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2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515)最新文献

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Ultrahigh-resolution small-animal imaging using a silicon detector 使用硅探测器的超高分辨率小动物成像
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352269
T. Peterson, Donald W. Wilson, H. Barrett
We have developed a prototype ultrahigh-resolution small-animal imaging system that utilizes a silicon detector with a multiple-pinhole aperture. This system is suitable for imaging low-energy photons such as those from I-125 decay (27.2-35.5 keV) or the X-rays from I-123 decay (27.2-31.8 keV). The silicon detector is a double-sided strip detector of 300-micrometer thickness and 50-micrometer strip pitch, with 560 strips on one side and 1260 strips on the other. The readout utilizes VaTaGP2.2 ASICs from IDEAS ASA, Norway. When the detector is coupled with a multiple-pinhole aperture and operated in a synthetic-collimator configuration it should be possible to do tomographic image reconstructions without rotation of either the object or imager.
我们已经开发了一种原型的超高分辨率小动物成像系统,它利用了一个带有多针孔孔径的硅探测器。该系统适用于成像低能量光子,如来自I-125衰变(27.2-35.5 keV)或来自I-123衰变(27.2-31.8 keV)的x射线。硅探测器是厚度为300微米,带间距为50微米的双面带探测器,一面560条,另一面1260条。读出采用挪威IDEAS ASA的VaTaGP2.2 asic。当检测器与一个多针孔孔径相耦合并在一个合成准直器配置中操作时,它应该可以在不旋转物体或成像仪的情况下进行层析图像重建。
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引用次数: 8
Multiple pinhole aperture design using a modified Uniform Cramer-Rao Bound 采用改进的均匀Cramer-Rao边界进行多针孔孔径设计
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352358
L. Meng, N. Clinthorne
This work presents a design study of using multiple pinhole apertures in small animal SPECT imaging applications. The SPECT system is based on the use of an existing ADAC gamma camera. For quantifying the performance of a detector design, we used the minimum achievable variance at several locations in the images, given some constraints on the resulting spatial resolution. This approach was formerly proposed as the Uniform Cramer-Rao Bound (UCRB). In this work, we propose to use a resolution constraint that is imposed on the mean gradient vector. This partially overcomes the limitations of the former UCRB approach based on the bias-gradient norm constraint. We applied this method for studying the effect of design parameters, such as number of pinholes and pinhole size, on the performance of the detector system.
这项工作提出了在小动物SPECT成像应用中使用多个针孔孔径的设计研究。SPECT系统是基于现有的ADAC伽马相机的使用。为了量化探测器设计的性能,我们使用了图像中几个位置的最小可实现方差,给出了对所得空间分辨率的一些限制。这种方法以前被称为统一Cramer-Rao边界(UCRB)。在这项工作中,我们建议使用对平均梯度向量施加的分辨率约束。这在一定程度上克服了以往基于偏倚梯度范数约束的UCRB方法的局限性。应用该方法研究了针孔数和针孔尺寸等设计参数对探测器系统性能的影响。
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引用次数: 1
Practically feasible histogram-mode and list-mode EM reconstructions with full motion compensation 具有全运动补偿的直方图模式和列表模式EM重建
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352420
A. Rahmim, P. Bloomfield, S. Houle, M. Lenox, C. Michel, V. Sossi
With continuous improvements in spatial resolution of PET scanners, small patient movements during PET imaging become a significant source of resolution degradation. This work explores incorporation of motion information into EM reconstruction algorithms. Precorrection of the data for attenuation and normalization as well as weighted schemes, in which these correction factors are incorporated into the system matrix, are considered. An important issue addressed is the existence of LORs corresponding to no actual pairs of detectors and their motion-induced "interaction" with the detectable LORs. An example of this is a scanner design with gaps existing in-between the detector heads. It is shown that to properly account for such LORs in histogram-mode and list-mode EM reconstructions, in addition to motion-correction of the data, the algorithms themselves must be modified. This modification is implemented by including time-weighted sensitivity correction factors. A practically feasible method for calculation of sensitivity factors is derived based on image-space monitoring of voxel motion during the scan.
