patterns were segregated in six main clusters: adapting high frequency cluster 1 and 2 (AHF1 and AHF2), adapting low frequency cluster 1 and 2 (ALF1 and ALF2), strongly adapting low frequency group (sALF) and one spike cluster (OS). A morphological analysis showed that some spiking patterns tend to be associated with specific neuronal morphology. OS group included only pyramidal cells while adapting high frequency groups (AHF1 &AHF2) displayed typical interneuron phenotype. Finally, we found that CBZ does not uniformly suppress neuronal activity as only ~27% of interneurons and ~40% of pyramidal cells were carbamazepine insensitive. These data indicate that in humans with DRE there is a heterogeneous CBZ insensitivity in all sub-populations of neurons.
{"title":"Electrophysiological properties and carbamazepine sensitivity of epileptic human cortical neurons","authors":"C. Gavrilovici, R. McLachlan, M. Poulter","doi":"10.14800/MCE.132","DOIUrl":"https://doi.org/10.14800/MCE.132","url":null,"abstract":"There are between 20 and 30 drugs available for the treatment of seizures but despite this ~30% of the epilepsy population remains unresponsive to treatment. The underlying mechanisms behind drug resistance in temporal lobe epilepsy (TLE) have not been completely identified. The purpose of this study was to determine if distinct types of neuronal firing patterns occurring in human epileptic cortex are altered by carbamazepine (CBZ). We used whole-cell patch-clamp techniques combined with intracellular labeling to electrophysiologically and morphologically characterize neuronal populations in resected cortical tissue from patients with drug resistant epilepsy. We then determined if cells were uniformly resistant to carbamazepine or whether only a subset did not respond. Cortical spiking patterns were segregated in six main clusters: adapting high frequency cluster 1 and 2 (AHF1 and AHF2), adapting low frequency cluster 1 and 2 (ALF1 and ALF2), strongly adapting low frequency group (sALF) and one spike cluster (OS). A morphological analysis showed that some spiking patterns tend to be associated with specific neuronal morphology. OS group included only pyramidal cells while adapting high frequency groups (AHF1 &AHF2) displayed typical interneuron phenotype. Finally, we found that CBZ does not uniformly suppress neuronal activity as only ~27% of interneurons and ~40% of pyramidal cells were carbamazepine insensitive. These data indicate that in humans with DRE there is a heterogeneous CBZ insensitivity in all sub-populations of neurons.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89574982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan-Feng Zhang, Shu-lei Li, Tianqing Xiong, Yan-Chao Li
Post status epilepticus (SE) and chemical kindling are two widely used animal models for epileptic studies The pilocarpine-treated C57BL/6 mice exhibited stereotypical alterations of F-actin networks, including a severe reduction of F-actin in area CA1-CA3 and in the hilum. By contrast, F-actin networks seemed less affected by pentylenetetrazol kindling, and almost no remarkable alterations were noted in area CA1 or in the hilum. The overall labeling of F-actin in the hippocampus was generally consistent with the pathological observations on dendritic spines reported in both the epileptic models. Because the reorganized F-actin network can lead to long-term stabilization of synaptic changes and to consolidation of the enhanced neuronal activity, the alterations of F-actin networks may be related to the aberrant hyperexcitability in the epileptic animals.
{"title":"The rearrangement of synaptic actin networks after pilocarpine-induced status epilepticus and pentylenetetrazol-induced kindling","authors":"Yan-Feng Zhang, Shu-lei Li, Tianqing Xiong, Yan-Chao Li","doi":"10.14800/MCE.128","DOIUrl":"https://doi.org/10.14800/MCE.128","url":null,"abstract":"Post status epilepticus (SE) and chemical kindling are two widely used animal models for epileptic studies The pilocarpine-treated C57BL/6 mice exhibited stereotypical alterations of F-actin networks, including a severe reduction of F-actin in area CA1-CA3 and in the hilum. By contrast, F-actin networks seemed less affected by pentylenetetrazol kindling, and almost no remarkable alterations were noted in area CA1 or in the hilum. The overall labeling of F-actin in the hippocampus was generally consistent with the pathological observations on dendritic spines reported in both the epileptic models. Because the reorganized F-actin network can lead to long-term stabilization of synaptic changes and to consolidation of the enhanced neuronal activity, the alterations of F-actin networks may be related to the aberrant hyperexcitability in the epileptic animals.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75033431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Excessive neocortical cellular excitability secondary to complex molecular mechanisms involving Sodium Pottasium ATPase & elevated glutamate ,potassium levels in extracellular fluid form the possible common underlying mechanism for causation of ophthalmoplegic migraine & juvenile myoclonic epilepsy both alike and further research is needed to establish these hypothesis in the future.