随着PET扫描仪空间分辨率的不断提高,患者在PET成像过程中的微小运动成为分辨率下降的重要来源。这项工作探讨了将运动信息整合到EM重建算法中。考虑了衰减和归一化数据的预校正以及将这些校正因子纳入系统矩阵的加权方案。一个重要的问题是LORs的存在对应于没有实际的检测器对以及它们与可检测LORs的运动诱导的“相互作用”。这方面的一个例子是扫描器的设计与存在的间隙之间的探测器头。结果表明,为了在直方图模式和列表模式的EM重建中正确考虑这种LORs,除了对数据进行运动校正外,还必须对算法本身进行修改。这种修正是通过加入时间加权灵敏度校正因子来实现的。基于扫描过程中体素运动的图像空间监测,推导出一种切实可行的灵敏度因子计算方法。
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引用次数: 3
Implementation of short-scan reconstruction with compensation for geometric alignment for a microCT system 微ct系统几何对准补偿短扫描重建的实现
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352511
S.A. Sawyer, E. Frey, B. He, Yuchuan Wang, B. Tsui
Typical microCT systems for in vivo small animal imaging have a total acquisition time on the order of 10 minutes for a single scan, with the detector read-out time often a major contributor to acquisition length. Reduction of the portion of the scan time spent in read-out can be achieved through short-scan acquisition. Knowledge of and correction for geometric misalignments is another crucial factor in obtaining high quality microCT images. In this work, we have implemented a short-scan Feldkamp algorithm with correction geometric misalignment. Due to our system misalignments, severe ghosting artifacts are present in the reconstruction. We have implemented a reconstruction algorithm with correction for the misalignments which eliminates the ghosting artifacts. Comparisons of full-scan and short-scan reconstructions of both phantom and mouse data show similar image quality. We have also compared short-scan reconstructions to full-scan reconstructions from projection data with roughly the same total acquisition time. In this case, blurring is visible in sagittal slices of the full-scan reconstructions that is not present in the short-scan reconstructions. Short-scan acquisition provides reduction of the total acquisition time resulting in microCT images without the loss in image quality obtained by simply reducing the number of projections for a full-scan acquisition. Axis of rotation horizontal transversal off-center shift and the X-ray source horizontal transversal shift are the most sensitive parameters.
用于活体小动物成像的典型微ct系统单次扫描的总采集时间约为10分钟,检测器读出时间通常是采集时间的主要贡献者。通过短扫描采集可以减少用于读出的扫描时间部分。几何偏差的知识和校正是获得高质量微ct图像的另一个关键因素。在这项工作中,我们实现了一种具有校正几何偏差的短扫描费尔德坎普算法。由于我们的系统错位,在重建中存在严重的重影伪影。我们实现了一种重建算法,对不对齐进行校正,消除了重影伪影。幻影和小鼠数据的全扫描和短扫描重建比较显示出相似的图像质量。我们还比较了投影数据的短扫描重建和全扫描重建,它们的总采集时间大致相同。在这种情况下,在全扫描重建的矢状面切片中可见模糊,而在短扫描重建中不存在。短扫描采集减少了获得微ct图像的总采集时间,而无需通过简单地减少全扫描采集的投影数量而降低图像质量。旋转轴水平横向偏移和x射线源水平横向偏移是最敏感的参数。
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引用次数: 1
Upgrade of the XFT trigger for CDF 升级CDF的XFT触发器
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352033
R. Hughes, M. Kasten, B. Kilminster, K. Lannon, S. Levine, K. Pitts, G. Veramendi, B. Winer
The CDF Detector at the Tevatron currently uses an online track trigger, known as the XFT, to identify charged tracks with P/sub T/ > 1.5 GeV/c which are then utilized in a number of ways to produce an event-by-event trigger decision. The tracks found by the XFT are utilized in approximately 80 percent of the physics triggers, including identification of high energy leptons (e, /spl mu/, /spl tau/), events containing heavy, flavor (c, b, t) and events with interesting topologies in for searches for new phenomena. The XFT is functioning well in the current system. As the Tevatron luminosity grows, occupancy in the tracking chamber increases from multiple proton-antiproton interactions. In the trigger, this additional occupancy will cause the tracking resolution to degrade and the rate of fake tracks to grow. We propose to upgrade the existing system to mitigate these effects and allow the CDF detector to operate at its fullest capacity at the highest possible luminosity.
Tevatron的CDF探测器目前使用在线轨道触发器,称为XFT,以识别P/sub T/ > 1.5 GeV/c的带电轨道,然后以多种方式利用这些轨道来产生逐个事件的触发决策。XFT发现的轨迹被用于大约80%的物理触发器,包括识别高能轻子(e, /spl mu/, /spl tau/),包含重、味(c, b, t)的事件,以及用于搜索新现象的具有有趣拓扑结构的事件。XFT在当前系统中运行良好。随着Tevatron光度的增加,跟踪室中的占用率因多质子-反质子相互作用而增加。在触发器中,这种额外的占用将导致跟踪分辨率降低和假跟踪率增加。我们建议升级现有系统,以减轻这些影响,并允许CDF探测器在尽可能高的亮度下以最大容量运行。
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引用次数: 0
Spatial-resolution enhancement in micro-CT 微ct的空间分辨率增强
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352589
Xiaochuan Pan, Lifeng Yu, C. Kao, C. Pelizzari
We propose a new strategy to improve sampling density and image resolution in micro-CT without changing hardware and without sacrificing the size of the allowable maximum field of view (FOV). Such a strategy is achieved by use of the asymmetric scanning configurations in which the center of rotation is moved to an off-center position and a reconstruction algorithm specifically developed for such configurations. We conducted numerical studies to validate and evaluate the proposed strategy, and quantitative results in these studies confirm that the proposed configurations and algorithm can significantly improve spatial resolution properties in micro-CT.
本文提出了一种在不改变硬件和不牺牲允许最大视场(FOV)尺寸的情况下提高微ct采样密度和图像分辨率的新策略。这种策略是通过使用旋转中心移动到偏离中心位置的非对称扫描配置和专门为这种配置开发的重建算法来实现的。我们进行了数值研究来验证和评估所提出的策略,这些研究的定量结果证实了所提出的配置和算法可以显著提高微ct的空间分辨率特性。
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引用次数: 0
A comparison of four image reconstruction algorithms for detection of small lesions in brain phantom 脑幻影小病灶检测的四种图像重建算法的比较
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352419
H. Baghaei, W. Wong, J. Uribe, H. Li, Y. Wang, Y. Liu, T. Xing, R. Ramirez, S. Xie, S. Kim
We compared two fully three-dimensional (3-D) image reconstruction algorithms and two 3-D rebinning algorithms followed by reconstruction with a two-dimensional (2-D) filtered backprojection algorithm. The two 3-D image reconstruction algorithms were ordered subsets expectation maximization (3D-OSEM) and 3-D reprojection (3DRP). The two rebinning algorithms were Fourier rebinning (FORE) and single slice rebinning (SSRB). The 3-D projection data used for this work were acquired with a high-resolution PET scanner (MDAPET) with an intrinsic transaxial resolution of 2.8 mm. The scanner has 14 detector rings covering an axial field-of-view of 38.5 mm. We scanned three phantoms: (1) a uniform cylindrical phantom with inner diameter of 20.5 cm, (2) a 11.5-cm cylindrical phantom with four embedded small lesions with diameters of 3, 4, 5, and 6 mm, and (3) the 3-D Hoffman brain phantom with three embedded small lesion phantoms with diameters of 3, 5, and 8.6 mm. We evaluated the different reconstruction methods by comparing the noise variance of images, contrast recovery and contrast-noise trade-off, lesion detectability, and by visually inspecting images. We found that overall the 3D-OSEM algorithm followed by post filtering produced the best results. Even though the MDAPET camera has a relatively small maximum axial acceptance (/spl plusmn/5 deg), the 3DRP algorithm produced slightly better images compared to the faster 2-D rebinning methods.
我们比较了两种全三维(3-D)图像重建算法和两种3-D重建算法,然后用二维(2-D)滤波后的反向投影算法进行重建。三维图像重建算法分别为有序子集期望最大化算法(3D-OSEM)和三维重投影算法(3DRP)。两种重构算法分别是傅里叶重构(FORE)和单片重构(SSRB)。这项工作使用的三维投影数据是通过高分辨率PET扫描仪(MDAPET)获得的,其固有的跨轴分辨率为2.8 mm。该扫描仪有14个探测器环,覆盖38.5毫米的轴向视野。我们扫描了三个幻象:(1)内径为20.5 cm的均匀圆柱形幻象,(2)直径为3、4、5和6 mm的直径为4个内嵌小病灶的11.5 cm圆柱形幻象,以及(3)直径为3、5和8.6 mm的3个内嵌小病灶的3- d Hoffman脑幻象。我们通过比较图像的噪声方差、对比度恢复和对比度-噪声权衡、损伤可检测性以及视觉检查图像来评估不同的重建方法。我们发现,总体而言,3D-OSEM算法之后的后滤波产生了最好的结果。尽管MDAPET相机具有相对较小的最大轴向接受度(/spl + /5度),但与更快的二维重建方法相比,3DRP算法产生的图像略好一些。
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引用次数: 1
Electronics design for a low-cost high-sensitivity rodent-research PET (RRPET) 低成本高灵敏度啮齿动物研究PET (RRPET)的电子设计
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352350
H. Li, Y. Liu, T. Xing, Wang Y, S. Xie, J. Uribe, H. Baghaei, R. Ramirez, S. Kim, W. Wong
We designed and implemented electronics for a low-cost high-sensitivity positron emission tomography camera for research involving rodents. To reduce cost and increase sensitivity, we used continuous full-ring photomultiplier tube (PMT) with quadrant sharing (PQS) detector design. In this prototype camera, 168 PMTs decode 144 scintillation detector blocks consisting of 9216 crystal elements. An Anger position matrix board weight sums the 144 detector blocks as eight individual gamma camera zones. The full-ring detector decoding is performed by eight fixed local zones. However, in the PMT-quadrant-sharing design, every two adjacent zones share seven axial PMTs. A boundary