{"title":"Ophthalmoplegic Migraine and Juvenile Myoclonic Epilepsy: Two side of the same coin?","authors":"A. Deshpande, Supriya Khardenavis, Aakash Shetty","doi":"10.14800/MCE.70","DOIUrl":"https://doi.org/10.14800/MCE.70","url":null,"abstract":"Excessive neocortical cellular excitability secondary to complex molecular mechanisms involving Sodium Pottasium ATPase & elevated glutamate ,potassium levels in extracellular fluid form the possible common underlying mechanism for causation of ophthalmoplegic migraine & juvenile myoclonic epilepsy both alike and further research is needed to establish these hypothesis in the future.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77034857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Catedra de Quimica Medicinal; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - La Plata; Argentina
{"title":"How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?","authors":"M. D. Ianni, A. Talevi","doi":"10.14800/MCE.30","DOIUrl":"https://doi.org/10.14800/MCE.30","url":null,"abstract":"Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Catedra de Quimica Medicinal; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - La Plata; Argentina","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82593449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Homeobox-containing transcription factors crucially regulate the patterning and regionalization of the developing nervous system, as well as the proliferation, survival and differentiation of distinct neuronal populations. Altered expression of these factors markedly impacts the structure and function of the embryonic and adult central nervous system (CNS). In both humans and mice, mutations of homeobox genes have been associated to severe syndromes characterized by developmental CNS defects, which often lead to the occurrence of seizures in the adult life. Among homeobox genes, Otx genes ( Otx1 and Otx2) are crucially involved in brain regionalization. Our previous work showed that mice lacking Otx1 present cerebral cortex defects and develop epilepsy, whereas mice with conditional deletion or overexpression of Otx2 show profound alterations in midbrain-to-forebrain circuits, which are accompanied by an abnormal response to experimentally-induced seizures. In this brief review, we highlight and discuss the major findings suppporting the role of Otx genes in sculpting midbrain and forebrain circuits involved in epileptogenesis.
{"title":"Otx genes and seizure susceptibility","authors":"Y. Bozzi, A. Simeone","doi":"10.14800/MCE.74","DOIUrl":"https://doi.org/10.14800/MCE.74","url":null,"abstract":"Homeobox-containing transcription factors crucially regulate the patterning and regionalization of the developing nervous system, as well as the proliferation, survival and differentiation of distinct neuronal populations. Altered expression of these factors markedly impacts the structure and function of the embryonic and adult central nervous system (CNS). In both humans and mice, mutations of homeobox genes have been associated to severe syndromes characterized by developmental CNS defects, which often lead to the occurrence of seizures in the adult life. Among homeobox genes, Otx genes ( Otx1 and Otx2) are crucially involved in brain regionalization. Our previous work showed that mice lacking Otx1 present cerebral cortex defects and develop epilepsy, whereas mice with conditional deletion or overexpression of Otx2 show profound alterations in midbrain-to-forebrain circuits, which are accompanied by an abnormal response to experimentally-induced seizures. In this brief review, we highlight and discuss the major findings suppporting the role of Otx genes in sculpting midbrain and forebrain circuits involved in epileptogenesis.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81257079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The seizure prognosis of using P450 enzyme inducing and non-enzyme inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery has been investigated in several clinical studies. However, the results of these studies are inconsistent. Additional multicenter RCTs are necessary to provide class I evidence on the role of AEDs in the treatment of glioma associated seizure.
{"title":"Is non-P450 enzyme inducing antiepileptic drugs the best ADEs choice for glioblastoma patients?","authors":"Mao Qing","doi":"10.14800/MCE.32","DOIUrl":"https://doi.org/10.14800/MCE.32","url":null,"abstract":"The seizure prognosis of using P450 enzyme inducing and non-enzyme inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery has been investigated in several clinical studies. However, the results of these studies are inconsistent. Additional multicenter RCTs are necessary to provide class I evidence on the role of AEDs in the treatment of glioma associated seizure.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74892409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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