processing technique has been developed for the PMT-quadrant-sharing detector blocks so that the decoding of the full-ring detector can be performed by individual zones. A high-yield-pileup-event-recovery decoding board, a module-based coincidence processing system and a data acquisition computer, which were originally developed for a whole-body PET, can still be used by this rodent PET camera. The camera needs only eight decoding boards, and each board decodes 18 detector blocks of one detector zone. The entire decoding electronics need only 24 ADCs and can handle about six million events/second of single-rate. A motherboard decodes the control commands from the data acquisition computer, performs the real-time boundary processing and distributes DC power signals to all the eight decoding boards. To further reduce the cost and size of the camera, we have developed a new compact PMT voltage divider with adjustable PMT gain that can be controlled by programming the dynode high voltages directly. The very front-end preamplifier is also integrated into this divider board to increase the signal-to-noise ratio. A new instantaneous light-emitting diode automatic PMT gain calibration method is also used in this camera for better quality control; the gains of 168 PMTs can be equalized within 1 minute.
我们设计并实现了一种低成本的高灵敏度正电子发射断层成像相机,用于研究啮齿类动物。为了降低成本和提高灵敏度,我们采用了连续全环光电倍增管(PMT)和象限共享(PQS)探测器设计。在这个原型相机中,168个pmt解码由9216个晶体元素组成的144个闪烁检测器块。Anger位置矩阵板权重将144个探测器块相加为8个单独的伽马相机区域。全环探测器解码由8个固定的局部区域完成。然而,在pmt象限共享设计中,每两个相邻区域共享7个轴向pmt。针对pmt象限共享检测器块,提出了一种边界处理技术,使全环检测器的解码可以由单个区域进行。原本为全身PET开发的高产量堆积事件恢复解码板、基于模块的巧合处理系统和数据采集计算机仍然可以用于该啮齿动物PET相机。摄像机只需要8块译码板,每块译码板可以译码一个探测区的18个探测块。整个解码电子设备只需要24个adc,可以处理大约600万个事件/秒的单速率。主板对来自数据采集计算机的控制命令进行解码,进行实时边界处理,并将直流电源信号分配给所有八个解码板。为了进一步降低相机的成本和尺寸,我们开发了一种新的紧凑型PMT分压器,具有可调的PMT增益,可以通过直接编程dynode高压来控制。非常前端的前置放大器也集成到这个分频板,以提高信噪比。为了更好地控制相机的质量,该相机还采用了一种新的瞬时发光二极管自动PMT增益校准方法;168个pmt的增益可在1分钟内均衡。
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引用次数: 8
All-sky survey high resolution air-shower detector (Ashra) 全天巡天高分辨率风淋探测器(Ashra)
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352017
Y. Asaoka
We propose a new air fluorescence and Cerenkov detector Ashra. The Ashra phase-1 detector consists of 1+1/3 observational stations installed at the distance of 30-40 km in a mountain site. It ensures the large target mass for neutrinos and low-energy threshold for TeV gamma rays. The observational station is composed of 12 wide-angle high-precision telescope, which can cover completely all-sky view. Each telescope has a field-of-view of 50 deg. x 50 deg. and spot size resolution of 1 arcmin. To realize the Ashra telescope concept, we newly apply the following techniques matured in the other fields: i) Baker-Nunn optics optimized to keep better than 1 arcmin resolution in 50 deg. field of view, ii) electrostatic lens image intensifier tube with the resolution matched with that of the above optics, iii) photoelectric image pipeline with self triggering capability using light splitting after sufficient amplification, and iv) CMOS image sensor which read triggered images out of the above IIT. These novel techniques allow us an excellent opportunity for simultaneous observation of air fluorescence and Cerenkov lights with 1 arcmin resolution in entirely all sky. This will open a new field, "Observational Particle Astrophysics" by continuously observing TeV gamma-rays, VHE-neutrinos. Knee-CRs, and UHECRs.
提出了一种新的空气荧光和切伦科夫探测器Ashra。Ashra第一阶段探测器由1+1/3观测站组成,观测站安装在距离30-40公里的山区。它保证了中微子的大目标质量和TeV伽马射线的低能量阈值。观测站由12台广角高精度望远镜组成,可完全覆盖全天视野。每台望远镜的视场为50度x 50度,光斑尺寸分辨率为1角分。为了实现Ashra望远镜的概念,我们新应用了以下在其他领域成熟的技术:i)优化的贝克-纳恩光学元件在50度视场内保持优于1角分的分辨率;ii)静电透镜像增强管,其分辨率与上述光学元件相匹配;iii)光电图像管道,在充分放大后利用分光自触发能力;iv) CMOS图像传感器从上述IIT中读取触发图像。这些新技术使我们有机会在整个天空同时观测空气荧光和切伦科夫光,分辨率为1角分。这将打开一个新的领域,“观测粒子天体物理学”,通过连续观察TeV伽马射线,vhe中微子。膝cr和uhecr。
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引用次数: 3
Large-area balloon-borne polarized gamma ray observer (PoGO) 大面积球载偏振伽马射线观测仪
Pub Date : 2003-12-01 DOI: 10.1109/NSSMIC.2003.1352208
R. BIanford, P. Chen, T. Kamae, G. Madejski, J. Ng, T. Mizuno, H. Tajima, T. Thurston, L. Barbier, P. Bloser, T. Cline, S. Hunter, A. Harding, J. Krizmanic, J. Mitchell, R. Streitmatter, J. Tueller, E. Groth, R. Fernholz, D. Marlow, G. Bogaert, S. Gunji, H. Sakurai, Y. Saito, T. Takahashi, J. Kataoka, N. Kawai, Y. Fukazawa, P. Carlson, W. Klamra, M. Pearce, C. Bjornsson, C. Fransson, S. Larsson, F. Ryde
We are developing a new balloon-borne instrument (PoGO), to measure polarization of soft gamma rays (25-200 keV) using asymmetry in azimuth angle distribution of Compton scattering. PoGO will detect 10% polarization in 100mCrab sources in a 6-8 hour observation and bring a new dimension to studies on gamma ray emission/transportation mechanism in pulsars, AGNs, black hole binaries, and neutron star surface. The concept is an adaptation to polarization measurements of well-type phoswich counter technology used in balloon-borne experiments (Welcome-1) and AstroE2 Hard X-ray Detector. PoGO consists of close-packed array of 397 hexagonal well-type phoswich counters. Each unit is composed of a long thin tube (well) of slow plastic scintillator, a solid rod of fast plastic scintillator, and a short BGO at the base. A photomultiplier coupled to the end of the BGO detects light from all 3 scintillators. The rods with decay times < 10 ns, are used as the active elements; while the wells and BGOs, with decay times /spl sim/ 250 ns are used as active anti-coincidence. The fast and slow signals are separated out electronically. When gamma rays entering the field-of-view (fwhm /spl sim/3deg/sup 2/) strike a fast scintillator, some are Compton scattered. A fraction of the scattered photons are absorbed in another rod (or undergo a second scatter). A valid event requires one clean fast signal of pulse-height compatible with photo-absorption (> 20 keV) and one or more compatible with Compton scattering (< 10 keV). Studies based on EGS4 (with polarization features) and Geant4 predict excellent background rejection and high sensitivity.
我们正在开发一种新的球载仪器(PoGO),利用康普顿散射方位角分布的不对称性来测量软伽马射线(25-200 keV)的偏振。PoGO将在6-8小时的观测时间内探测到100mCrab源的10%极化,为脉冲星、agn、黑洞双星和中子星表面伽玛射线发射/输运机制的研究带来新的维度。该概念适用于球囊实验(Welcome-1)和AstroE2硬x射线探测器中使用的井型光子计数器技术的偏振测量。PoGO由397个六边形井型光控计数器组成。每个单元由一根细长的慢速塑料闪烁体管(井)、一根固体的快速塑料闪烁体棒和底部的短BGO组成。连接到BGO末端的光电倍增管可以检测所有3个闪烁体发出的光。将衰变时间< 10ns的棒作为活性元素;采用衰减时间为/spl sim/ 250 ns的井和bgo作为主动反重合。快慢信号通过电子方式分离。当伽玛射线进入视场(fwhm / sp1sim /3deg/sup /)击中一个快速闪烁体时,一些是康普顿散射。一部分散射的光子被另一根棒吸收(或经历第二次散射)。一个有效的事件需要一个干净的快速信号,其脉冲高度与光吸收兼容(> 20 keV),一个或多个与康普顿散射兼容(< 10 keV)。基于EGS4(具有极化特征)和Geant4的研究预测了良好的背景抑制和高灵敏度。
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引用次数: 5
期刊
2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515)
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